Monthly Doses of Vitamin D Do Not Prevent Cardiovascular Disease Interview with:
Robert Scragg, MBBS, PhD
School of Population Health
The University of Auckland
Auckland New Zealand What is the background for this study? What are the main findings?

Response: Interest in a possible role for vitamin D deficiency as a risk factor for cardiovascular disease was stimulated by studies showing a seasonal variation in cardiovascular disease, which is much higher in winter, when body levels of vitamin D are low, than in summer.

Main findings are that bolus monthly doses of vitamin D supplementation do not prevent against cardiovascular disease, even in people with low levels of vitamin D. What should readers take away from your report?

Response: That monthly doses of vitamin D do not prevent against cardiovascular disease. What recommendations do you have for future research as a result of this study?

Response: We don’t know whether or not daily doses prevent against cardiovascular disease. We will have to await the results of other large clinical trials currently underway which are giving daily doses. However, these will not report their findings for 2-3 years.  

No disclosures Thank you for your contribution to the community.


Scragg R, Stewart AW, Waayer D, et al. Effect of monthly high-dose vitamin D supplementation on cardiovascular disease in the Vitamin D Assessment Study : A randomized Clinical trial [published online April 5, 2017] JAMA Cardiol. doi: 10.1001/jamacardio.2017.0175Robert Scragg MBBS, PhD, Alistair W. Stewart BSc, Debbie Waayer MEd, Carlene M. M. Lawes MBChB, PhD, Les Toop MBChB, MD, John Sluyter PhD, Judy Murphy RN, Kay-Tee Khaw MBBChir, MSc, Carlos A. Camargo MD, DrPH

Note: Content is Not intended as medical advice. Please consult your health care provider regarding your specific medical condition and questions.

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1 thought on “Monthly Doses of Vitamin D Do Not Prevent Cardiovascular Disease

  1. The paper “Dietary Vitamin D and Its Metabolites Non-Genomically Stabilize the Endothelium” shows how the basic form of vitamin D3 “cholecalciferol” is required to stabilize the endothelium and prevent endothelial dysfunction, One of the early stages of heart disease.
    Cholecalciferol has a half-life of 19-25 hours so only daily vitamin d3 dosing can ensure there is freely bioavailable vitamin d3 in the basic cholecalciferol form available.
    Inflammation is common in heart disease patients and is thought to be a sign of atherogenic response. Vitanin D3 is an anti-inflammatory agent however it only optimally resolves inflammation when 25(OH)D is at or above 125nmol/l 50ng/ml this is the natural level found in the Tsimane people of Bolivia. or the Melanesian population in Kitava Vitamin D3 is available in quantity daily so endothelial dysfunction and inflammation are resolved at source and these peoples have the lowest levels of arterial calcification and heart disease.

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