17 May Heart Disease Biomarkers, Including Lipoprotein(a) Elevated in Psoriasis
MedicalResearch.com Interview with:
Michael S. Garshick, MD
Department of Medicine
Grossman School of Medicine
MedicalResearch.com: What is the background for this study?
Response: Patients with psoriasis have a 50% higher risk of cardiovascular disease when compared to patients without psoriasis, the mechanisms of which are still under investigation
Dyslipidemia is also highly prevalent in psoriasis including elevation in a variety of lipoproteins causal in atherosclerosis. Lipoprotein(a) is an LDL like particle which is associated with atherosclerosis, atherothrombosis, and the development of clinical cardiovascular disease. Traditionally lipoprotein(a) is felt to be inherited rather than acquired, but some evidence suggest that lipoprotein(a) is elevated in those with underlying inflammatory conditions and associated with systemic inflammation including circulating IL-6.
We therefore aimed to determine if lipoprotein(a) is elevated in psoriasis and associated with underlying systemic inflammatory profiles and biomarkers of cardiovascular risk.
MedicalResearch.com: What are the main findings?
Response: In this study we show a suggestive trend of elevated lipoprotein(a) in psoriasis when compared to matched controls. We show a strong association between lipoprotein(a) , Il-6 (r=0.36, p<0.01) and IL-17A (r=0.38, p<0.01) in psoriasis. Finally, lipoprotein(a) was negatively associated with flow-mediated brachial artery reactivity (r=-0.63, p<0.01) and this association remained after adjustment for multiple covariates and confounders (β=-0.79, p<0.01).
MedicalResearch.com: What should readers take away from your report?
Response: Lipoprotein (a) is association with systemic inflammation and biomarkers of cardiovascular risk in psoriasis and may be one reason why the relative risk of a cardiovascular event is higher in patients with psoriasis.
MedicalResearch.com: What recommendations do you have for future research as a result of this work?
Response: Given lipoprotein(a)’s role as a cardiovascular risk enhancer in clinical cardiovascular guidelines, future studies should evaluate the utility of checking lipoprotein (a) and its prognostic implications in psoriasis.
ACC 21 Abstract:
Lipoprotein(A) Is Elevated In Psoriasis And Associated With Cardiovascular Risk
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