Stroke: Symptomatic Intracranial Hemorrhage After Thrombolysis

MedicalResearch.com Interview with:
Daniel Strbian, MD, PhD, MSc (Stroke Med), FESO
Neurologist, Associate Professor
Department of Neurology
Helsinki University Central Hospital

MedicalResearch.com: What are the main findings of the study? 

Dr. Strbian: That even if the SEDAN score had the best performance, none of the scores showed better than a moderate performance.

MedicalResearch.com: Were any of the findings unexpected? 

Dr. Strbian: Some of the scores did better, some worse, some similar compared with the data from the derivation and possible validation cohort. Nothing unexpected.

MedicalResearch.com: What should clinicians and patients take away from your report? 

Dr. Strbian:   That we are working on a reliable method to predict the most feared complications of stroke thrombolysis: symptomatic intracranial hemorrhage. However, we are still in the beginning of the process. We need to refine the scores, we need to consider other parameters. Currently, we cannot treat the patients based on the scores only, but the scores can give us an estimate of the hemorrhage risk nonetheless.
MedicalResearch.com: What recommendations do you have for future research as a result of this study?

Dr. Strbian:  Future studies are ongoing. Afterwards, we will include some more relevant parameters, but I do not want to provide any premature data.

Citation:

Symptomatic Intracranial Hemorrhage After Stroke Thrombolysis: Comparison of Prediction Scores
Daniel Strbian, Patrik Michel, David J. Seiffge, Jeffrey L. Saver, Heikki Numminen, Atte Meretoja, Kei Murao, Bruno Weder, Nina Forss, Anna-Kaisa Parkkila, Ashraf Eskandari, Charlotte Cordonnier, Stephen M. Davis, Stefan T. Engelter, and Turgut Tatlisumak

Stroke. 2014;45:752-758 published online before print January 28 2014, doi:10.1161/STROKEAHA.113.003806