[caption id="attachment_72613" align="aligncenter" width="500"] Unsplash image[/caption] Music has always held a quiet power over the human mind. Long before modern medicine,...
[caption id="attachment_72613" align="aligncenter" width="500"] Unsplash image[/caption] Music has always held a quiet power over the human mind. Long before modern medicine,...
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Acute trauma has long been associated with visible physical damage. However, the invisible neurological consequences often shape long-term recovery just as strongly.
Cognitive symptoms such as memory lapses, reduced attention span, slower processing speed, and emotional instability emerge after traumatic events. Growing research suggests that neuroinflammation plays a central role in determining the impact on cognitive function.
For instance, the blood-brain barrier (BBB) can be affected by injury-induced inflammation. Studies have linked BBB disruption to cognitive decline. Some of the most associated factors are inflammation, metabolic imbalance, cellular aging, oxidative and nitrosative stress, and excitotoxicity.
Studies also suggest that altering BBB permeability can produce either protective or harmful neurological effects, depending on the context.
Understanding how inflammatory pathways respond to trauma offers insight into why some individuals regain their previous level of functioning while others don’t.
Dr. Young-Wolff[/caption]
Kelly Young-Wolff, PhD, MPH
Licensed clinical psychologist and Research Scientist
Kaiser Permanente Northern California Division of Research
Associate Professor, Psychiatry
School of Medicine
UCSF Weill Institute for Neurosciences
MedicalResearch.com: What is the background for this study?
Response: Cannabis is widely used by adolescents, and it’s often first used during the same developmental window when many psychiatric disorders begin to emerge. At the same time, cannabis has become more accessible and more socially accepted. While prior studies have linked adolescent cannabis use to mental health symptoms, fewer large studies have examined whether it’s associated with later clinically diagnosed psychiatric disorders. We wanted to address that gap.
Photo by cottonbro studio[/caption]
Many people wonder whether a diagnosed social anxiety disorder makes them disabled. The simple answer is most likely yes, it is when a person's daily life and work are affected by social anxiety that it can be considered a disability. Many people are actually unable to function normally in social interactions, a direct result of this condition.
If someone is unable to work, form personal relationships, or even perform daily tasks due to social anxiety, it is a sign that the disorder has become disabling.
Federal laws recognize mental health problems as disabilities. Social anxiety disorder is listed on the Americans with Disabilities Act and the Social Security Administration's list of disabilities. These laws, on the same level, recognize that mental disorders can be as limiting as physical injuries.
Social Anxiety as a Disability
Social anxiety disorder is a common condition that affects millions of people. Most people with severe social anxiety remain stuck in patterns of fear and avoidance. They are eager to work and become functioning fellows of society, but mental barriers get in their way. Even simple tasks like answering phone messages, attending meetings, or dealing with customers become almost impossible obstacles for people with this disorder.
However, social anxiety disorder affects different people differently. While some people sweat, tremble, or feel nauseous when faced with social situations, others are so afraid that they literally run away from people they have to meet. It is most disabling when it interferes with:
Prof. Chu Chen[/caption]
Chu Chen, PhD
Professor and Joe R. and Teresa Lozano Long Chair in Neural Physiology
Department of Cellular and Integrative Physiology
Center for Biomedical Neuroscience
Joe R. and Teresa Lozano Long School of Medicine
University of Texas at San Antonio Health Science Center
San Antonio, TX 78229
MedicalResearch.com: What is the background for this study?
Response: Alzheimer’s disease (AD) is the most common cause of dementia in the elderly, yet no effective therapies currently exist to prevent, treat, or halt its progression. Cannabis has been used for thousands of years for both recreational and medicinal purposes; however, its therapeutic application has been limited by undesirable neurocognitive side effects, particularly impairments in learning and memory. Δ9-Tetrahydrocannabinol (Δ9-THC), the primary psychoactive component of cannabis, has been shown to reduce amyloid-β (Aβ) pathology in animal models of AD, but at high doses (>5.0 mg/kg) it also disrupts synaptic function and impairs cognition.
