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11 Apr Can Greebles Help Identify People At Risk of Alzheimer’s Disease?

Posted at 21:57h in Alzheimer's - Dementia, Author Interviews

MedicalResearch.com Interview with: Emily Mason, Ph.D. Postdoctoral Associate Department of Neurological Surgery University of Louisville MedicalResearch.com: What is the background for this study? What are the main findings? Response: Alzheimer’s disease is a devastating neurodegenerative disease that currently affects one in eight Americans over the age of 65. Unfortunately, there...

11 Apr Animal Study Suggests Lorcaserin (Belviq®) May be Useful to Reduce Opioid Intake

Posted at 11:32h in Author Interviews, Opiods, Pharmacology, University Texas

MedicalResearch.com Interview with: Christina R. Merritt and Kathryn A. Cunningham Center for Addiction Research University of Texas Medical Branch Galveston, TX 77555 MedicalResearch.com: What is the background for this study? What are the main findings? Response: Opioid use disorder (OUD) is one of the top public health problems in the...

04 Apr Effects of ICD Shock and Anti-Tachycardia Pacing on Anxiety and Quality of Life

Posted at 22:07h in AHA Journals, Author Interviews, Heart Disease, Mental Health Research

MedicalResearch.com Interview with: Alessandro Paoletti Perini, MD, PhD and Valentina Kutyifa MD, PhD University of Rochester Medical Center Heart Research Follow-Up Program Rochester, New York, 14642 MedicalResearch.com: What is the background for this study? What are the main findings? Response: The present study is a pre-specified sub-study of the Multicenter...

29 Mar Knee Replacement Would Be More Cost Effective If Limited To Those With Severe Symptoms

Posted at 23:17h in Author Interviews, BMJ, Cost of Health Care, Orthopedics

MedicalResearch.com Interview with: Bart S Ferket, MD, PhD Assistant Professor, Population Health Science and Policy Icahn School of Medicine at Mount Sinai MedicalResearch.com: What is the background for this study? Response: The annual rate of total knee replacement in the US has doubled since 2000, and especially in those aged...

29 Mar Phase 3 Study Finds XARELTO® Superior to Aspirin for Long-Term Prevention of Recurrent Blood Clots in VTE

Posted at 16:26h in Author Interviews, Clots - Coagulation, Heart Disease, Thromboembolism

MedicalResearch.com Interview with: Paul Burton, MD, PhD, FACC Vice President, Medical Affairs Janssen MedicalResearch.com: What is the background for this study? What are the main findings? Response: Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), affects more than 900,000 Americans each year; one-third of these occurrences...

28 Mar Adolescents Perinatally Infected with HIV Are At Increased Risk of Serious Physical and Mental Health Problems

Posted at 00:12h in Author Interviews, Brigham & Women's - Harvard, HIV, Pediatrics

MedicalResearch.com Interview with: Anne M Neilan, MD,MPH Assistant in Medicine and Pediatrics Massachusetts General Hospital Instructor at Harvard Medical School Department: Medicine Service Division: Infectious Disease Department: Pediatric Service Massachusetts General Hospital Boston, MA 02114 MedicalResearch.com: What is the background for this study? What are the main findings? Response: Adolescents...

23 Mar Association Between Cardiovascular Risk Factors and Aortic Stenosis

Posted at 01:58h in Author Interviews, Heart Disease, JACC, Lifestyle & Health

MedicalResearch.com Interview with: Andrew T. Yan, MD Terrence Donnelly Heart Centre St Michael’s Hospital University of Toronto Toronto, Ontario, Canada MedicalResearch.com: What is the background for this study? What are the main findings? Response: The pathogenesis of aortic stenosis is complex and incompletely understood. Previous experimental data and epidemiologic studies...

21 Mar Critical Neural Pathways Identified in OCD Behavior

Posted at 18:48h in Author Interviews, Mental Health Research

MedicalResearch.com Interview with: Dr. Melanie Ullrich PhD Universität Würzburg Physiologisches Institut Würzburg MedicalResearch.com: What is the background for this study? Response: Shortly after the first description of SPRED proteins in 2001, their in vivo functions, especially that of SPRED2, were completely unexplored. Thus we generated a mouse model which lacks...

