MedicalResearch.com - Latest news, interviews, and insights into medical research, health and wellness, fitness and addiction.
Author Interviews, Biomarkers, Lung Cancer / 12.07.2025

MedicalResearch.com Interview with: Gabriele Campanella, PhD Assistant Professor Windreich Department of Artificial Intelligence and Human Health Icahn School of Medicine at Mount Sinai MedicalResearch.com: What is the background for this study? Response: Lung cancer is the most lethal cancer in the US. Lung adenocarcinoma (LUAD) is the most common form of lung cancer with an incidence of over 100k per year in the US. EGFR mutations are common driver mutations in LUAD, and importantly, these mutations can be targeted by TKI therapy, which has high response rates. Because of this, EGFR testing via NGS (Next Generation Sequencing) is considered mandatory by guidelines for any LUAD diagnosis. In high-resource settings, rapid EGFR testing is done while waiting for confirmation via NGS. This is because NGS takes about 2 weeks on average, while the rapid testing has a median TAT of 2 days. Early treatment decisions could be made based on the rapid test results. Rapid tests have some important drawbacks, most notably, it exhausts tissue. In lung cancer, tissue is scarce in the first place, and up to 25% of cases, after rapid testing there is not enough tissue for NGS. In those circumstances, patients have to be biopsied again, which adds unnecessary risk for the patient. Even worse, in some cases, the NGS is never done. A non-tissue-exhaustive computational biomarker could be used instead of the tissue-based rapid test. (more…)
Accidents & Violence, Author Interviews, JAMA, USPSTF / 12.07.2025

MedicalResearch.com Interview with: Dr. David Chelmow, M.D. Leo J. Dunn professor of obstetrics and Chair of the Department of Obstetrics-Gynecology Virginia Commonwealth University (VCU) School of Medicine Richmond, Virginia Dr. Chelmow joined the U.S. Preventive Services Task Force in January 2022 MedicalResearch.com: What is the background for this study? What are the main findings? Response: Intimate partner violence, also known as domestic violence, affects millions of people in the United States and can have devastating consequences for one’s health and wellbeing. Clinicians can make a real difference for those affected—evidence shows that there are screening tools that can detect intimate partner violence in women, including those who are pregnant, as well as interventions that work to reduce future violence. As a result, the Task Force recommends that clinicians screen all women of reproductive age, including those who are pregnant and postpartum, for intimate partner violence and refer those who screen positive to ongoing services so they can get the care they need to stay safe. The Task Force also recognizes that caregiver abuse of older and vulnerable adults is an important issue. Unfortunately, right now there is not enough evidence to recommend for or against screening for caregiver abuse and neglect of older and vulnerable adults, so we are calling for more research in these important areas. (more…)
Author Interviews / 11.07.2025

Medical research is at the heart of clinical advancement. Whether evaluating the safety of new treatments or analyzing trends across patient populations, the integrity and efficiency of research practices have direct implications on healthcare delivery. Among the most labor-intensive tasks in medical research are literature reviews and meta-analyses—two foundational methodologies that aggregate findings from multiple studies to draw broader, evidence-based conclusions. With the volume of published medical literature increasing exponentially each year, traditional methods of reviewing research have become less sustainable. Today, artificial intelligence (AI) is beginning to play a transformative role in this process, offering ways to streamline literature searches, extract relevant data, reduce bias, and increase reproducibility. AI isn't replacing researchers—it’s empowering them with tools that can manage scale, speed, and complexity in ways manual methods cannot match. (more…)
Author Interviews, Cancer Research / 07.07.2025

MedicalResearch.com Interview with: Hideyuki Saya, MD, PhD Director, Oncology Innovation Center Fujita Health University Toyoake, Japan MedicalResearch.com: What is the background for this study? Response: Benzaldehyde, a simple aromatic compound found in the natural aroma of almonds and apricots, has long been reported to have anticancer activity, with clinical trials even conducted in Japan in the 1980s. However, the molecular mechanism underlying its anticancer effect has remained unclear for decades. Our study was initiated by Dr. Jun Saito, whose father was one of the original researchers studying benzaldehyde. Driven by a personal motivation to clarify the scientific basis of this compound’s effect, Dr. Saito spent over a decade in our lab to finally uncover its mechanism of action. (more…)
Author Interviews, Gout / 27.06.2025