Research from our laboratory and others has demonstrated that Δ9-THC-induced deficits in long-term synaptic plasticity, learning, and memory are associated with the induction of cyclooxygenase-2 (COX-2), an inducible enzyme that converts arachidonic acid into pro-inflammatory prostaglandins. Notably, pharmacological inhibition or genetic deletion of COX-2 attenuates Δ9-THC-induced synaptic and cognitive impairments. Based on these findings, we proposed a combination (“cocktail”) therapy consisting of low-dose Δ9-THC and the anti-inflammatory drug celecoxib, a selective COX-2 inhibitor, as a potential therapeutic strategy for AD. This approach is designed to preserve the beneficial effects of Δ9-THC while minimizing its adverse neurocognitive effects and COX-2-mediated inflammatory responses.
Dr. Fyfe[/caption]
Dr. Caroline Fyfe PhD
Postdoctoral Research Associate
Life Long Health and Wellbeing Theme
University of Edinburgh
MedicalResearch.com: What is the background for this study?
Response: Autism (ASD) has traditionally been seen as a condition that disproportionately affects males. This study quantifies the sex bias across birth cohorts, ages, and calendar time, using the Swedish national population registers to follow ~ 2.7 million individual born between 1985 and 2020 throughout their lives. Among children under ten years old the male-to-female diagnosis ratio remained relatively stable at about 3:1.
In contrast, a rapid increase in diagnoses of ASD among females during adolescence, produced a “female catch-up effect” that resulted in near parity of ASD prevalence between males and females by adulthood.
Photo by SHVETS production[/caption]
Mental and behavioral health care is often discussed in terms of access, affordability, and availability. Yet one of the most influential factors in treatment success receives far less public attention: continuity of care. Across diagnoses, age groups, and treatment settings, research consistently shows that how long a person remains engaged in care, and how well that care is coordinated over time, plays a critical role in long-term outcomes. Understanding the relationship between treatment length, care setting, and recovery is essential for clinicians, researchers, and policymakers alike.
Rather than viewing mental health care as a single episode, modern research increasingly frames it as a continuum. Individuals may move between outpatient therapy, intensive programs, and residential treatment depending on symptom severity, life stability, and response to intervention. Examining how these settings interact helps clarify why treatment duration and setting should be considered strategic clinical decisions rather than logistical ones.
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Specialized mental health care continues to gain attention as more people seek support for complex emotional and psychological needs. Nurses hold a vital place in this landscape because they understand how mental health affects every aspect of a person’s life. Their work involves careful assessment, compassionate communication, and steady guidance through moments that often feel overwhelming for patients.
Their presence helps create stability, structure, and safety at times when individuals may feel disconnected or uncertain about the future. Their involvement strengthens the entire care process since they provide consistent support throughout every stage of treatment.
Dr. Gaynor[/caption]
Leslie S. Gaynor, PhD
Clinical Neuropsychologist & Assistant Professor of Medicine
Division of Geriatric Medicine
Department of Medicine
Vanderbilt University Medical Center
Nashville, TN 37203
MedicalResearch.com: What is the background for this study?
Response: The US population is rapidly aging, and the oldest members of our population are also the most vulnerable to developing clinical dementia. We are interested in studying older adults ages 80+ who display cognitive resilience despite this increased risk of dementia and actually display exceptional memory performance compared to their same-aged, typically performing peers. These “SuperAgers,”—i.e., 80+-year-old adults with memory performance that is comparable to or surpasses that of adults 20 to 30 years their junior—may hold the key to uncovering genetic factors that predict exceptionally healthy longevity.
Dr. Vyshedskiy[/caption]
Andrey Vyshedskiy, Ph.D.
Neuroscientist from Boston University
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Certain conditions, such as autism and Down syndrome, can limit a child’s ability to develop full language comprehension. In these cases, children often become “stuck” at a specific, quantized level of understanding:
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Court-mandated treatment is a type of substance use or mental health treatment that a person is required to complete as part of a legal case. It might be ordered instead of jail time, alongside probation, or as a condition to reduce charges, regain driving privileges, or meet child custody requirements. While the details vary by state and court, most court-ordered programs follow a similar structure: assessment, a required level of care, documentation of compliance, and ongoing monitoring.
If you are entering court-mandated treatment, it is normal to feel nervous, frustrated, or skeptical. Some people worry it will be harsh or purely punitive. Others worry it will not be private. In reality, many mandated programs use the same evidence-based approaches as voluntary treatment. The difference is that attendance and participation are tied to legal requirements, and progress is usually reported to the court or probation.
Dr. Pieper[/caption]
Andrew A. Pieper M.D., Ph.D.
