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30 Apr Ovarian Cancer: Novel Mechanism Regulating Angiogenesis

Posted at 15:35h in General Medicine

MedicalResearch.com: Egle Avizienyte, PhD Senior Research Fellow, Institute of Cancer Sciences Faculty of Medical and Human Sciences The University of Manchester, Manchester M20 4BX MedicalResearch.com: What are the main findings of the study? Dr. Avizienyte: Angiogenesis, the formation of new blood vessels, has been validated as a target in ovarian...

29 Apr Many Breast Cancer Patients Do Not Understand Gene Expression Profiling

Posted at 19:18h in Author Interviews, Breast Cancer, Genetic Research

MedicalResearch.com Interview with: Dr. Yvonne Bombard, PhD Scientist in the Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael’s Hospital Assistant Professor, Institute of Health Policy, Management and Evaluation, Faculty of Medicine, University of Toronto MedicalResearch.com: What are the main findings of the study? Dr. Bombard:...

09 Apr Aspirin Found Generally Not Effective in Reducing Pregnancy Loss

Posted at 15:31h in Author Interviews, Lancet, OBGYNE

MedicalResearch.com Interview with: Enrique F. Schisterman, Ph.D. Chief and Senior Investigator Epidemiology Branch, DIPHR Eunice Kennedy Shriver National Institute of Child Health and Human Development Rockville, MD 20854 MedicalResearch.com: What are the main findings of the study? Dr. Schisterman: Our results indicate that aspirin is not effective for reducing the...

26 Feb Diabetes and Depression: Cognitive Therapy Improved Both

Posted at 02:09h in Author Interviews, Depression, Diabetes, Diabetes Care

MedicalResearch.com Interview with: Steven A. Safren, Ph.D., ABPP Professor of Psychology, Harvard Medical School Director, Behavioral Medicine, Department of Psychiatry Massachusetts General Hospital, Boston, MA 02114 MedicalResearch.com: What are the main findings of the study? Dr. Safren: The main findings of the study are that, in patients with uncontrolled type 2 diabetes and...

25 Feb Acute Coronary Syndrome: Genotyping Guided Antiplatelet Therapy After Stent Surgery

Posted at 03:23h in Annals Internal Medicine, Author Interviews, Cost of Health Care, Heart Disease, UCSF

MedicalResearch.com Interview with: Dhruv S. Kazi, MD, MSc, MS Assistant Adjunct Professor Division of Cardiology San Francisco General Hospital Department of Medicine, and Department of Epidemiology and Biostatistics University of California San Francisco MedicalResearch.com: What is the background of your study? Dr. Kazi: When we first asked the research question...

20 Feb Advanced Cervical Cancer: Adding Avastin to Chemotherapy Prolonged Survival

Posted at 13:59h in Author Interviews, Cancer Research, Chemotherapy, NEJM

MedicalResearch.com Interview with: Krishnansu S. Tewari, MD, FACOG, FACS| Professor & Director of Research Principal Investigator – The Gynecologic Oncology Group at UC Irvine, Division of Gynecologic Oncology University of California, Irvine Medical Center Orange, CA 92868 MedicalResearch.com: What are the main findings of the study? Dr. Tewari: The main...

26 Dec Pediatric Migraines: Cognitive Therapy Plus Amitriptyline

Posted at 19:07h in Author Interviews, JAMA, Pain Research, Pediatrics

MedicalResearch.com Interview with: Scott W. Powers, PhD APBB Division of Behavioral Medicine and Clinical Psychology and Division of Neurology, Cincinnati Children’s Hospital Medical Center Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio MedicalResearch.com: What are the main findings of the study? Dr. Powers: Cognitive behavioral therapy plus amitriptyline resulted...

20 Dec Breast Cancer: PIK3CA Mutation to Predict Chemotherapy Resistance

Posted at 13:56h in Author Interviews, Breast Cancer, Chemotherapy

MedicalResearch.com Interview with: Prof. Dr. med. Sibylle Loibl MD Unit Head of Medicine & Research Member of Management Board Associate Professor University Frankfurt GBG Forschungs GmbH  Neu-Isenburg MedicalResearch.com: What are the main findings of the study? Dr. Loibl: We could demonstrate that patients with a HER2+ primary breast cancer harbouring...

15 Dec Traumatic Brain Injury: Dietary Therapy

Posted at 23:55h in Author Interviews, Brain Injury, Nutrition, Sleep Disorders

MedicalResearch.com Interview with: Miranda M. Lim, MD, PhD Assistant Professor, Sleep Medicine Division of Pulmonary and Critical Care Portland VA Medical Center and Oregon Health & Science University MedicalResearch.com: What are the main findings of the study? Dr. Lim: People with traumatic brain injury (TBI) often have persistent sleep-wake disturbances...

