This image depicts the head of a gray-headed flying fox, Pteropus poliocephalus CDC/ Brian W.J. Mahy,

Bat Borne Nipah Virus Transmitted by Human Secretions Interview with:


Dr. Nikolay

Birgit Nikolay PhD
Institut Pasteur What is the background for this study? What are the main findings?

Response: Nipah virus was identified by the World Health Organization as an emerging infectious disease that may cause major epidemics if the pathogen evolves to become more transmissible, leading the organization to prioritize it for research to prevent future health emergencies. In the absence of efficient treatments or vaccines, the only way to control Nipah virus outbreaks is through targeted interventions that limit opportunities of spread. Designing such interventions is challenging in a context where transmission mechanisms remain poorly understood. The study provides important insights to better understand these mechanisms.

This image depicts the head of a gray-headed flying fox, Pteropus poliocephalus CDC/ Brian W.J. Mahy,

This image depicts the head of a gray-headed flying fox, Pteropus poliocephalus
CDC/ Brian W.J. Mahy, Can you tell us a little about the Nipah virus? Where is it found? What kind of disease does it cause?

Response: Nipah virus is a bat-borne virus found throughout South and South East Asia. It causes severe neurological and respiratory disease in humans, with a case fatality >70%. Currently no treatment or vaccines are available. What are the main findings?

Response: The study showed that, in particular, adult cases with respiratory symptoms transmitted the virus to more individuals than others, while contacts exposed to body fluids, including respiratory secretions, were more likely to get infected than others. What should readers take away from your report?

Response: When the isolation of all suspected Nipah cases is not possible, adult cases with respiratory symptoms should be targeted for interventions. Moreover, protective measures should be implemented among contacts to avoid exposure to body fluids. What recommendations do you have for future research as a result of this work?

Response: Future research should focus on investigating biological characteristics of Nipah patients in order to help better understand how the virus propagates in the human body and refine criteria to identify likely Nipah spreaders.


Transmission of Nipah Virus — 14 Years of Investigations in Bangladesh

Birgit Nikolay, Dr.rer.nat., Henrik Salje, Ph.D., M. Jahangir Hossain, M.B., B.S., A.K.M. Dawlat Khan, M.S.S., Hossain M.S. Sazzad, M.B., B.S., Mahmudur Rahman, Ph.D., Peter Daszak, Ph.D., Ute Ströher, Ph.D., Juliet R.C. Pulliam, Ph.D., A. Marm Kilpatrick, Ph.D., Stuart T. Nichol, Ph.D., John D. Klena, Ph.D., et al.
May 9, 2019
N Engl J Med 2019; 380:1804-1814
DOI: 10.1056/NEJMoa1805376


May 8, 2019 @ 9:28 pm


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