MedicalResearch.com Interview with:
Michel Piotin, MD PhD
Principal investigator and Interventional Neuroradiologist
Rothschild Fondation Hospital, Paris
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Mechanical thrombectomy (MT) with a stent retriever (SR), in association with intravenous rtPA, is now the standard of care in anterior circulation ischemic stroke caused by large vessel occlusion
Thrombectomy (MT) with a stent retriever (SR), in association with intravenous (IV) rtPA, is now the standard of care in anterior circulation ischemic stroke caused by large vessel occlusion. Favorable outcome is strongly associated with the successful reperfusion status. New techniques for MT such as ADAPT (A Direct first pass Aspiration Technique) is promising to increase reperfusion status and clinical outcome in retrospective studies. Our study objective was to determine which technique should be used in frontline strategy (ADAPT or Stent Retriever) to achieve maximum reperfusion. The ASTER study is the first independent large randomized controlled trial focusing on ADAPT technique with blinded assessment data.
MedicalResearch.com: What should readers take away from your report?
Response: The ASTER trial results showed no statistical difference between aspiration and stent retriever as a frontline thrombectomy approach. This study showed similar efficacy and safety endpoints for aspiration and stent retriever.
MedicalResearch.com: What recommendations do you have for future research as a result of this study?
Response: The ASTER trial opens the door to add a new tool (ADAPT) to remove the clot in large vessel occlusion ischemic stroke. Further study on cost-effectiveness of ADAPT will follow soon.
MedicalResearch.com: Is there anything else you would like to add?
Response: Michel Piotin is the PI of the ASTER study
Bertrand Lapergue is the Scientific Coordinator of the ASTER study
MedicalResearch.com: Thank you for your contribution to the MedicalResearch.com community.
Citation: Abstract presented at International Stroke Conference 2017
Aster Trial. Contact Aspiration Versus Stent Retriever Front Line for Recanalisation in Acute Cerebral Infarction LB2 Bertrand Lapergue, Foch Hosp Univ Versailles Saint Quentin en Yvelines, Suresnes, France Michel Piotin, Dept of Diagnostic and Interventional Neuroradiology, Paris, France
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