We studied a large panel of antimicrobials besides Colistin, and we found evidence of sharing of the mcr-1 colistin resistance gene harbored by the similar multidrug resistant Escherichia coli clone colonizing the GI tract of both a dog with a skin infection and his owner.
We identify a 48-gene mesothelioma prognostic signature whose expression is highly predictive of patient survival. Some of these genes could be potential drug targets in treating malignant mesothelioma patients
This is a first-of-its-kind clinical trial in which a DNA medicine encoding for tumor-specific antigens is combined with an immune checkpoint inhibitor, and given together with the standard of care, in patients with newly diagnosed glioblastoma.
The study, in which 343 patients received LENVIMA plus everolimus, helps to contribute to the growing body of evidence supporting the role of this TKI-mTOR combination in the advanced RCC treatment paradigm.
This study has utilized both clinical and biomedical approaches to better understand how a rare mutation in the PCSK9 gene can have a number of surprisingly protective effects on several different diseases.
To understand the importance of these results, it is important to understand the patient population. Despite advances in treatment for men with metastatic castration-resistant prostate cancer, the disease continues to be very deadly and five-year survival remains low.
Response: This is the first randomized trial reporting results combining chemotherapy with immune checkpoint blockade in urothelial cancer versus chemotherapy alone or immune checkpoint blockade monotherapy versus chemotherapy.
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