MedicalResearch.com Interview with: Orrin M. Troum, MD Orrin M. Troum, MD, is a Clinical Professor of Medicine and Voluntary Faculty Member of the Division of Rheumatology Keck School of Medicine- UCLA Director, Clinical Rheumatology Research Providence St John's Hospital Santa Monica, California MedicalResearch.com: What is the background for this study? Who is more likely to develop uncontrolled gout? Response: The Phase 4, open-label FORWARD trial was designed to evaluate the safety and efficacy of less frequent, monthly dosing of KRYSTEXXA® (pegloticase) co-administered with methotrexate (MTX) in patients with uncontrolled gout. KRYSTEXXA remains the only FDA-approved therapy for this challenging condition, but with continued research like the FORWARD trial, we can further improve and evolve the treatment landscape for patients. This study reflects a broader effort to optimize gout care with approaches that are not only effective but also more sustainable in real-world settings. Uncontrolled gout happens when gout is not properly treated and uric acid levels continue to rise, which can have a damaging impact on the body beyond the pain of regular flares. Those experiencing uncontrolled gout continue to have signs and symptoms of gout despite taking oral urate-lowering medicines. (more…)
Author Interviews, Cancer Research, Chemotherapy, Melanoma, NYU / 27.06.2025

MedicalResearch.com Interview with: Tomas Kirchhoff, PhD (corresponding author) Associate ProfessorLaura and Isaac Perlmutter Cancer Center New York University School of Medicine Robert Ferguson PhD Senior Scientist at NYU Langone Medical Center Kelsey Monson, PhD Immuno-Oncology Postdoctoral Researcher Icahn School of Medicine at Mount Sinai MedicalResearch.com: What is the background for this study? Would you briefly explain how mitochondrial DNA differs from chromosomal DNA? TK: Immune checkpoint blockade has changed the way we treat several cancers, including advanced melanoma. Before these therapies, the treatment options were very limited, but now more than half of patients experience significant tumor shrinkage or disease control. KRM: Despite these advances, many patients still do not respond to treatment. One of the main challenges in cancer medicine today is to find ways to predict which patients will benefit from these therapies before treatment begins. This approach is key to personalizing care and improving outcomes. RF: Mitochondria are small structures inside our cells that produce the energy needed for cells to function. Unlike most of our DNA, mitochondrial DNA is inherited only from the mother. Scientists can categorize this mitochondrial DNA into groups called haplogroups, based on unique variations in the genetic code. These haplogroups can provide insight into how cells produce energy and may affect a person’s health or response to cancer treatment. (more…)
Author Interviews / 25.06.2025

Key Takeaways

  • Recreation therapy is emerging as an essential part of holistic patient care across healthcare and community settings.
  • Pursuing an online recreation therapy degree gives learners the flexibility to advance their careers without putting their lives on hold.
  • The ongoing shortage of credentialed recreation therapists has fueled job growth in hospitals, rehabilitation centers, and specialized care facilities.
  • Recent research underscores recreation therapy’s measurable positive effects on diverse populations' physical, emotional, and social health.
  • Remote learning and technology are helping to break down barriers, making education and therapy more accessible and effective than ever.
(more…)
Author Interviews, JAMA, Osteoporosis, USPSTF / 24.06.2025

MedicalResearch.com Interview with: Esa M. Davis, M.D., M.P.H. Vice chair, USPSTF Professor of Family and Community Medicine Senior Associate Dean of Population and Community Medicine University of Maryland School of Medicine MedicalResearch.com: What is the background for this study? What are the main findings? Response: Osteoporosis causes bones to become weak and break or fracture more easily. It is more common as people age and can lead to serious disability, chronic pain, loss of independence, and even death. The Task Force looked at the evidence and found that all women who are 65 and older should be screened for osteoporosis. Menopause causes hormone changes that affect a person's bone density and causes their bones to break down faster than they can rebuild, thereby increasing a person's risk of osteoporosis. As a result, women younger than 65 who have already gone through menopause and have at least one additional risk factor for osteoporosis should receive a formal risk assessment to determine whether they should then be screened. It's important to note that men can also get osteoporosis and have similar risk factors as women, but unfortunately there is not enough evidence to determine whether or not screening and then treating men can help prevent fractures. (more…)
Author Interviews / 24.06.2025

