Cannabis, Mental Health Research / 25.04.2026

[caption id="attachment_73388" align="aligncenter" width="500"]cbd-affecting-anxiety-differently.png SOURCE: IMAGE[/caption]

Editor's note: Cannabis and THCA/Hemp CBD products should have an active ingredient list on the container and a Certificate of Analysis (COA). Discuss your use of THC, cannabis, or CBD products with your health care provider. Dosing of cannabis products is variable, especially since they are not FDA regulated. Cannabis/CBD may interfere with other medications and should not be used in individuals with certain health conditions, including liver issues. CBD skin care products can be absorbed through the skin and have similar effects. Do not use cannabis products including edibles, drinks, and CBD if you are pregnant, nursing, or may become pregnant. Do not use cannabis products if driving or operating difficult or dangerous machinery. Children should not be exposed to cannabis or CBD products.

A question that comes up constantly in cannabis research is one that patients have been asking for years: why does CBD ease anxiety in one person and make another feel worse? For a long time, the honest answer was that nobody fully knew. A landmark study out of McGill University changedthat, and the findings reveal something that most consumer guides on CBD have never properly explained.

The answer is not about product quality, dosage form, or brand. It comes down to how cannabis interacts with serotonin — and specifically why that interaction is not the same at every dose.
Mental Health Research / 08.04.2026

Editor's note: This piece discusses mental health issues. If you have experienced suicidal thoughts or have lost someone to suicide and want to seek help, you can contact the Crisis Text Line by texting "START" to 741-741 or call the Suicide Prevention Lifeline at 800-273-8255. Some Antidepressants Work Differently For Different People.png

Photo courtesy of Pexels

Two people can take the same antidepressant at the same dose and have very different experiences. One may improve within weeks, while another may develop side effects or feel little benefit. This variation is well documented and is one reason clinicians increasingly look at biology, not just symptoms, when treatment is not going as expected. Large treatment studies have also shown that only about one-third of patients achieve remission after a first antidepressant trial — which helps explain why medication selection often involves careful adjustment rather than a one-size-fits-all approach.
Mental Health Research / 08.04.2026

Editor's note: This piece discusses mental health issues. If you have experienced suicidal thoughts or have lost someone to suicide and want to seek help, you can contact the Crisis Text Line by texting "START" to 741-741 or call the Suicide Prevention Lifeline at 800-273-8255.

Personalized OCD Treatment.jpg

Obsessive-Compulsive Disorder (OCD) is a complex mental health condition that goes far beyond repetitive thoughts and behaviours. While traditional treatment methods such as medication and therapy can help manage symptoms, many individuals continue to experience recurring cycles that significantly affect their daily lives. At the Center for Integrative Psychiatry (CIP), Dr. Tahir N. Khwaja offers a personalised, patient-centred approach to OCD treatment that focuses on long-term outcomes — not just short-term symptom control. By combining integrative psychiatry with advanced therapies, CIP is redefining how OCD is treated.
Exercise - Fitness, Health and Wellness, Stress / 02.04.2026

[caption id="attachment_73029" align="aligncenter" width="500"] Short-Term Yoga Immersions on Stress.jpg Photo by Yoga Vidya Mandiram[/caption] The physiological benefits of mindful movement have transitioned from holistic theory to empirical science. Medical researchers and clinical practitioners increasingly view structured physical recovery programmes as essential interventions for mitigating chronic stress. For decades, the medical community evaluated these practices based on subjective patient reports. Today, clinical evaluations measure highly specific biomarkers, such as salivary cortisol and pro-inflammatory cytokines, to determine exactly how short-term immersive practices affect the human body. Understanding the precise biological mechanisms behind active recovery has never been more relevant.
Addiction, Mental Health Research / 02.04.2026

Editor's note: This piece discusses mental health issues. If you have experienced suicidal thoughts or have lost someone to suicide and want to seek help, you can contact the Crisis Text Line by texting "START" to 741-741 or call the Suicide Prevention Lifeline at 800-273-8255. [caption id="attachment_73024" align="aligncenter" width="500"]mental-health-long-term-recovery.jpg Image Source[/caption]
Why do people return to old habits – especially when they know better? This question shadows every recovery story. Someone finishes treatment feeling ready and then life happens. A job falls through. A relationship fractures. Coping skills that worked in a safe environment suddenly feel flimsy. This is not a failure of willpower. It is a failure of understanding. Recovery does not end when treatment ends. Mental health and recovery are not separate. They determine whether sobriety lasts six months or six decades. In this blog, we will share how mental healthcare makes recovery sustainable and why treating only the substance ignores the person underneath.
Health and Wellness, Mental Health Research / 31.03.2026

[caption id="attachment_73001" align="aligncenter" width="500"]cognitive-behavorial-therapy-long-term-health.png Source[/caption] Without a doubt, living with a long-term health condition can affect so much more than just the body. For instance, a chronic illness can impact emotions, thoughts, and everyday habits. It is quite self-explanatory why many people dealing with chronic illnesses experience low mood, worry, and stress, which can make it even harder for them to manage their health.  This is exactly where the importance of cognitive behavioral therapy comes in. In simple terms, CBT is a structured approach that focuses on the link between feelings, thoughts, and behaviors. Essentially, CBT helps people understand how their thoughts influence their actions and general well-being.
Alzheimer's - Dementia, Author Interviews, Genetic Research, JAMA, Karolinski Institute / 24.03.2026

