27 Apr PFAS in Everyday Products May Have Liver Risks
MedicalResearch.com Interview with:
Sarah Rock, MPH
PhD student, Department of Population and Public Health Sciences
Keck School of Medicine
University of Southern California
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Per- and polyfluoroalkyl substances (PFAS) are persistent, man-made chemicals widely used in industry and consumer products. Exposure to these chemicals has been linked to multiple disease outcomes including cancer, glucose dysregulation, and as reported in the current study, liver injury. We compiled results from more than 100PFAS studies in humans and rodents and found consistent evidence that PFAS are related to liver injury.
MedicalResearch.com: What should readers take away from your report?
Response: The findings of this paper demonstrate convincing evidence that PFAS exposure is related to liver damage. Readers should be made aware that chemicals used in everyday products may have health risks. We need to continue to evaluate the safety of the common industry and consumer products, even after they have made it to the shelf.
MedicalResearch.com: What recommendations do you have for future research as a result of this work?
Response: In this study, we evaluated the impact of single PFAS exposure and focused largely on the legacy PFAS, like PFOA and PFOS, as there was limited data on exposure mixtures and newly developed PFAS, like GenX. Next steps in PFAS research should focus on evaluating the health risks of exposure to multiple PFAS mixtures as well as the health risks of the next-generation PFAS, which currently have more limited data.
We have no disclosures to add.
Elizabeth Costello,Sarah Rock,Nikos Stratakis,Sandrah P. Eckel,Douglas I. Walker,Damaskini Valvi,Dora Cserbik,Todd Jenkins,Stavra A. Xanthakos,Rohit Kohli,Stephanie Sisley,Vasilis Vasiliou,Michele A. La Merrill,Hugo Rosen,David V. Conti,Rob McConnell,and Leda Chatzi 2022
Exposure to per- and Polyfluoroalkyl Substances and Markers of Liver Injury: A Systematic Review and Meta-Analysis
Environmental Health Perspectives 130:4 CID: 046001 https://doi.org/10.1289/EHP10092
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