04 Nov Childhood Nitrogen Dioxide Exposure Associated With Elevated Risk of Schizophrenia
MedicalResearch.com: What is the background for this study?
Response: Recent studies have suggested that exposure to nitrogen dioxide during childhood is associated with elevated risk of subsequently developing schizophrenia. We know that schizophrenia has a genetic component, and that individuals with higher genetic loading for schizophrenia tend to live in more densely urban areas. It is not known whether the increased risk associated with exposure to nitrogen dioxide during childhood is owing to a greater genetic liability among those exposed to highest nitrogen dioxide levels.
Exposure to nitrogen dioxide during childhood and genetic liability (as measured by a polygenic risk score) for schizophrenia were independently associated with increased schizophrenia risk.
MedicalResearch.com: What are the main findings?
Response: Childhood nitrogen dioxide exposure was associated with elevated risk of schizophrenia that was only slightly explained by a polygenic risk score for schizophrenia.
MedicalResearch.com: What should readers take away from your report?
Response: As polygenic risk scores become more powerful, environmental epidemiology will be able to build more accurate, precise, and comprehensive models of the complex causal pathways between genes, environment, and health outcomes.
Horsdal HT, Agerbo E, McGrath JJ, et al. Association of Childhood Exposure to Nitrogen Dioxide and Polygenic Risk Score for Schizophrenia With the Risk of Developing Schizophrenia. JAMA Netw Open. Published online November 01, 20192(11):e1914401. doi:10.1001/jamanetworkopen.2019.14401
The information on MedicalResearch.com is provided for educational purposes only, and is in no way intended to diagnose, cure, or treat any medical or other condition. Always seek the advice of your physician or other qualified health and ask your doctor any questions you may have regarding a medical condition. In addition to all other limitations and disclaimers in this agreement, service provider and its third party providers disclaim any liability or loss in connection with the content provided on this website.