Mental Health Research

08 Aug

Posted at 14:25h in Mental Health Research
Online psychiatry has become an increasingly popular option for mental health care, mainly due to its convenience and accessibility. With many studies showing that online therapy can be as effective as in-person sessions, it's no wonder that more people are considering this alternative. Virtual therapy removes geographical barriers, making it easier to access professional help regardless of your location. In contrast, in-person therapy offers a face-to-face connection that some individuals find essential. The physical presence of a therapist can encourage a stronger bond and a sense of comfort for many. Yet, with advancements in technology, Reimagine Psychiatry services are bridging the gap by providing expert online psychiatric care that's both reliable and covered by insurance. Ultimately, the choice between online and in-person therapy hinges on your personal needs and preferences. If convenience and flexibility are your priorities, online psychiatry can be a viable and effective option. On the other hand, if you value direct human interaction, traditional in-office visits might suit you better.

06 Aug

Posted at 13:53h in Addiction, Mental Health Research
[caption id="attachment_62745" align="alignleft" width="130"] Luke Cavanah[/caption] Luke Cavanah, BS Department of Medical Education Geisinger Commonwealth School of Medicine Scranton, PA 18509     MedicalResearch.com: What is the background for this study? Response:  “Selective” serotonin reuptake inhibitors (SSRI) are a class of medications that are first-line treatments for many anxiety, depressive, and other psychiatric disorders.1–3 Despite their name, SSRIs often have activity on other receptors and chemicals.4 One such SSRI that is known for being particularly nonselective is paroxetine.5 Paroxetine’s mechanisms of action are summarized in the figure below which shows binding not only to the serotonin transporter (SERT) but also to the norepinephrine transporter (NET), nitric oxide synthetase (NOS), the muscarinic (M1) receptor, and the liver cytochrome 2D6 enzyme. Paroxetine’s receptor promiscuity, especially its anticholinergic activity, can contribute to unfavorable adverse effects.5 Older adults (65+) are particularly vulnerable to some of these adverse effects. The American Geriatrics Society (AGS) regularly publishes an explicit list, called the Beer’s List, of what they call “potentially inappropriate medications (PIMs)”, which are medications they recommend avoiding in this demographic when having certain disorders/conditions or most clinical contexts. The AGS Beers Criteria, in 2012, 2019, and most recently in 2023, has identified paroxetine as a PIM due to its strong anticholinergic activity and high risk of sedation and orthostatic hypotension, and thus they recommend it should be avoided in this population in most circumstances.6–8 Given the recommendation against the use of paroxetine in older adults, we were interested in examining the utilization of paroxetine by U.S. Medicare beneficiaries. Medicare patients primarily consist of people 65+ and cover 94% of non-institutionalized people in this age group.9

02 Aug

Posted at 10:09h in Brain Injury, Legal-Malpractice
  [caption id="attachment_62703" align="alignleft" width="200"]brain-injuries Image source[/caption] A traumatic brain injury occurs when there is an impact on the brain from an external force, like a jolt to the head, or from an object puncturing the brain, like a piece of metal in a car crash. Brain injuries can occur in any type of accident, like a car accident or at a workplace. The most common type of brain injury is a concussion, which results from a blow to the head and can happen in a variety of situations. If you or anyone you know has been the victim of an accident, you may consider consulting a personal injury lawyer to file a claim for your injuries.

Brain injuries are classified into two types:

Penetrating injuries: Injuries that involve an object puncturing the skull and causing damage to the brain tissues as a result are classified as penetrating injuries. Example: a knife or a bullet piercing your skull. Blunt injuries: When an object collides with your skull but doesn't puncture it, it’s called a blunt injury. These injuries are more common than penetrating injuries. They can happen due to a fall or while playing a sport.