[caption id="attachment_72900" align="alignleft" width="200"]MedicalResearch.com Interview with:Jakob Norgren | PhD, Postdoctoral Researcher Department of Neurobiology, Care Sciences and Society (NVS) | Karolinska Institutet Division of Clinical Geriatrics | Center for Alzheimer Research Huddinge, Sweden Jakob Norgren, Ph.D.[/caption] MedicalResearch.com Interview with: Jakob Norgren | PhD, Postdoctoral Researcher Department of Neurobiology, Care Sciences and Society (NVS) | Karolinska Institutet Division of Clinical Geriatrics | Center for Alzheimer Research Huddinge, Sweden     MedicalResearch.com: What is the background for this study? Response: This study tested the hypothesis that people with APOE 3/4 and 4/4 would have a reduced risk of cognitive decline and dementia with higher meat intake, based on the fact that APOE4 is the evolutionarily oldest variant of the APOE gene and may have arisen during a period when our evolutionary ancestors ate a more animal-based diet.
Author Interviews, Medical Research Journals, Mental Health Research / 24.03.2026

[caption id="attachment_72893" align="alignleft" width="200"]MedicalResearch.com Interview with:Francis J. Gesel Geisinger Commonwealth School of Medicine Scranton, Pennsylvania Francis J. Gesel[/caption] MedicalResearch.com Interview with: Francis J. Gesel Geisinger Commonwealth School of Medicine Scranton, Pennsylvania MedicalResearch.com: What is the background for this study? Response: Conflicts of interest (COIs) in psychiatric research represent a longstanding ethical challenge, given the close relationship between the pharmaceutical industry and psychiatry. Journals require authors to disclose these relationships, while the U.S. Open Payments database, created under the Sunshine Act, provides a record of payments from manufacturers to physicians. However, whether physician-authors in psychiatry’s most influential journals consistently disclose these relationships had not been systematically assessed. We focused on the American Journal of Psychiatry (AJP) and JAMA Psychiatry (JAMA-PSY), two of the highest-impact journals in the field, to evaluate the prevalence and magnitude of undisclosed financial COIs.
Mental Health Research, Telemedicine / 24.03.2026

Editor's note: This piece discusses mental health issues. If you have experienced suicidal thoughts or have lost someone to suicide and want to seek help, you can contact the Crisis Text Line by texting "START" to 741-741 or call the Suicide Prevention Lifeline at 800-273-8255. The world of mental healthcare has always been influenced by the world that people live in. As the world that people live in changes, the symptoms change too. A generation ago, there were many discussions in the world of psychiatry that focused on workplace stress, family problems, grief, addiction, and mood disorders that were quite familiar to most practitioners. Of course, these are still important issues, although the world that they occur in is quite different. Today, people are carrying around social pressure, information overload, algorithmic pressure, financial obsession, and always being available. The result is a new kind of emotional strain that often builds quietly before anyone names it. That is one reason more clinics and community systems are paying attention to telehealth psychiatry as a practical way to connect patients with specialists when local access is thin, schedules are crowded, or a person simply feels more able to open up through a screen. In many settings, this model has become especially relevant for people dealing with newer patterns of distress tied to technology itself, from compulsive market checking and online isolation to the strange emotional fallout of spending too much time in synthetic digital environments. When Care Arrives Through a Device
Gender Differences, Mental Health Research / 23.03.2026

Editor's note: This piece discusses mental health issues. If you have experienced suicidal thoughts or have lost someone to suicide and want to seek help, you can contact the Crisis Text Line by texting "START" to 741-741 or call the Suicide Prevention Lifeline at 800-273-8255. [caption id="attachment_72850" align="aligncenter" width="500"]women-mental-health-treatment.jpg Photo by SHVETS production[/caption]

The Growing Case for Women-Only Mental Health Programs

Mental health conditions do not affect men and women equally. Research consistently demonstrates that women experience depression at roughly twice the rate of men, are more likely to develop PTSD following trauma, and face unique psychological consequences from emotional abuse, disordered eating, and chronic anxiety. Despite these well-documented differences, the majority of residential mental health treatment programs in the United States continue to use a one-size-fits-all model that does not account for how gender shapes the experience of mental illness or the process of recovery. A growing body of evidence suggests that gender-specific treatment — particularly women-only residential mental health treatment — may produce stronger clinical outcomes for women dealing with trauma, PTSD, depression, anxiety, and emotional abuse. Understanding why requires looking at what makes women's mental health distinct and how treatment environments influence recovery.
Mental Health Research / 19.03.2026

[caption id="attachment_72816" align="aligncenter" width="500"]Albuquerque-mental-health.jpg Photo by SHVETS production[/caption]

Key Takeaways

  • Medicaid offers comprehensive mental health coverage for eligible individuals in Albuquerque.
  • Albuquerque Therapy Center, a trusted local provider, accepts Medicaid to make mental health services accessible and affordable.
  • Using online resources and support organizations helps simplify the search for a qualified therapist.
  Accessing quality mental health care can be daunting for many people in Albuquerque because of financial barriers and a lack of available providers. Yet, Medicaid makes it possible for eligible individuals to receive a wide range of mental health services, including therapy, counseling, and psychiatric care, without the burden of high costs. Finding a qualified Medicaid therapist Albuquerque at Albuquerque Therapy Center is an important first step in making sure those in need get the support they deserve.
Addiction, Author Interviews, Cannabis, Memory / 12.03.2026

