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11 Aug Team reports genetic sequences most common bladder cancer
August 11, 2011 (Aurora, CO)–In an article published online this week in Nature Genetics, a University of Colorado Cancer Center team in partnership with universities in China and Denmark. Recognizing the genetic mutations that make bladder cancer cells different than their healthy neighbors may allow early genetic screenings for cancer...04 Aug Scientists map genetic mutations in the second-most common form of brain cancer, oligodendroglioma
Posted at 18:44h
in Brain Cancer - Brain Tumors
Johns Hopkins Kimmel Cancer Center scientists have completed a comprehensive map of genetic mutations occurring in the second-most common form of brain cancer, oligodendroglioma. The findings, reported in the Aug. 4 issue of Science, also appear to reveal the biological cause of the tumors, they say. To create the map,...
26 Jul New Avenues Open Up for Mesothelioma Targeted Therapy
Posted at 00:12h
in Cancer Research
Newswise — July 25, 2011 (Philadelphia, PA) –Researchers from the lab of Antonio Giordano, M.D., Ph.D., the Founder and Director of the Sbarro Institute for Cancer Research and Molecular Medicine, have identified new potential anti-tumor agents that might be effective in treating mesothelioma, one of the deadliest cancer tumors. Scientists...
24 Jul 2 genetic variations predict second cancers after radiation for children with Hodgkin lymphoma
A genome-wide association study published in the August issue of Nature Medicine has found two tiny genetic variations that can predict which patients with Hodgkin’s lymphoma are most likely to develop radiation-induced second cancers years after treatment. Knowing in advance who is at risk could help physicians tailor treatment to...
26 Mar The Evolving Landscape of Immunogenicity Risk Assessment in Biologic Drug Development
Modern immunogenicity programs must also account for patient-level risk factors: prior exposure to related biologics, concomitant immunosuppressive therapy, disease state, and genetic background all modulate ADA incidence and clinical impact.
13 Oct The challenge of cartilage repair
The progress in viral vector manufacturing and gene editing means orthopedic specialists may soon be able to offer treatments that genuinely restore cartilage, not just mask symptoms. Ongoing developments focus on increasing the specificity of gene delivery, enhancing the durability of therapeutic effects, and scaling up production methods to allow widespread clinical adoption.
17 Sep Inside the Longevity World Cup’s Quest to Delay Aging
Longevity science is a proactive approach to the universal problem of disease and aging. It no longer makes sense to wait until someone is old and grey to spend tons of money managing a disease that could’ve been avoided altogether. Instead, longevity experts recommend lifestyle changes and scientific interventions to prevent the onset of the disease in the first place.
04 Feb The Future of Tinnitus Treatment: Breakthroughs That Could Silence the Noise
Posted at 11:17h
in Hearing Loss
Treatment for tinnitus is advancing beyond symptom management. Innovations in neuromodulation, regenerative medicine, and AI-driven therapies are creating new possibilities that could redefine how the condition is treated.
28 Jan Roswell Parks Opens Largest Engineering and Cell Manufacturing Facility to Expand Cancer Research
MedicalResearch.com Interview with: Christopher Choi, PhD, MBA Senior Vice President of Industry Partnerships Associate Professor of Oncology Technical Director of GMP Engineering & Cell Manufacturing Roswell Park Comprehensive Cancer Center Buffalo, NY MedicalResearch.com: What is the background for this study? What is a GMP facility? Response: The opening of the...
25 Jul Funding Breakthroughs: How Financial Incentives Drive Medical Innovation
Posted at 12:11h
in Pharmaceutical Companies
There are ways to make getting funding easier and more effective. One idea is to simplify the application process for grants and tax credits. This could help more small companies and new researchers get support. Some countries are already doing this.
25 Jul HAE Treatment: Weighing the Benefits and Risks for Individual Patients
Posted at 10:52h
in Dermatology
Managing HAE involves balancing benefits and risks. Each patient requires a personalized
approach. Regular monitoring and patient feedback are key
29 Jun Clincierge Personalizes Patient Support Services to Facilitate Clinical Trials
Posted at 00:00h
in Author Interviews
The team at Clincierge is very conscious of the need to expand the diversity profile of patients included in clinical trials. We do this by first identifying the particular barriers to access that deter participants, such as emotional, physical, and financial considerations. Then we create strategies to address them head-on.
12 Jan Short Telomeres LInked to More Severe COVID-19 Disease
Those patients that have the more severe disease including severe respiratory distress tend to have shorter telomeres than those with longer telomeres.
27 Apr CRISPR-Edited Stem Cells Cured Diabetes in a Mouse Model
Our study suggests that we may be able to cure monogenic diseases, especially monogenic diabetes (i.e., diabetes caused by gene mutations) and monogenic retinal degeneration, using gene editing in combination with patient-derived iPSCs.
07 Apr Single-Dose, Intranasal Vaccine with Recombinant Virus May Block COVID-19
A similar approach could be tested against the SARS-CoV-2 that is associated with the current pandemic.01 Jun Engineered Single Cell ‘Cured’ Patient of CLL
Posted at 23:27h
in Author Interviews, Cancer Research, Leukemia, Nature, University of Pennsylvania
MedicalResearch.com Interview with: Dr. J Joseph Melenhorst, PhD Director, Product Development & Correlative Sciences laboratories (PDCS) Adjunct Associate Professor Penn Medicine Center for Cellular Immunotherapies University of Pennsylvania MedicalResearch.com: What is the background for this study? Would you briefly explain what is meant by CLL and CAR T cells? Response: We...
