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11 Sep Circadian Body Clock Helps Explain Why Asthma Worsens at Night

Posted at 12:42h in Asthma, Author Interviews, Brigham & Women's - Harvard, Circadian Rhythm, Occupational Health, PNAS, Pulmonary Disease, Sleep Disorders

Those people who have the worst asthma in general are the ones who suffer from the greatest circadian-induced drops in pulmonary function at night, and also had the greatest changes induced by behaviors, including sleep.

10 Sep Pronounced Regional Disparities in Methadone Availability in the United States

Posted at 14:33h in Addiction, Author Interviews, Opiods, Race/Ethnic Diversity

Methadone for the treatment of opioid use disorder (OUD) is exclusively provided by federally regulated opioid treatment programs (OTPs) and has provoked significant community-based and legal controversy regarding its role in the management of this condition.

Joy M. Schmitz, Ph.D. Professor and Faillace Chair Director, Center for Neurobehavioral Research on Addiction (CNRA) Faillace Department of Psychiatry and Behavioral Sciences Behavioral and Biomedical Sciences Building (BBSB) Houston, TX 77054

07 Aug New Approach to Addiction: Diabetes Drug May Curb Cravings and Protect Brain White Matter

Posted at 22:03h in Addiction, Author Interviews, Cocaine, Diabetes, Methamphetamine

We think this research points to a new direction in medication development for the treatment of cocaine use disorder, and possibly other stimulants like methamphetamine.

22 Jul Melanoma: Animal Model Suggests Antibiotics May One Day Be Helpful in Controlling Resistant Disease

Posted at 17:23h in Author Interviews, Cancer Research, Melanoma

I would definitely discourage patients to take antibiotics without the supervision of their treating physician, since it is well known that some antibiotics (belonging to a different pharmacological category) can actually interfere with their treatment.

01 Jul NEJM: First Effective Non-Dietary Treatment of Celiac Disease

Posted at 14:13h in Author Interviews, Beth Israel Deaconess, Gastrointestinal Disease, NEJM

We hope that ZED1227 will be generally available to patients with celiac disease who need to “neutralize” minor to moderate amounts of gluten in ill-defined foods, or to patients with complicated (highly gluten sensitive) celiac disease, after a successful completion of these follow up studies.

Yerem Yeghiazarians, MD Professor of Medicine Leone-Perkins Family Endowed Chair in Cardiology San Francisco Board Past-President, American Heart Association Co-Director, Adult Cardiac Catheterization Laboratory Director, Peripheral Interventional Cardiology Program Director, Translational Cardiac Stem Cell Program Cardiovascular Research Institute Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research Associate Member in Experimental Therapeutics, UCSF Helen Diller Cancer Center University of California, San Francisco

21 Jun AHA Scientific Statement Highlights Link Between Obstructive Sleep Apnea and Heart Disease

Posted at 22:13h in AHA Journals, Author Interviews, Obstructive Sleep Apnea, UCSF

The risk of OSA correlates with body mass index, and obesity remains the one major modifiable risk factor for obstructive sleep apnea.

Dr. Frank Vicini, MD, FACR, FASTRO Principal Investigator Radiation Oncologist at GenesisCare Member of NRG Oncology

18 Jun DCISionRT Tool Identifies DCIS Patients With High Risk of Recurrence After Surgery and Radiation

Posted at 19:22h in ASCO, Author Interviews, Biomarkers, Breast Cancer

DCISionRT analyzes the biology of a patient’s unique tumor and provides a quantified risk of a woman’s cancer coming back within 10 years-- either as invasive cancer or a DCIS recurrence-- in the form of her Decision Score on a scale of zero to 10.

18 Jun Simple Tool Allows Patients to Stop Hiccups

Posted at 17:30h in Author Interviews, JAMA

The main etiology of hiccups is not known, however in some people ,certain things trigger hiccups, such as spicy foods, drinking alcohol or eating fast as well as Cancer Chemotherapy medications.

Mai Takahashi MD MPH Mount Sinai Beth Israel - Resident Physician New York, New York

07 Jun HPV Oropharyngeal Cancer: Reduced Dose ChemoRadiation Linked to Better 5 Year Quality of Life

Posted at 21:52h in ASCO, Author Interviews, Cancer Research

MedicalResearch.com Interview with: Mai Takahashi MD MPH Mount Sinai Beth Israel – Resident Physician New York, New York MedicalResearch.com: What...