Editor’ note:  Cannabis and THCA/HEMP CBD products should have an active ingredient list on the container and have a Certificate of Analysis (COA). Discuss your use of THC, Cannabis or CBD products with your health care provider.  Dosing of Cannabis products is variable, especially since they are not FDA regulated. Cannabis/CBD may interfere with other medications and should not be used in individuals with certain health conditions, including liver issues. CBD skin care products can be absorbed through the skin and have similar effects. Do not use Cannabis products including edibles, drinks and CBD if you are pregnant, nursing or may become pregnant. Do not use cannabis products if driving or operating difficult or dangerous machinery. Children should not be exposed to cannabis or CBD products. MedicalResearch.com Interview with: [caption id="attachment_72752" align="alignleft" width="200"]Carrie Cuttler, Ph.D.The Health & Cognition (THC) Lab Associate Professor Director, Experimental Psychology Doctoral Program Co-Director, Cannabis Research Center (CRC) Department of Psychology Washington State University Dr. Cutttler, Ph.D.[/caption] Carrie Cuttler, Ph.D. The Health & Cognition (THC) Lab Associate Professor Director, Experimental Psychology Doctoral Program Co-Director, Cannabis Research Center (CRC) Department of Psychology Washington State University MedicalResearch.com: What is the background for this study? Response: One of the most well-documented effects of acute cannabis intoxication is impairment in memory. However, memory is not a single process. It is a complex system made up of multiple distinct subsystems that rely on different neural mechanisms and support different types of remembering. Most prior research examining the acute effects of cannabis in humans has focused on a relatively narrow set of memory tests—primarily verbal memory tasks, which involve recalling lists of words, and working memory tasks, which require temporarily holding and manipulating information in consciousness. Far fewer studies have examined how cannabis affects other types of memory that are more relevant to everyday life. These include temporal order memory (remembering the order in which events occurred), prospective memory (remembering to perform tasks in the future), source memory (remembering where information came from), false memory (recalling information that was never presented), and episodic content memory (recalling personally experienced events). To address this gap, we conducted a randomized, double-blind, placebo-controlled study examining the acute effects of cannabis across multiple memory domains. In total, 120 participants were randomly assigned to vaporize either a placebo, a moderate dose of cannabis (20 mg THC), or a high dose of cannabis (40 mg THC).
Addiction, Mental Health Research / 12.03.2026

[caption id="attachment_72767" align="aligncenter" width="500"]Rebuilding-life-after-hardship.jpg Freepix[/caption] Life can sometimes throw challenges that feel insurmountable. Whether it is the loss of a loved one, a period of severe illness, a financial setback, or struggles with addiction, these difficult times can leave people feeling lost, overwhelmed, and uncertain about the future. However, many individuals find ways to rebuild their lives, often emerging stronger and more resilient than before. Understanding the steps people take to recover and grow can offer hope and guidance to those navigating their own hardships. Acknowledging the Pain The first step in rebuilding life after a difficult period is acknowledging the pain. Denying or minimizing struggles can prolong the healing process. By confronting emotions head-on, people begin to understand the impact of their experiences and take ownership of their healing journey. This can involve seeking support from friends, family, or professional counsellors who can offer a safe space to express feelings without judgment. Journaling, art, or other forms of creative expression can also provide an outlet for processing complex emotions.
Accidents & Violence, Brain Injury, Legal-Malpractice, Neurology / 23.02.2026

[caption id="attachment_72574" align="aligncenter" width="500"]Neuroinflammation Shapes Cognitive Outcomes Pexels image[/caption] Acute trauma has long been associated with visible physical damage. However, the invisible neurological consequences often shape long-term recovery just as strongly. Cognitive symptoms such as memory lapses, reduced attention span, slower processing speed, and emotional instability emerge after traumatic events. Growing research suggests that neuroinflammation plays a central role in determining the impact on cognitive function. For instance, the blood-brain barrier (BBB) can be affected by injury-induced inflammation. Studies have linked BBB disruption to cognitive decline. Some of the most associated factors are inflammation, metabolic imbalance, cellular aging, oxidative and nitrosative stress, and excitotoxicity. Studies also suggest that altering BBB permeability can produce either protective or harmful neurological effects, depending on the context. Understanding how inflammatory pathways respond to trauma offers insight into why some individuals regain their previous level of functioning while others don’t.

The Immediate Immune Response to Trauma

Immune activation is a central factor in traumatic brain injury (TBI) pathophysiology. A balanced immune response supports recovery, while persistent inflammation and immune dysregulation can worsen survival rates and increase disability. After the initial injury, an innate immune response develops. The inflammasome drives programmed cell death and the release of inflammatory mediators that activate microglia and amplify inflammation. This process can expand systemically, contributing to edema and immune cell migration. Trauma does not have to directly involve the brain to trigger these effects. Systemic inflammation resulting from bodily injury can influence neural activity through circulating inflammatory mediators. Such types of injuries can occur in various ways, such as a motorcycle accident. For instance, a motorcyclist was severely injured in a crash with an SUV in Oxnard. The motorcyclist was transported to Ventura County Medical Center. Patients hospitalized after such a serious injury in a motorcycle accident may face brain trauma. According to Wells Law, it is also important to find a lawyer during such incidents. They can help victims calculate damages for medical expenses and obtain compensation for them. This can offer patients peace of mind, which can help with the recovery.
Author Interviews, Cannabis, JAMA, Mental Health Research / 22.02.2026