29 Jul

Posted at 09:12h in Mental Health Research, OBGYNE
It’s no secret pregnancy causes many changes in a woman’s body - physically and emotionally. One of the most common changes occurs in the brain, a phenomenon known as the pregnancy brain.  Pregnancy Brain ExplainedThe pregnancy brain is often referred to as momnesia or baby brain. This condition underlies the cognitive struggles and difficulty associated with concentrating that some women experience during pregnancy and sometimes after giving birth.  Generally, pregnancy is characterized by an increase in steroid hormones such as estrogen, progesterone, and cortisol. These hormones will be discussed in detail in the following sections. Steroid hormones are responsible for handling metabolism, inflammation, immune functions, salt and water balance, the development of sexual characteristics, and the ability to withstand injury and illness during pregnancy.   The genesis of pregnancy brain stems at least partially from the influx of these steroid hormones. This, among other factors, will be mentioned in this article.

26 Jul

Posted at 18:21h in Dermatology, Mental Health Research
Hair loss can have profound psychological effects, impacting self-esteem and overall well-being. However, advancements in hair loss treatments, such as Minoxidil, offer hope by not only addressing physical symptoms but also improving mental health outcomes. Understanding the psychological benefits of these treatments is crucial for individuals seeking to regain confidence and emotional balance.

Addressing the Emotional Impact of Hair Loss

Hair loss is more than a cosmetic concern; it can significantly affect mental health. Many individuals experience feelings of embarrassment, anxiety, and reduced self-confidence due to changes in their appearance. Effective hair loss treatments play a pivotal role in alleviating these psychological burdens, fostering a positive outlook and enhancing quality of life.

How Minoxidil Works

[caption id="attachment_62607" align="alignleft" width="200"]hairloss-minoxidil_pexels-zvolskiy-1570807 Image source[/caption] Minoxidil, a topical medication approved by the FDA for hair loss treatment, stimulates hair follicles' growth phase and increases hair density. It promotes blood flow to the scalp, revitalizing dormant follicles and encouraging new hair growth. Minoxidil hair treatment offers a proactive approach that not only addresses thinning hair but also restores confidence in one's appearance.

25 Jul

Posted at 18:18h in Mental Health Research
Editor's note: This piece discusses mental health issues. If you have experienced suicidal thoughts or have lost someone to suicide and want to seek help, you can contact the Crisis Text Line by texting "START" to 741-741 or call the Suicide Prevention Lifeline at 800-273-8255. As life becomes increasingly complex and challenging, acknowledging and supporting mental health is crucial. Mental health influences how we think, feel, and behave in daily life, and it affects our ability to handle stress, relate to others, and make decisions. In our fast-paced world, finding the right support networks and resources can be daunting yet essential. Just as we nourish our bodies for physical health, our minds also require care and attention. Keep reading to discover why mental health is so important and how to find the support you need.

23 Jul

Posted at 12:36h in Education, Mental Health Research, Nursing
  [caption id="attachment_62428" align="alignleft" width="200"] Image Source[/caption] Becoming a registered nurse (RN) is an achievement that brings immense pride and opportunities. After successfully completing your licensing requirements, you might feel a wave of excitement mixed with apprehension. The reality of your new role can quickly set in, with its demanding shifts, emotional challenges, and high responsibilities. This sudden surge in duties can take a toll on both your mental and physical health. However, maintaining your well-being is crucial not only for your own sake but also for providing the best care to your patients. Here are eight useful tips to help new RNs stay fit both mentally and physically.
  1. Don’t Skimp on Sleep
As a new RN, you may find your schedule to be erratic and demanding, which can disrupt your sleep patterns. Sleep deprivation can lead to decreased attention, impaired memory, and increased susceptibility to stress. Therefore, it's crucial to establish a routine that promotes quality sleep. Start by creating a sleep-friendly environment. How can you do this? Make sure your bedroom temperature is comfortable, and no external light enters your room. Also, block out any noise by using a white noise machine if necessary. Skip the coffee and any form of caffeine or nicotine close to bedtime, no matter how much you crave it, as they can interfere with your ability to fall asleep. Similarly, limit your intake of heavy meals before bed. Have a light salad or snack if you’re really hungry.

