10 Apr PDE5i for ED and Survival in Men with Coronary Artery Disease
MedicalResearch.com Interview with:
Martin J Holzmann MD PhD
Department of Emergency Medicine
Karolinska University Hospital
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: We published a paper 2007 in Heart where we showed that PDE5i lower mortality in men with a recent myocardial infarction. With this study we wanted to investigate if PDE5i led to a beneficial outcome in men with stable coronary artery disease.
MedicalResearch.com: What should readers take away from your report?
Response: Clinicians who meet men with coronary artery disease should raise the question of erectile dysfunction. If there is any indication of ED the patient should be prescribed a PDE5i.
MedicalResearch.com: What recommendations do you have for future research as a result of this work?
Response: In order to answer the question if PDE5i prolong life in men with CAD a RCT is needed.
I received consultancy honoraria from Idorsia.
MedicalResearch.com Editors’ Note: PDE5i drugs are used to treat erectile dysfunction.
Daniel P. Andersson, Laura Landucci, Ylva Trolle Lagerros, Alessandra Grotta, Rino Bellocco, Mikael Lehtihet, Martin J. Holzmann,
Association of Phosphodiesterase-5 Inhibitors Versus Alprostadil With Survival in Men With Coronary Artery Disease,
Journal of the American College of Cardiology,
Volume 77, Issue 12, 2021, Pages 1535-1550, ISSN 0735-1097,
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