01 Nov Proton Therapy Radiation: Decreased Need for Feeding Tubes in Oropharnygeal Cancer Patients

Posted at 19:14h in Cancer Research, MD Anderson, Radiation Therapy

MedicalResearch.com Interview with: Steven J. Frank, M.D., associate professor of Radiation Oncology at The University of Texas MD Anderson Proton Therapy Center discusses the findings of his latest study, “Gastrostomy Tubes Decrease by Over 50% with Intensity Modulated Proton Therapy during the Treatment of Oropharyngeal Cancer Patients.” MedicalResearch.com: What are...

17 Oct Anorexia Nervosa: Optimized Psychodynamic, Cognitive Behavior Therapy

Posted at 14:09h in Author Interviews, Eating Disorders, Weight Research

MedicalResearch.com Interview with Stephan Zipfel MD Professor of Medicine & Dean of Medical Education Head Department of Internal Medicine VI (Psychosomatic Medicine and Psychotherapy) University Medical Hospital Tuebingen President of the German College of Psychosomatic Medicine (DKPM) Co-Director of the centre for nutritional Medicine Tuebingen-Hohenheim 72076 Tuebingen / Germany MedicalResearch.com:...

10 Oct Breast Cancer: 7 Triple-Negative Subtypes and Chemotherapy Response

Posted at 18:56h in Author Interviews, Breast Cancer, Chemotherapy, MD Anderson, Vanderbilt

MedicalResearch.com Interview with: Hiroko Masuda MD Morgan Welch Inflammatory Breast Cancer Research Program and Clinic; Departments of 2Breast Medical Oncology, 3Bioinformatics and Computational Biology The University of Texas MD Anderson Cancer Center, Houston, Texas; W. Fraser Symmans, MD Anderson Cancer Center, Department of Pathology, Unit 85, 1515 Holcombe Blvd., Houston,...

23 Aug Stretch Marks: Four Genetic Markers Near Elastin Gene Identified

Posted at 12:38h in Author Interviews, Dermatology, Genetic Research, Nature

MedicalResearch.com Interview with: Joyce Y Tung Ph.D. Research Team 23andMe Inc. Mountain View, California, USA MedicalResearch.com: What are the main findings of the study? Dr. Tung: 23andMe researchers identified four genetic markers that were significantly associated with the development of stretch marks, including one near the elastin (ELN) gene. This finding...

08 Aug HIV-Lymphoma Survival – Not Improving in Anti-Retroviral Therapy Era

Posted at 13:55h in Author Interviews, HIV, Infections, JNCI, Lymphoma

MedicalResearch.com Interview with: Satish Gopal, MD, MPH Program in Global Oncology, Lineberger Comprehensive Cancer Center UNC Project-Malawi, Tidziwe Center, Private Bag A-104, Lilongwe, Malawi MedicalResearch.com: What is the primary message our physician readers should take away from the piece?” Answer: Lymphoma is one of the leading causes of HIV-associated death...

09 May Randomized Controlled Trial of a Ragweed Allergy Immunotherapy Tablet in North American and European Adults

Posted at 01:29h in Allergies, Author Interviews

MedicalResearch.com eInterview with Author Peter S. Creticos, M.D. (corresponding author) Dr. Creticos’ Comments: This paper reports the first successful randomized, double-blind, pivotal trial of sublingual immunotherapy with a ragweed tablet. The relevance of this lies in the recognition that ragweed is the dominant seasonal allergen in North America (~26% of...

03 Apr Genome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer

Posted at 00:39h in Author Interviews, Breast Cancer, Genetic Research, PNAS

MedicalResearch.com eInterview with Dr. Mathieu Lupien PhD Princess Margaret Cancer Centre, University Health Network Ontario Cancer Institute (OCI) Assistant Professor Department of Medical Biophysics University of Toronto MedicalResearch.com: What are the main findings of the study? Dr. Lupien: Approximately 50% of breast cancer patients fail to respond to the standard...

12 Apr Chemotherapy Proves Life-Saving for Some Leukemia Patients Who Fail Induction Therapy

Posted at 00:28h in Cancer Research, Leukemia

Newswise — (MEMPHIS, Tenn. – April 11, 2012) An international study found that bone marrow transplants are not the best option for some young patients with acute lymphoblastic leukemia (ALL) who fail to attain clinical remission after the initial weeks of intense chemotherapy known as induction therapy. The largest study ever...

26 Oct Through-the-Nipple Breast Cancer Therapy Shows Promise in Early Tests

Posted at 19:32h in Breast Cancer, Chemotherapy

October 26 2011 Newswise — Delivering anticancer drugs into breast ducts via the nipple is highly effective in animal models of early breast cancer, and has no major side effects in human patients, according to a report by Johns Hopkins Kimmel Cancer Center researchers in Science Translational Medicine on October...

26 Oct Gene responsible for relapses in young leukemia patients

Posted at 19:30h in Cancer Research, Leukemia

One of the causes of resistance to cancer treatment in children is now beginning to be elucidated. Acute lymphoblastic leukemia patients with a particular form of the ATF5 gene are at higher risk of having a relapse when treated with E. coli asparaginase, a key chemotherapy drug for this type...