02 Jun EU Discusses Increasing Prevention of Melanoma and Non-Melanoma Skin Cancer

Posted at 12:42h in Author Interviews, Cancer Research, Dermatology, Melanoma

Malignant melanoma is the most lethal form of skin cancer.[viii] Historically, melanoma was a rare cancer, but in the past 50 years its incidence has risen faster than almost any other cancer.

19 May Dental Caries: New Approach Breaks Down Harmful Biofilm

Posted at 22:49h in Author Interviews, Dental Research, Microbiome, University of Pennsylvania

In the era of antimicrobial resistance, we may need novel nonbiocidal, precise therapeutic measures to address microbially induced infectious diseases.

16 May DDW21: Semaglutide Augments Weight Loss With Minimal Surgical Procedure

Posted at 11:47h in Author Interviews, Diabetes, Gastrointestinal Disease, Weight Research

Bariatric surgery remains the gold standard for significant, sustained weight loss and improvement of metabolic outcomes. However, less than 2% of eligible patients pursue this option.

04 May Personalized Radiation Shields May Protect Normal Tissues During Cancer Treatments

Posted at 23:20h in Author Interviews, Brigham & Women's - Harvard, Cancer Research, Colon Cancer, Radiation Therapy

We used patients’ CT scans to personalize these devices so that they could comfortably and reliably fit to areas that are at risk for damage.

Aditya Bardia MD, MPH Director, Breast Cancer Research Program, Attending Physician, Massachusetts General Hospital Harvard Medical School

22 Apr Triple Negative Breast Cancer: TRODELVY® (sacituzumab govitecan) Trial Demonstrates Significant Improvement Compared to Standard Chemo

Posted at 11:44h in Author Interviews, Breast Cancer, Brigham & Women's - Harvard, NEJM

The significant survival benefit seen in the landmark ASCENT study is practice-changing and positions sacituzumab govitecan-hziy as a potential standard of care for pre-treated Triple Negative Breast Cancer.

05 Apr Mechanism of Horrible Itching of Liver Disease Identified in Superficial Skin Cells

Posted at 23:56h in Author Interviews, Dermatology

The skin can function as a sensory organ through its epithelial cells, keratinocytes, which can assume a quasi-neural function, telling itch neurons what to do by directly signaling to them cell-to-cell.

17 Mar Tips for Managing Anxiety

Posted at 18:34h in Author Interviews, Mental Health Research

When someone is anxious, their adrenaline is pumping, and they tend to engage in shallow breathing. Regular abdominal breathing can not only help ease an anxious episode, but it can also help prevent them in the long run.

Giordano Bottà, PhD CEO and Co-founder Allelica The Polygenic Risk Score Company

08 Mar Polygenic Risk Score Identifies Patients with Average LDL Who Could Benefit from Statins

Posted at 18:18h in AHA Journals, Author Interviews, Genetic Research, Heart Disease

Our study paved the way for the understanding of plaque formation in different polygenic backgrounds.

Khalid Shah, MS, PhD Vice Chair of Research, Department of Neurosurgery Director, Center for Stem Cell Therapeutics and Imaging Director, Center for Excellence in Biomedicine Brigham and Women's Hospital Associate Professor, Harvard Medical School Principal Faculty, Harvard Stem Cell Institute

05 Mar Breast Cancer: Using Blood Brain Barrier-Crossing Stem Cells to Attack Metastases

Posted at 00:15h in Author Interviews, Breast Cancer, Brigham & Women's - Harvard, Stem Cells

MedicalResearch.com Interview with: Khalid Shah, MS, PhD Vice Chair of Research, Department of Neurosurgery Director, Center for Stem Cell Therapeutics...

Dr. Steven L. Wagner PhD University of California, San Diego Department of Neurosciences Professor in Residence School of Medicine, Medical Teaching Facility Room 150 La Jolla, California 92093-0624

03 Mar Alzheimer’s Disease: Animal Model Demonstrates Ability of Novel Enzyme to Decrease Amyloid Plaques

Posted at 00:27h in Alzheimer's - Dementia, Author Interviews, UCSD

The novel GSM was then tested in a mouse model of early-onset AD, treating the animals either before or shortly after they began to form amyloid plaques.

01 Mar Liver Metastases Treatment

Posted at 15:50h in Cancer Research

The main benefit of chemoembolization in the treatment for liver metastases is the minimal harm to the patient's health. This is because the procedure causes a local impact on the tumor, namely on the vessels that feed it.

25 Feb 4 Treatment Options To Help You Cope With Phobia

Posted at 22:17h in Mental Health Research

Living with a phobia forces you to resign to a life of worrying about a certain object or situation that makes you anxious. Fortunately, you can cope with phobias with the help of different treatment options.

