Gastrointestinal Disease

09 Sep

Posted at 20:29h in Gastrointestinal Disease

Most people pass gas throughout the day, and it is completely normal. In fact, gas is simply part of the digestive process. We swallow small amounts of air when we eat, drink, talk, or chew gum, while bacteria in the large intestine produce gas as they break down certain foods. For some people, though, gas seems to become much more noticeable at night. You may finish dinner, settle into bed, and suddenly feel bloated, uncomfortable, or unusually gassy. Sometimes it happens after a particularly heavy meal. Other times, it seems to happen for no obvious reason. If it is an occasional problem, there is usually little cause for concern. But when excessive gas at night becomes frequent, painful, or disruptive, it may be worth looking more closely at what is happening in your digestive system. For more detail on what causes nighttime gas and bloating and practical strategies for reducing it, additional guidance is available from digestive health specialists. According to the NIADD  National Institute of Diabetes and Digestive and Kidney Diseases, passing gas 13 to 21 times per day is considered normal, and most gas-related discomfort is related to diet, eating habits, or an underlying digestive condition rather than anything serious.

[caption id="attachment_75930" align="aligncenter" width="500"]abdomen-gas-pexels.jpg Photo by Kindel Media[/caption]

28 Aug

Posted at 16:58h in Gastrointestinal Disease

Living with unpredictable digestion, abdominal bloating, or changes in bowel habits creates quiet daily anxiety. You constantly guess which foods trigger discomfort while hoping your symptoms resolve on their own. Trying endless elimination diets without a clear diagnosis often wastes time and leads to nutritional gaps. Booking a diagnostic endoscopy singapore allows specialists to evaluate your digestive tract directly and deliver precise medical clarity. According to the National Institute of Diabetes and Digestive and Kidney Diseases, endoscopic procedures allow physicians to directly visualize the lining of the digestive tract, identify structural abnormalities, take tissue samples, and in many cases remove polyps during the same procedure — making them significantly more informative than dietary elimination alone.

[caption id="attachment_75789" align="aligncenter" width="500"]Make Sense of Chronic Digestive Symptoms Photo by cottonbro studio[/caption]

28 Aug

Posted at 16:31h in Gastrointestinal Disease

You sit at the table after a heavy evening meal. The house is quiet, but a sudden, sharp pressure builds beneath your right ribs. You might assume it is simply heavy digestion struggling with the roasted meat. But deep beneath the surface, a dark and jagged stone has quietly shifted into a perilous position. Many people endure this mysterious agony for months, treating it as a mild gastric disturbance. They swallow antacids and wait for the shadow to pass. But if you seek the expertise of a gallbladder surgeon, you will uncover a hidden mechanical failure. The small organ designed to store your digestive fluids has become a dangerous trap. According to the National Institute of Diabetes and Digestive and Kidney Diseases, gallstones affect approximately 10–15% of adults in the United States, and symptomatic gallstones — particularly those that block the bile duct — require prompt medical evaluation to avoid serious complications.

[caption id="attachment_75783" align="aligncenter" width="500"]The Hidden Stones Waiting In The Dark Photo by DS stories[/caption]

24 Aug

Posted at 12:53h in Dental Research, Gastrointestinal Disease

Supplement Notice: These products have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition. Supplements are not a substitute for regular medical checkups or professional healthcare. Do not delay seeking medical evaluation or treatment by taking supplements. Some supplements should not be taken if you are pregnant, nursing, or may become pregnant. Supplements may interact with prescription medications and other drugs — always inform your physician or qualified healthcare provider about any and all supplements you are taking. Always consult your healthcare provider before beginning any new supplement regimen, especially if you have an existing health condition or take other medications.

Mastic gum is a natural resin obtained from Pistacia lentiscus, an evergreen shrub native to the Mediterranean. The most recognized commercial source is the Greek island of Chios, where growers collect hardened drops of resin traditionally called "tears." Mastic has been chewed and used in foods for centuries. Modern laboratory and clinical research has examined its relationship with oral bacteria, plaque formation, and digestive symptoms. The evidence is interesting, but narrower than many online health claims suggest.

[caption id="attachment_75701" align="aligncenter" width="500"]mastic-gum-pexels-image.jpg Photo by Arina Krasnikova[/caption]

06 Aug

Posted at 11:22h in Gastrointestinal Disease, Surgical Research

Most discussions about hemorrhoids focus on itching, mild discomfort, or bleeding. But sometimes, the situation changes abruptly. You may feel a sudden, sharp pain and discover a hard, sensitive lump near the anus. This isn't a typical flare-up; it's a distinct event that can be alarming and intensely painful, often making it difficult to sit, walk, or have a bowel movement.

