Martin J Holzmann MD PhD Department of Emergency Medicine Karolinska University Hospital Stockholm, Sweden

10 Apr PDE5i for ED and Survival in Men with Coronary Artery Disease

Posted at 14:18h in Author Interviews, Erectile Dysfunction, Heart Disease, JACC, Karolinski Institute by

MedicalResearch.com Interview with:

Martin J Holzmann MD PhD Department of Emergency Medicine Karolinska University Hospital Stockholm, Sweden

Dr. Holzmann

Martin J Holzmann MD PhD
Department of Emergency Medicine
Karolinska University Hospital
Stockholm, Sweden 

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: ​We published a paper 2007 in Heart where we showed that PDE5i lower mortality in men with a recent myocardial infarction. With this study we wanted to investigate if PDE5i led to a beneficial outcome in men with stable coronary artery disease.

MedicalResearch.com: What should readers take away from your report? 

Response: ​Clinicians who meet men with coronary artery disease should raise the question of erectile dysfunction. If there is any indication of ED the patient should be prescribed a PDE5i.

MedicalResearch.com: What recommendations do you have for future research as a result of this work?

Response: ​In order to answer the question if PDE5i prolong life in men with CAD a RCT is needed.

Any disclosures?

​I received consultancy honoraria from Idorsia.

 MedicalResearch.com Editors’ Note:  PDE5i drugs are used to treat erectile dysfunction.

Citation:

Daniel P. Andersson, Laura Landucci, Ylva Trolle Lagerros, Alessandra Grotta, Rino Bellocco, Mikael Lehtihet, Martin J. Holzmann,
Association of Phosphodiesterase-5 Inhibitors Versus Alprostadil With Survival in Men With Coronary Artery Disease,
Journal of the American College of Cardiology,
Volume 77, Issue 12, 2021, Pages 1535-1550, ISSN 0735-1097,
https://doi.org/10.1016/j.jacc.2021.01.045.

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Last Updated on April 10, 2021 by Marie Benz MD FAAD

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