22 Jul

Posted at 21:02h in Mental Health Research
Key Takeaways:
  • Simple daily practices can significantly improve mental health.
  • Mindfulness, proper nutrition, and social connections are crucial.
  • Professional help is valuable and should not be stigmatized.
Table of Contents:
  • The Importance of Mental Health
  • Practicing Mindfulness
  • Nutrition and Mental Health
  • The Role of Exercise
  • Building Strong Social Connections
  • Seeking Professional Help
  • Creating a Balanced Daily Routine
  • Final Thoughts
The Importance of Mental Health Mental health is integral to our well-being, affecting our thoughts, emotions, and behaviors. Setting mental health first might result in a more balanced and enjoyable life. Everyone, from young infants to adults, needs to prioritize their mental health, according to the Centers for Disease Control and Prevention (CDC). Your capacity to manage stress, interact with others, and make decisions is all impacted by your mental health. Thus, being mindful of mental wellness can lead to better life decisions, improved relationships, and overall emotional stability. Click for more info on how mental health can be managed effectively.

15 Jul

Posted at 19:41h in Mental Health Research, Surgical Research
Cosmetic surgery is more than a nip-and-tuck; it's a journey of self-discovery that can help people debunk the myth of inadequacy, shatter the shell of low self-esteem, and emerge stronger, bolder, and more radiant on the other side. Picture this: a transformed you, radiating confidence and self-acceptance. But can cosmetic surgery really deliver on this promise? We'll get to the bottom of the psychological advantages that make it all possible.

Enhanced Self-Esteem and Body Image

[caption id="attachment_62318" align="alignleft" width="200"]Psychological Benefits of Cosmetic Surgery Photo by cottonbro studio[/caption] One of the most significant psychological benefits of cosmetic surgery is the enhancement of self-esteem and body image. We've all got our own physical quirks that can make us feel, well, less than confident. Whether you're looking to revitalize your facial features or refine your neck and jawline, surgical solutions like rhinoplasty, neck lifts, and facelifts can reshape your confidence from the inside out. Exploring various surgical solutions can bring profound changes, such as enhanced facial symmetry or a more defined neckline, which in turn can boost your self-esteem immensely. Think about it: when you feel good about how you look, your entire outlook changes. That's exactly what happens for many people after surgery, as the evidence clearly shows. With a stronger sense of self, social interactions become more enjoyable, professional opportunities abound, and life takes on a sunny disposition.

15 Jul

Posted at 11:40h in Addiction, Alcohol, Mental Health Research
  Introduction Alcohol addiction, also known as alcohol use disorder (AUD), is a pervasive issue that affects millions of individuals worldwide. Beyond its well-documented physical consequences, alcohol addiction significantly impacts mental health, leading to a range of emotional and psychological challenges. Understanding the relationship between alcohol addiction and mental health is crucial for developing effective treatment strategies and providing support to those affected. Alcohol and the Brain [caption id="attachment_62302" align="alignleft" width="200"]alcohol_pexels-edwardeyer Image Source[/caption] Alcohol's influence on the brain is profound and multifaceted. When consumed, alcohol quickly enters the bloodstream and reaches the brain, where it interferes with neurotransmitters—chemical messengers that regulate mood, cognition, and behavior. One primary target of alcohol is gamma-amino butyric acid (GABA), a neurotransmitter that inhibits brain activity. By enhancing GABA's effects, alcohol induces feelings of relaxation and sedation. Simultaneously, alcohol inhibits glutamate, an excitatory neurotransmitter, further dampening brain activity and impairing cognitive functions.

11 Jul

Posted at 14:50h in Exercise - Fitness, Mental Health Research
The mental health of an individual relates to emotional, psychological, and social well-being and it has to do with how well the person can manage stress, interact with others, and make decisions. Because mental health is a dynamic state, many variables can cause it to alter over time. The connection between physical activity and mental wellness is becoming more and more prominent in society as it is difficult to keep a healthy balance between physical activity and mental health in the busy world. This blog delves into the complex connection between mental health and physical fitness, emphasising the significance of a healthy balance between both. It also explores the value of the Mental Health Course in comprehending and resolving Mental Health Issues in the framework of a comprehensive strategy.  Table Of Contents 
  • The Mind-Body Connection 
  • Stress Reduction and Cortisol Regulation 
  • Improved Sleep Patterns 
  • Enhanced Cognitive Function and Memory 
  • Social Interaction and Community Engagement 
  • The Role of Mental Health Courses 
  • Creating a Holistic Wellness Plan 
  • Individualized Approaches to Mental Wellness 
  • Conclusion 