This specific condition is known as a thrombosed hemorrhoid. The term "thrombosis" simply means a blood clot has formed inside an external hemorrhoid, stretching the tissue and causing severe inflammation. The pressure from this clot is what creates the characteristic firm lump and the acute pain. Understanding the specific signs of a thrombosed hemorrhoid is the first step toward getting the right kind of relief and preventing complications. For additional context on managing hemorrhoid discomfort, see this overview of hemorrhoid pain relief strategies and gastrointestinal health on MedicalResearch.com.

Quick answer: A thrombosed hemorrhoid is a blood clot that forms inside an external hemorrhoid, causing a sudden, painful, and hard lump. While not typically dangerous, the condition can be extremely uncomfortable. A medical evaluation is necessary to confirm the diagnosis and determine the best course of action, which can range from home care to a minor in-office procedure.

What's inside:

  • What Exactly Is a Thrombosed Hemorrhoid?
  • How Is This Different From Other Hemorrhoids?
  • What Are the Main Treatment Options?
  • Can This Be Managed at Home?
  • Frequently Asked Questions
  • When Is It Time to See a Specialist?
[caption id="attachment_75465" align="aligncenter" width="267"]thrombosed-hemorrhoids-pexels.jpg Photo by Tima Miroshnichenko[/caption]

14 Jul

Posted at 12:22h in Dental Research, Gastrointestinal Disease, Microbiome

Your mouth is the gateway to your body, and it is not just a saying. More research is continuing to confirm that oral health plays a significant role in determining your overall well-being. For this reason, dental care has now moved beyond fixing cavities or whitening teeth. It is now viewed as an essential component of preventive health care.

If you're in Australia, working with expert Melbourne dentists can help you stay ahead of these health connections. Let's explore how your oral health influences key areas of your body and why dental care should be a priority.

[caption id="attachment_74978" align="aligncenter" width="500"]Gut Health and Your Oral Microbiome Dental health from Pixabay[/caption]

08 Jul

Posted at 21:05h in Gastrointestinal Disease
[caption id="attachment_74872" align="alignleft" width="150"]Dr. Johnston, Ph.D. Dr. Johnston, Ph.D.[/caption]

MedicalResearch.com Interview with:

Nikki Johnston, Ph.D.

Professor of Otolaryngology and Communication Sciences & Microbiology and Immunology

Medical College of Wisconsin

Co-founder and Chief Scientific Officer, N-Zyme Biomedical Inc.

MedicalResearch.com: Please provide a summary of your findings in your Modulation of Pepsin-Mediated Inflammatory Responses in Vocal Cord Epithelial Cells by Amprenavir and how that is impacting your future research studies.

Dr. Johnston: In this study, we wanted to know whether pepsin — the key nonacid component of reflux — could trigger inflammatory signaling in vocal cord epithelial cells, and whether a pepsin inhibitor could reverse that response. We found that exposing human vocal cord cells to pepsin at neutral pH, mimicking the nonacidic conditions typical of laryngopharyngeal reflux (LPR), significantly increased the transcription factor HIF-2α along with the downstream inflammatory genes IL8, IL1B, and ICAM1. Co-treatment with amprenavir, a pepsin inhibitor and the active metabolite of fosamprenavir, reduced HIF-2α levels and significantly suppressed IL8, ICAM1, and TNF expression.

Interestingly, when we blocked HIF-2α's transcriptional activity directly, only IL1B expression was reduced; IL8 and ICAM1 were unaffected or even further increased. This tells us that HIF-2α is one contributor to pepsin-driven inflammation in the vocal cords, but not the whole story — pepsin is very likely activating several parallel stress pathways (NF-κB and MAPK signaling, among others) at the same time. For our future work, this reinforces that a single downstream pathway inhibitor is unlikely to fully quiet pepsin-induced inflammation, whereas a pepsin inhibitor acting further upstream, like amprenavir, has the potential to blunt several of these pathways at once. We are now examining whether similar mechanisms extend to pepsin's emerging role in pulmonary fibrotic disease and gastro-esophageal reflux disease (GERD).

