03 Mar IMAGINE Trial: Worse Outcomes For Women Than Men After CABG
Medical Research: What is the background for this study? What are the main findings?
Response: Although cardiovascular diseases are often considered a disease of men, more women than men die each year of cardiovascular diseases. Sex-differences are increasingly being researched and acknowledged. For treatment and prognosis of coronary artery disease, however, many discrepancies exist between studies that investigated sex-differences. For example, it remains unclear whether the observed differences in the outcome after coronary artery bypass grafting (CABG) are due to a different risk burden between men and women or whether female sex is an independent risk factor.
In a group of 2553 patients followed up during a median of 2.5 years after CABG we found an increased risk for worse outcome in women versus men. We found a strong indication for female sex as an independent risk factor, but lacked power to definitively prove th
Medical Research: What should clinicians and patients take away from your report?
Response: Sex-differences exist in cardiovascular diseases and cannot be ignored in treatment decisions that are made in everyday practice.
Medical Research: What recommendations do you have for future research as a result of this study?
Response: Definite answers regarding sex-differences in long-term outcome after CABG should come from future pooling of studies comprising a larger number of women.
MedicalResearch.com Interview with: Saskia Haitjema MD PhD candidate (2015). IMAGINE Trial: Worse Outcomes For Women Than Men After CABG