Long-Term Effects Of Ischemic Post-Conditioning With PCI for STEMI

MedicalResearch.com Interview with:
Joo-Yong Hahn, MD, PhD
Associate Professor
Heart Vascular Stroke Institute, Samsung Medical Center
Sungkyunkwan University School of Medicine

Medical Research: What is the background for this study? What are the main findings?

Response: In the Effects of Postconditioning on Myocardial Reperfusion in Patients with ST-segment Elevation Myocardial Infarction (POST) trial, ischemic postconditioning failed to improve myocardial reperfusion (Hahn JY et al. Circulation 2013;128:1889-96) . However, long-term effects of ischemic postconditioning on clinical outcomes are not known in patients with ST-segment elevation myocardial infarction (STEMI). Therefore, the aim of this study was to investigate the long-term effects of ischemic postconditioning on clinical outcomes. In this prospective, randomized trial, ischemic postconditioning with primary percutaneous coronary intervention  (PCI) did not improve clinical outcomes compared with conventional primary PCI in patients with STEMI. There was no significant difference in a composite of death, myocardial infarction, severe heart failure, or stent thrombosis between the 2 groups. Beneficial effects of ischemic postconditioning were not found in any of various subgroups.

Medical Research: What should clinicians and patients take away from your report?

Response: Ischemic postconditioning does not seem to improve clinical outcomes in patients undergoing primary PCI with current standard practice. Therefore, routine ischemic postconditioning is not recommended during primary PCI.

Medical Research: What recommendations do you have for future research as a result of this study?

Response: Further studies are warranted to investigate other strategies such as remote conditioning or pharmacologic conditioning to prevent lethal reperfusion injury in patients undergoing primary PCI.

Citation:

Long-term effects of ischemic postconditioning on clinical outcomes: 1year follow-up of the POST randomized trial

Hahn, Joo-Yong et al.
American Heart Journal Published Online: February 28, 2015

DOI: http://dx.doi.org/10.1016/j.ahj.2015.01.015

 
MedicalResearch.com Interview with: Joo-Yong Hahn, MD, PhD (2015). Long-Term Effects Of Ischemic Post-Conditioning With PCI for STEMI 

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