20 Apr Obstructive Sleep Apnea Associated with Hypertension in Perimenopausal Women
MedicalResearch.com Interview with:
Rodrigo Pinto Pedrosa, MD, PhD
Sleep and Heart Laboratory,
Pronto Socorro Cardiológico de Pernambuco
MedicalResearch.com: What are the main findings of the study?
Dr. Pedrosa: Perimenopause is associated with increased cardiovascular risk. This study evaluated the association between obstructive sleep apnea (OSA) and arterial stiffness and hypertension in perimenopausal women. OSA (apnea-hypopnea index: ≥5 events/hour) and moderate/severe OSA (apnea-hypopnea index: ≥15 events/h) were diagnosed in 111 (40.1%) and 31 (11.1%) of women, respectively. Women with moderate/severe obstructive sleep apnea had a higher prevalence of hypertension, were prescribed more medications for hypertension, had higher awake blood pressure, nocturnal blood pressure, diastolic blood pressure, as well as higher arterial stiffness (pulse wave velocity: 11.5 [10.1 to 12.3] vs 9.5 [8.6 to 10.8] m/s, p<0.001) than women without obstructive sleep apnea, respectively. Oxygen desaturation index during the night was independently associated with 24h arterial blood pressure and with arterial stiffness.
MedicalResearch.com: Were any of the findings unexpected?
Dr. Pedrosa: No. Previously, we had more evidence of the association between arterial stiffness and obstructive sleep apnea among men. Now, our results extends this knowledge to the perimenomausal population.
MedicalResearch.com: What should clinicians and patients take away from your report?
Dr. Pedrosa: Obstructive sleep apnea is common, underdiagnosed and independently associated with high blood pressure and increased arterial stiffness in the perimenopause.
MedicalResearch.com: What recommendations do you have for future research as a result of this study?
Dr. Pedrosa: Future studies must address the role of OSA treatment in this population to evaluate blood pressure and arterial stiffness reductions.