27 Sep Blocking Gherlin May Be Key To Preventing Weight Gain After Dieting
MedicalResearch.com Interview with: Dr. W. Stephen Brimijoin PhD Department of Molecular Pharmacology and Experimental Therapeutics Mayo Clinic, Rochester, MN 55905 MedicalResearch.com: What is the background for this study? What are the main findings? Response: The background for this study was: 1) Ordinary C57 black mice readily become obese when given unrestricted access...04 Aug Skin-Grafted Stem Cells May Treat Obesity and Diabetes
MedicalResearch.com Interview with: Dr. Xiaoyang Wu PhD Ben May Department for Cancer Research The University of Chicago, Chicago, IL MedicalResearch.com: What is the background for this study? What are the main findings? Response: We have been working on skin somatic stem cells for many years. As one of the most...19 Mar Promising Biologic Stimulates Blood Flow Into Critical Limb Ischemia
MedicalResearch.com Interview with: Dr. Emerson C. Perin MD, PhD Texas Heart Institute Medical Director, BSLMC Catheterization Laboratory Director, Research in Cardiovascular Medicine Medical Director, Stem Cell Center MedicalResearch.com: What is the background for this study? Dr. Perin: Critical limb ischemia (CLI) is a devastating and debilitating disease characterized by reduced...18 Mar Preclinical Engineered Troponin Keeps Heart Beating Longer
MedicalResearch.com Interview with: Jonathan P. Davis , Ph.D. Associate ProfessorThe Ohio State University Medical Center Department of Physiology & Cell Biology. Columbus, OH 43210 MedicalResearch.com: What is the background for this study? What are the main findings? Dr. Davis: Myocardial infarction (MI) is a leading cause of heart failure and...22 Aug Novel DNA Vaccine Provides Protection Against MERS Virus
MedicalResearch.com Interview with: David B. Weiner, Ph.D. Professor, Department of Pathology and Laboratory Medicine Chair, Gene Therapy and Vaccine Program, CAMB Co-Leader Tumor Virology Program, Abramson Cancer Program University of Pennsylvania, Perelman School of Medicine Medical Research: What is the background for this study? What are the main findings? Dr. Weiner:...15 Apr Important Protein Pathway In Brain Plasticity Identified
MedicalResearch.com Interview with: Erwin G. Van Meir, PhD Professor, Departments of Neurosurgery and Hematology & Medical Oncology Leader, Winship Cancer Institute Cancer Cell Biology Program Founding Director, Graduate Program in Cancer Biology Director, Laboratory for Molecular Neuro-Oncology Emory University School of Medicine Atlanta GA 30322 Medical Research: What is the background...06 Mar Hepatocyte Growth Factor May Improve Painful Diabetic Neuropathy
MedicalResearch.com Interview with: Dr. John A Kessler MD The Ken and Ruth Davee Professor of Stem Cell Biology Department of Neurology Professor, Department of Pharmacology Northwestern University Feinberg School of Medicine Medical Research: What is the background for this study? What are the main findings? Dr. Kessler: Painful diabetic neuropathy...16 Sep Dental Caries and Head and Neck Cancer
MedicalResearch.com Interview with: Mine Tezal, DDS, PhD Oral Biology University at Buffalo NYS Center of Excellence in Bioinformatics and Life Sciences MedicalResearch.com: What are the main findings of the study? Dr. Tezal: We observed an inverse association between dental caries and head and neck cancer (HNSCC), which persisted among...20 Mar Outcomes of transplantation using various hematopoietic cell sources in children with Hurler’s syndrome after myeloablative conditioning
MedicalResearch.com Interview with Dr. Boelens Pediatric Blood and Marrow Transplantation Program, University Medical Center Utrecht, Utrecht, Netherlands MedicalResearch.com: What are the main findings of the study? Dr. Boelens: For children with Hurler’s syndrome, the receipt of a hematopoietic cell transplant (HCT) early in life with the best available human leukocyte...
15 Oct Why Women Are More Likely to Hide Their Struggles With Addiction
Posted at 12:31h
in Addiction
Stigma, motherhood, relationships and shame can lead women to hide addiction. Learn the barriers to treatment and how to find confidential support.
15 Oct Understanding the Different Levels of Mental Health Care
Posted at 00:24h
in Author Interviews
Mental health care ranges from weekly outpatient therapy to intensive, structured programs. Learn how levels of care work and how to find the right fit.
14 Oct Choosing a Therapist Online: What Should You Look For?
Posted at 12:13h
in Author Interviews
How to choose an online therapist: experience, therapy approach, personal fit, licensing and practical factors to consider before booking sessions.
14 Oct A Look Into The Part of Stroke Recovery We Rarely Talk About
Posted at 11:10h
in Stroke
Post-stroke fatigue, emotional changes and communication difficulties often get less attention than physical recovery. Here’s what families should know.