Steroids Associated With Reduced Mortality in Adults with Sepsis

MedicalResearch.com Interview with:

Dr. Jianguo Xu, MD West China Hospital, Sichuan University Chengdu, Sichuan, China

West China Hospital Sichuan University

Dr. Jianguo Xu, MD
West China Hospital, Sichuan University
Chengdu, Sichuan, China

MedicalResearch.com: What is the background for this study?

Response: Since the mid-20th century, corticosteroids have been used as adjuvant therapy in the context of sepsis. Although evaluated in numerous randomized clinical trials and meta-analyses, both the safety and efficacy of corticosteroids remain controversial.

MedicalResearch.com: What are the main findings? 

Response: Corticosteroid use is associated with reduced 28-day mortality compared with placebo use or standard supportive care.  

MedicalResearch.com: What should readers take away from your report?

Response: The administration of corticosteroids in patients with sepsis is an effective way to prevent death.

MedicalResearch.com: What recommendations do you have for future research as a result of this work? 

Response: The optimal strategy for the administration of corticosteroids in patients with sepsis is uncertain. Future studies are needed to associate personalized medicine with clinical phenotyping, genotyping, or metabolomics with the treatment of sepsis for the selection of suitable patients who are more likely to show a benefit. 

Citation:

Fang F, Zhang Y, Tang J, et al. Association of Corticosteroid Treatment With Outcomes in Adult Patients With Sepsis: A Systematic Review and Meta-analysis. JAMA Intern Med. Published online December 21, 2018. doi:10.1001/jamainternmed.2018.5849

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