Editor's note: Please check with your health care provider regarding your specific diet and nutritional needs and before beginning or changing any medications for erectile dysfunction.  ED drugs may have side effects which should be discussed with your doctor before beginning treatment. Diet and good health go hand in hand. Without the right diet, how are you supposed to have good health? Think of your health as your car engine that needs the best fuel to run smoothly for years. Without the right diet, any kind of health issue may occur. In today’s world, more health issues occur because of improper diet and food habits other than any other reason. As per studies, it has been found that close to 70% of all the health issues that may occur is because it links to our diet.   foods-influence-male-impotence.jpg However, did you know that your diet also has a connection with your sexual life? Without the right diet men can be predisposed to sexual problems. In this article, we are going to explore the relationship between diet and one such sexual health issue that occurs in men known as impotence ED. Consider ED or erectile dysfunction as a form of sexual health issue that does not allow you to get a hard erection. Men may treat this problem with the help of medications such as Vidalista 20 mg tadalafil. In this article, we are going to find out how an improper diet may lead to or exacerbate this condition and diets that may reduce its incidence. (more…)
Author Interviews, Brain Injury, Exercise - Fitness / 21.06.2025

MedicalResearch.com Interview with: Jenny T. Makhoul, MBS Department of Medical Education Geisinger Commonwealth School of Medicine Scranton, PA 18509 MedicalResearch.com: What is the background for this study? Response: Chronic Traumatic Encephalopathy (CTE) is a progressive neurodegenerative disorder caused by repeated head trauma, particularly in contact sports such as American football, boxing, and soccer. It was first described in 1928 as “punch drunk syndrome” and later formally named as CTE by Dr. Bennet Omalu in 2002. It is characterized by cognitive decline, mood disturbances, and motor dysfunction. Recent findings show that even teenage athletes can develop CTE, this is a growing public health issue. Despite increasing awareness, CTE remains diagnosable only post-mortem, and no effective treatments exist. Our focused review explores the sport-specific clinical presentations, neurobiological mechanisms, diagnostic challenges, and the use of rodent models to deepen our understanding and support future prevention development. (more…)
AI and HealthCare, Author Interviews, Genetic Research, Neurology / 17.06.2025

MedicalResearch.com Interview with: Prof.  Amy Kuceyeski Ph.D. Professor of Mathematics in Radiology and Neuroscience Weill Cornell Medicine MedicalResearch.com: What is the purpose of the Krankencoder tool? Response: The Krakencoder is a tool that allows us to compactly represent brain networks, or the connections between different parts of the brain. This compact representation helps us to take a step toward achieving the goal of understanding how complex human behavior, like thinking, social interactions, and emotion, arise from the complex network that is the human brain. (more…)
Author Interviews, Cancer Research, HPV / 13.06.2025

MedicalResearch.com Interview with: Pragati Advani MD, MPH, DrPH Assistant Professor of Oncology, Department of Thoracic Surgery And on faculty with the Department of Cancer Prevention and Population Sciences Roswell Park Comprehensive Cancer Center Buffalo, NY MedicalResearch.com: What is the background for this study? Response: In oncology, a study of second primary malignancy (SPM) is an emerging field that is predominantly driven by our success in identifying and treating the first primary cancers (FPCs). HPV is responsible for nearly a third of all infectious agent-related FPCs (including cancer of the oropharynx, anus, vulva, vagina, cervix and penis). Advances in diagnostic and treatment methods have resulted in improved survivorship among these patients. However, they remain at risk for developing a SPM. No studies thus far had examined the risk of SPMs after HPV-associated FPCs, stratified by cancer site and gender. (more…)
Author Interviews / 12.06.2025

