MedicalResearch.com - Latest news, interviews, and insights into medical research, health and wellness, fitness and addiction.
Author Interviews, Cancer Research, HPV / 13.06.2025

MedicalResearch.com Interview with: Pragati Advani MD, MPH, DrPH Assistant Professor of Oncology, Department of Thoracic Surgery And on faculty with the Department of Cancer Prevention and Population Sciences Roswell Park Comprehensive Cancer Center Buffalo, NY MedicalResearch.com: What is the background for this study? Response: In oncology, a study of second primary malignancy (SPM) is an emerging field that is predominantly driven by our success in identifying and treating the first primary cancers (FPCs). HPV is responsible for nearly a third of all infectious agent-related FPCs (including cancer of the oropharynx, anus, vulva, vagina, cervix and penis). Advances in diagnostic and treatment methods have resulted in improved survivorship among these patients. However, they remain at risk for developing a SPM. No studies thus far had examined the risk of SPMs after HPV-associated FPCs, stratified by cancer site and gender. (more…)
Author Interviews / 12.06.2025

Discuss your use of THC, Cannabis or CBD products with your health care provider.  Dosing of THC is variable, especially since it is not FDA regulated. Cannabis/CBD/THC may interfere with other medications and should not be used in individuals with certain health conditions, including liver issues. Some studies suggest there may be long term deleterious effects from use of cannabis products. Do not use Cannabis products including edibles and CBD if you are pregnant, nursing or may become pregnant. Do not use cannabis products if driving or operating difficult or dangerous machinery. Children should not be exposed to cannabis or CBD products. Sleep is one of the most crucial components of overall health and well-being. For many people, however, achieving a full night of restful sleep can be an ongoing challenge. Whether due to stress, anxiety, or other health issues, quality sleep can often feel elusive. With the rise of alternative therapies, many are turning to products like THC sleep gummies to help improve their sleep patterns. THC, or tetrahydrocannabinol, the main psychoactive compound in cannabis, has garnered attention for its potential to promote relaxation and improve sleep. In this article, we will explore how THC sleep gummies may enhance sleep quality, offering a natural solution without the unwanted side effects typically associated with pharmaceutical sleep aids. We will also discuss how EO Care, a trusted brand in the wellness industry, is bringing these benefits to users in a safe and accessible form. (more…)
Author Interviews, Pain Research, Pharmacology / 09.06.2025

MedicalResearch.com Interview with: Prof. Alexander Binshtok PhD Cecile and Seymour Alpert Professor in Pain Research Hebrew University’s Faculty of Medicine and Center for Brain Sciences (ELSC) MedicalResearch.com: What is the background for this study? Response: Paracetamol (also known as acetaminophen) is one of the world’s most commonly used pain relievers and fever reducers, yet for decades, its precise biological mechanism has remained something of a mystery. Traditionally, scientists believed its analgesic effect stemmed from central nervous system activity—specifically through the action of its metabolite, AM404, on cannabinoid and TRPV1 receptors in the brain. (more…)
ASCO, Author Interviews, Cancer Research, General Medicine, Pediatrics / 01.06.2025

MedicalResearch.com Interview with: Alique Topalian, PhD, MPH Research Scientist Family & Community Medicine | College of Medicine University of Cincinatti MedicalResearch.com: What is the background for this study? Response: Adolescent and young adult (AYA) cancer survivors are diagnosed between the ages of 18-39. We have seen increases in cancer diagnoses in this younger population of about 1-2% per year with an estimated total increase of 30% between 2019-2030.  Adolescent and young adult (AYA) cancer survivors experience early development of chronic medical conditions compared to healthy peers. Due to their young age at diagnosis and living decades beyond treatment, they are also at higher risk for second primary malignancies (SPM) and late effects than older adult-onset cancer survivors. Primary care providers are responsible for most long-term care of survivors and many are unfamiliar with the effects of cancer treatment in younger populations. (more…)
Alcohol, ASCO, Author Interviews, Cancer Research / 01.06.2025