03 Mar

Posted at 20:58h in Gastrointestinal Disease, Supplements
Please note: Supplements, including human milk oligoaccharides which contain dairy products, are generally not FDA tested or approved. Some supplements can interfere with medications and/or cause side effects. Do not delay seeking medical attention for medical concerns by taking supplements without medical advice. Please discuss any and all supplements you take or are considering taking with your health care provider. [caption id="attachment_72682" align="aligncenter" width="500"]Human milk oligosaccharides and GI health.jpg Photo by Kindel Media[/caption]

Key Takeaways

  • Human Milk Oligosaccharides( HMOs) are structurally complex sugars that selectively promote beneficial gut bacteria while blocking pathogens, without the bloating associated with traditional prebiotics.
  • Clinical trials show HMO supplementation may support increased Bifidobacterium populations (25%+), improved gut barrier integrity (19% reduction in permeability markers), and reduced IBS symptoms (37% greater improvement vs. placebo).
  • Human lactoferrin works synergistically with HMOs by managing iron availability and reducing inflammation by up to 40%.
  • Unlike probiotics, HMOs reshape the existing gut ecosystem rather than introducing foreign bacteria — mirroring nature’s original design.
  • kēpos combines HMOs with effera™, a human-identical lactoferrin, representing a next-generation approach to gut health backed by peer-reviewed clinical evidence.
For decades, the gut health conversation has revolved around probiotics and fiber. Take a capsule of Lactobacillus, eat more oats, and hope for the best. But emerging research points to a far more sophisticated system — one that nature perfected millions of years ago in human breast milk. Human milk oligosaccharides (HMOs) are complex sugars found in breast milk that serve as the primary architects of a newborn’s gut microbiome. They don’t just feed bacteria — they selectively nourish beneficial strains, block pathogens from attaching to intestinal walls, and modulate the immune system from the ground up. And now, a growing body of clinical evidence suggests these same bioactives can reshape adult gut health in ways probiotics alone cannot.

08 Jul

Posted at 16:46h in Gastrointestinal Disease, Supplements
Please note: Bitters and other supplements are not FDA tested or approved. Some supplements including bitters can interfere with medications and/or cause side effects.  Bitters may relieve, but in some individuals, worsen symptoms so their use must be monitored by your health care provider.  Do not delay seeking medical attention for medical concerns by taking bitters without medical advice. A serious medical condition should be ruled out before considering supplements or bitters for your symptoms. [caption id="attachment_69409" align="aligncenter" width="200"]digestive-bitters Photo by ROMAN ODINTSOV[/caption] Acid reflux is a widespread condition, affecting millions worldwide. Many turn to medications, but natural remedies like digestive bitters may offer effective relief by addressing the root causes of reflux rather than simply masking symptoms. In this article, we explore how digestive bitters can help manage acid reflux naturally.

What Are Digestive Bitters?

Digestive bitters are herbal preparations designed to stimulate digestion by activating bitter taste receptors on the tongue and throughout the digestive tract. Traditionally used in herbal medicine, common bitter herbs include gentian, dandelion, artichoke, and chamomile. These herbs support digestion by increasing digestive secretions and improving overall gastrointestinal motility.

13 May

Posted at 09:14h in Author Interviews, Gastrointestinal Disease, Hepatitis - Liver Disease
MedicalResearch.com discussion with: Dr. Bertus Eksteen PhD, MBChB, FRCP Founder of the Calgary PSC Clinic Member of the Calgary Liver Unit and the Southern Alberta Liver Transplant Clinic Aspen Woods Clinic Calgary, Canada [caption id="attachment_68489" align="aligncenter" width="500"]Dr. Bertus Eksteen Dr. Bertus Eksteen[/caption] Primary sclerosing cholangitis (PSC) is a liver disease characterized by progressive inflammation and scarring of the bile ducts. PSC still has no known cause or cure and often leads to liver failure or cancer. For patients and clinicians, the lack of answers is deeply frustrating. But that's beginning to change. Thanks to genetic research, we’re uncovering clues about PSC’s origins—and why it behaves differently from patient to patient. By learning more about the genomic underpinnings of PSC, researchers can create new treatment targets, devise risk profiles for early diagnosis, and even develop better clinical tools for detecting the disease in its earliest stages.  And that path forward doesn’t just start with new treatments — it begins in the lab.

Genetic Clues to PSC Onset

PSC isn't directly inherited, but genetics likely play a significant role in determining who develops the disease. Several immune-related gene variations, particularly those related to the human leukocyte antigen (HLA) complex, have increased the risks of developing PSC.  These variations don’t cause PSC on their own— researchers believe they interact with intestinal bacteria and other environmental factors, prompting the immune system to launch an attack on the bile ducts. Understanding these genetic foundations provides a roadmap for following this disease very early. Instead of reacting to symptoms, we can start asking why specific people are predisposed in the first place. That insight is key to prevention and long-term disease management.