Editor’ note:  Cannabis and THCA/HEMP CBD products should have an active ingredient list on the container and have a Certificate of Analysis (COA). Discuss your use of THC, Cannabis or CBD products with your health care provider.  Dosing of Cannabis products is variable, especially since they are not FDA regulated. Cannabis/CBD may interfere with other medications and should not be used in individuals with certain health conditions, including liver issues. CBD skin care products can be absorbed through the skin and have similar effects. Do not use Cannabis products including edibles, drinks and CBD if you are pregnant, nursing or may become pregnant. Do not use cannabis products if driving or operating difficult or dangerous machinery. Children should not be exposed to cannabis or CBD products. MedicalResearch.com Interview with: [caption id="attachment_72552" align="alignleft" width="200"]Kelly Young-Wolff, PhD, MPHLicensed clinical psychologist and Research Scientist Kaiser Permanente Northern California Division of Research Associate Professor, Psychiatry School of Medicine UCSF Weill Institute for Neurosciences Dr. Young-Wolff[/caption] Kelly Young-Wolff, PhD, MPH Licensed clinical psychologist and Research Scientist Kaiser Permanente Northern California Division of Research Associate Professor, Psychiatry School of Medicine UCSF Weill Institute for Neurosciences MedicalResearch.com: What is the background for this study? Response: Cannabis is widely used by adolescents, and it’s often first used during the same developmental window when many psychiatric disorders begin to emerge. At the same time, cannabis has become more accessible and more socially accepted. While prior studies have linked adolescent cannabis use to mental health symptoms, fewer large studies have examined whether it’s associated with later clinically diagnosed psychiatric disorders. We wanted to address that gap.
Depression, Disability Research, Mental Health Research, Social Issues / 17.02.2026

[caption id="attachment_72446" align="aligncenter" width="500"]social-anxiety-disorder.jpg Photo by cottonbro studio[/caption] Many people wonder whether a diagnosed social anxiety disorder makes them disabled. The simple answer is most likely yes, it is when a person's daily life and work are affected by social anxiety that it can be considered a disability. Many people are actually unable to function normally in social interactions, a direct result of this condition. If someone is unable to work, form personal relationships, or even perform daily tasks due to social anxiety, it is a sign that the disorder has become disabling. Federal laws recognize mental health problems as disabilities. Social anxiety disorder is listed on the Americans with Disabilities Act and the Social Security Administration's list of disabilities. These laws, on the same level, recognize that mental disorders can be as limiting as physical injuries. Social Anxiety as a Disability Social anxiety disorder is a common condition that affects millions of people. Most people with severe social anxiety remain stuck in patterns of fear and avoidance. They are eager to work and become functioning fellows of society, but mental barriers get in their way. Even simple tasks like answering phone messages, attending meetings, or dealing with customers become almost impossible obstacles for people with this disorder. However, social anxiety disorder affects different people differently. While some people sweat, tremble, or feel nauseous when faced with social situations, others are so afraid that they literally run away from people they have to meet. It is most disabling when it interferes with:
  • Job performance and career advancement, as well as personal skills development
  • Basic daily activities like shopping and banking
  • Maintaining personal relationships
  • Finding necessary medical care or other services
  • Using public transportation
  • Making phone calls or appointments
Studies have shown that people with this level of social anxiety often isolate themselves from others. They may avoid jobs, stay home, or skip going to the academy/workplace. This type of isolation leads to additional problems such as depression, financial stress, and health issues.
Alzheimer's - Dementia, Author Interviews, Cannabis / 06.02.2026

Editor's note: Do Not Use these products alone or in combination without the specific guidance of your health are provider, due to risks of untoward side effects. THC/CBD and other cannabis products should not be used if you are pregnant, planning to become pregnant or nursing. Children should not be exposed to cannabis in any form. MedicalResearch.com Interview with: [caption id="attachment_72277" align="alignleft" width="200"]Chu Chen, PhDProfessor and Joe R. and Teresa Lozano Long Chair in Neural Physiology Department of Cellular and Integrative Physiology Center for Biomedical Neuroscience Joe R. and Teresa Lozano Long School of Medicine University of Texas at San Antonio Health Science Center San Antonio, TX 78229 Prof. Chu Chen[/caption] Chu Chen, PhD Professor and Joe R. and Teresa Lozano Long Chair in Neural Physiology Department of Cellular and Integrative Physiology Center for Biomedical Neuroscience Joe R. and Teresa Lozano Long School of Medicine University of Texas at San Antonio Health Science Center San Antonio, TX 78229 MedicalResearch.com: What is the background for this study? Response: Alzheimer’s disease (AD) is the most common cause of dementia in the elderly, yet no effective therapies currently exist to prevent, treat, or halt its progression. Cannabis has been used for thousands of years for both recreational and medicinal purposes; however, its therapeutic application has been limited by undesirable neurocognitive side effects, particularly impairments in learning and memory. Δ9-Tetrahydrocannabinol (Δ9-THC), the primary psychoactive component of cannabis, has been shown to reduce amyloid-β (Aβ) pathology in animal models of AD, but at high doses (>5.0 mg/kg) it also disrupts synaptic function and impairs cognition. Research from our laboratory and others has demonstrated that Δ9-THC-induced deficits in long-term synaptic plasticity, learning, and memory are associated with the induction of cyclooxygenase-2 (COX-2), an inducible enzyme that converts arachidonic acid into pro-inflammatory prostaglandins. Notably, pharmacological inhibition or genetic deletion of COX-2 attenuates Δ9-THC-induced synaptic and cognitive impairments. Based on these findings, we proposed a combination (“cocktail”) therapy consisting of low-dose Δ9-THC and the anti-inflammatory drug celecoxib, a selective COX-2 inhibitor, as a potential therapeutic strategy for AD. This approach is designed to preserve the beneficial effects of Δ9-THC while minimizing its adverse neurocognitive effects and COX-2-mediated inflammatory responses.
Author Interviews, Autism, BMJ, Parkinson's / 05.02.2026