21 Mar High risks of mortality following bleeding and ischemic events occurring 1 year after coronary stenting

Posted at 18:37h in Author Interviews, Heart Disease, JAMA

MedicalResearch.com Interview with: Eric A. Secemsky, MD, MSc Interventional Cardiology Fellow Massachusetts General Hospital Harvard Medical School Baim Institute for Clinical Research MedicalResearch.com: What is the background for this study? What are the main findings? Response: We know from previous trials that continuing dual antiplatelet therapy longer than 12 months...

19 Mar Curcumin Gel May Speed Healing of Scalds and Burns

Posted at 00:24h in Author Interviews, Dermatology, UCLA

MedicalResearch.com Interview with: Madalene Heng MD, FRACP, FACD, FAAD Professor of Medicine/Dermatology UCLA School of Medicine MedicalResearch.com: What is the background for this study? What are the main findings? Response: Curcumin, the active ingredient in the spice, turmeric, is an excellent anti-inflammatory agent with unique healing properties. However, this is...

16 Mar Human Placenta May Be Most Vulnerable To Zika In First Trimester

Posted at 14:49h in Author Interviews, OBGYNE, PNAS, Zika

MedicalResearch.com Interview with: R. Michael Roberts PhD Curators’ Distinguished Professor 240b Bond Life Sciences Center Columbia, Missouri 65211-7310 MedicalResearch.com: What is the background for this study? Response: My background in placental biology and in communication between the embryo and the mother in early pregnancy made me curious about how the...

16 Mar Older Women Face Greater Risk of Diabetes From Statins

Posted at 11:31h in Author Interviews, Diabetes, Gender Differences, Lipids

MedicalResearch.com Interview with: Dr Mark Jones, Senior Lecturer Faculty of Medicine and Biomedical Sciences, School of Public Health The University of Queensland MedicalResearch.com: What is the background for this study? Response: Multiple clinical trials have shown statins reduce LDL cholesterol, cardiovascular events, and all-cause mortality. However statins are also associated with...

15 Mar Prostate Artery Embolization Is Less Invasive Choice For BPH Treatment

Posted at 20:40h in Author Interviews, Prostate, Radiology, Urology

MedicalResearch.com Interview with: Dr. João Martins Pisco, MD PhD Hospital St. Louis, International Prostate Medical Center Lisbon, Portugal MedicalResearch.com: What is the background for this study? What are the main findings? Response: Enlarged prostate, also known as benign prostatic hyperplasia (BPH), is one of the most common prostate problems occurring in...

14 Mar Home-Based Rehabilitation Found As Effective As Inpatient After Knee Replacement

Posted at 23:16h in Author Interviews, JAMA, Orthopedics

MedicalResearch.com Interview with: Justine M. Naylor, PhD Braeside Hospital, HammondCare, Australia South West Sydney Clinical School, University of New South Wales, Liverpool Hospital South West Sydney Local Health District, Liverpool 2170, NSW, Australia MedicalResearch.com: What is the background for this study? Response: Total knee arthroplasty (replacement) for end-stage arthritis is a very...

09 Mar Drug For Diabetic Neuropathy May Also Target an Aggressive Form of Breast Cancer

Posted at 11:46h in Author Interviews, Breast Cancer, Science

MedicalResearch.com Interview with: Chenfang Dong Department of Pathology and Pathophysiology Zhejiang Key Laboratory for Disease Proteomics Zhejiang University School of Medicine Hangzhou China MedicalResearch.com: What is the background for this study? What are the main findings? Response: Basal-like breast cancer (BLBC), which generally falls into the triple-negative breast cancer subtype,...