Professor, Department of Psychiatry, School of Medicine
Professor, Department of Neurosciences
Professor, Department of Pathology
Investigator, University Hospitals Harrington Discovery Institute, Harrington Discovery Institute
Associate Director, Medical Scientist Training Program, School of Medicine
Case Western Reserve University, University Hospitals Cleveland Medical Center, and
at the Louis Stokes Cleveland VA Medical Center
MedicalResearch.com: What is the background for this study?
Response: NAD+, a central cellular energy and signaling molecule, declines with age throughout the body, including the brain. When NAD+ falls below necessary levels, cells lose their ability to carry out essential maintenance and survival functions. We found that the NAD+ decline is more severe in brains from people with Alzheimer’s disease (AD) and in mouse models of AD, whereas brains of people with AD pathology but preserved cognition show gene-expression patterns consistent with maintained NAD+ homeostasis.
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Applied Behavior Analysis, commonly known as ABA therapy, is a widely recognized and evidence-based treatment designed to support individuals, especially children, with autism spectrum disorder (ASD) and other developmental challenges. ABA therapy focuses on understanding behavior, identifying its causes, and using structured techniques to teach positive skills while reducing behaviors that may interfere with learning or daily life.
So, what exactly is ABA therapy and how does it work? At its core, ABA therapy uses principles of behavioral science to shape and reinforce desired behaviors. Therapists begin by conducting a detailed assessment of the individual, identifying strengths, challenges, and specific behaviors that need attention. Based on this assessment, a customized plan is created that breaks down complex skills into smaller, achievable steps.
Samson Nivins PhD
Postdoctoral Researcher, specializing in Perinatal and Pediatric Neurology
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Dr. Klingberg[/caption]
Torkel Klingberg, M.D., Ph.D.
Professor of Cognitive Neuroscience at the Stockholm Brain Institute
Karolinska Institutet, Stockholm Sweden
MedicalResearch.com: What is the background for this study?
Response: In the modern era, children’s use of digital media such as watching videos, playing video games, and using social media has increased substantially, often coinciding with a decline in outdoor activities. As many school-aged children now own personal devices, particularly smartphones, it has become easier for them to spend more time on screens than intended. For example, a German survey cited in an EU briefing reported that in 2020, 27% of 8-9-year-olds and 54% of 10-11-year-olds owned a smartphone. In the U.S., ~30% of children own a smartphone by age eight, with many receiving their first device between ages 10 and 11.
With growing concerns about screen time, numerous studies have examined its potential consequences and have reported associations between higher screen use and increased ADHD symptoms. However, most of this research has been cross-sectional and has tended to combine different types of digital media such as television, video games, and social media into a single composite measure. This approach may obscure important differences, as various forms of digital media may have distinct effects on ADHD symptoms. To date, relatively few studies have examined the impact of specific types of digital media use on ADHD in a longitudinal framework, and even fewer have accounted for the heritable nature of ADHD.
To address these gaps, this U.S. longitudinal study followed children from ages 9-10 to 13-14 years. The study collected repeated measures of daily time spent on specific digital activities, including television and videos, video games, and social media platforms such as TikTok, Instagram, and Facebook. ADHD symptoms specifically inattention and hyperactivity/impulsivity were assessed using parent reports, and analyses adjusted for genetic factors and socioeconomic status.
Dr. Dakwar-Kawar, PhD[/caption]
Dr. Ornella Dakwar-Kawar
Hebrew University with
Prof. Mor Nahum and Prof. Itai Berger
Hebrew University
in collaboration with Prof. Jyoti Mishra from the University of California San Diego (UCSD)
Prof. Roi Cohen Kadosh from the University of Surre,
Dr. Pragathi Priyadharsini and
Ashwin Amal from ITT Karpur, India and InnoSphere Ltd
MedicalResearch.com: What is the background for this study?
Response: Children with ADHD often exhibit aberrant neural activity, specifically imbalances in excitation and inhibition levels alongside dysfunction in brain networks like the frontoparietal network. While our previous research showed that Transcranial Random Noise Stimulation or tRNS improves clinical symptoms, the specific neural modulation effects during cognitive tasks remained unclear. This study investigated these mechanisms by analyzing the aperiodic exponent, a marker of excitation inhibition balance, during an inhibitory control task to compare children with ADHD to healthy controls and assess changes following tRNS combined with cognitive training.
Alexa T. Diianni[/caption]
MedicalResearch.com Interview with:
Alexa T. Diianni, MBS
Department of Medical Education
Geisinger College of Health Sciences
Scranton, PA 19409
MedicalResearch.com: What is the background for this study?