MedicalResearch.com Interview with: [caption id="attachment_72249" align="alignleft" width="150"]Dr. Caroline Fyfe PhDPostdoctoral Research Associate Life Long Health and Wellbeing Theme University of Edinburgh Dr. Fyfe[/caption] Dr. Caroline Fyfe PhD Postdoctoral Research Associate Life Long Health and Wellbeing Theme University of Edinburgh MedicalResearch.com: What is the background for this study? Response: Autism (ASD) has traditionally been seen as a condition that disproportionately affects males. This study quantifies the sex bias across birth cohorts, ages, and calendar time,  using the Swedish national population registers to follow ~ 2.7 million individual born between 1985 and 2020 throughout their lives. Among children under ten years old the male-to-female diagnosis ratio remained relatively stable at about 3:1. In contrast, a rapid increase in diagnoses of ASD among females during adolescence, produced a “female catch-up effect” that resulted in near parity of ASD prevalence between males and females by adulthood.
Mental Health Research / 20.01.2026

[caption id="attachment_72054" align="aligncenter" width="500"]Mental health recovery Photo by SHVETS production[/caption] Mental and behavioral health care is often discussed in terms of access, affordability, and availability. Yet one of the most influential factors in treatment success receives far less public attention: continuity of care. Across diagnoses, age groups, and treatment settings, research consistently shows that how long a person remains engaged in care, and how well that care is coordinated over time, plays a critical role in long-term outcomes. Understanding the relationship between treatment length, care setting, and recovery is essential for clinicians, researchers, and policymakers alike. Rather than viewing mental health care as a single episode, modern research increasingly frames it as a continuum. Individuals may move between outpatient therapy, intensive programs, and residential treatment depending on symptom severity, life stability, and response to intervention. Examining how these settings interact helps clarify why treatment duration and setting should be considered strategic clinical decisions rather than logistical ones.
Mental Health Research, Nursing / 20.01.2026

[caption id="attachment_72045" align="aligncenter" width="500"]nursing-specialized-mental-care.jpg Image Source[/caption] Specialized mental health care continues to gain attention as more people seek support for complex emotional and psychological needs. Nurses hold a vital place in this landscape because they understand how mental health affects every aspect of a person’s life. Their work involves careful assessment, compassionate communication, and steady guidance through moments that often feel overwhelming for patients. Their presence helps create stability, structure, and safety at times when individuals may feel disconnected or uncertain about the future. Their involvement strengthens the entire care process since they provide consistent support throughout every stage of treatment.

Evolution of Nursing Responsibilities in Mental Health Care

A long history of shifting expectations shaped modern mental health nursing. Early roles focused on basic care and supervision, which limited the scope of practice. Growing awareness surrounding mental health eventually encouraged a broader approach. Nurses became active participants in assessment, planning, and treatment. More structured training and research introduced evidence-based methods that strengthened clinical decision-making. Nurses gradually gained responsibilities involving therapeutic communication, medication support, and participation in structured interventions.
Alzheimer's - Dementia, Author Interviews, Lipids, Vanderbilt / 18.01.2026

MedicalResearch.com Interview with: [caption id="attachment_72035" align="alignleft" width="200"]Leslie S. Gaynor, PhDClinical Neuropsychologist & Assistant Professor of Medicine Division of Geriatric Medicine Department of Medicine Vanderbilt University Medical Center Nashville, TN 37203 Dr. Gaynor[/caption] Leslie S. Gaynor, PhD Clinical Neuropsychologist & Assistant Professor of Medicine Division of Geriatric Medicine Department of Medicine Vanderbilt University Medical Center Nashville, TN 37203 MedicalResearch.com: What is the background for this study? Response: The US population is rapidly aging, and the oldest members of our population are also the most vulnerable to developing clinical dementia. We are interested in studying older adults ages 80+ who display cognitive resilience despite this increased risk of dementia and actually display exceptional memory performance compared to their same-aged, typically performing peers. These “SuperAgers,”—i.e., 80+-year-old adults with memory performance that is comparable to or surpasses that of adults 20 to 30 years their junior—may hold the key to uncovering genetic factors that predict exceptionally healthy longevity.
Author Interviews, Autism, Nature / 16.01.2026

MedicalResearch.com Interview with: [caption id="attachment_72018" align="alignleft" width="200"]Andrey Vyshedskiy, Ph.D.Neuroscientist from Boston University Dr. Vyshedskiy[/caption] Andrey Vyshedskiy, Ph.D. Neuroscientist from Boston University MedicalResearch.com: What is the background for this study? What are the main findings? Response: Certain conditions, such as autism and Down syndrome, can limit a child’s ability to develop full language comprehension. In these cases, children often become “stuck” at a specific, quantized level of understanding:
  • Command Phenotype: Individuals at this level understand single words and simple commands but have difficulty combining nouns with adjectives or interpreting more complex instructions.
  • Modifier Phenotype: Individuals at this level can comprehend combinations of nouns and adjectives—for example, they can identify a small yellow pencil among pencils, straws, and Lego pieces of varying sizes and colors. However, they struggle with more complex language structures, such as sentences containing spatial prepositions, possessive pronouns, verb tenses, and narratives like fairy tales.
  • Syntactic Phenotype: Most children naturally progress to this most-advanced level of comprehension, characterized by the ability to understand full syntactic structures and more sophisticated language forms.
While the Command and Syntactic Phenotypes were anticipated by linguistics and developmental psychology, the distinct Modifier Phenotype was unexpected. Across several studies involving nearly 100,000 participants, these three phenotypes consistently emerged. Together with a recent longitudinal study of language development in over 15,000 participants, these findings highlight the critical importance of early engagement in syntactic conversations for the acquisition of the Syntactic Phenotype.
Addiction, addiction-treatment, Legal-Malpractice, Mental Health Research / 05.01.2026