10 Jul

Posted at 11:37h in Exercise - Fitness, Mental Health Research
Meditation, an ancient practice, has become more popular in recent years, largely due to its myriad health benefits. For seniors, meditation holds significant value. According to the Cleveland Clinic, it provides a natural method to manage stress, enhance mental clarity, and improve overall well-being. The National Institute on Aging emphasizes that as we age, maintaining both physical and mental health becomes increasingly crucial. Meditation serves as a simple yet effective tool to support these goals. WebMD reports that meditation can help seniors sleep better. This practice can also help deal with symptoms associated with depression. If you're a senior looking to get started with meditation, here are a few expert tips to help you out.

Understanding the Benefits of Meditation

meditation-pexels-photo-4498219.webp Meditation, as explained by Mayo Clinic, has been shown to reduce stress, lower blood pressure, and improve sleep quality. For seniors, these benefits are particularly significant as they can help manage chronic conditions and promote a sense of calm and relaxation. Regular meditation practice can also enhance focus and cognitive function, which can be beneficial in maintaining mental sharpness as one ages. Furthermore, meditation promotes inner peace and enhances emotional health, thereby contributing to an improved overall quality of life.

04 Jul

Posted at 10:48h in Education, Mental Health Research
  [caption id="attachment_62234" align="alignleft" width="300"]mental-health-tips-college-students Image source[/caption] College life is a major milestone, filled with opportunities for personal and professional growth. However, the stakes are high for students pursuing health sciences. Fields like medicine, nursing, and other health-related professions demand rigorous study, long hours, and a deep emotional commitment. The pressure to excel can lead to stress, anxiety, and other mental health challenges. Hence, it is crucial to find effective ways to maintain mental health to thrive academically and personally. Here are nine tips to help you keep your sanity while studying.

01 Jul

Posted at 09:52h in Mental Health Research
In the 21st century, mental health is very important. Moreover, it is common to suffer from mental health issues such as depression, anxiety, etc.  Psychotherapy may be needed to improve mental health. If you want more details, check out the guide below. 

How Does Psychotherapy Work?

h-1.png July 1, 2024 43 KB 200 by 113 pixels Edit Image Delete permanently It is also known as talk therapy, which gives a structured framework to patients that helps them cope with the situation.  There could be anything related to mental illness that requires talk therapy, such as depression, anxiety, trauma, etc.  Its core is the bond between you and your therapist or therapeutic relationship.  The Psychotherapist and you both will work together to fix your mental illness, stress, depression, etc. Anyone can take part in these psychotherapy sessions, either individually or with your partner or family. Talk therapy sessions are typically 30-60 minutes. It is important to be open and honest during these sessions.

When You Should Seek Therapy?

There are many signs that can help you recognize, and one of the most common signs is a sense of feeling that you suddenly start feeling stress.
  • Do not act or think aggressively about harming anyone, including yourself.
  • Start drinking alcohol or taking drugs.
  • Suddenly, I start feeling sad or lonely.
  • Unable to think properly or focus on something.
  • Always feel anxious.

27 Jun

Posted at 10:05h in Alzheimer's - Dementia, Social Issues
Caring for a loved one with dementia at home can be challenging. As a caregiver, it is important to educate yourself on strategies to provide the best care while also taking care of your own wellbeing. Here are some helpful tips for caregivers managing dementia care at home.

Understand the Stages of Dementia

The first step is understanding the different stages of dementia - mild, moderate and severe. Knowing what stage your loved one is in will help you plan care accordingly. In the early stages, maintaining independence may be possible with reminders and the help of home caregivers such as home care services in Greensboro, NC. In the later stages, full-time care is usually required for basic activities like eating, bathing and dressing. Understanding the dementia stage will help you adapt care needs.

caregivers-eldercare_pexels-kampus-7551618Create a Safe, Comfortable Environment

As dementia progresses, people can become disoriented and confused. To limit risks, make sure your home environment is safe and comfortable. Reduce clutter, improve lighting, install handrails and non-slip mats in bathrooms. Lock away medications and toxic products. Consider monitoring systems like motion sensors if the person wanders. Also, ensure favorite belongings and familiar objects are around to provide comfort.