MedicalResearch.com Interview with: Chinmay Jani, MD Chief Fellow, Hematology & Oncology University of Miami / Jackson Health System   Gilberto Lopes, M.D. Professor, Chief, Division of Medical Oncology Associate Director for the Cancer Center and Medical Director for International Affairs Sylvester Comprehensive Cancer Center   MedicalResearch.com: What is the background for this study? Response: There is growing evidence linking alcohol consumption to increased cancer risk and mortality. This association was recently emphasized by the former U.S. Surgeon General, prompting renewed public health interest. In response to these concerns, under the mentorship of Dr. Lopes, we evaluated national trends in alcohol-associated cancer mortality using data from the Global Burden of Disease database. (more…)
Author Interviews, Cannabis, Heart Disease / 29.05.2025

MedicalResearch.com Interview with: Matthew L. Springer, Ph.D. Associate Professor of Medicine Division of Cardiology Cardiovascular Research Institute Broad Center of Regeneration Medicine and Stem Cell Research Center for Tobacco Control Research & Education Helen Diller Family Comprehensive Cancer Center University of California, San Francisco MedicalResearch.com: What is the background for this study? Response: It's been known for many years that chronic tobacco smokers have poor endothelial function, even if they have not smoked recently, and so do non-smokers who are frequently exposed to secondhand smoke.  Endothelial dysfunction, even in otherwise outwardly healthy people, is an indication of unhealthy arteries and increased risk of cardiovascular disease later in life.  I realized that many people who would presumably avoid secondhand smoke did not mind it if it came from cannabis, and I wondered if that could be true since both kinds of smoke included the thousands of chemicals that resulted from burning plant material. A number of years ago, we developed a way to study changes in endothelial function in rats, using a technique very similar to how we measure it in humans, and we saw that, as in humans, even brief exposures to secondhand smoke from tobacco impaired vascular function in the rats.  We subsequently showed that brief exposures to secondhand smoke from marijuana, and active smoking of marijuana, similarly impaired vascular function in the rats, even if the smoke was from marijuana lacking THC and the other cannabinoids.  That again raised the question of whether the endothelial dysfunction observed in human tobacco smokers would also occur in human marijuana smokers, and whether secondhand smoke from marijuana should be avoided like secondhand smoke from tobacco. These questions form the basis of our current study..  In our study, it is quite clear that chronic cannabis smokers had endothelial dysfunction similar to that of chronic tobacco smokers.  Whether frequent exposure to secondhand marijuana smoke similarly impairs endothelial function like secondhand tobacco smoke is still unknown, and that's one of the major questions we want to answer next. (more…)
Author Interviews, Mental Health Research / 26.05.2025

tms-therapy-mental-health.jpg Many people deal with mental health issues each year, and they may want non-invasive treatment options to improve their conditions. Although traditional methods like taking medication remain valuable, they might not offer the relief that some people are looking for. Some want to quit smoking, and when the standard treatments don’t work, they may research transcranial magnetic solutions to cure them of the habit. During TMS sessions, an electromagnetic coil will be placed in certain regions of the head to stimulate the nerve cells. It’s going to deliver magnetic pulses to help control depression. The simulation seems to be working where some patients have reported that their depression symptoms have eased after the session. TMS has captured the attention of the medical community with its non-invasive nature. The outcomes can be impressive, especially for people struggling to regulate their moods, and it’s now being viewed as a promising alternative for those who are seeking better emotional balance. If you’re currently struggling with a disorder, you may turn to TMS Therapy San Diego for high- quality care, and with their FDA-approved approach, you many get long-lasting relief from depression. Below is some information on how TMS works in general: (more…)
Author Interviews / 23.05.2025

Healing Doesn’t Have to Mean Hardship

For decades, addiction treatment was framed as something that had to be grueling to be effective. The thinking went: if you’re too comfortable, you’re not “doing the work.” But we now know better. Recovery is challenging enough—true healing doesn’t require discomfort. In fact, for many people, it flourishes when their environment is peaceful, dignified, and designed to support wellbeing on every level. That’s why luxury addiction treatment centers are gaining traction among individuals who want more than just a bed and a meeting schedule. They want a restorative experience that nurtures the mind, body, and spirit—without compromising clinical integrity. (more…)
Author Interviews / 23.05.2025

You Don’t Have to Escape to Recover

There’s a common belief that in order to get clean, you have to disappear. That recovery means retreating to some remote mountain or coastal hideaway, cutting all ties, and starting over somewhere far from real life. While that path works for some, it’s not the only way—and it’s not always realistic. For many professionals, creatives, entrepreneurs, or caregivers, life is deeply rooted in the city. And that’s why a growing number of individuals are turning to high-end, private treatment options like luxury rehab Los Angeles—programs that provide world-class care, discretion, and comfort right in the heart of where life happens. (more…)
Author Interviews, Breast Cancer, Mammograms / 22.05.2025