Discuss your use of THC, Cannabis or CBD products with your health care provider.  Dosing of THC is variable, especially since it is not FDA regulated. Cannabis/CBD/THC may interfere with other medications and should not be used in individuals with certain health conditions, including liver issues. Some studies suggest there may be long term deleterious effects from use of cannabis products. Do not use cannabis products including edibles and CBD if you are pregnant, nursing or may become pregnant. Do not use cannabis products if driving or operating difficult or dangerous machinery. Children should not be exposed to cannabis or CBD products. Sleep is one of the most crucial components of overall health and well-being. For many people, however, achieving a full night of restful sleep can be an ongoing challenge. Whether due to stress, anxiety, or other health issues, quality sleep can often feel elusive. With the rise of alternative therapies, many are turning to products like THC sleep gummies to help improve their sleep patterns. THC, or tetrahydrocannabinol, the main psychoactive compound in cannabis, has garnered attention for its potential to promote relaxation and improve sleep. In this article, we will explore how THC sleep gummies may enhance sleep quality, offering a natural solution without the unwanted side effects typically associated with pharmaceutical sleep aids. We will also discuss how EO Care, a trusted brand in the wellness industry, is bringing these benefits to users in a safe and accessible form. (more…)
Author Interviews, Pain Research, Pharmacology / 09.06.2025

MedicalResearch.com Interview with: Prof. Alexander Binshtok PhD Cecile and Seymour Alpert Professor in Pain Research Hebrew University’s Faculty of Medicine and Center for Brain Sciences (ELSC) MedicalResearch.com: What is the background for this study? Response: Paracetamol (also known as acetaminophen) is one of the world’s most commonly used pain relievers and fever reducers, yet for decades, its precise biological mechanism has remained something of a mystery. Traditionally, scientists believed its analgesic effect stemmed from central nervous system activity—specifically through the action of its metabolite, AM404, on cannabinoid and TRPV1 receptors in the brain. (more…)
ASCO, Author Interviews, Cancer Research, General Medicine, Pediatrics / 01.06.2025

MedicalResearch.com Interview with: Alique Topalian, PhD, MPH Research Scientist Family & Community Medicine | College of Medicine University of Cincinatti MedicalResearch.com: What is the background for this study? Response: Adolescent and young adult (AYA) cancer survivors are diagnosed between the ages of 18-39. We have seen increases in cancer diagnoses in this younger population of about 1-2% per year with an estimated total increase of 30% between 2019-2030.  Adolescent and young adult (AYA) cancer survivors experience early development of chronic medical conditions compared to healthy peers. Due to their young age at diagnosis and living decades beyond treatment, they are also at higher risk for second primary malignancies (SPM) and late effects than older adult-onset cancer survivors. Primary care providers are responsible for most long-term care of survivors and many are unfamiliar with the effects of cancer treatment in younger populations. (more…)
Alcohol, ASCO, Author Interviews, Cancer Research / 01.06.2025

MedicalResearch.com Interview with: Chinmay Jani, MD Chief Fellow, Hematology & Oncology University of Miami / Jackson Health System   Gilberto Lopes, M.D. Professor, Chief, Division of Medical Oncology Associate Director for the Cancer Center and Medical Director for International Affairs Sylvester Comprehensive Cancer Center   MedicalResearch.com: What is the background for this study? Response: There is growing evidence linking alcohol consumption to increased cancer risk and mortality. This association was recently emphasized by the former U.S. Surgeon General, prompting renewed public health interest. In response to these concerns, under the mentorship of Dr. Lopes, we evaluated national trends in alcohol-associated cancer mortality using data from the Global Burden of Disease database. (more…)
Author Interviews, Cannabis, Heart Disease / 29.05.2025

