“Magic Mouthwash” Can Decrease Mouth Pain from Radiation Therapy

MedicalResearch.com Interview with:

Robert C. Miller, MD, MS, MBADepartment of Radiation Oncology, Mayo Clinic, Jacksonville, FloridaUniversity of Maryland School of Medicine, Baltimore

Dr. Miller

Robert C. Miller, MD, MS, MBA
Department of Radiation Oncology, Mayo Clinic, Jacksonville, Florida
University of Maryland School of Medicine, Baltimore

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: “Magic Mouthwash” is one of the most commonly prescribed medications for oral mucositis pain during cancer therapy, but there has not been good evidence in the past to support its use.

This trial is the first large randomized controlled trial to demonstrate that both “Magic” mouthwash and doxepin rinse reduce patient reported pain during cancer therapy.

MedicalResearch.com: What should readers take away from your report? 

Response:  Magic mouthwash and doxepin rinse both can provide additional non-narcotic pain relief in addition to other analgesics and mouth rinses.  

MedicalResearch.com: What recommendations do you have for future research as a result of this work?

Response: We plan a followup trial combining the two rinses to examine if that rinse provides even more pain relief in combination fashion. 


Sio TT, Le-Rademacher JG, Leenstra JL, et al. Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial. JAMA. 2019;321(15):1481–1490. doi:10.1001/jama.2019.3504 


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