25 Feb Bladder and Colon Cancer: E. coli Bacteria Breakdown Protein Driver of Cancer Progression

Posted at 21:02h in Author Interviews, Cancer Research

If you make room for serendipity in science you can make some new discoveries. Targeting MYC is highly desirable for cancer therapy but has proven extremely difficult and MYC has long been regarded as ‘’undruggable’’.

Dr. Richard Gallo, MD, PhD Ima Gigli Distinguished Professor of Dermatology Chair of the Department of Dermatology UC San Diego School of Medicine

24 Feb Bacteria From Healthy Human Skin Can Be Used to Treat Atopic Dermatitis – Eczema

Posted at 23:46h in Author Interviews, Microbiome, UCSD

The exciting part of the work is that this is the first time the approach of targeted bacteriotherapy has been used for a skin disease, and the trial shows it is safe and helped most of the patients who received it.

“Peanuts” by Daniella Segura is licensed under CC BY 2.0

24 Feb Peanut Allergy: Painless Microneedle Patch Has Potential To Induce Desensitization

Posted at 23:12h in Allergies, Author Interviews

Microneedle patches loaded with peanut proteins were able to induce robust immunologic responses in mice using low doses of peanut protein

masters-psychology-counseling-mental-health

23 Feb An Online Masters in Mental Health Counseling: The Basics

Posted at 17:37h in Education, Mental Health Research

Studying for a masters in mental health counseling online can open up many different career paths. It is a great step in deciding what kind of counseling you would excel best in, and helping prepare you for the challenges to come.

Raymond L. Benza, MD, FACC, FAHA, FACP Professor of Medicine Temple University School of Medicine Philadelphia, PA

11 Feb REVEAL Risk Calculator Allows Primary Care Physicians To Assess Pulmonary Arterial Hypertension Risk

Posted at 23:35h in Author Interviews

The analysis demonstrated that REVEAL Lite 2 offers a simplified method of risk assessment that may be implemented routinely in daily clinical practice and can be used in conjunction with REVEAL 2.0, and differentiates patients among low, intermediate and high risk of one-year mortality

Eirini Papapetrou, MD, PhD Associate Professor Department of Oncological Sciences Icahn School of Medicine at Mount Sinai New York, NY 10029

11 Feb Icahn Scientists Make Model of Deadly Leukemia Using CRISPR-Edited Stem Cells

Posted at 19:54h in Author Interviews, Leukemia, Stem Cells, Technology

Most current models capture late stages of cancers, including AML. We wanted to develop a model that could capture the earlier stages and, in particular, track the progression from early stages to the fully developed Acute myeloid leukemia.

David-Dan Nguyen Research Fellow | Center for Surgery and Public Health, Brigham and Women's Hospital MPH (Health Policy) Student | Harvard T.H. Chan School of Public Health Medical Student | McGill University

01 Feb COVID-19: Does Surgical Delay for Intermediate and High Risk Prostate Cancer Affect Prognosis?

Posted at 11:16h in Author Interviews, Brigham & Women's - Harvard, Cancer Research, COVID -19 Coronavirus, Prostate, Prostate Cancer, Surgical Research, Urology

Future research explicitly examining cohort of patients whose care have been delayed during the COVID-19 pandemic are needed.

Kent Hoskins, MD Eileen Lindsay Heidrick Professor in Oncology Division of Hematology/Oncology University of Illinois at Chicago Director of Cancer Genetics Co-Leader, Breast Cancer Research Group University of Illinois Cancer Center

22 Jan Breast Cancer: Genome Assays May Need Recalibration for Racial and Ethnic Groups

Posted at 09:55h in Author Interviews, Breast Cancer, Genetic Research, JAMA, Race/Ethnic Diversity

I think the main message here is that even among women with presumably favorable prognosis breast tumors (HR-positive, axillary node-negative), Black women die from their cancer at a significantly higher rate than women from most other racial/ethnic groups, even after controlling for treatment and known prognostic variables (including the Oncotype recurrence score).

21 Jan Oteseconazole: Mycovia Pharmaceuticals Reports Positive Phase 3 Data for their Oral Drug for Recurrent Vaginal Yeast Infections

Posted at 11:14h in Author Interviews, Infections, OBGYNE, Pharmaceutical Companies

Historically, investment and innovation in women’s health have been limited. However, Mycovia is committed to recognizing and empowering those living with unmet medical needs, which is one of the reasons we focused first on developing oteseconazole for recurrent vaginal yeast infections.