07 May

Posted at 12:21h in Author Interviews, Cancer Research, Gastrointestinal Disease
MedicalResearch.com Interview with: [caption id="attachment_68401" align="alignleft" width="150"]Mohamed Tausif Siddiqui, MDThe study’s lead author and a Gastroenterology fellow Cleveland Clinic. Dr. Siddiqui[/caption] Mohamed Tausif Siddiqui, MD The study’s lead author and a Gastroenterology fellow Cleveland Clinic. MedicalResearch.com: What is the background for this study? Response: Our study looked at how the stage of gastric cancer diagnosis has changed over the past two decades in the U.S., using national SEER data. Gastric cancer has long been a challenge because it’s often diagnosed late, when treatment options are limited and survival rates are poor. But with advancements in endoscopic technology—like high-definition imaging, narrow-band imaging, and endoscopic ultrasound—we wanted to see if these tools were making a difference in catching cancers earlier.

07 May

Posted at 12:19h in Author Interviews, Cancer Research, Colon Cancer, Gastrointestinal Disease, HPV
MedicalResearch.com Interview with: [caption id="attachment_68399" align="alignleft" width="150"]Ashley Robinson, MD, lead authorSecond-year internal medicine resident Advocate Lutheran General Hospital Dr. Robinson[/caption] Ashley Robinson, MD, lead author Second-year internal medicine resident Advocate Lutheran General Hospital MedicalResearch.com: What is the background for this study? Response: Briefly, anal cancer makes up around 1% of gastrointestinal cancers and more than 90% of all anal cancers are caused by chronic human papillomavirus or HPV infections. In previous research, it has been noted that women over the age of 65 have rates that were increasing more than other groups and myself along with my colleagues and the principal investigator of this project, Dr. Eli Ehrenpreis, wanted to further characterize these findings, looking into more specific details of these previously noted trends. Using data from a public database ran by the National Cancer Institute called the Surveillance, Epidemiology and End Results program, also known as SEER, and their statistical analysis software, SEER*Stat, we analyzed anal cancer incidence trends, looking at differences between sex, age, and ethnicity in order to further identify specific groups that have more rapidly increasing rates than others.

07 May

Posted at 08:46h in Author Interviews, Gastrointestinal Disease, Hepatitis - Liver Disease, Weight Research
[caption id="attachment_68344" align="alignleft" width="200"]MedicalResearch.com Interview with:Dr. Katilyn Gernhard Dr. Gernhard[/caption] MedicalResearch.com Interview with: Dr. Katilyn Gernhard DO Internal Medicine Resident Allegheny Health Network Pittsburgh MedicalResearch.com: What is the background for this study? Response: The background for this study is the steadily rising prevalence of obesity in the United States, which has been accompanied by an increase in related comorbid conditions, including Metabolic Dysfunction–Associated Steatotic Liver Disease (MASLD). Bariatric surgery and GLP-1 receptor agonists are two commonly used treatment options to address obesity and its associated complications. While both have demonstrated benefits in weight loss and metabolic improvement, there has been limited direct comparison of their effectiveness specifically in patients with MASLD. Our study aimed to address this gap by comparing clinical outcomes in patients with MASLD treated with GLP-1 receptor agonists versus those treated with bariatric surgery.

07 May

Posted at 08:44h in Author Interviews, Gastrointestinal Disease
MedicalResearch.com Interview with: [caption id="attachment_68373" align="alignleft" width="160"]Dr. Simon Steenson PhDPostdoctoral Research Associate Department of Nutritional Sciences King’s College London Dr. Steenson[/caption] Dr. Simon Steenson PhD Postdoctoral Research Associate Department of Nutritional Sciences King’s College London MedicalResearch.com: What is the background for this study? Response: Chronic constipation is something that can be embarrassing, but it affects 1 in 10 people globally. It has a big impact on people’s quality of life and treating constipation has substantial costs for the healthcare system. Dried fruits are recommended for managing constipation, but there are very few studies that have actually tested whether following this advice is helpful. To fill this gap in our knowledge, we completed the largest clinical trial to date to see whether dried fruits and fruit juices could benefit constipation symptoms. 