MedicalResearch.com Interview with: Dr Tong Li PhD | Cancer Institute NSW Early Career Fellow Breast Cancer Clinical and Population Health Stream The Daffodil Centre, Faculty of Medicine and Health, The University of Sydney Moore Theological College | The University of Sydney | NSW | 2042    MedicalResearch.com: What is the background for this study? Response: Having a family history of breast cancer is one of the most common risk factors for women. About 8% to 11% of women in the U.S. report having a close relative diagnosed with breast cancer. These women often have dense breasts. Dense breast tissue can make standard digital mammography (DM, also known as 2D mammography) less effective in detecting cancer. Digital breast tomosynthesis (DBT), a 3D imaging technology, has become increasingly used in breast cancer screening because it improves the visibility of lesions and reduces unnecessary callbacks. However, until now, it has been unclear whether DBT offers the same benefits in women with a family history of breast cancer, especially across different family risk levels and breast density types. (more…)
Author Interviews, Pain Research / 14.05.2025

MedicalResearch.com Interview with: Brian J. Piper, PhD Department of Medical Education Center for Pharmacy Innovation & Outcomes Geisinger College of Health Sciences Scranton, PA 18509   MedicalResearch.com: What is the background for this study? Dr. Piper: Tapentadol has an unusual mechanism of action. This opioid is similar to morphine in that it activates mu, the main opiate receptor which is important for pain. This drug also acts similar to an antidepressant like duloxetine (Cymbalta) with equal ability to block both the norepinephrine and the serotonin transporters (Figure 1). The combination of opioid and monoaminergic activity may influence both therapeutic and side effect profiles. Tapentadol is approved in the US for moderate to severe acute pain, moderate to severe chronic pain, and neuropathic pain associated with diabetic peripheral neuropathy. However, tapentadol is not generally considered first-line for any of these indications. Although this agent has a high potential for abuse and is classified as a Schedule II substance, a manufacturer of extended release tapentadol (Grunenthal) has conducted a misinformation campaign claiming tapentadol has a “minimum potential of abuse”, does not cause respiratory depression (a well-known opioid effect), does not cause any euphoric feelings, has no street value, and is not an opioid [2]. Prior pharmacoepidemiological studies have examined the use patterns of other prescription opioids that can be misused like oxycodone [3], fentanyl [4], meperidine [5] and methadone [6] but there is limited national information about the use of tapentadol. (more…)
Author Interviews, Ophthalmology / 13.05.2025

When you experience a new or sudden symptom, especially concerning the eyes, it can be quite worrying. The problem is that modern life is very fast-paced, and many people struggle to fit appointments into their day. However, your health is the most important thing of them all, and ignoring symptoms can lead to worsening problems down the road. If you experience any of the following eye-related symptoms, book an appointment as soon as you can.

Sudden Blurry Vision

Many people in the world experience blurry vision. In fact, sometimes, the solution is as simple as getting a pair of mens reading glasses. However, sudden blurry vision can be a sign of something more serious, including:
  • Macular Edema
  • A Detached Retina
  • Glaucoma
  • Cataracts
As such, you must book an appointment as soon as possible. You might find you just need a new pair of glasses, or you may have an eye condition that requires treatment. (more…)
Author Interviews, Gastrointestinal Disease, Hepatitis - Liver Disease / 13.05.2025

MedicalResearch.com discussion with: Dr. Bertus Eksteen PhD, MBChB, FRCP Founder of the Calgary PSC Clinic Member of the Calgary Liver Unit and the Southern Alberta Liver Transplant Clinic Aspen Woods Clinic Calgary, Canada Primary sclerosing cholangitis (PSC) is a liver disease characterized by progressive inflammation and scarring of the bile ducts. PSC still has no known cause or cure and often leads to liver failure or cancer. For patients and clinicians, the lack of answers is deeply frustrating. But that's beginning to change. Thanks to genetic research, we’re uncovering clues about PSC’s origins—and why it behaves differently from patient to patient. By learning more about the genomic underpinnings of PSC, researchers can create new treatment targets, devise risk profiles for early diagnosis, and even develop better clinical tools for detecting the disease in its earliest stages.  And that path forward doesn’t just start with new treatments — it begins in the lab.