22 Jun

Posted at 21:36h in Alzheimer's - Dementia, Author Interviews, JAMA
MedicalResearch.com Interview with: [caption id="attachment_62050" align="alignleft" width="150"]Mabel Seto, PhDHarvard Aging Brain Study, Department of Neurology Massachusetts General Hospital, Center for Alzheimer Research and Treatment Department of Neurology Brigham and Women’s Hospital Harvard Medical School Boston, Massachusetts Vanderbilt Memory and Alzheimer’s Center Vanderbilt University Medical Center Nashville, Tennessee Dr. Seto[/caption] Mabel Seto, PhD Harvard Aging Brain Study, Department of Neurology Massachusetts General Hospital, Center for Alzheimer Research and Treatment Department of Neurology Brigham and Women’s Hospital Harvard Medical School, Boston, Massachusetts Vanderbilt Memory and Alzheimer’s Center Vanderbilt University Medical Center Nashville, Tennessee   MedicalResearch.com: What is the background for this study? Response: The background for this study is that individuals with a family history of Alzheimer’s disease (i.e., one or more first-degree relatives) have a higher risk for the disease than individuals that don’t have a family history. Previous studies suggested a preferential maternal inheritance of AD, though they were limited in sample size and statistical power. In our study, we wanted to focus on a larger, cognitively unimpaired sample. Using data from the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) study, a randomized clinical trial aimed at AD prevention, we examined the relationship between a parental history of significant memory impairment as a proxy for AD (as some individuals may not have pursued formal diagnosis) and amyloid-beta burden in the offspring.

20 Jun

Posted at 12:47h in Mental Health Research
The pandemic may be over, but its effects linger. According to a paper on the psychological impact of COVID-19 on children and adults in the United Arab Emirates, 71% of the UAE general population have generalized anxiety disorder. Younger people and females register the highest levels of anxiety, and teachers also report a higher incidence of emotional problems in children. Mental health awareness and solutions are more crucial than ever in the face of this increased risk for anxiety. Fortunately, you and the people you care about have access to interventions like neurofeedback in Dubai to address various mental health conditions.

What Is Neurofeedback Therapy?

Neurofeedback therapy is a biofeedback technique that monitors brain waves and provides real-time feedback about those brainwaves to the brain. The brain can learn to self-regulate its functions by becoming aware of its activity. Through consistent brain training, the brain can instinctively prevent, manage, or control undesirable brain wave patterns. Consequently, it can be more effective at curbing the negative behavior, mental state or physiological symptoms associated with unwelcome brain activity.

11 Jun

Posted at 14:36h in Mental Health Research
Personalizing Mental Health InterventionsMental health is a deeply personal journey, and finding the right treatment strategy can significantly affect one's quality of life. With a range of mental health conditions affecting millions globally, it's crucial to understand that there's no one-size-fits-all solution. This article explores how to personalize mental health interventions, ensuring that individuals can choose the most effective strategies for their unique situations. Understanding Mental Health Conditions and Their Complexities Mental health issues range from common disorders like anxiety and depression to more complex conditions such as bipolar disorder and schizophrenia. Each condition affects individuals differently, making personalized treatment not just beneficial but necessary. The effectiveness of any mental health treatment largely depends on its alignment with the specific symptoms and circumstances of the individual. Therefore, understanding the nuances of one's mental health condition is the first step toward effective treatment.

10 Jun

Posted at 12:44h in Health Care Workers, Mental Health Research
Social work demands emotional resilience and dedication, since it often involves dealing with complex and challenging situations, ranging from supporting individuals in crisis to navigating the intricacies of social systems and policies. This constant exposure to stress can take a toll on a social worker. Therefore, this guide covers various practical strategies for stress management to help social workers continue to perform their vital roles while safeguarding their well-being.

Stress in Social Work and Its Impact

how-to-handle-stress pic Engin_AkyurtStress in the workplace is the body's response to the demands and pressures encountered in professional situations. It can manifest as acute stress, which is short-term and often related to specific events, or chronic stress, which persists over a long period due to ongoing challenges.  Common sources of stress for social workers may include high caseloads, administrative burdens, exposure to traumatic situations, and the emotional demands of supporting clients. Signs of stress can vary. You may have physical indicators like fatigue, headaches, and muscle tension. On the other hand, you may also have emotional and psychological signs like anxiety, irritability, and feelings of helplessness.

