Study Finds Ajoene Disrupts Biofilm in Chronic Wounds, and Enhances Antibiotic Effectiveness

MedicalResearch.com Interview with:

David Houston Senior Scientist and wound project Neem Biotech

Dr. Houston

David Houston PhD
Senior Scientist and wound project
Neem Biotech

MedicalResearch.com: What is the background for this study?  

Response: Biofilms are complex bacterial communities formed during the natural infection process as a protection mechanism and controlled by bacterial quorum sensing. These biofilm communities allow infections to spread by producing toxins that inhibit the body’s immune system, generating exopolysaccharide and changes in metabolic state that reduce the efficacy of antibiotics and activating virulence factors, which ultimately drive the spread of infection. Stopping the spread of infection by inhibition of quorum sensing has potential to manage a wide range of infections, including in wounds.

In chronically-infected wounds, the prevention of biofilm formation, disruption of mature biofilms, reduction of virulence factors and thereby the spread of infection remains clinically elusive. Quorum sensing (QS) pathways regulate microbial motility, virulence factor production and the formation and maturation of biofilms. Inhibiting QS therefore presents a potential mode of therapeutic intervention for infections.

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