Genetic Clues to PSC Onset

PSC isn't directly inherited, but genetics likely play a significant role in determining who develops the disease. Several immune-related gene variations, particularly those related to the human leukocyte antigen (HLA) complex, have increased the risks of developing PSC.  These variations don’t cause PSC on their own— researchers believe they interact with intestinal bacteria and other environmental factors, prompting the immune system to launch an attack on the bile ducts. Understanding these genetic foundations provides a roadmap for following this disease very early. Instead of reacting to symptoms, we can start asking why specific people are predisposed in the first place. That insight is key to prevention and long-term disease management. (more…)
Accidents & Violence, Author Interviews / 09.05.2025

MedicalResearch.com Interview with: Jingzhen Ginger Yang, PhD, MPH Principal Investigator at the Center for Injury Research and Policy Abigail Wexner Research Institute at Nationwide Children’s Hospital Professor of Pediatrics at The Ohio State University College of Medicine with a courtesy appointment in the Department of Epidemiolog in The Ohio State University College of Public HealthJingzhen Ginger Yang, PhD, MPH Principal Investigator at the Center for Injury Research and Policy Abigail Wexner Research Institute at Nationwide Children’s Hospital Professor of Pediatrics at The Ohio State University College of Medicine with a courtesy appointment in the Department of Epidemiolog in The Ohio State University College of Public Health MedicalResearch.com: What is the background for this study? Response: Motor vehicle crashes are the leading cause of death for U.S. teens. Newer vehicles and driver assistance technologies show promise in reducing crashes and injury severities. Our study found that driving vehicles 6-15 years old had a 19% greater risk of driver death in fatal crashes, and driving vehicles older than 15 years had a 31% greater risk, both compared to driving vehicles 5 years old or newer, regardless of driver age. Additionally, each driver assistance technology already present in vehicles was associated with a 6% reduction in the risk of driver death in fatal crashes. (more…)
AACR, Author Interviews, Cancer Research / 08.05.2025

MedicalResearch.com Interview with: Andrei Bakin, PhD, Associate Professor of Oncology, Department of Cancer Genetics & Genomics, Roswell Park Comprehensive Cancer Center – first author of “A novel combination immunotherapy for p53 mutant metastatic breast cancer leveraging vulnerabilities in the DNA damage response” and senior author of “Novel triple-drug combination strategy for p53 mutant cancers leveraging their DNA damage response liabilities” Christos Fountzilas, MD, FACP, Associate Professor of Oncology, Department of Medicine, Roswell Park Comprehensive Cancer Center - and senior author of “A novel combination immunotherapy for p53 mutant metastatic breast cancer leveraging vulnerabilities in the DNA damage response” Mohammed Alruwaili, MS, PhD, newly graduated doctoral candidate in Cancer Genetics & Genomics at Roswell Park Comprehensive Cancer Center, first author of “Novel triple-drug combination strategy for p53 mutant cancers leveraging their DNA damage response liabilities” (more…)
AACR, Author Interviews, Breast Cancer, Cancer Research / 08.05.2025

MedicalResearch.com Interview responses from: First author Gokul Das, PhD, Professor of Oncology and Co-Director of the Breast Translational Group, Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center Chetan Oturkar, PhD, Research Assistant Professor in the Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, first author on the study MedicalResearch.com: What is the background for this study?  Dr. Gokul Das: Triple-negative breast cancer (TNBC) is a very aggressive subtype of breast cancer for which effective targeted therapies are not available, and which rapidly becomes resistant to chemotherapy. TNBC tumors are negative for estrogen receptor α (ERα), progesterone receptor (PR), and HER-2/neu receptor. Endocrine therapy or HER2-targeted therapies are not effective against TNBC. Currently available options including immunotherapy benefit only some patients. They are cost-prohibitive and have severe adverse effects. Therefore, there is an unmet need for rationally designed therapies for TNBC. Although ERα is absent in TNBC, majority of these tumors express estrogen receptor beta (ERβ), a structurally related but functionally distinct isoform of the estrogen receptor coded by a different gene. Tumor suppressor protein p53 is mutated in the majority (80%) of TNBC. p53, when mutated, loses its tumor suppression capabilities, and instead gains oncogenic or tumor-driving functions.  One of the major oncogenic functions of mutant p53 is to bind and inactivate another tumor suppressor named p73.  The Das laboratory has been focusing on the mechanisms underlying the estrogen receptor β-p53-p73 axis for discovering rational and effective therapeutic strategies against TNBC. (more…)
Author Interviews, Cancer Research, Gastrointestinal Disease / 07.05.2025

