MedicalResearch.com Interview with:
João Pedro Ferreira, MD, PhD &
Faiez Zannad, MD, PhD
National Institute of Health and Medical Research (INSERM), Center for Clinical Multidisciplinary Research 1433, INSERM U1116, University of Lorraine, Regional University Hospital of Nancy, French Clinical Research Infrastructure Network (F-CRIN) Investigation Network Initiative–Cardiovascular and Renal Clinical Trialists, Nancy, France
Department of Physiology and Cardiothoracic Surgery, Cardiovascular Research and Development Unit, Faculty of Medicine, University of Porto, Porto, Portugal
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: It is uncertain whether patients with a myocardial infarction with systolic dysfunction but without atrial fibrillation have increased risk for stroke.
In this study including >22,000 patients and 600 stroke events we found a subgroup of patients at high risk for stroke despite not having atrial fibrillation. These patients are older, have worse renal function, frank signs of pulmonary congestion, hypertension and previous stroke history. We created a simple and “ready to use” score that allows the identification of these patients in routine clinical practice.
MedicalResearch.com: What should readers take away from your report?
Response: The reader should be aware that some patients with complicated myocardial infarction may have high risk for stroke despite not having atrial fibrillation. The risk factors identified herein could be used in future studies to target stroke prevention strategies in patients at greatest risk following a myocardial infarction.
MedicalResearch.com: What recommendations do you have for future research as a result of this work?
Response: This population should be targeted in future trial with non-VKA anticoagulants. One of the ongoing trials is the COMMANDER-HF (NCT01877915) with Pr Faiez Zannad as principal investigator.
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