  [caption id="attachment_71935" align="aligncenter" width="500"]court-mandated-treatment-program.jpg Freepix image[/caption] Court-mandated treatment is a type of substance use or mental health treatment that a person is required to complete as part of a legal case. It might be ordered instead of jail time, alongside probation, or as a condition to reduce charges, regain driving privileges, or meet child custody requirements. While the details vary by state and court, most court-ordered programs follow a similar structure: assessment, a required level of care, documentation of compliance, and ongoing monitoring. If you are entering court-mandated treatment, it is normal to feel nervous, frustrated, or skeptical. Some people worry it will be harsh or purely punitive. Others worry it will not be private. In reality, many mandated programs use the same evidence-based approaches as voluntary treatment. The difference is that attendance and participation are tied to legal requirements, and progress is usually reported to the court or probation.

Why Courts Mandate Treatment

Courts often mandate treatment when substance use is seen as a contributing factor to legal trouble or ongoing risk. The goal is usually to reduce repeat offenses and support stabilization. Mandated treatment is commonly connected to:
  • DUI or DWI cases
  • Drug possession or drug-related charges
  • Probation violations linked to substance use
  • Domestic disputes where substance use is a factor
  • Child welfare or custody-related requirements
  • Mental health court or diversion programs
Even when it feels forced, treatment can still be useful. Many people start reluctantly and later find it helps them build structure and avoid repeated legal consequences.
Alzheimer's - Dementia, Author Interviews, Case Western / 25.12.2025

MedicalResearch.com Interview with: [caption id="attachment_71888" align="alignleft" width="150"]Andrew A. Pieper M.D., Ph.D.Professor, Department of Psychiatry, School of Medicine Professor, Department of Neurosciences Professor, Department of Pathology Investigator, University Hospitals Harrington Discovery Institute, Harrington Discovery Institute Associate Director, Medical Scientist Training Program, School of Medicine Case Western Reserve University, University Hospitals Cleveland Medical Center, and at the Louis Stokes Cleveland VA Medical Center Dr. Pieper[/caption] Andrew A. Pieper M.D., Ph.D. Professor, Department of Psychiatry, School of Medicine Professor, Department of Neurosciences Professor, Department of Pathology Investigator, University Hospitals Harrington Discovery Institute, Harrington Discovery Institute Associate Director, Medical Scientist Training Program, School of Medicine Case Western Reserve University, University Hospitals Cleveland Medical Center, and at the Louis Stokes Cleveland VA Medical Center   MedicalResearch.com: What is the background for this study? Response: NAD+, a central cellular energy and signaling molecule, declines with age throughout the body, including the brain. When NAD+ falls below necessary levels, cells lose their ability to carry out essential maintenance and survival functions. We found that the NAD+ decline is more severe in brains from people with Alzheimer’s disease (AD) and in mouse models of AD, whereas brains of people with AD pathology but preserved cognition show gene-expression patterns consistent with maintained NAD+ homeostasis.
Author Interviews, Autism, Pediatrics / 20.12.2025

[caption id="attachment_71843" align="aligncenter" width="500"]aba-autism-therapy.jpg Freepix image[/caption] Applied Behavior Analysis, commonly known as ABA therapy, is a widely recognized and evidence-based treatment designed to support individuals, especially children, with autism spectrum disorder (ASD) and other developmental challenges. ABA therapy focuses on understanding behavior, identifying its causes, and using structured techniques to teach positive skills while reducing behaviors that may interfere with learning or daily life. So, what exactly is ABA therapy and how does it work? At its core, ABA therapy uses principles of behavioral science to shape and reinforce desired behaviors. Therapists begin by conducting a detailed assessment of the individual, identifying strengths, challenges, and specific behaviors that need attention. Based on this assessment, a customized plan is created that breaks down complex skills into smaller, achievable steps.
Author Interviews, Cognitive Issues, Karolinski Institute, Pediatrics / 18.12.2025