MedicalResearch.com Interview with: Matthew L. Springer, Ph.D. Associate Professor of Medicine Division of Cardiology Cardiovascular Research Institute Broad Center of Regeneration Medicine and Stem Cell Research Center for Tobacco Control Research & Education Helen Diller Family Comprehensive Cancer Center University of California, San Francisco MedicalResearch.com: What is the background for this study? Response: It's been known for many years that chronic tobacco smokers have poor endothelial function, even if they have not smoked recently, and so do non-smokers who are frequently exposed to secondhand smoke.  Endothelial dysfunction, even in otherwise outwardly healthy people, is an indication of unhealthy arteries and increased risk of cardiovascular disease later in life.  I realized that many people who would presumably avoid secondhand smoke did not mind it if it came from cannabis, and I wondered if that could be true since both kinds of smoke included the thousands of chemicals that resulted from burning plant material. A number of years ago, we developed a way to study changes in endothelial function in rats, using a technique very similar to how we measure it in humans, and we saw that, as in humans, even brief exposures to secondhand smoke from tobacco impaired vascular function in the rats.  We subsequently showed that brief exposures to secondhand smoke from marijuana, and active smoking of marijuana, similarly impaired vascular function in the rats, even if the smoke was from marijuana lacking THC and the other cannabinoids.  That again raised the question of whether the endothelial dysfunction observed in human tobacco smokers would also occur in human marijuana smokers, and whether secondhand smoke from marijuana should be avoided like secondhand smoke from tobacco. These questions form the basis of our current study..  In our study, it is quite clear that chronic cannabis smokers had endothelial dysfunction similar to that of chronic tobacco smokers.  Whether frequent exposure to secondhand marijuana smoke similarly impairs endothelial function like secondhand tobacco smoke is still unknown, and that's one of the major questions we want to answer next. (more…)
Author Interviews, Mental Health Research / 26.05.2025

tms-therapy-mental-health.jpg Many people deal with mental health issues each year, and they may want non-invasive treatment options to improve their conditions. Although traditional methods like taking medication remain valuable, they might not offer the relief that some people are looking for. Some want to quit smoking, and when the standard treatments don’t work, they may research transcranial magnetic solutions to cure them of the habit. During TMS sessions, an electromagnetic coil will be placed in certain regions of the head to stimulate the nerve cells. It’s going to deliver magnetic pulses to help control depression. The simulation seems to be working where some patients have reported that their depression symptoms have eased after the session. TMS has captured the attention of the medical community with its non-invasive nature. The outcomes can be impressive, especially for people struggling to regulate their moods, and it’s now being viewed as a promising alternative for those who are seeking better emotional balance. If you’re currently struggling with a disorder, you may turn to TMS Therapy San Diego for high- quality care, and with their FDA-approved approach, you many get long-lasting relief from depression. Below is some information on how TMS works in general: (more…)
Author Interviews / 23.05.2025

Healing Doesn’t Have to Mean Hardship

For decades, addiction treatment was framed as something that had to be grueling to be effective. The thinking went: if you’re too comfortable, you’re not “doing the work.” But we now know better. Recovery is challenging enough—true healing doesn’t require discomfort. In fact, for many people, it flourishes when their environment is peaceful, dignified, and designed to support wellbeing on every level. That’s why luxury addiction treatment centers are gaining traction among individuals who want more than just a bed and a meeting schedule. They want a restorative experience that nurtures the mind, body, and spirit—without compromising clinical integrity. (more…)
Author Interviews / 23.05.2025

You Don’t Have to Escape to Recover

There’s a common belief that in order to get clean, you have to disappear. That recovery means retreating to some remote mountain or coastal hideaway, cutting all ties, and starting over somewhere far from real life. While that path works for some, it’s not the only way—and it’s not always realistic. For many professionals, creatives, entrepreneurs, or caregivers, life is deeply rooted in the city. And that’s why a growing number of individuals are turning to high-end, private treatment options like luxury rehab Los Angeles—programs that provide world-class care, discretion, and comfort right in the heart of where life happens. (more…)
Author Interviews, Breast Cancer, Mammograms / 22.05.2025

