Efficacy of SSRIs for Anxiety Influenced By Patient’s Expectations

MedicalResearch.com Interview with:
Vanda Faria PhD
Department of Psychology
Uppsala, Sweden 

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: It has been debated whether selective serotonin reuptake inhibitors (SSRIs), which are commonly prescribed for depression and anxiety, are more effective than placebo. Concerns have been raised that the beneficial effects of SSRIs, as measured in double-blind clinical trials, may be explained by expectancies (a crucial placebo mechanism) rather than the biochemical compound. But no study has tested experimentally the extent to which the SSRI treatment effect can be influenced by expectancies induced by verbal suggestions.

We compared the efficacy of overt vs. covert administration of an SSRI (escitalopram) in patients with social anxiety disorder. Rather than comparing the SSRI with placebo, we compared it with itself while manipulating the patients’ expectations of improvement. This was achieved by informing one group correctly about the SSRI and its effectiveness (overt group) whereas the comparison (covert) group received incorrect information. By use of a cover story, the covert group was led to believe they were treated with a so called “active placebo”, an ineffective neurokinin-1 antagonist yielding similar side effects as the SSRI but lacking anxiety-reducing properties. But the treatment, dosage and duration was in fact identical in both groups.

Results showed that overt outperformed covert SSRI treatment, as the number of treatment responders was more than three times higher on the main clinical outcome measure when correct information was given. Using neuroimaging (fMRI) we also noted differences between the overt and covert SSRI groups on objective brain activity measures. There were differences between the groups e.g. with regard to activation of the posterior cingulate cortex with treatment, and the functional coupling between this region and the amygdala which is a brain region crucially involved in fear and anxiety. The fMRI  results may reflect the interaction between cognition and emotion as the brain changes differently with treatment pending on the expectations of improvement.

MedicalResearch.com: What should clinicians and patients take away from your report?

Response: While a patient suffering from anxiety may feel much better after being treated with an SSRI, the biochemical compound does only half the job, or may be even less than so. The efficacy of the SSRI treatment is largely influenced by psychological factors like cognitive expectations induced by the information given at prescription. This underscores the importance of the communication between prescriber and patient. The presentation of the treatment may be as important as the treatment itself.

MedicalResearch.com: What recommendations do you have for future research as a result of this study?

Response: Both drug and expectancies should be manipulated experimentally in future SSRI treatment studies. We only manipulated the expectancies, with correct vs. incorrect information about the SSRI. The drug-level can be varied by also including another group treated with placebo while being informed (incorrectly) that it is an SSRI. This may answer if drug and placebo effects are truly additive, which is an underlying but unproved assumption of typical randomized placebo-controlled trials. This may also answer if there is an effect of expectancies independent of the drug, i.e. if expectancies affect the clinical outcome regardless if a drug was actually given or not.

No disclosures.

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Do You Believe It? Verbal Suggestions Influence the Clinical and Neural Effects of Escitalopram in Social Anxiety Disorder: A Randomized Trial

Vanda Faria, Malin Gingnell1, Johanna Motilla Hoppe, Olof Hjorth, Iman Alaie, Andreas Frick, Sara Hultberg, Kurt Wahlstedt, Jonas Engman, Kristoffer N.T. Månsson, Per Carlbring, Gerhard Andersson, Margareta Reis, Elna-Marie Larsson, Mats Fredrikson, Tomas Furmark

Note: Content is Not intended as medical advice. Please consult your health care provider regarding your specific medical condition and questions.


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