Salivary Assay Developed for HIV Can Be Used To Detect Zika

MedicalResearch.com Interview with:

Researchers at NYU College of Dentistry are developing a test for Zika virus that uses saliva to identify diagnostic markers of the virus in a fraction of the time of current tests. NYU/Sapna Parikh

Researchers at NYU College of Dentistry are developing a test for Zika virus that uses saliva to identify diagnostic markers of the virus in a fraction of the time of current tests.
NYU/Sapna Parikh

Maite Sabalza Ph.D
Post Doctoral Associate
Department of Basic Science and Craniofacial Biology
College of Dentistry, New York University
New York, NY 10010

MedicalResearch.com: What is the background for this study? What are the main findings? 

Response: With previous NIH funding we were able to develop an automated “dual assay” (able to detect both host antibodies and viral RNA) for HIV.

In relatively short time, we were able to migrate those findings into the new assay for ZIKA Virus.

MedicalResearch.com: What should readers take away from your report?

Response: Saliva is a good choice for diagnostics because it is a viable and noninvasive clinical matrix to detect both the presence of the infectious agent, and evidence of prior exposure (i.e., antibodies).

MedicalResearch.com: What recommendations do you have for future research as a result of this work?

Response: We believe that a dual assay for the presence of both ZIKV RNA and host antibodies provides a timeline of the stage of the infection.

MedicalResearch.com: Is there anything else you would like to add?

Response: We have developed a protocol that can be adapted for the next emerging infection.

Citations:

Detection of Zika virus using reverse-transcription LAMP coupled with reverse dot blot analysis in saliva

Maite Sabalza ,Rubina Yasmin,Cheryl A. Barber,Talita Castro,Daniel Malamud,Beum Jun Kim,Hui Zhu,Richard A. Montagna,William R. Abrams
Published: February 5, 2018

https://doi.org/10.1371/journal.pone.0192398

 

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