Inflammatory Biomarkers Found Linked to Risk of Mortality Interview with:
Archana Singh-Manoux, PhD

Research Professor (Directeur de Recherche)
Epidemiology of ageing & age-related diseases
INSERM,France What is the background for this study? What are the main findings?

Response: A recent metabolomics study examined 106 biomarkers and found alpha-1-acid glycoprotein (AGP), an acute phase protein, to be the strongest predictor of five-year mortality. It is also unknown how well AGP compares with other sensitive, dynamic, and commonly measured markers of systemic inflammation, such as CRP and IL-6, as a predictor of mortality.

We examined the association of these three inflammatory markers with short- and long-term mortality in a large sample of middle-aged adults, followed for 17 years. Our analysis of all-cause, cancer and cardiovascular mortality suggests that for all these outcomes IL-6 may be a better prognostic marker, both in the short and the long-term. What should readers take away from your report?

Response: Inflammatory markers are associated with a range of health conditions. Our study was based on community-dwelling, middle-aged adults and we found high levels of inflammatory markers to carry risk of mortality. What recommendations do you have for future research as a result of this study?

Response: Omics technologies allow the concurrent assessment of many biomarkers, some of which may turn out to be important to detect preclinical states of diseases or be markers of future disease. Thank you for your contribution to the community.

Russ Tom C, Stamatakis Emmanuel, Hamer Mark, Starr John M, Kivimäki Mika, Batty G David et al.Association between psychological distress and mortality: individual participant pooled analysis of 10 prospective cohort studies BMJ 2012; 345:e4933

Note: Content is Not intended as medical advice. Please consult your health care provider regarding your specific medical condition and questions.

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