Gregory Carter

Novel Models of Late-Onset Alzheimer’s Disease Based on GWAS Interview with:

Gregory Carter

Dr. Carter

Gregory Carter, PhD
Associate Professor at The Jackson Laboratory What is the background for this study? What are the main findings?

Response: Animal models for late-onset Alzheimer’s disease (LOAD) will be of significant benefit for the discovery and characterization of links between specific genetic factors and the molecular pathways associated with the disease. To date, most animal models have been based on rare, early-onset Alzheimer’s disease genes that incompletely capture the complexity of LOAD and have not translated well to therapies. Therefore, developing and utilizing animal models based on genes hypothesized to play a role in LOAD will provide new insights into its basic biological mechanisms. What should readers take away from your report?

Response: Previous research has identified risk genes for late-onset Alzheimer’s disease in the human population. By analyzing gene expression in mouse models with associated gene variants or mutations in addition to post-mortem human brains from AD patients, we found changes in gene expression in AD-related pathways. These results begin to provide a detailed map of the specifics effects produced by each risk gene and what molecular mechanisms underlie disease pathology. What recommendations do you have for future research as a result of this work?

Response: This is a pilot study that provides a platform for further exploration into the causes and progression of late-onset Alzheimer’s disease . Assessing animal models and different ages and/or with different combinations of  late-onset Alzheimer’s disease risk variants can provide novel insight for finding molecular targets and developing new drugs for Alzheimer’s disease.

No disclosures.

Citation AAIC 18 abstract

Whole-Exome Analysis of Late-Onset Alzheimer’s Disease Reveals Novel Candidate Genes Involved in Cognitive Function

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Jul 27, 2018 @ 5:47 pm

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