28 May

Posted at 11:05h in Mental Health Research, Nursing
Nurses play a crucial role in the healthcare system, often serving as the frontline of patient care. Their responsibilities are vast and demanding, from administering medications to providing emotional support to patients and their families. Given the high-stress nature of their work, it is imperative to recognize the importance of mental health support for nurses. Mental health support not only enhances their well-being but also improves patient care and the overall efficiency of healthcare services. This article explores the various facets of mental health support for nurses and why it is essential for the healthcare industry.

The High-Stress Environment of Nursing

Nursing is inherently a high-stress profession. Nurses are often required to work long hours, deal with critically ill patients, and make quick decisions that can significantly impact patient outcomes. This constant exposure to stress can lead to burnout, anxiety, and depression if not properly managed. The high-pressure environment can affect their mental and physical health, making it crucial to address these issues proactively. Providing mental health support helps nurses cope with the stressors of their job, ensuring they can continue to provide high-quality care without compromising their own health.

23 May

Posted at 13:32h in Addiction, Mental Health Research
healthy-lifestyles-longevityAdopting a healthy lifestyle is essential for enhancing longevity and improving overall well-being, and it involves making conscious choices that benefit both physical and mental health. While physical health often gets the spotlight, mental health is equally crucial. The United States of America is grappling with mental health issues, and San Antonio serves as a bitter reminder. Despite San Antonio investing $26 invested in the Metropolitan Health District's Mental Health initiatives in 2022, much more effort is needed. A new study has revealed that Texas is the state with the worst access to mental healthcare in America. This finding highlights the importance of holistic approaches to health that encompass both mental and physical aspects. In this guide, we will discuss six key lifestyle modifications that can enhance longevity.

1.   Embrace Sober Living

Maintaining sobriety is a fundamental aspect of enhancing both physical and mental health. Substance abuse can lead to a myriad of health issues, including liver disease, cardiovascular problems, and mental health disorders. A sober lifestyle can significantly improve your quality of life and increase your lifespan. This journey often requires support, which is where sober living facilities come into play. For those willing to embrace sober living San Antonio facilities, like New Day Sober Living, offers a secure environment where residents are surrounded by people who have similar goals and mindsets, which entails achieving long-term sobriety. These facilities offer structured living conditions and a community of peers who are also on the path to recovery. The supportive atmosphere helps individuals stay committed to their sobriety goals, reducing the risk of relapse and promoting overall well-being. By choosing sober living, you are taking a proactive step towards a healthier, longer life.

21 May

Posted at 12:08h in Health Care Systems, Mental Health Research
In the fast-paced world of healthcare, where clinical skills and knowledge are paramount, the power of empathy in leadership can sometimes be overlooked. However, leading with empathy in the healthcare sector is not just a nice-to-have quality; it's a pivotal trait that can shape patient outcomes, staff satisfaction, and the overall healthcare environment. This article delves into why empathy is crucial in healthcare leadership, supported by real-world insights and strategies to foster a culture of empathy.

The Impact of Technological Advancements

As technology continues to evolve within the healthcare sector, creating new opportunities for enhancing patient care, it's crucial that empathy doesn't get lost in the shuffle. Innovative tools and systems should be seen as avenues to deepen our understanding and connection with patients, rather than as barriers to the human touch. Embracing technology with empathetic intention can lead to an even greater level of personalized care. One specific area where empathy can play a transformative role is in addressing HR challenges in behavioral health. Understanding the unique nature of these challenges, and the emotional toll they can take on staff, is crucial for leaders who strive to create a supportive work environment. This deeper understanding can drive the implementation of effective solutions, fostering a workplace where empathy and professionalism thrive together.