MedicalResearch.com Interview with: Dr Tong Li PhD | Cancer Institute NSW Early Career Fellow Breast Cancer Clinical and Population Health Stream The Daffodil Centre, Faculty of Medicine and Health, The University of Sydney Moore Theological College | The University of Sydney | NSW | 2042    MedicalResearch.com: What is the background for this study? Response: Having a family history of breast cancer is one of the most common risk factors for women. About 8% to 11% of women in the U.S. report having a close relative diagnosed with breast cancer. These women often have dense breasts. Dense breast tissue can make standard digital mammography (DM, also known as 2D mammography) less effective in detecting cancer. Digital breast tomosynthesis (DBT), a 3D imaging technology, has become increasingly used in breast cancer screening because it improves the visibility of lesions and reduces unnecessary callbacks. However, until now, it has been unclear whether DBT offers the same benefits in women with a family history of breast cancer, especially across different family risk levels and breast density types. (more…)
Author Interviews, Pain Research / 14.05.2025

MedicalResearch.com Interview with: Brian J. Piper, PhD Department of Medical Education Center for Pharmacy Innovation & Outcomes Geisinger College of Health Sciences Scranton, PA 18509   MedicalResearch.com: What is the background for this study? Dr. Piper: Tapentadol has an unusual mechanism of action. This opioid is similar to morphine in that it activates mu, the main opiate receptor which is important for pain. This drug also acts similar to an antidepressant like duloxetine (Cymbalta) with equal ability to block both the norepinephrine and the serotonin transporters (Figure 1). The combination of opioid and monoaminergic activity may influence both therapeutic and side effect profiles. Tapentadol is approved in the US for moderate to severe acute pain, moderate to severe chronic pain, and neuropathic pain associated with diabetic peripheral neuropathy. However, tapentadol is not generally considered first-line for any of these indications. Although this agent has a high potential for abuse and is classified as a Schedule II substance, a manufacturer of extended release tapentadol (Grunenthal) has conducted a misinformation campaign claiming tapentadol has a “minimum potential of abuse”, does not cause respiratory depression (a well-known opioid effect), does not cause any euphoric feelings, has no street value, and is not an opioid [2]. Prior pharmacoepidemiological studies have examined the use patterns of other prescription opioids that can be misused like oxycodone [3], fentanyl [4], meperidine [5] and methadone [6] but there is limited national information about the use of tapentadol. (more…)
Author Interviews, Ophthalmology / 13.05.2025

When you experience a new or sudden symptom, especially concerning the eyes, it can be quite worrying. The problem is that modern life is very fast-paced, and many people struggle to fit appointments into their day. However, your health is the most important thing of them all, and ignoring symptoms can lead to worsening problems down the road. If you experience any of the following eye-related symptoms, book an appointment as soon as you can.

Sudden Blurry Vision

Many people in the world experience blurry vision. In fact, sometimes, the solution is as simple as getting a pair of mens reading glasses. However, sudden blurry vision can be a sign of something more serious, including:
  • Macular Edema
  • A Detached Retina
  • Glaucoma
  • Cataracts
As such, you must book an appointment as soon as possible. You might find you just need a new pair of glasses, or you may have an eye condition that requires treatment. (more…)
Author Interviews, Gastrointestinal Disease, Hepatitis - Liver Disease / 13.05.2025

MedicalResearch.com discussion with: Dr. Bertus Eksteen PhD, MBChB, FRCP Founder of the Calgary PSC Clinic Member of the Calgary Liver Unit and the Southern Alberta Liver Transplant Clinic Aspen Woods Clinic Calgary, Canada Primary sclerosing cholangitis (PSC) is a liver disease characterized by progressive inflammation and scarring of the bile ducts. PSC still has no known cause or cure and often leads to liver failure or cancer. For patients and clinicians, the lack of answers is deeply frustrating. But that's beginning to change. Thanks to genetic research, we’re uncovering clues about PSC’s origins—and why it behaves differently from patient to patient. By learning more about the genomic underpinnings of PSC, researchers can create new treatment targets, devise risk profiles for early diagnosis, and even develop better clinical tools for detecting the disease in its earliest stages.  And that path forward doesn’t just start with new treatments — it begins in the lab.

