Lyme Borrelia: Different Antibody Responses in Late-stage infection with American vs European strains Interview with: Xin Li, Ph.D.
Assistant Professor
Department of Veterinary Biosciences
The Ohio State University
344 Veterinary Medicine Academic Building
Columbus, OH 43210 What are the main findings of the study?

Dr. Xin Li : Antibody responses to borrelial antigens that are primarily expressed during the tick phase the spirochetes’ life cycle are common in American patients with Lyme arthritis, a late-stage manifestation of Lyme borreliosis, but are rare in American patients with early-stage infection or European patients with early- or late-stage infection. What should clinicians and patients taken away from your report?

Dr. Xin Li : Late-stage infection with either American or European Lyme Borrelia strains results in differential antibody responses to a specific set of Borrelial antigens. What recommendations do you have for future research as a result of this study?

Dr. Xin Li : Determine why concerted upregulation or de-repression of tick-specific borrelial antigens occurs only with American but not European Lyme Borrelia strains, and try to understand its implication in disease pathogenesis.


Tick-Specific Borrelial Antigens Appear to Be Up-Regulated in American but Not European Patients with Lyme Arthritis, a Late Manifestation of Lyme Borreliosis
Xin Li, Klemen Strle, Peng Wang, David I. Acosta, Gail A. McHugh, Nikhil Sikand, Franc Strle, and Allen C. Steere
J Infect Dis. first published online June 12, 2013 doi:10.1093/infdis/jit269