23 Jul Study Evaluates Cannabis For Pain From Diabetic Neuropathy
Medical Research: What is the background for this study? What are the main findings?
Dr. Wallace: The study was funded by the center for medicinal cannabis research at the University of California San Diego. The center was funded by the state of California. The center was the first to fund a series of double-blind randomized controlled trials with inhaled cannabis for neuropathic pain. My trial is the first in diabetic peripheral neuropathy pain which is one of the most prevalent pain syndromes in our society with limited treatments. We found a dose dependent reduction in pain. However there was also a dose dependent increase in euphoria and sedation which may limit clinical use. Effects on neurocognitive functioning were minimal.
Medical Research: What should clinicians and patients take away from your report?
Dr. Wallace: This was a single dose study and results should be interpreted with caution. This study used cannabis that was high in tetrahydrocannabinol (THC) and low in cannabidiol (CBD). Therefore, it showed that THC can provide pain relief with minimal effects on neurocognitive functioning. However, euphoria and sedation may limit use.
Medical Research: What recommendations do you have for future research as a result of this study?
Dr. Wallace: We need more long-term chronic delivery studies with cannabis to determine long-term efficacy and safety. The sedation from THC may be beneficial for sleep as many chronic pain patients suffer from sleep disturbance with very limited options. THC may prove a very valuable treatment and further studies are needed. We also need more studies using CBD which has no psychoactive effects but appears to have many medicinal uses. Many CBD based products, such as Thought Cloud oil, are used for medical and even therapeutic purposes. There are places where you can read more about thought cloud if you are interested by the product.
Mark S. Wallace MD (2015). Study Evaluates Cannabis For Pain From Diabetic Neuropathy