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Rotavirus Vaccination Reduced Severe Illness and Hospitalizations in Young Children

MedicalResearch.com Interview with:

Daniel C. Payne, PhD, MSPH Senior Scientific Advisor Viral Gastroenteritis Branch US Centers for Disease Control and Prevention

Dr. Payne

Daniel C. Payne, PhD, MSPH
Senior Scientific Advisor
Viral Gastroenteritis Branch
US Centers for Disease Control and Prevention 

MedicalResearch.com: What is the background for this study?

Response: Rotavirus vaccines have been recommended for US infants for more than 10 years.  This study used seven years of active surveillance data from seven hospitals around the US to evaluate the effectiveness of rotavirus vaccines in the US. 

MedicalResearch.com: What are the main findings?

Response: Both rotavirus vaccines currently licensed in the US continue to be effective, particularly in preventing hospitalizations and severe infections, in young children. Rotavirus vaccines significantly reduced the clinical severity of rotavirus infections in childhood.  These vaccines were over 90% effective at preventing severe rotavirus disease, and approximately 80% effective at preventing inpatient and emergency department visits.

MedicalResearch.com: What should readers take away from your report?

Response: This large, multi-center study showed rotavirus vaccines to be effective, especially at preventing severe illnesses and hospitalizations. This real-world evaluation of rotavirus vaccine performance in US children suggests that the recommendation for universal childhood rotavirus vaccination should continue. 

MedicalResearch.com: What recommendations do you have for future research as a result of this work?

Response: A mixed course of both licensed rotavirus vaccines, pursuant to current recommendations, was highly protective in US children. Whether mixed doses offer additional immunologic benefits is not known and has not previously been observed, but warrants further investigation. 

Citation:

Payne DC, Englund JA, Weinberg GA, et al. Association of Rotavirus Vaccination With Inpatient and Emergency Department Visits Among Children Seeking Care for Acute Gastroenteritis, 2010-2016. JAMA Netw Open. Published online September 27, 20192(9):e1912242. doi:10.1001/jamanetworkopen.2019.12242

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2752101 

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Oct 4, 2019 @ 9:13 pm 

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