Nausea and Vomiting During Pregnancy May Signal Less Risk of Pregnancy Loss Interview with:
Stefanie N. Hinkle, Ph.D.

Staff Scientist | Epidemiology Branch
Division of Intramural Population Health Research
Eunice Kennedy Shriver National Institute of Child Health and Human Development
National Institutes of Health What is the background for this study? What are the main findings?

Response: Thank you for the interest in our research. Nausea and vomiting are very common early in pregnancy and these symptoms can be difficult for women. Before we began this study there was very limited high-quality data on the implications of these difficult symptoms in pregnancy. Our study is unique because we asked women to report their symptoms continuously throughout their pregnancy before they may or may not have gone on to have a loss. We found that among women with 1 or 2 prior pregnancy losses, women who have nausea, and particularly nausea with vomiting, were less likely to have a pregnancy loss. What should readers take away from your report?

Response: Our findings should be reassuring to women experiencing these symptoms, as the risk for a pregnancy loss is greatly reduced in women with these symptoms. However, it is important for women who do not have these symptoms to understand that not all pregnancies are the same and everyone is different, so just because they do not have symptoms does not mean that they will go on to have a loss. What recommendations do you have for future research as a result of this study?

Response: Future research understanding the potential mechanisms of this link between nausea in pregnancy and a reduced risk for a pregnancy loss will be important. Is there anything else you would like to add?

Response: This research was a secondary analysis of a larger NICHD study and more details regarding the EAGeR study are available at Thank you for your contribution to the community.


Hinkle SN, Mumford SL, Grantz KL, Silver RM, Mitchell EM, Sjaarda LA, Radin RG, Perkins NJ, Galai N, Schisterman EF. A prospective analysis of nausea and vomiting during pregnancy and its relation to pregnancy loss. JAMA Internal Medicine. [Epub ahead of print Sept. 26, 2016]

Note: Content is Not intended as medical advice. Please consult your health care provider regarding your specific medical condition and questions.

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