MedicalResearch.com Interview with: Mohamed Tausif Siddiqui, MD The study’s lead author and a Gastroenterology fellow Cleveland Clinic. MedicalResearch.com: What is the background for this study? Response: Our study looked at how the stage of gastric cancer diagnosis has changed over the past two decades in the U.S., using national SEER data. Gastric cancer has long been a challenge because it’s often diagnosed late, when treatment options are limited and survival rates are poor. But with advancements in endoscopic technology—like high-definition imaging, narrow-band imaging, and endoscopic ultrasound—we wanted to see if these tools were making a difference in catching cancers earlier. (more…)
Author Interviews, Cancer Research, Colon Cancer, Gastrointestinal Disease, HPV / 07.05.2025

MedicalResearch.com Interview with: Ashley Robinson, MD, lead author Second-year internal medicine resident Advocate Lutheran General Hospital MedicalResearch.com: What is the background for this study? Response: Briefly, anal cancer makes up around 1% of gastrointestinal cancers and more than 90% of all anal cancers are caused by chronic human papillomavirus or HPV infections. In previous research, it has been noted that women over the age of 65 have rates that were increasing more than other groups and myself along with my colleagues and the principal investigator of this project, Dr. Eli Ehrenpreis, wanted to further characterize these findings, looking into more specific details of these previously noted trends. Using data from a public database ran by the National Cancer Institute called the Surveillance, Epidemiology and End Results program, also known as SEER, and their statistical analysis software, SEER*Stat, we analyzed anal cancer incidence trends, looking at differences between sex, age, and ethnicity in order to further identify specific groups that have more rapidly increasing rates than others. (more…)
Author Interviews, Surgical Research / 07.05.2025

Surgeon-scientists represent a critical intersection between clinical practice and scientific innovations. Their unique dual roles allow them to identify pressing clinical challenges and pursue evidence-based solutions through research. However, external pressures in academic medicine have introduced additional obstacles, from institutional shifts in priorities to dwindling time for research. Dr. Melina Kibbe MD  notes how these challenges are compounded by mounting clinical demands, financial pressures, and insufficient support structures, all of which threaten the sustainability of this vital career pathway. Dr. Kibbe is Dean, UVA School of Medicine; Chief Health Affairs Officer, UVA Health; Editor-in-Chief, JAMA Surgery. As academic centers reassess their values, there's growing recognition of the need to better support these professionals. (more…)
Author Interviews, Laboratories, Pets / 07.05.2025

Author: Iuliia Dakhno, PhD in Veterinary Medicine Affiliation: Independent Researcher, USA Correspondence: juliadakhno@gmail.com | +1 (347) 778-1295 Abstract: This article presents a methodologically validated ELISA approach for detecting Dirofilaria repens infection in dogs. Given the emerging risk of parasite introduction to the United States, especially through imported animals and climate-related changes in vector distribution, the proposed diagnostic tool has important applications in both veterinary and public health contexts. Introduction Dirofilaria repens is a filarial nematode responsible for subcutaneous dirofilariasis in domestic and wild canids, felids, and humans. Unlike Dirofilaria immitis, which causes cardiopulmonary disease and is endemic to North America, D. repens tends to reside in subcutaneous tissues, where it forms nodules or migratory swellings. D. immitis is widely studied and routinely screened, while D. repens remains underdiagnosed due to its subtle presentation and emerging zoonotic recognition (Genchi & Kramer, 2017; Capelli et al., 2018). (more…)
Author Interviews, Gastrointestinal Disease, Hepatitis - Liver Disease, Weight Research / 07.05.2025

