Multiple Gut Bacteria Associated with Atherosclerosis Interview with:

Dr. Tove Fall

Tove Fall, PhD
Professor in Molecular Epidemiology
Department of Medical Sciences, Molecular Epidemiology
Uppsala University
Uppsala, Sweden What is the background for this study?

Response: It is unclear if and how the gut microbiome affect the risk of myocardial infarction. In this study we assessed the association of the gut microbiome measured at high resolution with atherosclerosis, the main underlying pathology of myocardial infarction, in over 8000 participants without any previous cardiovascular events. What are the main findings?

Response: We found 64 species that were associated with atherosclerosis levels. Several of these bacterial species were streptococci, which were in turn also associated with markers of inflammation and specific metabolites. What should readers take away from your report?

Response: There seems to be a clear association of certain gut species with atherosclerosis, but more studies are needed to determine causality and the mechanisms of action. Our results point to a role or streptococci in atherosclerotic disease, but this needs verification in other studies. What recommendations do you have for future research as a results of this study?

Response: It is important to account for differences in diet and medication in any microbiome-disease study.

Also, a high resolution mapping of the microbiome as in our study helps to identify specific species as different species in the same family of bacteria may have different effects

Disclosure Some authors are employed by the company Clinical Microbiomics, which analyzes microbiome samoles.


Streptococcus Species Abundance in the Gut Is Linked to Subclinical Coronary Atherosclerosis in 8973 Participants From the SCAPIS Cohort

Sergi Sayols-Baixeras, PhD, Koen F. Dekkers, MSc, Gabriel Baldanzi, MD, Daniel Jönsson, DDS, PhD, Ulf Hammar, BSc, Yi-Ting Lin, MD, PhD, Shafqat Ahmad, PhD, Diem Nguyen, PhD, Georgios Varotsis, DVM, Sara Pita, MSc, Nynne Nielsen, MSc, Aron C. Eklund, PhD, Jacob B. Holm, PhD, H. Bjørn Nielsen, PhD, Ulrika Ericson, PhD, Louise Brunkwall, PhD, Filip Ottosson, PhD, Anna Larsson, MD, Dan Ericson, DDS, PhD, Björn Klinge, DDS, PhD, Peter M. Nilsson, MD, PhD, Andrei Malinovschi, MD, PhD, Lars Lind, MD, PhD, Göran Bergström, MD, PhD, Johan Sundström, MD, PhD, Johan Ärnlöv, MD, PhD, Gunnar Engström, MD, PhD, J. Gustav Smith, MD, PhD, Marju Orho-Melander, PhD, Tove Fall, DVM, PhD

Originally published 12 Jul 2023 Circulation. 2023;0

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Last Updated on July 17, 2023 by Marie Benz MD FAAD