MedicalResearch.com Interview with:
Seoyoung C. Kim, MD, ScD, MSCE
Director, Program in Rheumatologic, Immunologic, and Musculoskeletal PharmacoEpidemiology
Associate Professor of Medicine
Division of Pharmacoepidemiology & Pharmacoeconomics
Division of Rheumatology, Immunology and Allergy
Brigham and Women’s Hospital
Harvard Medical School
MedicalResearch.com: What is the background for this study?
Response: Given a high cardiovascular (CV) risk among patients with psoriasis and psoriatic arthritis, it is important to have more information with regard to potential effect of different treatment agents on CV risk.
As the number of treatment options for psoriasis and psoriatic arthritis has been rising over the few decades, it is even more crucial to have high-quality evidence on comparative safety of different treatment options so physicians and patients can choose an agent based on the benefit-risk profile of each drug they are considering.
MedicalResearch.com: What are the main findings?
Response: In our large cohort study of over 60,000 patients with psoriasis or psoriatic arthritis who initiated ustekinumab versus a TNF inhibitor, we found overall no difference in the risk of incident atrial fibrillation, or a composite CV endpoint of myocardial infarction, stroke and coronary revascularization.
MedicalResearch.com: What recommendations do you have for future research as a result of this work?
Response: While the comparative safety of these drugs needs to be further examined in subgroups of patients (e.g., older age, men vs. women, presence of diabetes at baseline) as more data get accumulated in future, the current study provides CV safety data from an important head-to-head comparison ( two most commonly used categories of biologic drugs for the conditions) in a real-world setting.
Citation: Association of Ustekinumab vs TNF Inhibitor Therapy With Risk of Atrial Fibrillation and Cardiovascular Events in Patients With Psoriasis or Psoriatic Arthritis
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