21 May Genes Linked to Melanoma of the Eye Identified
Though we don’t really understand why yet, there does seem to be a higher number of uveal melanoma cases in people with light colour irises.
19 May Metastatic Bladder Cancer: Study Evaluates Combination of Checkpoint Blocker with Chemotherapy
Response: This is the first randomized trial reporting results combining chemotherapy with immune checkpoint blockade in urothelial cancer versus chemotherapy alone or immune checkpoint blockade monotherapy versus chemotherapy.
04 May Metastatic Breast Cancer: Tumor Profiling by Liquid Biopsy Can Help Drive Therapy
Testing more broadly beyond PIK3CA and with a liquid biopsy can help identify potential mechanisms of resistance to therapy and determine those patients most likely to respond to a PI3K inhibitor.
18 Feb Clarus Therapeutics Lauches JATENZO® – Oral Testosterone Replacement Therapy
"We believe JATENZO addresses a long-standing need for a safe and effective oral testosterone replacement product that meets current day FDA safety and efficacy standards."
12 Feb Two-Drug Combo Induces Human Beta Cells to Regenerate and Make Insulin
MedicalResearch.com Interview with: Andrew F. Stewart MD Director, Diabetes Obesity and Metabolism Institute Irene and Dr. Arthur M. Fishberg Professor...
08 Jan Despite Better Chemotherapy, US Women Choosing More Rather Than Less TNBC Surgery
Posted at 20:32h
in Author Interviews, Breast Cancer, Brigham & Women's - Harvard, JAMA, Surgical Research
Why there is such a big difference between women who have the same treatment and information in the US versus the rest of the world?
08 Jan Pulse Ultrasound Therapy May Improve Memory in Alzheimer’s Patients
In contrast to electrophysiological brain stimulation techniques, the new technique allows also focal brain activation deep in the brain.
23 Dec The Wistar Institute Discovers New Therapeutic Strategy for Chemotherapy Resistance in Ovarian Cancer
MedicalResearch.com Interview with: Rugang Zhang, Ph.D Professor & Co-Leader, Gene Expression & Regulation Program Deputy Director, The Wistar Institute Cancer...
26 Sep Precision Medicine: Genetic Variants Predict Response of Eosinophilic Esophagitis to PPIs
For the pediatric EoE field, this is a landmark study that may eventually change how we prescribe PPIs for the treatment of EoE.
23 Sep Epigenetic Changes Linked to Hypersexual Disorder and Addictive Behaviors
Hypersexual disorder contains addictive elements, but is not to be seen as exclusively an addiction.
08 Aug Study Doubles Number of Genes Linked to Squamous and Basal Cell Skin Cancer
Our study is the world’s largest genetic study on keratinocyte cancers to date. In total we identified total of 79 independent genetic loci associated with keratinocyte cancer risk.
22 Jul Testosterone Replacement Therapy Linked to Increased Risk of Heart Attack and Stroke
The potential harms of testosterone replacement therapy should be weighed against its expected benefits when considering this treatment in aging men.
15 Jul Prostate Cancer: Effects of Hormone Therapy on Cognitive Function Addressed in Large Study
Posted at 17:57h
in Author Interviews, Cancer Research, Hormone Therapy, JAMA, Prostate Cancer, University of Pennsylvania
Our results suggest that clinicians need to carefully weigh the long-term risks and benefits of exposure to androgen deprivation therapy, particularly in patients with a long life expectancy or patients who already show signs of cognitive decline.
12 Jul Genetic Variants Linked to Life-threatening Cardiac Arrhythmias in Patients With Dilated Cardiomyopathy and Implanted Defibrillators
TTNtv genetic variants were associated with a 4.9-fold increased risk of receiving an appropriate ICD therapy
02 Jul Americans Support Gene Therapies Even If They Cost More
83% of Americans support efforts to advance the medical innovations offered by gene therapies.
11 Jun Updated Expert Consensus Statement on Platelet Function/Genetic Testing for Guiding P2Y12 Receptor-Inhibitor Treatment in PCI
According to large-scale trials and the respective guidelines, clopidogrel is the recommended P2Y12 inhibitor in stable patients, while prasugrel and ticagrelor are recommended, in the absence of contraindications, in patients with ACS.
19 Apr AI Poised to Revolutionize Radiation Therapy for Cancer
Posted at 12:42h
in Author Interviews, Brigham & Women's - Harvard, Cancer Research, JAMA, Radiation Therapy, Technology
Applying crowd innovation to problems in healthcare can lead to rapid prototyping of AI solutions and catalyze transformations in healthcare delivery.
18 Apr Stem Cell Therapy Improved Motor Deficit in Traumatic Brain Injury Trial
Posted at 12:04h
in Author Interviews, Brain Injury, Stem Cells, Surgical Research, University of Pittsburgh
Stem cell therapy with SB623 cells in chronic TBI patients with fixed motor deficits achieved the primary efficacy endpoint of the Phase 2 clinical trial
28 Mar Gene Transfer Improved Cardiac Function in Diabetic Mouse Model
The concept of a single administration of an agent that reduces blood sugar while increasing heart function, would be attractive to patients with diabete
25 Mar Genentech Submits New Drug Application to FDA for Venclexta Plus Gazyva for Untreated CLL with Co-Existing Medical Conditions
These results indicate that Venclexta plus Gazyva could provide a chemotherapy-free, fixed-duration treatment option for people with previously untreated CLL with co-existing medical conditions.
13 Mar Genetic Evidence Suggests New LDL-C Lowering Drug May Decrease Cardiovascular Events and Have Additive Effect with Statins
We found that lifelong exposure to lower LDL-C due to genetic inhibition of ATP-citrate lyase and HMG-CoA reductase were NOT associated with an increased risk of cancer.
04 Mar Egg Allergy: Oral Immunotherapy Has Potential for Lasting Benefit
Egg egg oral immunotherapy has the potential to allow for introduction of egg products into the diet that can improve safety from allergic reactions and overall quality of life
21 Jan Tinnitus: Study of Adoptees Suggests Genetic Predisposition
MedicalResearch.com Interview with: Christopher R. Cederroth | Ph.D. Docent Associate Professor Experimental Audiology | Department of Physiology and Pharmacology Karolinska Institutet...
29 Nov Data Support National Guidelines for ARNI Therapy in Eligible Patients with Heart Failure with Reduced Ejection Fraction
MedicalResearch.com Interview with: Pratyaksh K. Srivastava, MD Division of General Internal Medicine, UCLA Gregg C. Fonarow, MD Ahmanson-UCLA Cardiomyopathy Center...
27 Nov Multiple Sclerosis: T Cell Immunotherapy Targeting EBV Infected Cells Shows Promise
This study lends support to the EBV hypothesis in Multiple Sclerosis and suggests that a T cell immunotherapy targeting EBV infected B lymphocytes and plasma cells may be safe and have a positive effect on disease activity.
26 Nov Second Generation 3-Drug Combination Found Safe & Effective for Newly Diagnosed Multiple Myeloma
The second generation 3-drug combination KRd is safe and highly efficacious.
10 Oct Breast Cancer: Gene Expression of Receptors on a Chip Can Enhance Precision Diagnosis
We have considered just two genes for each receptor. Many more genome data items would lend themselves to be included in the future
28 Sep Hyperbaric Oxygen Therapy Can Salvage Hearing In Some Sensorineural Loss Cases
Hyperbaric oxygen therapy is basically a very safe and effective treatment with few side effects.