04 May

Posted at 17:03h in Author Interviews, Colon Cancer, Gastrointestinal Disease, Race/Ethnic Diversity
MedicalResearch.com Interview with: [caption id="attachment_68341" align="alignleft" width="125"]Douglas Corley, MD, PhD  Chief Research Officer, The Permanente Medical Group Kaiser Permanente, Northern California Dr. Corley[/caption] Douglas Corley, MD, PhD Chief Research Officer, The Permanente Medical Group Kaiser Permanente, Northern California MedicalResearch.com: What is the background for this study? Response: Kaiser Permanente Northern California (KPNC) is an integrated health care system that designs and implements population-based programs that support cancer prevention and early detection. In 2006, KPNC began to implement a comprehensive colorectal cancer screening program with the goal of increasing member screening rates, preventing colorectal cancer through polyp removal, and reducing cancer mortality. The initiative identifies whether screening-eligible KPNC members are up to date with their colorectal cancer screening test by either a colonoscopy or by stool-based tests, such as a fecal immunochemical testing (FIT) kit. If they are not up to date with screening, it mails them a FIT kit for at-home testing. Members can also choose other options for colorectal cancer screening, such as a colonoscopy, through their physician.

25 Apr

Posted at 20:53h in Author Interviews, Gastrointestinal Disease, Genetic Research, Hepatitis - Liver Disease
MedicalResearch.com Interview with: [caption id="attachment_68138" align="alignleft" width="125"]Ashley Jowell, MD, Internal Medicine Resident Physician Duke University  Dr. Jowell[/caption] Ashley Jowell, MD, Internal Medicine Resident Physician Duke University   [caption id="attachment_68139" align="alignleft" width="125"]Cynthia Moylan, MDAssociate Professor of Medicine, Division of Gastroenterology Duke University Health System Dr. Moyland[/caption] Cynthia Moylan, MD Associate Professor of Medicine, Division of Gastroenterology Duke University Health System       MedicalResearch.com: What is the background for this study? Response: Metabolic dysfunction can lead to several health problems including metabolic dysfunction associated steatotic liver disease (MASLD), is driven by different factors, including: a person’s behavioral or lifestyle factors, environmental factors, and genetics. Limited research exists regarding genetic , epigenetic, or other factors that might impact development of metabolic dysfunction and MASLD. Our group has previously shown that alterations in DNA methylation (a type of epigenetic change), identifiable both in liver tissue and in blood, associate with MASLD and its progression to more severe liver disease.  Whether DNA methylation that impacts imprinted gene expression also associates with metabolic dysfunction and MASLD risk remains largely unknown. In this project, we explored imprinted genes: imprinting is a normal process that regulates genes by silencing one parental copy (either the maternal or the paternal) so that only one copy is expressed. Imprinting is an important biological process for development and has a disproportionate impact on disease  - in fact, imprinted genes are hypothesized to affect 1-6% of the human genome. We sought to explore how altered DNA methylation of imprint control regions (ICRs) that help ‘control’ these imprinted genes might impact development of metabolic dysfunction in children (and hence potentially even in adults).

19 Mar

Posted at 13:05h in Gastrointestinal Disease
Please consult your health care provider for specific recommendations regarding your digestive health.  This post is for informational purposes only and not specific medical advice. Do not delay medical attention based on information discussed here. [caption id="attachment_67268" align="aligncenter" width="500"]endoscopy-gastroenterology Image source[/caption] Our digestive system is essential for overall health, yet millions experience gastrointestinal disorders each year. Issues like acid reflux, peptic ulcers, and inflammatory bowel disease are becoming more common. When left undiagnosed or untreated, these conditions can lead to severe complications, impacting daily life and long-term well-being. Endoscopy has become an essential tool in diagnosing GI disorders. In this blog post, we’ll talk about endoscopy in managing GI disorders.  However, if you’re experiencing persistent digestive issues, always search for an endoscopy specialist near me on Google to get an accurate diagnosis. They can offer tailored treatment options, ensuring better outcomes and improved quality of life.