MedicalResearch.com Interview with: Samson Nivins PhD Postdoctoral Researcher, specializing in Perinatal and Pediatric NeurologySamson Nivins PhD Postdoctoral Researcher, specializing in Perinatal and Pediatric Neurology [caption id="attachment_71834" align="alignleft" width="92"]Torkel Klingberg, M.D., Ph.D.Professor of Cognitive Neuroscience at the Stockholm Brain Institute Dr. Klingberg[/caption] Torkel Klingberg, M.D., Ph.D. Professor of Cognitive Neuroscience at the Stockholm Brain Institute Karolinska Institutet, Stockholm Sweden   MedicalResearch.com: What is the background for this study? Response: In the modern era, children’s use of digital media such as watching videos, playing video games, and using social media has increased substantially, often coinciding with a decline in outdoor activities. As many school-aged children now own personal devices, particularly smartphones, it has become easier for them to spend more time on screens than intended. For example, a German survey cited in an EU briefing reported that in 2020, 27% of 8-9-year-olds and 54% of 10-11-year-olds owned a smartphone. In the U.S., ~30% of children own a smartphone by age eight, with many receiving their first device between ages 10 and 11. With growing concerns about screen time, numerous studies have examined its potential consequences and have reported associations between higher screen use and increased ADHD symptoms. However, most of this research has been cross-sectional and has tended to combine different types of digital media such as television, video games, and social media into a single composite measure. This approach may obscure important differences, as various forms of digital media may have distinct effects on ADHD symptoms. To date, relatively few studies have examined the impact of specific types of digital media use on ADHD in a longitudinal framework, and even fewer have accounted for the heritable nature of ADHD. To address these gaps, this U.S. longitudinal study followed children from ages 9-10 to 13-14 years. The study collected repeated measures of daily time spent on specific digital activities, including television and videos, video games, and social media platforms such as TikTok, Instagram, and Facebook. ADHD symptoms specifically inattention and hyperactivity/impulsivity were assessed using parent reports, and analyses adjusted for genetic factors and socioeconomic status.
ADHD, Author Interviews, Neurology, Pediatrics / 15.12.2025

MedicalResearch.com Interview with: [caption id="attachment_71800" align="alignleft" width="200"]Dr. Ornella Dakwar-KawarHebrew University with Prof. Mor Nahum and Prof. Itai Berger Hebrew University  Dr. Dakwar-Kawar, PhD[/caption] Dr. Ornella Dakwar-Kawar Hebrew University with Prof. Mor Nahum and Prof. Itai Berger Hebrew University  in collaboration with Prof. Jyoti Mishra from the University of California San Diego (UCSD) Prof. Roi Cohen Kadosh from the University of Surre, Dr. Pragathi Priyadharsini and Ashwin Amal from ITT Karpur, India and InnoSphere Ltd MedicalResearch.com: What is the background for this study? Response: Children with ADHD often exhibit aberrant neural activity, specifically imbalances in excitation and inhibition levels alongside dysfunction in brain networks like the frontoparietal network. While our previous research showed that Transcranial Random Noise Stimulation or tRNS improves clinical symptoms, the specific neural modulation effects during cognitive tasks remained unclear. This study investigated these mechanisms by analyzing the aperiodic exponent, a marker of excitation inhibition balance, during an inhibitory control task to compare children with ADHD to healthy controls and assess changes following tRNS combined with cognitive training. 
Author Interviews, Gender Differences, Mental Health Research, Race/Ethnic Diversity / 07.12.2025

