05 Jan Stress May Aggravate GI Symptoms in Autism Spectrum Disorder
MedicalResearch.com Interview with:
David Q. Beversdor MD
Center for Translational Neuroscience
University of Missouri Health System
Columbia, MO 65212
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Altered stress reactivity, alterations in cytokines and a high incidence of gastrointestinal disturbances have all been observed in autism spectrum disorder (ASD). We wished to examine the interactions between these factors.
What we found was that patients with greater stress reactivity, as indicated by cortisol response in the testing environment, had greater symptomatology involving the lower gastrointestinal tract, which was predominated by constipation.
MedicalResearch.com: What should readers take away from your report?
Response: In autism spectrum disorder, there may be a range of contributors to comorbid conditions, including constipation. Stress reactivity may be one factor related to constipation in ASD. Constipation is currently treated with laxatives in this population. This raises the question as to whether treatment addressing other factors may be beneficial in some of these patients.
MedicalResearch.com: What recommendations do you have for future research as a result of this study?
Response: It will be of particular interest to see if treatment of constipation in autism spectrum disorder, can be augmented by targeting the mechanisms of stress reactivity, particularly for those least responsive to laxatives and those with the greatest stress reactivity.
MedicalResearch.com: Is there anything else you would like to add?
Response: This research would not have been possible without the support of the Autism Treatment Network and the Autism Intervention Research Network on Physical Health by the Health Resources Services Administration (UA3MC11054), and our collaborators at Vanderbilt University, Columbia University and Massachusetts General Hospital.
MedicalResearch.com: Thank you for your contribution to the MedicalResearch.com community.
Bradley J. Ferguson, Sarah Marler, Lily L. Altstein, Evon Batey Lee, Micah O. Mazurek, , Aaron McLaughlin, Eric A. Macklin, Erin McDonnell, Daniel J. Davis, Anthony M. Belenchia,,Catherine H. Gillespie, Catherine A. Peterson, Margaret L. Baumani, Kara Gross Margolisj, Jeremy Veenstra-VanderWeele, David Q. Beversdorf
Brain, Behavior, and Immunity
Volume 58, November 2016, Pages 57–62
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