Medical Research News

The Latest Medical Research Studies in Medical News

MedicalResearch.com specializes in exclusive interviews with medical researchers from major and specialty journals and presenters at health care meetings.

Learn directly from the researchers as they discuss the ideas behind their investigations and their plans for future medical research studies.

Recent Posts

Stroke: Experimental Antiplatelet Antibody Only Attacks Clots, Without Increasing Bleeding Risk

MedicalResearch.com Interview with:

MedicalResearch.com Interview with:Martine Jandrot-Perrus MD, PhD.Emeritus Research ProfessorInserm University Paris DiderotActicor BiotechHôpital BichatFrance

Dr. Jandrot-Perrus


Martine Jandrot-Perrus MD, PhD.
Emeritus Research Professor
Inserm University Paris Diderot
Acticor Biotech
Hôpital Bichat
France 

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: Blood platelets are key actors in thrombosis a leading cause of global mortality estimated to account for 1 in 4 death worldwide in 2010.

Thrombosis is associated with cardiovascular diseases (myocardial infarction, stroke, lower limb ischemia, venous thromboembolism), and with numerous pathologies such as cancer, infections or inflammatory diseases. Currently available antiplatelet drugs are the cornerstone of therapy for patients with acute coronary syndromes. However, these drugs all carry an inherent risk of bleeding that restricts their use in sensitive populations and when arterial thrombosis occurs in the cerebral territory. At present the only acute treatment option available for ischemic stroke consists in revascularization by thrombolysis, and/or mechanical thrombectomy. But the number of patients eligible to these treatments is low (» 15% of all patients) and the success rate does not exceed 50%. The responsibility of platelets in the failure for thrombolysis / thrombectomy to restore vascular patency is strongly suspected.

There is thus a clear medical need for new antiplatelet drugs with an improved safety profile. We set out to develop ACT017, a novel, first in class, therapeutic antibody to platelet glycoprotein VI with potent and selective antiplatelet effects. The interest of GPVI resides in the fact that it’s a receptor involved in the development of occlusive thrombi but that it is not strictly required for physiological hemostasis.
Continue reading

  1. AI Poised to Revolutionize Radiation Therapy for Cancer Leave a reply
  2. “Magic Mouthwash” Can Decrease Mouth Pain from Radiation Therapy Leave a reply
  3. Just a Picture of Coffee Can Give Your Heart Rate, and Brain, a Lift Leave a reply
  4. Better Use of Nicotine Replacement Therapies Can Help Smokers Quit Leave a reply
  5. DNA Copy Number Variants Linked to Increased Risk of Depression Leave a reply
  6. Pediatric Melanoma Risk Increasing in Adolescents & Young Adults, Including in Non-Whites Leave a reply
  7. Oral Peanut Immunotherapy Evaluated for Preschool Children Leave a reply
  8. Cervical Cancer Subtypes Vary Among Population Sectors Leave a reply
  9. Pulse Ultrasound to the Brain Could Be Used To Affect Decision Making Leave a reply
  10. Most Diabetes Apps Do Not Provide Real Time Decision Support (yet) 1 Reply
  11. Ying and Yang of Empathy and Aggression Differ for Boys and Girls Leave a reply
  12. RNA Genetic Testing Improves Analysis of Hereditary Cancer Genes Leave a reply
  13. Stem Cell Therapy Improved Motor Deficit in Traumatic Brain Injury Trial Leave a reply
  14. Short Rest Periods Are Performance Enhancers Leave a reply
  15. Diet Rich in Red Meat Linked to Earlier Death 73 Replies
  16. Very Low LDL Cholesterol Associated with Hemorrhagic Stroke in Women Leave a reply
  17. Unhealthy, Binge Behaviors in College Students Disrupts Brain Chemistry Leave a reply
  18. Despair Rising in Young Middle Aged Adults, Regardless of Ethnicity or Education Leave a reply
  19. Sentinel Lymph Node Drainage Can Be Used to Test For Marker of Melanoma Relapse Risk Leave a reply
  20. Travelers Can Bring Home Drug-Resistant Bacteria as Souvenirs from Low and Middle Income Countries Leave a reply
  21. Brain Training Can Strengthen Cognitive Function in Patients With Mild Impairment Leave a reply
  22. Medical Interns Spend 87 percent of Their Work Time Away From Patients Leave a reply
  23. Changes in Medicare’s Hospital Readmissions Reduction Program Affect Poor and Low Poverty Hospitals Differently Leave a reply
  24. Home Responsibilities Encourage Physician Mothers in Procedural Specialties To Consider Career Change Leave a reply