[caption id="attachment_71691" align="alignleft" width="150"]MedicalResearch.com Interview with:Alexa T. Diianni, MBS Department of Medical Education Geisinger College of Health Sciences Scranton, PA 19409 MedicalResearch.com: What is the background for this study? During a previous study, my research team and I examined the financial conflicts of interest (COIs) between industry and academia- namely those that exist between authors of The American Psychiatric Association’s Diagnostic and Statistical Manual of Mental Disorders (DSM), and industry (1). The DSM is a diagnostic tool widely used for the diagnosis of psychiatric disorders, and is thus of interest in assessing COIs (1,2). We previously found that authors of the DSM-5-TR had received over $14.2m in undisclosed payments from industry (1). Our current study examines the gender and geographic disparities of the DSM-5-TR authors, in relation to these payments. While previous investigations have evaluated financial COIs in recent editions of the DSM (3,4), the demographic information of its authors has not yet been examined. Equitable representation of DSM authors is paramount as this manual serves a diverse population across the United States and beyond. It is important that the authorship of this manual be reflective of the population in which it serves, as there have been reported differences in both the type and prevalence of psychiatric care sought out by gender, as well as varying clinical treatment by geographic location (5-8). MedicalResearch.com: What are the main findings? Of the 225 physicians that were identified as contributors to the DSM-5-TR task force, panels, and cross-cutting review groups, 116 contributors met the inclusion criteria of being a US-based physician with an active National Provider Identifier. Of these included individuals, 69.8% were men and 30.2% were women. Just three states accounted for 43.9% of contributors (New York, 17.2%; California, 14.7%; Massachusetts, 12.1%), while twenty-three states received no author representation. Of the total $14.6m in industry payments received by contributors, $13.2m (91.8%) was received by male contributors. Male contributors thus received an average of $287k in payment, while female contributors received $72k. MedicalResearch.com: What should readers take away from your report? Due to the prevalent use of the DSM, it is important that transparency regarding financial conflicts of interest exists, with COIs minimized moving forward to avoid implicit bias and pro-industry thought (1,9-15). Furthermore, it is important that future editions of the DSM be representative of the population in which it serves. This can be attained by selecting an adequate proportion of male and female contributors for the DSM, which may provide more robust perspectives on current diagnoses. Additionally, representation of contributors from all regions across the US will allow for a more diverse and informed perspective on diagnostic criteria, allowing for improved public health and patient care within the United States. MedicalResearch.com: What recommendations do you have for future research as a result of this study? As gender and geographic disparities were shown to be significant through this study, I believe it would be interesting to address additional areas of demographic disparities among authors. Additional areas to examine may include non-US-based physicians, non-MD/DO authors, as well as ethnic and racial disparities among authors. Finally, similar studies may be applied to additional clinical and diagnostic tools. Diagnostic manuals, such as the DSM, written by a diverse set of individuals, would provide unique perspectives that best reflect the population as a whole, and in turn, benefit patient care. For this reason, it is important that diagnostic manuals, such as the DSM, include a diverse set of authors that can provide adequate input regarding the patient population it serves. MedicalResearch.com: Is there anything else you would like to add? This research received no external funding. First author (AD) is employed by PerkinElmer, working on assignment at GlaxoSmithKline (2023-Present), outside of the submitted work; Last author (BP) contributed to an osteoarthritis research team supported by Pfizer and Eli Lilly (2019-21) and received grants from the Pennsylvania Academic Clinical Research Center, outside of the submitted work. New Paper Diianni AT, Davis LC, Piper BJ. Gender and geographic disparities among DSM-5-TR authors in relation to financial conflicts of interest and industry payments: cross-sectional analysis. BMJ Mental Health. 2025;28:e301913. https://doi.org/10.1136/bmjment-2025-301913 References: 1. Davis LC, Diianni AT, Drumheller SR, Elansary NN, D’Ambrozio GN, Herrawi F, Piper BJ, Cosgrove L. Undisclosed financial conflicts of interest in DSM-5-TR: cross sectional analysis. BMJ. 2024;384. 2. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. 2022. 3. Cosgrove L, Krimsky S, Vijayaraghavan M, Schneider L. Financial ties between DSM-IV panel members and the pharmaceutical industry. Psychother Psychosom 2006;75:154-60. doi:10.1159/000091772. Pmid:16636630 4. Cosgrove L, Krimsky S. A comparison of DSM-IV and DSM-5 panel members’ financial associations with industry: a pernicious problem persists. PLoS Med2012;9:e1001190. doi:10.1371/journal.pmed.1001190. Pmid:22427747 5. Piper BJ, Ogden CL, Simoyan OM, Chung DY, Caggiano JF, Nichols SD, et al. (2018) Trends in use of prescription stimulants in the United States and Territories, 2006 to 2016. PLoS ONE 13(11): e0206100. https://doi.org/10.1371/journal.pone.0206100 6. Bareis N, Olfson M, Wall M, Stroup TS. Variation in Psychotropic Medication Prescription for Adults With Schizophrenia in the United States. Psychiatric Services. American Psychiatric Publishing; 2022;73(5):492–500. https://doi.org/10.1176/appi.ps.202000932 7. Tedstone Doherty D, Kartalova-O'Doherty Y. Gender and self-reported mental health problems: predictors of help seeking from a general practitioner. Br J Health Psychol. 2010;15(Pt 1):213-28. 8. Terlizzi EP, Schiller, Jeannine S. Mental health treatment among adults Aged 18–44: United States, 2019–2021. Report. Hyattsville, MD: National Center for Health Statistics; 2022. 9. Grande D, Frosch DL, Perkins AW, Kahn BE. Effect of exposure to small pharmaceutical promotional items on treatment preferences. Arch Intern Med. 2009;169(9):887-893. doi:10.1001/archinternmed.2009.64 10. Institute of Medicine (US) Committee on Standards for Developing Trustworthy Clinical Practice Guidelines. In: Graham R, Mancher M, Miller Wolman D, et al., eds. Clinical Practice Guidelines We Can Trust. Washington (DC). National Academies Press, 2011, https://www.ncbi.nlm.nih.gov/books/NBK209539/?report=classic, doi:10.17226/13058. 11. Wazana A. Physicians and the pharmaceutical industry: is a gift ever just a gift? JAMA 2000;283:373-80. doi:10.1001/jama.283.3.373. Pmid:10647801 12. Moore DA, Tanlu L, Bazerman MH. Conflict of interest and the intrusion of bias. Judgm Decis Mak 2010;5:37-53. doi:10.1017/S1930297500002023 13. Dana J, Loewenstein G. A social science perspective on gifts to physicians from industry. JAMA 2003;290:252-5. doi:10.1001/jama.290.2.252. Pmid:12851281 14. Nejstgaard CH, Bero L, Hróbjartsson A, et al. Association between conflicts of interest and favourable recommendations in clinical guidelines, advisory committee reports, opinion pieces, and narrative reviews: systematic review. BMJ 2020;371:m4234. doi:10.1136/bmj.m4234. Pmid:33298430 15. Thompson DF. The challenge of conflict of interest in medicine. Z Evid Fortbild Qual Gesundhwes 2009;103:136-40. doi:10.1016/j.zefq.2009.02.021. Pmid:19554887 Alexa T. Diianni[/caption] MedicalResearch.com Interview with: Alexa T. Diianni, MBS Department of Medical Education Geisinger College of Health Sciences Scranton, PA 19409 MedicalResearch.com: What is the background for this study? Response: During a previous study, my research team and I examined the financial conflicts of interest (COIs) between industry and academia- namely those that exist between authors of The American Psychiatric Association’s Diagnostic and Statistical Manual of Mental Disorders (DSM), and industry (1). The DSM is a diagnostic tool widely used for the diagnosis of psychiatric disorders, and is thus of interest in assessing COIs (1,2). We previously found that authors of the DSM-5-TR had received over $14.2m in undisclosed payments from industry (1). Our current study examines the gender and geographic disparities of the DSM-5-TR authors, in relation to these payments. While previous investigations have evaluated financial COIs in recent editions of the DSM (3,4), the demographic information of its authors has not yet been examined. Equitable representation of DSM authors is paramount as this manual serves a diverse population across the United States and beyond. It is important that the authorship of this manual be reflective of the population in which it serves, as there have been reported differences in both the type and prevalence of psychiatric care sought out by gender, as well as varying clinical treatment by geographic location (5-8).