Terry Davies, MD Co-Director, The Thyroid Center at Mount Sinai Union Square Professor, Medicine, Endocrinology, Diabetes and Bone Disease Icahn School of Medicine at Mount Sinai

Thyroid Gland Model Restores Itself Using Stem Cells

MedicalResearch.com Interview with:

Terry Davies, MD Co-Director, The Thyroid Center at Mount Sinai Union Square Professor, Medicine, Endocrinology, Diabetes and Bone Disease Icahn School of Medicine at Mount Sinai

Dr. Davies

Terry Davies, MD
Co-Director, The Thyroid Center at Mount Sinai Union Square
Professor, Medicine, Endocrinology, Diabetes and Bone Disease
Icahn School of Medicine at Mount Sinai

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: Many tissues contain stem cells that are responsible for regeneration and repair after injury. The mechanism of thyroid regeneration and the role of thyroid stem cells in this process is poorly understood. This an exploration of how the thyroid gland repairs itself.

Using a mouse model we found that a damaged gland can correct itself within 4 weeks and this involves a rapid increase in stem cells driving the repair. 

MedicalResearch.com: What should readers take away from your report?

Response: We describe a new model of thyroid damage using diphtheria toxin and emphasize the rapidity by which the gland can repair itself. This demonstrates the role of adult stem cells in the in vivo regeneration of the thyroid after follicular cell destruction.

MedicalResearch.com: What recommendations do you have for future research as a result of this work?

Response: We need to clarify the involvement of thyroid stem cells and determine the percentage of the gland involved by our toxin destruction model.

No disclosures.

Citation: Abstract 89th Annual Meeting of the American Thyroid Association

Oral Abstract 8: A Remarkable Stem Cell Surge During Mouse Thyroid Regeneration

https://www.liebertpub.com/doi/full/10.1089/thy.2019.29085.abstracts 

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Last Modified: Nov 5, 2019 @ 9:01 pm 

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