10 May

Posted at 17:22h in Author Interviews, Mental Health Research, Pain Research, Personalized Medicine
On your path to recovery after an injury, you’ll find that medical science keeps evolving. New treatments and tech are not just healing; they’re changing the game of how we bounce back. Guided by fresh insights into technology, we make sure your way back is as effective as it is straightforward. Photo by cottonbro studio Healing Faster: Breakthroughs in Recovery from Personal InjuriesUnderstanding the Latest Diagnostic Tools Enhancing Personal Injury Recovery In the realm of personal injury recovery, precision in diagnosis is key. Advanced imaging techniques such as High-definition fiber tractography (HDFT) now allow for a superior visualization of neural pathways. Medical pros can pinpoint where you’re hurt with such precision, crafting a rehab plan that fits just right. Thanks to biomarker technology, figuring out how long recovery will take has gotten a whole lot smarter. Imagine doctors using clues from your body’s own building blocks—genes and proteins—to create a recovery plan that’s all about you. It means less wondering, “Will this work?” and more knowing it will help stitch things back together quickly.

07 May

Posted at 23:19h in ADHD, Author Interviews, Heart Disease, Stroke
MedicalResearch.com Interview with: [caption id="attachment_61634" align="alignleft" width="150"]Dr Anders HoltDepartment of Cardiology Copenhagen University Hospital–Herlev and Gentofte Gentofte Hospitalsvej Hellerup, Denmark Dr. Holt[/caption] Dr Anders Holt MD PhD Department of Cardiology Copenhagen University Hospital–Herlev and Gentofte Gentofte Hospitalsvej Hellerup, Denmark MedicalResearch.com: What is the background for this study? What types of ADHD treatments were in the study? Response: An increasing number of adults are being diagnosed with ADHD and subsequently treated. Taking the drugs' effect on the sympathetic nervous system into account, it seems relevant to investigate whether treatment could be associated with an elevated long-term risk of cardiovascular disease. The drugs included in the study were methylphenidate, atomoxetine, lisdexamfetamine, dexamfetamine, and modafinil. Owing to the fact that atomoxetine is not a sympathomimetic amine as the others, separate supplementary analyses were carried out for this drug, yielding similar results.

07 May

Posted at 23:07h in Author Interviews, Brain Injury, Cannabis
MedicalResearch.com Interview with: [caption id="attachment_61599" align="alignleft" width="150"]Pamela Maher, PhDResearch Professor Cellular Neurobiology Laboratory SALK Institute for Biologic Studies La Jolla California Dr. Maher[/caption] Pamela Maher, PhD Research Professor Cellular Neurobiology Laboratory SALK Institute for Biologic Studies La Jolla California   MedicalResearch.com: What is the background for this study? Response: Several years ago, we tested several different cannabinoids for protection against the oxytosis/ferroptosis regulated cell death pathway and found CBN (cannabinol) to be one of the most effective. While THC (tetrahydrocannabinol) and CBD (cannabidol) were also quite protective, we wanted to pursue non-psychoactive cannabinoids. Since we are interested in maintaining brain function in the context of aging and disease, we thought that a psychoactive compound could be problematic. In addition, there was already a lot of work on CBD, so we thought we could learn more and contribute more to the field by studying CBN.

07 May

Posted at 20:19h in Alzheimer's - Dementia, Author Interviews, Brigham & Women's - Harvard, JAMA, Nutrition
MedicalResearch.com Interview with: [caption id="attachment_61650" align="alignleft" width="200"]Marta Guasch-Ferré, PhDAssociate Professor and Deputy Head of Section, Section of Epidemiology University of Copenhagen  Group Leader, Novo Nordisk Foundation Center for Basic Metabolic Research  Adjunct Associate Professor, Department of Nutrition Harvard TH Chan School of Public Health  Dr. Guasch-Ferré[/caption] Marta Guasch-Ferré, PhD Associate Professor and Deputy Head of Section, Section of Epidemiology University of Copenhagen Group Leader, Novo Nordisk Foundation Center for Basic Metabolic Research Adjunct Associate Professor, Department of Nutrition Harvard TH Chan School of Public Health MedicalResearch.com: What is the background for this study? Response:  Olive oil is rich in monounsaturated fats and contains compounds with antioxidant activity that may play a protective role for the brain. Olive oil as part of a Mediterranean diet appears to have a beneficial effect against cognitive decline. Higher olive oil intake was previously associated with a lower risk of cardiovascular disease and mortality. But its association with dementia mortality was unknown.