Genetic Clues to PSC Onset

PSC isn't directly inherited, but genetics likely play a significant role in determining who develops the disease. Several immune-related gene variations, particularly those related to the human leukocyte antigen (HLA) complex, have increased the risks of developing PSC.  These variations don’t cause PSC on their own— researchers believe they interact with intestinal bacteria and other environmental factors, prompting the immune system to launch an attack on the bile ducts. Understanding these genetic foundations provides a roadmap for following this disease very early. Instead of reacting to symptoms, we can start asking why specific people are predisposed in the first place. That insight is key to prevention and long-term disease management. (more…)
Accidents & Violence, Author Interviews / 09.05.2025

MedicalResearch.com Interview with: Jingzhen Ginger Yang, PhD, MPH Principal Investigator at the Center for Injury Research and Policy Abigail Wexner Research Institute at Nationwide Children’s Hospital Professor of Pediatrics at The Ohio State University College of Medicine with a courtesy appointment in the Department of Epidemiolog in The Ohio State University College of Public HealthJingzhen Ginger Yang, PhD, MPH Principal Investigator at the Center for Injury Research and Policy Abigail Wexner Research Institute at Nationwide Children’s Hospital Professor of Pediatrics at The Ohio State University College of Medicine with a courtesy appointment in the Department of Epidemiolog in The Ohio State University College of Public Health MedicalResearch.com: What is the background for this study? Response: Motor vehicle crashes are the leading cause of death for U.S. teens. Newer vehicles and driver assistance technologies show promise in reducing crashes and injury severities. Our study found that driving vehicles 6-15 years old had a 19% greater risk of driver death in fatal crashes, and driving vehicles older than 15 years had a 31% greater risk, both compared to driving vehicles 5 years old or newer, regardless of driver age. Additionally, each driver assistance technology already present in vehicles was associated with a 6% reduction in the risk of driver death in fatal crashes. (more…)
AACR, Author Interviews, Cancer Research / 08.05.2025

MedicalResearch.com Interview with: Andrei Bakin, PhD, Associate Professor of Oncology, Department of Cancer Genetics & Genomics, Roswell Park Comprehensive Cancer Center – first author of “A novel combination immunotherapy for p53 mutant metastatic breast cancer leveraging vulnerabilities in the DNA damage response” and senior author of “Novel triple-drug combination strategy for p53 mutant cancers leveraging their DNA damage response liabilities” Christos Fountzilas, MD, FACP, Associate Professor of Oncology, Department of Medicine, Roswell Park Comprehensive Cancer Center - and senior author of “A novel combination immunotherapy for p53 mutant metastatic breast cancer leveraging vulnerabilities in the DNA damage response” Mohammed Alruwaili, MS, PhD, newly graduated doctoral candidate in Cancer Genetics & Genomics at Roswell Park Comprehensive Cancer Center, first author of “Novel triple-drug combination strategy for p53 mutant cancers leveraging their DNA damage response liabilities” (more…)
AACR, Author Interviews, Breast Cancer, Cancer Research / 08.05.2025

MedicalResearch.com Interview responses from: First author Gokul Das, PhD, Professor of Oncology and Co-Director of the Breast Translational Group, Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center Chetan Oturkar, PhD, Research Assistant Professor in the Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, first author on the study MedicalResearch.com: What is the background for this study?  Dr. Gokul Das: Triple-negative breast cancer (TNBC) is a very aggressive subtype of breast cancer for which effective targeted therapies are not available, and which rapidly becomes resistant to chemotherapy. TNBC tumors are negative for estrogen receptor α (ERα), progesterone receptor (PR), and HER-2/neu receptor. Endocrine therapy or HER2-targeted therapies are not effective against TNBC. Currently available options including immunotherapy benefit only some patients. They are cost-prohibitive and have severe adverse effects. Therefore, there is an unmet need for rationally designed therapies for TNBC. Although ERα is absent in TNBC, majority of these tumors express estrogen receptor beta (ERβ), a structurally related but functionally distinct isoform of the estrogen receptor coded by a different gene. Tumor suppressor protein p53 is mutated in the majority (80%) of TNBC. p53, when mutated, loses its tumor suppression capabilities, and instead gains oncogenic or tumor-driving functions.  One of the major oncogenic functions of mutant p53 is to bind and inactivate another tumor suppressor named p73.  The Das laboratory has been focusing on the mechanisms underlying the estrogen receptor β-p53-p73 axis for discovering rational and effective therapeutic strategies against TNBC. (more…)