08 Mar Psoriasis: Efficacy and Safety of Guselkumab vs Humira for Moderate to Severe Disease

Posted at 15:15h in Author Interviews, Boehringer Ingelheim, Dermatology, Pharmacology

MedicalResearch.com Interview with: Andrew Blauvelt, M.D., M.B.A. President and Investigator Oregon Medical Research Center MedicalResearch.com: What is the background for this study? What are the main findings? Response: Findings from the Phase 3 VOYAGE 1 study showed that patients with moderate to severe plaque psoriasis receiving guselkumab, an human anti-interleukin (IL)-23 monoclonal...

04 Mar Anorexia Nervosa: So Brain Changes Persist After Weight Restoration

Posted at 22:10h in Author Interviews, Eating Disorders

MedicalResearch.com Interview with: Guido K.W. Frank, M.D., FAED Associate Professor of Psychiatry and Neuroscience Associate Director, Eating Disorder Program Director, Developmental Brain Research Program Pediatric Mental Health Institute | Children’s Hospital | University of Colorado Anschutz Medical Campus Colorado MedicalResearch.com: What is the background for this study? Response: Anorexia nervosa...

01 Mar Reduction in Radiation Has Reduced Second Tumors in Pediatric Cancer Patients

Posted at 17:47h in Author Interviews, Cancer Research, JAMA, Pediatrics, Radiation Therapy

MedicalResearch.com Interview with: Lucie Turcotte, MD, MPH University of Minnesota Masonic Children’s Hospital Division of Pediatric Hematology-Oncology Assistant Professor Minneapolis, MN 55455 MedicalResearch.com: What is the background for this study? What are the main findings? Response: We have observed dramatic improvements in the number of survivors of childhood cancer over...

01 Mar Safety and Immunogenicity of the Tau Vaccine AADvac1 in Patients with Alzheimer’s Disease

Posted at 14:17h in Alzheimer's - Dementia, Author Interviews, Lancet, Vaccine Studies

MedicalResearch.com Interview with: Petr Novak, MD, PhD AXON Neuroscience Bratislava, Slovakia MedicalResearch.com: What is the background for this study? Response: Alzheimer’s disease is a complex, multifactorial disorder, with many-faceted neuropathology. A hallmark finding is the co-existence of neurofibrillary pathology (such as neurofibrillary tangles) composed of tau protein, and amyloid-β pathology...

28 Feb mGlu2 receptor Agonist ADX71149 Plus Levetiracetam May Reduce Seizures With Fewer Side Effects

Posted at 17:51h in Author Interviews, Epilepsy, Pharmacology

MedicalResearch.com Interview with: Robert Lutjens, PhD Head of Discovery at Addex Therapeutics Geneva, Switzerland MedicalResearch.com: What is the background for this study? What are the main findings? Response: Metabotropic glutamate receptors represent an attractive therapeutic target for various neurologic conditions. In particular, the metabotropic glutamate receptor subtype 2 (mGlu2) can affect...

27 Feb Aspirin Desensitization in Patients With Coronary Artery Disease

Posted at 12:41h in AHA Journals, Allergies, Author Interviews, Heart Disease

MedicalResearch.com Interview with: Dr. Roberta Rossini, MD, PhD USC Cardiologia, Cardiovascular Department Bergamo, Italy MedicalResearch.com: What is the background for this study? What are the main findings? Response: Aspirin (ASA) is stilll the cornerstone of antithrombotic therapy in patients with coronary artery disease, especially after PCI, both in the acute...

25 Feb Increase In Subdural Hematomas Associated With Increase Use of Antithrombotic Drugs

Posted at 21:28h in Author Interviews, Heart Disease, JAMA

MedicalResearch.com Interview with: MedicalResearch.com: What is the background for this study? What are the main findings? Response: The incidence of subdural hematoma (SDH; a bleed located within the skull, but outside the brain) has been reported to be on the increase. Previous studies have shown an association between use of...

24 Feb Singing Enhances Mother-Infant Bond Even When Mom Has PostPartum Depression

Posted at 02:03h in Author Interviews, Mental Health Research, OBGYNE, Pediatrics

MedicalResearch.com Interview with: Shannon K. de l’Etoile, Ph.D., MT-BC Associate Dean of Graduate Studies Professor, Music Therapy University of Miami Phillip and Patricia Frost School of Music Coral Gables, FL MedicalResearch.com: What is the background for this study? Response: Infant-directed (ID) singing allows infants to have emotionally-synchronized interactions with caregivers,...

