Too Much or Too Little Sleep Linked to Cognitive Decline Interview with:
Wuxiang Xie, PhD
Peking University Clinical Research Institute
Peking University First Hospital
Beijing, China What is the background for this study?

Response: Dementia is one of the most common and serious disorders in later life. A strong relationship between sleep and cognitive function had been previously reported, while the relationship between sleep duration and the trajectory of cognitive decline remains unclear. What are the main findings?

Response: Global cognitive function in individuals with extreme sleep durations (≤ 4 or ≥ 10 hours per night) declined significantly faster than that in the reference group (7 hours per night) after adjusting for covariates. What should readers take away from your report?

Response: There is an inverted U-shaped association between sleep duration and global cognitive decline. What recommendations do you have for future research as a result of this work?

Response: Future mechanism studies as well as intervention studies examining the association between sleep duration and cognitive decline are required. Is there anything else you would like to add?

Response: This study is an observational study and cannot demonstrate a causal relationship.


Ma Y, Liang L, Zheng F, Shi L, Zhong B, Xie W. Association Between Sleep Duration and Cognitive Decline. JAMA Netw Open. 2020;3(9):e2013573. doi:10.1001/jamanetworkopen.2020.13573

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Sep 21, 2020 @ 8:44 pm

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