11 Feb

Posted at 15:35h in Author Interviews, Gastrointestinal Disease
MedicalResearch.com Interview with: [caption id="attachment_66492" align="alignleft" width="144"]Arun B. Jesudian, MDAssociate Professor of Clinical Medicine Medicine  Weill Cornell Medical Center Transplant hepatologist at NewYork-Presbyterian/Weill Cornell Medical Center Dr. Jesudian[/caption] Arun B. Jesudian, MD Associate Professor of Clinical Medicine Medicine Weill Cornell Medical Center Transplant hepatologist at NewYork-Presbyterian/Weill Cornell Medical Center MedicalResearch.com: What is the background for this study? Response: In recent years, the demand for gastroenterologists continues to increase due to an aging population, increase in the prevalence of gastrointestinal and hepatology diseases, updates in screening and surveillance recommendations, and advances in therapeutic techniques. In this study, we set out to examine geographic distributions of gastroenterologists in the United States. MedicalResearch.com: What are the main findings? Response:  We found that on a national level, over 80% of the population lives within 25 miles of the closest gastroenterologist. However, 2,183 (69%) of the US counties do not have a practicing gastroenterologist, and 454 of the 1,167 metropolitan counties in the US do not have a gastroenterologist. Additionally, gastroenterologists in non-metropolitan counties tend to be older, with almost a third over the age of 65.

02 Jan

Posted at 22:06h in Gastrointestinal Disease, Supplements
Please note: Supplements are generally not FDA tested or approved. Some supplements can interfere with medications and/or cause side effects. Do not delay seeking medical attention for medical concerns by taking supplements without medical advice. Please discuss any and all supplements you take with your health care provider and be sure to follow your provider’s recommendations for your prostate and overall health. Supplements should not be given to children, breast feeding or pregnant women without the specific advice or your medical provider.  In addition some supplements, including berberine may interfere with other medications and prescription drugs. Please do not ignore new or continuing gastrointestinal symptoms, as they may indicate a more serious condition including ulcers, inflammatory bowel disease, genitourinary issues and cancer. See your health care provider for specific medical advice. [caption id="attachment_65775" align="aligncenter" width="500"]5 Steps to Revitalize Your Gut Health Naturally Image source[/caption] When it comes to feeling your best, gut health is often the missing piece of the puzzle. Your gut isn’t just responsible for digesting food—it plays a role in everything from energy levels to immunity and even mental health. If you’ve been dealing with issues like bloating, irregular digestion, or low energy, it might be time to give your gut some extra attention. The good news is that you don’t need drastic measures to see results. With these five simple steps, you can naturally revitalize your gut health and improve your overall well-being.

1. Include Gut-Friendly Supplements

Supplements are a simple yet effective way to give your gut the boost it needs. While diet and lifestyle changes are crucial, adding targeted supplements can speed up the process of restoring balance to your gut microbiome. One supplement to consider is berberine, a natural compound with powerful benefits for gut health. Berberine works by reducing harmful bacteria in the gut while encouraging the growth of beneficial bacteria. This makes it a potential option for improving your gut's overall environment. If you’re considering berberine, Lakeview Pharmacy offers Berberine XL, an option that’s designed for maximum absorption. Unlike other berberine products, Berberine XL is purported to be formulated for enhanced absorption, so you get the most out of every dose. Berberine benefits may extend beyond gut health, too—it’s thought to support metabolic health, reduce inflammation, and more.  Just remember, supplements work best when paired with other healthy habits. Berberine should not be taken by pregnant or nursing women, women who are planning to become pregnant or children. See your health care provider for specific medical advice.

03 Dec

Posted at 11:24h in Gastrointestinal Disease, Microbiome, Probiotics, Supplements, Weight Research
Editor's note:  Please consult with your health care provider before using any supplements including probiotics. Side effects are uncommon but may occur. The connection between the gut and the brain is one of the most fascinating areas of research in recent years, with scientists uncovering how the microbiome—the trillions of microorganisms residing in our digestive system—can affect not just our digestion and immune system but also our feelings of hunger and satiety. As the science behind the gut-brain axis continues to unfold, it’s becoming increasingly clear that the health of our gut microbiome plays a pivotal role in regulating appetite, food intake, and body weight. [caption id="attachment_65262" align="aligncenter" width="333"]hunger-appetitie-gutbacteria Photo by cottonbro studio [/caption] Understanding the intricate relationship between gut health and appetite regulation has profound implications for combating obesity, overeating, and eating-related disorders. In this article, we’ll explore how the microbiome influences hunger, the role it plays in appetite regulation, and what you can do to optimize gut health for better control over your hunger and eating habits. We will also look at products which aim to support a healthy microbiome and improve overall well-being.