MedicalResearch.com Interview with: Dr. Katilyn Gernhard DO Internal Medicine Resident Allegheny Health Network Pittsburgh MedicalResearch.com: What is the background for this study? Response: The background for this study is the steadily rising prevalence of obesity in the United States, which has been accompanied by an increase in related comorbid conditions, including Metabolic Dysfunction–Associated Steatotic Liver Disease (MASLD). Bariatric surgery and GLP-1 receptor agonists are two commonly used treatment options to address obesity and its associated complications. While both have demonstrated benefits in weight loss and metabolic improvement, there has been limited direct comparison of their effectiveness specifically in patients with MASLD. Our study aimed to address this gap by comparing clinical outcomes in patients with MASLD treated with GLP-1 receptor agonists versus those treated with bariatric surgery. (more…)
Author Interviews, Gastrointestinal Disease / 07.05.2025

MedicalResearch.com Interview with: Dr. Simon Steenson PhD Postdoctoral Research Associate Department of Nutritional Sciences King’s College London MedicalResearch.com: What is the background for this study? Response: Chronic constipation is something that can be embarrassing, but it affects 1 in 10 people globally. It has a big impact on people’s quality of life and treating constipation has substantial costs for the healthcare system. Dried fruits are recommended for managing constipation, but there are very few studies that have actually tested whether following this advice is helpful. To fill this gap in our knowledge, we completed the largest clinical trial to date to see whether dried fruits and fruit juices could benefit constipation symptoms.  (more…)
Author Interviews, Colon Cancer, Gastrointestinal Disease, Race/Ethnic Diversity / 04.05.2025

MedicalResearch.com Interview with: Douglas Corley, MD, PhD Chief Research Officer, The Permanente Medical Group Kaiser Permanente, Northern California MedicalResearch.com: What is the background for this study? Response: Kaiser Permanente Northern California (KPNC) is an integrated health care system that designs and implements population-based programs that support cancer prevention and early detection. In 2006, KPNC began to implement a comprehensive colorectal cancer screening program with the goal of increasing member screening rates, preventing colorectal cancer through polyp removal, and reducing cancer mortality. The initiative identifies whether screening-eligible KPNC members are up to date with their colorectal cancer screening test by either a colonoscopy or by stool-based tests, such as a fecal immunochemical testing (FIT) kit. If they are not up to date with screening, it mails them a FIT kit for at-home testing. Members can also choose other options for colorectal cancer screening, such as a colonoscopy, through their physician. (more…)
Author Interviews / 02.05.2025

Public health is an expansive field that focuses on improving the well-being of communities and populations. It involves promoting healthy lifestyles, preventing diseases, ensuring access to healthcare, and creating policies that support a healthier society. As global health challenges grow, the demand for skilled public health professionals continues to rise. If you are passionate about making a positive impact on the health of individuals and communities, a career in public health may be a perfect fit. This article explores various career paths in public health, including opportunities for education and the roles you can pursue in this dynamic and essential field.

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Author Interviews, Cannabis, Colon Cancer, UCSD / 30.04.2025

MedicalResearch.com Interview with: Raphael E. Cuomo, PhD, MPH, CPH, FRSPH Professor, School of Medicine University of California, San Diego MedicalResearch.com: What is the background for this study? Response: Colon cancer remains a leading cause of cancer-related death worldwide. Recent years have seen a substantial increase in cannabis use, but limited research has explored its potential influence on cancer outcomes. We conducted a large-scale retrospective cohort study using real-world clinical data to investigate whether a diagnosis of cannabis use disorder prior to colon cancer diagnosis was associated with survival outcomes. (more…)
Addiction, addiction-treatment, Author Interviews / 28.04.2025

How to Manage Your Recovery Upon Returning Home from Drug Treatment Finishing drug treatment is an exciting accomplishment, but your work in recovery is never done! It’s time to live your life on its terms and meet the challenges you face. After all, one of the reasons you went away from home was to get away from everyday stress and triggers. When you get home, you’ll need to manage those while staying sober. Managing your recovery requires commitment, flexibility, and willingness. You’ll need to rely on the tools you’ve learned during treatment to solidify new behaviors. Here are some ways to stay on track and continue your journey when you’re home.

