Mark Hoon, PhD Senior Investigator,Molecular Genetics Unit Sensory Biology NIH NIDCR, Bethesda, MD

19 Jul New Target To Treat Itch Identified

Posted at 03:56h in Author Interviews, Dermatology, NIH by

MedicalResearch.com Interview with:

Mark Hoon, PhD Senior Investigator,Molecular Genetics Unit Sensory Biology NIH NIDCR, Bethesda, MD

Dr. Moon

Mark Hoon, PhD
Senior Investigator,Molecular Genetics Unit
Sensory Biology
NIH NIDCR, Bethesda, MD

MedicalResearch.com: What is the background for this study?

Response: Itch is a condition that at some point effects all people. For most of us itch is not a major problem, but for some people with certain chronic conditions it severely effects their quality of life.

Examples of diseases which cause chronic itch are atopic dermatitis, psoriasis, and renal failure. However, current therapies for chronic itch are mainly ineffective and there is a unmet clinical need.

MedicalResearch.com: What are the main findings?

Response: The main finding was that the receptor Npr1 is a feasible target for inhibition of itch. 

MedicalResearch.com: What should readers take away from your report?

Response: The take away message is that, there new ways to treat itch are being actively investigated and these will likely, in the future, lead to novel therapies. 

MedicalResearch.com: What recommendations do you have for future research as a result of this work?

Response: We would recommend searching for better antagonist of Npr1 which have improved pharmacodynamics compared with the compounds we discovered in this study. 

Any disclosures?

NIH has a patent pending his work.

Citation: 

Hans Jürgen Solinski, Patricia Dranchak, Erin Oliphant, Xinglong Gu, Thomas W. Earnest, John Braisted, James Inglese, Mark A. Hoon. Inhibition of natriuretic peptide receptor 1 reduces itch in mice. Science Translational Medicine, 2019; 11 (500): eaav5464 DOI: 10.1126/scitranslmed.aav5464

 

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Last Updated on July 19, 2019 by Marie Benz MD FAAD

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