The Gut-Brain Axis: A Two-Way Communication

The gut-brain axis refers to the bidirectional communication between the gastrointestinal system (gut) and the brain. This connection is facilitated by the vagus nerve, immune pathways, and hormones, which allow the gut and brain to send signals back and forth. Recent research has shown that gut bacteria play a significant role in this communication, influencing not only digestion but also emotions, mental health, and, importantly, appetite regulation. The microbiome, composed of bacteria, viruses, fungi, and other microorganisms, affects the brain’s perception of hunger and fullness through the production of various chemicals, including neurotransmitters, hormones, and metabolites. These signals impact brain regions that control appetite, cravings, and food intake.

25 Oct

Posted at 11:51h in Gastrointestinal Disease, Legal-Malpractice, Pediatrics
[caption id="attachment_64287" align="aligncenter" width="500"]baby-formula.jpg Image source[/caption]   As parents, we always want the best for our children. This is especially true when it comes to their nutrition and overall health. That's why choosing the right baby formula is crucial in ensuring that our little ones receive the necessary nutrients for healthy growth and development. Unfortunately, not all baby formulas on the market are safe and effective. In fact, there have been cases where certain brands of baby formula have caused serious health issues in infants, leading to lawsuits against the manufacturers. NEC baby formula lawsuit lawyers help parents hold the responsible parties accountable for their actions and secure compensation.

01 Oct

Posted at 08:25h in Gastrointestinal Disease
Editors' note:  Be sure to follow up with recommended colonoscopy examinations.  If you are having bowel or rectal symptoms,  consult your health care provider before relying on home remedies.  When you're in the grip of hemorrhoid pain, relief can't come soon enough. It’s a common misconception that hemorrhoids are untreatable. However, there are numerous strategies you can employ to prevent and manage hemorrhoids, offering a glimmer of hope and empowerment in your journey to wellness. Hemorrhoids, depending on their position, can cause cases of bleeding, itching, soreness, or pain. Internal hemorrhoids lead to painless bleeding, while external hemorrhoids lead to pain. Below are the five tips that can assist in reducing hemorrhoid discomfort.

26 Sep

Posted at 12:56h in Gastrointestinal Disease
[caption id="attachment_63533" align="aligncenter" width="500"]digestive-disorders.png Image source[/caption] Digestive disorders are far more common than many people realize, affecting around 40 million individuals in the US. Despite how widespread these conditions are, many people ignore the early signs, dismissing them as minor inconveniences. Unfortunately, what may seem like a little discomfort can often be a warning of a more significant health issue waiting to escalate. The key to preventing these issues from spiraling into long-term complications is recognizing the early signs. Many people don’t realize that digestive disorders, when caught early, can often be managed or even reversed with the right treatment plan. By ignoring symptoms like bloating, heartburn, or abdominal pain, we risk allowing our bodies to suffer silently, which could lead to more serious conditions. This article will help you guide you through the early signs of digestive disorders, helping you identify when it’s time to seek medical advice.

24 Jun

Posted at 14:17h in Gastrointestinal Disease, Nutrition
Crohn's disease is a type of inflammatory bowel disease. It causes inflammation in the digestive tract, which can lead to severe symptoms. The inflammation often spreads deep into the layers of affected bowel tissue. Crohn's disease can be painful and sometimes may lead to life-threatening complications. abdominal-pain-crohns_pexels-sora-shimazaki-5938358 Symptoms of Crohn's Disease Symptoms of Crohn's disease vary from mild to severe. Common symptoms include diarrhea, fever, fatigue, abdominal pain and cramping. People with Crohn's disease might also experience blood in their stool, mouth sores, reduced appetite and weight loss. The disease can affect different parts of the digestive tract in different people. The symptoms can change over time, with periods of severe symptoms (flares) and periods of no or mild symptoms (remission). Causes and Risk Factors The exact cause of Crohn's disease remains unknown. However, several factors may contribute to its development. These include immune system malfunctions, genetics and environmental factors. Crohn's disease tends to run in families, suggesting a genetic link. Smoking increases the risk of developing the disease and can make symptoms worse. People living in urban areas or industrialized countries have a higher risk, possibly due to diet and lifestyle factors.