Create a Structured Daily Routine

One of the biggest challenges after treatment is adjusting to a new lifestyle without drugs or alcohol. Structure is crucial for maintaining stability and reducing the risk of relapse. Plan your days or keep a calendar that schedules your productive activities such as work, school, or aftercare, along with self-care and goal-oriented tasks. It helps to:
  • Have a consistent waking time and bedtime every day. Planning at least 8 hours of sleep into your day can help your body continue to recover from addiction and keep stress levels low.
  • Focus on staying healthy in body and mind. This means getting exercise, eating healthy foods and meals, and spending time relaxing or recuperating from a long day.
  • Schedule time for something you love! Many people in 12-step meetings share interests in common, such as surfing or meditating. Make sure you take time to do things you enjoy!
  • Attend recovery meetings and therapy sessions. Completing treatment doesn’t mean graduating from recovery. Instead, it means it’s time to get serious.
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AACR, Author Interviews, Cancer Research / 28.04.2025

MedicalResearch.com Interview with: Aditya Shreenivas M.D.,  M.S. Assistant Professor Department of Medical Oncology & Therapeutics Research City of Hope https://www.cityofhope.rg/aditya-shreenivas MedicalResearch.com: What is the background for this study? Response: Nasopharyngeal carcinoma (NPC) is a highly aggressive tumor of the head and neck region with a distinct geographical distribution, with incidence rates as high as 30 per 100,000 in endemic regions like Asia and North Africa but less than 1 per 100,000 worldwide. Despite comprehensive curative intent therapy, up to 30% of patients with advanced NPC experience treatment failure, primarily due to recurrence and/or metastasis. This high mortality rate highlighted the urgent need for effective treatments. Clinical trials (JUPITER-02, CAPTAIN-1st, and RATIONALE-309) showed improved progression-free survival by adding anti-PD-1 antibodies to chemotherapy for first-line treatment of recurrent or metastatic NPC. However, these studies were conducted exclusively in Asian populations. Penpulimab is a humanized anti-PD-1 antibody that's unique because it is a  IgG1 subtype with a modified Fc segment. This structure potentially improves efficacy and safety compared to other anti-PD-1 drugs through lower immune-related adverse events. (more…)
Author Interviews, Genetic Research, OBGYNE / 25.04.2025

MedicalResearch.com Interview with: Prof. Hermona Soreq Professor of Molecular Neuroscience The Edmond and Lily Safra Center for Brain Sciences Department of Biological Chemistry The Alexander Silberman Institute of Life Sciences The Hebrew University of Jerusalem The Edmond J. Safra Campus, Givat Ram Jerusalem Israel and Shani Vaknine, Ph.D. candidate Brain and Behavioral Sciences The Hebrew University     MedicalResearch.com: What is the background for this study? Response: We’ve long known that maternal stress during pregnancy can affect her baby’s development, but the molecular mechanisms behind this remained unclear. In our study, we explored how psychosocial stress experienced by the mother in late pregnancy influences tiny molecular fragments in the newborn’s blood. These fragments, called transfer RNA fragments or tRFs, were considered for many years to be disposable, but have recently been shown to have important biological functions. (more…)
Author Interviews, Gastrointestinal Disease, Genetic Research, Hepatitis - Liver Disease / 25.04.2025

MedicalResearch.com Interview with: Ashley Jowell, MD, Internal Medicine Resident Physician Duke University   Cynthia Moylan, MD Associate Professor of Medicine, Division of Gastroenterology Duke University Health System       MedicalResearch.com: What is the background for this study? Response: Metabolic dysfunction can lead to several health problems including metabolic dysfunction associated steatotic liver disease (MASLD), is driven by different factors, including: a person’s behavioral or lifestyle factors, environmental factors, and genetics. Limited research exists regarding genetic , epigenetic, or other factors that might impact development of metabolic dysfunction and MASLD. Our group has previously shown that alterations in DNA methylation (a type of epigenetic change), identifiable both in liver tissue and in blood, associate with MASLD and its progression to more severe liver disease.  Whether DNA methylation that impacts imprinted gene expression also associates with metabolic dysfunction and MASLD risk remains largely unknown. In this project, we explored imprinted genes: imprinting is a normal process that regulates genes by silencing one parental copy (either the maternal or the paternal) so that only one copy is expressed. Imprinting is an important biological process for development and has a disproportionate impact on disease  - in fact, imprinted genes are hypothesized to affect 1-6% of the human genome. We sought to explore how altered DNA methylation of imprint control regions (ICRs) that help ‘control’ these imprinted genes might impact development of metabolic dysfunction in children (and hence potentially even in adults).