Response: During a previous study, my research team and I examined the financial conflicts of interest (COIs) between industry and academia- namely those that exist between authors of The American Psychiatric Association’s Diagnostic and Statistical Manual of Mental Disorders (DSM), and industry (1). The DSM is a diagnostic tool widely used for the diagnosis of psychiatric disorders, and is thus of interest in assessing COIs (1,2). We previously found that authors of the DSM-5-TR had received over $14.2m in undisclosed payments from industry (1). Our current study examines the gender and geographic disparities of the DSM-5-TR authors, in relation to these payments.
While previous investigations have evaluated financial COIs in recent editions of the DSM (3,4), the demographic information of its authors has not yet been examined. Equitable representation of DSM authors is paramount as this manual serves a diverse population across the United States and beyond. It is important that the authorship of this manual be reflective of the population in which it serves, as there have been reported differences in both the type and prevalence of psychiatric care sought out by gender, as well as varying clinical treatment by geographic location (5-8).
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Alcohol misuse among veterans requires more than generic treatment—it requires approaches that recognize military culture, address trauma, support emotional and...
Partnerships with schools, employers, and youth programs help identify early signs of behavioral health challenges, allowing for intervention before problems...
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Mental health is shaped by a wide mix of emotional, physical, social, and environmental influences. It’s not a single dimensional issue that can be solved with a single type of treatment. When someone struggles with anxiety, depression, trauma, or chronic stress, the impact touches every part of life. Thoughts, behaviors, mood, physical energy, sleep, and relationships all shift under the weight of emotional strain.
Because mental health is so deeply interconnected with overall well-being, an approach that considers only one angle often falls short. Treating symptoms without exploring root causes leaves people with temporary relief at best. This is why both holistic and medical perspectives are essential for creating lasting and meaningful improvement.
The Importance of a Holistic Perspective
Holistic care looks at the entire person. Instead of focusing only on the diagnosis or the symptoms, this approach considers what contributes to emotional distress. Factors such as diet, sleep patterns, daily stress, family dynamics, work pressures, unresolved trauma, and personal beliefs all play important roles in mental well-being.
For many people, mental health symptoms improve significantly when daily routines become healthier and more supportive. Practices like mindfulness, physical movement, grounding techniques, journaling, and lifestyle changes can strengthen emotional resilience and reduce vulnerability to stress. Therapy also serves as a core holistic tool, helping people uncover triggers, patterns, and emotional blocks that influence their current struggles. Over time, these strategies support deeper self-understanding and long-term growth.
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Complex post-traumatic stress disorder, often shortened to CPTSD or cPTSD, has moved from a niche clinical idea to a term many people now use for their own lived experience. At the same time, it is still not listed as a standalone diagnosis in the Diagnostic and Statistical Manual of Mental Disorders (DSM). That leaves many people asking a very specific question: Will CPTSD be added to the Diagnostic and Statistical Manual of Mental Disorders in 2026?
The most accurate answer is that there is currently no official commitment to adding complex PTSD to the DSM in 2026. As of late 2025, CPTSD is recognized in the World Health Organization’s International Classification of Diseases, 11th edition (ICD-11), but not in the DSM-5 Text Revision (DSM-5 TR). Clinicians and researchers are actively debating whether a new CPTSD diagnosis should be included in a future DSM edition, yet no formal decision or fixed timeline has been announced.
The question itself opens the door to important issues and questions, which MedicalResearch.com will review and address in this article. How do major diagnostic manuals change over time? Why is CPTSD in the ICD but not in the DSM? And what does any of this mean if you or someone you love is living with the effects of long-term trauma?
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Facing a divorce is one of life's most challenging and emotionally charged experiences. The path forward can feel uncertain, and the very first decision you have to make—choosing a lawyer—is often the most critical one. While it may feel isolating, you are not alone in this. Researchers estimate that 41 percent of all first marriages end in divorce, but even though the experience is common, the process is unique to every individual.
The right attorney does far more than just file paperwork. They are your strategic partner, your advocate, and your guide through a complex legal system. They protect your future, your finances, and your family. Making the right choice sets the foundation for a smoother process and a more secure post-divorce life.
This article provides a clear, actionable framework to help you navigate this choice with confidence. We will walk you through the essential steps to find a trustworthy North Carolina divorce attorney who can help you move forward.