04 Jun

Posted at 22:25h in Author Interviews, Colon Cancer, Gastrointestinal Disease, Immunotherapy
MedicalResearch.com Interview with: [caption id="attachment_61859" align="alignleft" width="130"]Steven H. Itzkowitz, MD, FACP, FACG, AGAFProfessor of Medicine and Oncological Sciences Director of the GI Fellowship Program Icahn School of Medicine at Mount Sinai Dr. Itzkowitz[/caption] Steven H. Itzkowitz, MD, FACP, FACG, AGAF Professor of Medicine and Oncological Sciences Director of the GI Fellowship Program Icahn School of Medicine at Mount Sinai MedicalResearch.com: What is the background for this study? What are the main findings? Response: This study looked at patients with inflammatory bowel disease (IBD) who had a history of cancer in the past 5 years and asked whether the medications they received for their IBD might have affected their rates of getting future cancer (new or recurrent cancers). Because many of the medicines that are used to treat IBD can affect the immune system in various ways, there has been concern that the medicines might predispose to subsequent cancers. We found that patients who received immunosuppressive medications had a numerically increased risk of subsequent cancer, this was not statistically higher than those who had not been exposed to these medications. While previous studies have looked at this question retrospectively, this is the first report that analyzed this issue prospectively using individuals from the United States.  Moreover, this study represents a multi-institutional collaboration among gastroenterologists at most of the major NYC healthcare systems.

20 May

Posted at 13:29h in Author Interviews, Cost of Health Care, Gastrointestinal Disease, Health Care Systems
MedicalResearch.com Interview with: [caption id="attachment_61735" align="alignleft" width="183"]Laura Targownik, MDLead author and Clinician-Investigator Mount Sinai Hospital in Toronto Departmental Division Director, Gastroenterology and Hepatology University of Toronto Dr. Targownik[/caption] Laura Targownik, MD Lead author and Clinician-Investigator Mount Sinai Hospital in Toronto Departmental Division Director, Gastroenterology and Hepatology University of Toronto MedicalResearch.com: What is the background for this study? Was there a difference in the types of patients or need for surgery seen by the female/male physicians? Response: The background for this study is that there is an emerging body of literature that having a female physician leads to better patient outcomes in many health care settings, especially amongst patients undergoing surgery or being admitted to hospital.  However, this has not previously been evaluated in gastroenterology.  Female and male gastroenterologists may have different styles of practice on average, and this potentially could lead to differences in how patients engage with the health care system following an initial assessment.

03 Feb

Posted at 01:55h in Addiction, Author Interviews, Gastrointestinal Disease, Opiods
MedicalResearch.com Interview with: [caption id="attachment_61309" align="alignleft" width="150"]Joshua D. Madera, MDDepartment of Medical Education Geisinger Commonwealth School of Medicine Scranton PA Dr. Madera[/caption] Joshua D. Madera, MD Department of Medical Education Geisinger Commonwealth School of Medicine Scranton PA What is the background for this study? Response: The US population continues to be drastically impacted by the opioid epidemic, with opioid-related deaths significantly increased compared to European countries. While prescription opioid distribution has gradually declined since its peak in 2011 [1], the rate of opioid prescriptions remains increased compared to 2000. Furthermore, there is considerable interstate variability in opioid distribution across the US. Identifying patterns in this variability may guide public health efforts to reduce opioid-related harms. Therefore, the primary objective of this study [2] from Geisinger Commonwealth School of Medicine was to explore variations in production quotas and state-level distribution of ten prescription opioids between 2010 and 2019.

18 Nov

Posted at 13:00h in Author Interviews, Brigham & Women's - Harvard, Gastrointestinal Disease, Obstructive Sleep Apnea, Technology
MedicalResearch.com Interview with: [caption id="attachment_61077" align="alignleft" width="150"]Giovanni Traverso MD PhDKarl Van Tassel (1925) Career Development Professor Department of Mechanical Engineering Koch Institute of Integrative Cancer Research Division of Gastroenterology Brigham and Women’s Hospital Harvard Medical School, Boston, MA, USA Dr. Traverso[/caption] Giovanni Traverso MD PhD Karl Van Tassel (1925) Career Development Professor Department of Mechanical Engineering Koch Institute of Integrative Cancer Research Division of Gastroenterology Brigham and Women’s Hospital Harvard Medical School, Boston, MA, USA   MedicalResearch.com: What is the background for this study? Response: I think its always important to acknowledge that this is a big team effort.  We have the teams from MIT, Celero Systems, West Virgnia University (WVU) and Brigham and Women’s Hospital (BWH) all working together on this.   For this study, Celero prototyped the devices that we tested in pre-clinical (Swine) models and in a first-in-human study with the team at WVU. Our lab focuses on the development of ingestible devices for drug delivery and sensing and these have informed the development of these efforts as you can see. MedicalResearch.com: What types of vital signs are measurable in this fashion? Response: Heart rate and respiratory rate.