06 Oct Tyk2 protein potential new Breast Cancer Therapy Target

Posted at 01:38h in Breast Cancer, Cleveland Clinic

New Rochelle, NY, October 5, 2011 — A possible new target for breast cancer therapy comes from the discovery that the Tyk2 protein helps suppress the growth and metastasis of breast tumors, as reported in Journal of Interferon & Cytokine Research, a peer-reviewed journal published by Mary Ann Liebert, Inc....

02 Sep Key function of mutation in BRCA1 gene discovered

Posted at 00:21h in Breast Cancer, Cancer Research, Ovarian Cancer

Richmond, Va. (September 1, 2011) –It is widely known that mutations in the breast cancer susceptibility 1 (BRCA1) gene significantly increase the chance of developing breast and ovarian cancers, but the mechanisms at play are not fully understood. Now, researchers at Virginia Commonwealth University Massey Cancer Center have shown that...

11 Aug Team reports genetic sequences most common bladder cancer

Posted at 21:45h in Cancer Research, Nature

August 11, 2011 (Aurora, CO)–In an article published online this week in Nature Genetics, a University of Colorado Cancer Center team in partnership with universities in China and Denmark. Recognizing the genetic mutations that make bladder cancer cells different than their healthy neighbors may allow early genetic screenings for cancer...

04 Aug Scientists map genetic mutations in the second-most common form of brain cancer, oligodendroglioma

Posted at 18:44h in Brain Cancer - Brain Tumors

Johns Hopkins Kimmel Cancer Center scientists have completed a comprehensive map of genetic mutations occurring in the second-most common form of brain cancer, oligodendroglioma. The findings, reported in the Aug. 4 issue of Science, also appear to reveal the biological cause of the tumors, they say. To create the map,...

26 Jul New Avenues Open Up for Mesothelioma Targeted Therapy

Posted at 00:12h in Cancer Research

Newswise — July 25, 2011 (Philadelphia, PA) –Researchers from the lab of Antonio Giordano, M.D., Ph.D., the Founder and Director of the Sbarro Institute for Cancer Research and Molecular Medicine, have identified new potential anti-tumor agents that might be effective in treating mesothelioma, one of the deadliest cancer tumors. Scientists...

24 Jul 2 genetic variations predict second cancers after radiation for children with Hodgkin lymphoma

Posted at 23:01h in Cancer Research, Nature, Sloan Kettering, University of Pennsylvania

A genome-wide association study published in the August issue of Nature Medicine has found two tiny genetic variations that can predict which patients with Hodgkin’s lymphoma are most likely to develop radiation-induced second cancers years after treatment. Knowing in advance who is at risk could help physicians tailor treatment to...

26 Mar The Evolving Landscape of Immunogenicity Risk Assessment in Biologic Drug Development

Posted at 18:02h in Immunotherapy, Pharmaceutical Companies

Modern immunogenicity programs must also account for patient-level risk factors: prior exposure to related biologics, concomitant immunosuppressive therapy, disease state, and genetic background all modulate ADA incidence and clinical impact.

Image retrieved from, https://www.vecteezy.com/photo/68647034-a-close-up-of-a-blue-cell-membrane

13 Oct The challenge of cartilage repair

Posted at 14:15h in Author Interviews, Genetic Research, Orthopedics

The progress in viral vector manufacturing and gene editing means orthopedic specialists may soon be able to offer treatments that genuinely restore cartilage, not just mask symptoms. Ongoing developments focus on increasing the specificity of gene delivery, enhancing the durability of therapeutic effects, and scaling up production methods to allow widespread clinical adoption.

17 Sep Inside the Longevity World Cup’s Quest to Delay Aging

Posted at 11:41h in Aging, Author Interviews, Exercise - Fitness

Longevity science is a proactive approach to the universal problem of disease and aging. It no longer makes sense to wait until someone is old and grey to spend tons of money managing a disease that could’ve been avoided altogether. Instead, longevity experts recommend lifestyle changes and scientific interventions to prevent the onset of the disease in the first place.

04 Feb The Future of Tinnitus Treatment: Breakthroughs That Could Silence the Noise

Posted at 11:17h in Hearing Loss

Treatment for tinnitus is advancing beyond symptom management. Innovations in neuromodulation, regenerative medicine, and AI-driven therapies are creating new possibilities that could redefine how the condition is treated.

Christopher Choi, PhD, MBA Senior Vice President of Industry Partnerships Associate Professor of Oncology Technical Director of GMP Engineering & Cell Manufacturing Roswell Park Comprehensive Cancer Center Buffalo, NY

28 Jan Roswell Parks Opens Largest Engineering and Cell Manufacturing Facility to Expand Cancer Research

Posted at 15:22h in Author Interviews, Cancer Research

MedicalResearch.com Interview with: Christopher Choi, PhD, MBA Senior Vice President of Industry Partnerships Associate Professor of Oncology Technical Director of GMP Engineering & Cell Manufacturing Roswell Park Comprehensive Cancer Center Buffalo, NY MedicalResearch.com: What is the background for this study? What is a GMP facility? Response: The opening of the...