02 May

Posted at 15:20h in Alzheimer's - Dementia, Author Interviews
MedicalResearch.com Interview with: [caption id="attachment_61640" align="alignleft" width="110"]Dr. Li Gan PhDBurton P. and Judith B. Resnick Distinguished Professor in Neurodegenerative Diseases Brain and Mind Research Institute Weill Cornell Medical College Dr. Li Gan[/caption] Dr. Li Gan PhD Burton P. and Judith B. Resnick Distinguished Professor in Neurodegenerative Diseases Brain and Mind Research Institute Weill Cornell Medical College [caption id="attachment_61627" align="alignleft" width="150"]Shiaoching Gong PhD Helen and Robert Appel Alzheimer’s Disease Institute Feil Family Brain and Mind Research Institute Weill Cornell Medicine, New York, NY Dr. Shiaoching Gong[/caption] Shiaoching Gong PhD Helen and Robert Appel Alzheimer’s Disease Institute Feil Family Brain and Mind Research Institute Weill Cornell Medicine, New York, NY MedicalResearch.com: What is the background for this study? Would you describe the process of making these neurons? Response: Primary tauopathies are a group of progressive neurodegenerative diseases characterized by the pathological aggregation of 3R or 4R tau protein in neurons and/or glial cells, where 4R tauopathies are more common primary tauopathies. The exact pathological mechanisms remain elusive. There are currently no therapies available that can halt or reverse the spread of tau aggregates since the drug effects found in animal models are not always reproduced in human clinical trials. The development of tau therapies from human cells have become urgently needed. Induced human pluripotent stem cells (iPSCs) offer a unique model to better understand pathological mechanisms underlying human diseases and to develop human cell-based therapy. However, a major challenge to study 4R tauopathy is iPSC-derived neurons express very low levels of 4R Tau isoforms making it difficult to study 4R tauopathy and the mutations located in 4R Tau. To address this need, we designed and engineered a robust human iPSC 4R tauopathy model using CRISPR/Cas9 technology. We first introduced specific mutations at the intron-exon 10 junctions and silent mutations within exon 10 to promote exon 10 inclusion, leading the increase of 4R isoforms expression in iPSC-derived neurons. Frontotemporal Dementia (FTD) mutation, P301S located in exon 10 is highly aggregation prone. To generate this human disease 4R tauopathy model, we then introduced this mutation to 4R iPSC to make it a 4RP301S iPSC line.

19 Apr

Posted at 00:01h in Author Interviews, Brigham & Women's - Harvard, Mental Health Research, NIH
MedicalResearch.com Interview with: [caption id="attachment_61582" align="alignleft" width="135"]Sharon Dekel PhDPrincipal Investigator Director of the Postpartum Traumatic Stress Disorders Research Program Department of Psychiatry, Massachusetts General Hospital Department of Psychiatry, Harvard Medical School Boston, MA, 02114 Dr. Dekel[/caption] Sharon Dekel PhD Principal Investigator Director of the Postpartum Traumatic Stress Disorders Research Program Department of Psychiatry, Massachusetts General Hospital Department of Psychiatry, Harvard Medical School Boston, MA, 02114 MedicalResearch.com: What is the background for this study? Response: Maternal psychopathologies affect a significant number of American women and are the leading complications of childbirth and a significant contributor to maternal death. Maternal (physical) morbidity in the US remain the highest among all countries in the West, suggesting that some women will have a traumatic childbirth experience. The most common mental illness associated with trauma is posttraumatic stress disorder (PTSD). PTSD stemming from childbirth is estimated to affect 6% of delivering women (https://pubmed.ncbi.nlm.nih.gov/28443054/). In high-risk groups, for example women who have unscheduled Cesareans the rate is estimated at 20% or higher (https://pubmed.ncbi.nlm.nih.gov/31041603/.). Although we screen for postpartum depression in hospitals in the USA there is no screening for what we define as childbirth-related PTSD (CB-PTSD). The overarching goal of the Dekel Lab is to develop novel and patient-friendly screening tools to identify women with this disorder. As importantly traumatic childbirth disproportionality affects Black and Latina women (https://pubmed.ncbi.nlm.nih.gov/35598158/).