Photo by cottonbro studio[/caption]
Divorce is consistently ranked as one of life's most stressful events, creating a perfect storm of emotional turmoil and financial uncertainty. You're not just ending a marriage; you're dismantling a shared life, and the stakes feel impossibly high. The anxiety over your financial future, the well-being of your children, and the sheer complexity of the legal system can be paralyzing.
This level of stress isn't just a feeling—it has tangible consequences. Research shows that divorced or widowed individuals have 20% more chronic health conditions, such as heart disease and diabetes, than married people. Attempting to navigate California’s intricate family law system on your own only adds to this immense pressure, putting both your health and your financial security at risk.
There is a clear path to regaining control and peace of mind. Working with an experienced Irvine family law attorney provides a strategic partner dedicated to protecting your interests and simplifying the path forward. They manage the complexities so you can focus on what matters most: your family, your career, and your well-being.
Prof. Kelleher[/caption]
Ian Kelleher PhD, MB BCh BAO (Medicine)
Professor of Child and Adolescent Psychiatry
Academy of Medical Sciences Professor
Institute for Neuroscience and Cardiovascular Research
University of Edinburgh
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Schizophrenia is a severe mental illness associated with hallucinations, delusions and a marked decline in functioning. It usually begins in adulthood, in the 20s, but we know from recent research that as many as half of all individuals who develop schizophrenia had attended child and adolescent psychiatry services earlier in life for other mental health problems. That’s exciting because it suggests: maybe there’s something we could do to reduce risk of schizophrenia in adolescent psychiatry services. But, at present, we don’t have evidence that any intervention reduces schizophrenia risk in this clinical population.
Lots of researchers are interested in the antibiotic doxycycline, and the structurally similarly minocycline, because it has potential neuroprotective effects. It crosses the blood brain barrier and seems to reduce inflammation and apoptosis (or programmed cell death). We think that excessive synaptic pruning may play a key role in the development of schizophrenia. In laboratory studies, doxycycline seems to reduce the level of synaptic pruning by its effect on the immune system. Some research suggests that even low dose exposure to doxycycline may lead to long-term effects in “dampening down” activity by microglia, the brain’s resident macrophages, which are central to the process of synaptic pruning.
The emerging research on biological markers of anxiety and depression ensures that the future of mental health care will be...
The best recovery outcomes are achievable when holistic therapies are seamlessly integrated with evidence-based behavioral interventions. Treatment centers are increasingly...
Source[/caption]
Today, maintaining mental health is just as important as staying physically fit. Unfortunately, not everyone has the time or access to attend in-person sessions with a therapist. That’s where virtual counseling comes in. A virtual counselor provides professional therapy sessions online, helping people receive support from the comfort of their homes.
When Mara described her panic, she didn’t start with a memory. She started with a body: “My chest tightens and I can’t get my breath,” she said. “Then the memory follows.”
That pattern — sensation first, story second — is exactly why traditional talk therapy sometimes stops short. Talking can change our view of a problem. When anxiety, shame, or trauma get trapped in the body, we need to address it. We can do this by focusing on sensations and finding ways to regulate our feelings.
The limits of words alone
Talk therapies (such as CBT) are said to be evidence-based for many problems. They help people reframe thoughts, test beliefs and build coping strategies. For some clients these approaches are sufficient.
The issue is that if the nervous system becomes dysregulated, cognitive change only provides a short-term solution. People can intellectually understand their patterns without changing them. They will still get “taken over” by bodily reactions — breath changes, tremor, numbness, tension. My clinical experience is that insight without regulation often gives short-lived relief.
Dr. Joshi[/caption]
Gagan Joshi, MD
Director, The Alan & Lorraine Bressler Clinical and Research Program for Autism Spectrum Disorder
Associate Director, The Pediatric Psychopharmacology Research Program
Associate Program Director, MGH Fellowship in Autism Spectrum Disorder
Rovee Endowed Chair in Child Psychiatry
Massachusetts General Hospital
Associate Professor of Psychiatry
Harvard Medical School
MedicalResearch.com: What is the background for this study?
Response: Intellectually capable individuals with autism often face significant challenges in social functioning, yet pharmacologic treatments specifically targeting social impairments are lacking. Our prior neuroimaging research identified abnormally elevated brain glutamate levels in intellectually capable youth with autism, suggesting a potential neurochemical pathway underlying social difficulties. Based on these findings, we examined the effects of memantine—a glutamate-modulating medication—for the treatment of autism.
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