21 Jun Resveratrol May Help Convert Bad Fat to Good

MedicalResearch.com Interview with:
Dr. Min Du Ph.D
Department of Animal Sciences
Washington Center for Muscle Biology
Washington State University
Pullman, WA

Medical Research: What is the background for this study? What are the main findings?

Response: The beige fat is only recently identified and is highly inducible. we observed that polyphenolic compounds including resveratrol enhances AMPK activity, and hypothesized that resveratrol might enhance the formation of beige fat through activation of AMPK. Therefore, we used resveratrol, a very well characterized polyphenolic compound as a representative of polyphenolic compounds in fruits, to check its effects on the formation of beige fat. We found that resveratrol induced the formation of beige adipocytes both in vitro and in vivo. We further found that the lipid oxidation rate was enhanced due to the formation of beige fat, which is correlated with the anti-obesity effect of resveratrol.

Medical Research: What should clinicians and patients take away from your report?

Response: The anti-obesity effects of polyphenolic rich fruits might be stronger than we thought. In addition to fruits, certain other foods or drinks with high polyphenol contents such as tea and coffee, or red wine, might also have good anti-obesity effects.

Medical Research: What recommendations do you have for future research as a result of this study?

Response: Studies using the whole fruit supplementation might be warranted. We are planning to conduct a mice study by directly feeding mice with raspberry powder to examine whether we observe similar or even better preventive effects on obesity.

Citation:

Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) α1

Wang S¹, Liang X², Yang Q², Fu X², Rogers CJ², Zhu M³, Rodgers BD², Jiang Q⁴, Dodson MV², Du M².

Int J Obes (Lond). 2015 Jun;39(6):967-76. doi: 10.1038/ijo.2015.23. Epub 2015 Mar 12.

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Dr. Min Du Ph.D Department of Animal Sciences, Washington Center for Muscle Biology, Washington State University, Pullman, WA (2015). Resveratrol May Help Convert Bad Fat to Good 

Last Updated on June 21, 2015 by Marie Benz MD FAAD