23 Feb Antidepressants Have Variable Effects On Symptom Clusters

Posted at 00:30h in Author Interviews, Depression, JAMA, Pharmacology, Yale

MedicalResearch.com Interview with: Adam Chekroud PhD Candidate Human Neuroscience Lab Department of Psychology Yale University MedicalResearch.com: What is the background for this study? Response: We know that depression includes a wide range of symptoms, from low mood and feeling worthless, to problems sleeping, slowed thinking, and suicidal ideation. We wanted...

21 Feb Tele-Rehabilitation Can Improve Physical Function In Chronic Knee Pain Patients

Posted at 11:49h in Annals Internal Medicine, Author Interviews, Pain Research, Telemedicine

MedicalResearch.com Interview with: Rachel Nelligan, BPhysio Physiotherapist & Research Physiotherapist Department of Physiotherapy | Centre for Health, Exercise and Sports Medicine The University of Melbourne Victoria Australia MedicalResearch.com: What is the background for this study? Response: This novel study investigated the efficacy of an internet delivered model of service delivery...

20 Feb Targeted Radiosurgery Beats Whole Brain Radiation For Brain Tumor Survival

Posted at 16:31h in Author Interviews, Brain Cancer - Brain Tumors, Radiation Therapy

MedicalResearch.com Interview with: N. Scott Litofsky, M.D. Chief of the Division of Neurological Surgery University of Missouri School of Medicine MedicalResearch.com: What is the background for this study? What are the main findings? Response: Radiosurgery is being used more often for treatment of brain metastases to avoid potential side effects...

17 Feb Effects of Riociguat in Treatment-Naïve vs Pretreated Patients With Pulmonary Arterial Hypertension

Posted at 19:02h in Author Interviews, Immunotherapy, Pulmonary Disease

MedicalResearch.com Interview with: Prof. Hossein-Ardeschir Ghofrani University of Giessen and Marburg Lung Center Giessen, Germany, and Member of the German Center of Lung Research and Department of Medicine Imperial College London London, UK MedicalResearch.com: What is the background for this study? Response: Pulmonary arterial hypertension (PAH) is characterised by increased...

17 Feb Transplanted Human Embryonic Stem Retinal Pigment Cells Survive 22 months in a Human Recipient

Posted at 12:10h in Author Interviews, Ophthalmology, Stem Cells

MedicalResearch.com Interview with: Won Kyung Song MD.PhD Assistant Professor, Vitreoretinal service, Department of Ophthalmology CHA Bundang Medical Center CHA University Republic of Korea MedicalResearch.com: What is the background for this study? What are the main findings? Response: The retina is a light-sensitive neural tissue lining the inner surface of the...

16 Feb Mammaprint Profiling Improves Breast Cancer Adjuvant Treatment Decisions

Posted at 20:21h in Author Interviews, Breast Cancer, Genetic Research

MedicalResearch.com Interview with: Dr. med. Rachel Würstlein Senior Specialist Clinic and Polyclinic for Obstetrics and Gynecology Klinikum der Ludwig-Maximilians-Universität München • Campus Innenstadt Munich MedicalResearch.com: What is the background for this study? Response: Gene expression profiles provide important information on the risk of recurrence, and subtyping in HR+ HER2- early...

14 Feb Ketamine Before Stressful Event May Reduce Risk of PTSD

Posted at 01:29h in Author Interviews, Columbia, Mental Health Research, Nature, PTSD

MedicalResearch.com Interview with: Christine Ann Denny, Ph.D. Assistant Professor Department of Psychiatry Columbia University Division of Integrative Neuroscience Research Foundation for Mental Hygiene, Inc. New York, NY 10032-2695 MedicalResearch.com: What is the background for this study? What are the main findings? Response: Post-traumatic stress disorder (PTSD) is one of the...