Aging, Alzheimer's - Dementia, Author Interviews, Supplements / 01.03.2023

MedicalResearch.com Interview with: Christopher R. Martens PhD Assistant Professor Director, Delaware Center for Cognitive Aging Research Department of Kinesiology & Applied Physiology University of Delaware Newark, DE MedicalResearch.com: What is the background for this study? Response: One of the main issues with Alzheimer's disease is an impaired ability to make energy in the brain. NAD+ is critically involved in the creation of energy within cells and there is strong evidence that nicotinamide riboside (NR), a precursor to NAD+, can restore brain function in mice that exhibit similar characteristics as people with Alzheimer's disease. We had previously studied the effects of NR in healthy older adults and wanted to see whether it is even capable of getting into brain tissue. We used remaining blood samples from our original study and measured the amount of NAD+ within tiny "vesicles" in the blood that we are quite confident originated from the brain and other neural tissue (more…)
Alzheimer's - Dementia, Author Interviews, Genetic Research, Race/Ethnic Diversity, Stanford / 21.02.2023

MedicalResearch.com Interview with: Yann Le Guen, Ph.D. Assistant Director, Computational Biology Quantitative Sciences Unit Stanford Medicine MedicalResearch.com: What is the background for this study? Response: Apart from aging, the strongest contributing factor for late-onset Alzheimer’s disease is a specific allele of the APOE gene, which has three common alleles E2, E3, and E4. While E3 is the most common and considered as the reference, E2 is associated with decreased Alzheimer’s disease risk and E4 is associated with increased Alzheimer’s disease risk. Notably the prevalence of E4 among Alzheimer’s patient is high with about 60% of these carrying at least one E4 allele, while solely about 30% Americans carry one E4 allele. It’s worth emphasizing that individuals with an E4/E4 genotype have an exponential increased in their risk to develop AD (10 times as likely than the reference E3/E3 genotype), and individuals with an E3/E4 genotype have an intermediate risk. Though, most studies of Alzheimer’s disease genetic have been focused on European ancestry, this is beginning to change thanks to NIH’s efforts to fund more studies in non-European ancestry individuals. Our study built on these recent efforts to assess the Alzheimer disease risk associated with an APOE variant (R145C) present in about ~4% African Americans, but extremely rare in Europeans. (more…)
Author Interviews, Autism, JAMA, Pediatrics, UCSD / 08.02.2023

MedicalResearch.com Interview with: Karen Pierce, Ph.D. Professor, Department of Neurosciences, UCSD Co-Director, Autism Center of Excellence, UCSD MedicalResearch.com: What is the background for this study? Response: The mean age of ASD diagnosis and eventual treatment remains at ~52 months in the United States1 - years beyond the disorder’s prenatal origins2, and beyond the age when it can be reliably diagnosed in many cases3. Currently the only way to determine if a child has autism spectrum disorder (ASD) is to receive a developmental evaluation from an experienced clinician (usually a licensed clinical psychologist). There are often long waiting lists, and only a small number of clinicians have the experience required to make early-age (i.e., between 12-36 months) diagnoses of ASD. Thus, there are many places in the country as well as world wide wherein children wait months or years to receive a formal diagnosis due to a lack of available expertise. Moreover, diagnostic evaluations are expensive and usually cost the parent and/or insurance approximately ~$2,000 or more per evaluation.  Finally, clinical evaluations usually take between 2-3 hours to complete and result in fatigue for both the parent and toddler. Eye-tracking, which generates biologically-relevant, objective, and quantifiable metrics of both visual and auditory preference profiles in babies and toddlers in just minutes, is a technology that can dramatically change how ASD is diagnosed. (more…)
Author Interviews, Gastrointestinal Disease, Mental Health Research / 08.02.2023

MedicalResearch.com Interview with: Yuan, Zhongshang PhD Department of Biostatistics School of Public Health Shandong University Jinan, Shandong, China What is the background for this study? Response: Comorbidities and genetic correlations between gastrointestinal tract diseases and psychiatric disorders have been widely reported, with the gut-brain axis (GBA) hypothesized as a potential biological basis. However, it is unclear the degree to which the shared genetic determinants contribute to these associations underlying GBA. (more…)
Aging, Alzheimer's - Dementia, Author Interviews, Hearing Loss, JAMA, Johns Hopkins / 10.01.2023

This article is for informational purposes only and is not a substitute for professional medical advice, diagnosis or treatment. Contact a qualified medical professional before engaging in any physical activity, or making any changes to your diet, medication or lifestyle,   MedicalResearch.com Interview with: Alison R. Huang, PhD MPH Senior Research Associate Cochlear Center for Hearing & Public Health Department of Epidemiology Johns Hopkins Bloomberg School of Public Health MedicalResearch.com: What is the background for this study? What are the main findings? Response: Hearing loss is a critical public health issue affecting two-thirds of older adults over 70 years old. There is growing understanding of a strong link between hearing loss and dementia, which impacts millions of Americans. Our main findings are that in a nationally representative sample of older adults in the United States from the National Health and Aging Trends Study, every 10 decibel increase in hearing loss was associated with 16% greater prevalence of dementia, such that prevalence of dementia in older adults with moderate or greater hearing loss was 61% higher than prevalence in those with normal hearing. We also found that in older adults with moderate or greater hearing loss, hearing aid use was associated with a 32% lower prevalence of dementia. (more…)
Accidents & Violence, Aging, Author Interviews, BMJ, Brain Injury, Brigham & Women's - Harvard, Exercise - Fitness / 15.12.2022

MedicalResearch.com Interview with: Rachel Grashow PhD Research Scientist Department of Environmental Health Football Players Health Study at Harvard University Harvard T.H. Chan School of Public Health MedicalResearch.com: What is the background for this study? Response: Anecdotally, we heard from former NFL players that they felt older than their chronological age. At the same time, doctors and medical care providers treating former players also observed that players appeared clinically older in some health domains. These observations motivated us to ask:  despite superior fitness and success as young men, are football players experiencing early aging and living with illness and disability for more years than their non-football peers? (more…)
Addiction, Author Interviews, JAMA, Mental Health Research, Race/Ethnic Diversity, University of Pennsylvania / 15.12.2022

MedicalResearch.com Interview with: Rebecca Arden Harris, MD, MSc Assistant Professor of Family Medicine and Community Health at the Hospital of the University of Pennsylvania Senior Fellow, Leonard Davis Institute of Health Economics Perelman School of Medicine, University of Pennsylvania MedicalResearch.com: What is the background for this study? Response: The impact of the nationwide overdose epidemic on Black women has received little attention from policy-makers, researchers, or the press. MedicalResearch.com: What are the main findings? Response:  Over the 7-year study period, preventable overdose deaths among Black women resulted in nearly 0.75 million years of life lost (YLL). Women aged 25-34 have suffered a rising proportion of this burden. (more…)
Author Interviews, Mental Health Research / 28.11.2022

Sound healing is an alternative therapy that uses sound waves to heal the mind and body. This therapy is based on the belief that all matter is vibrating at a certain frequency and that disease or ill health occurs when the body’s natural frequency is out of alignment. Sound healing practitioners use a variety of tools, including singing bowls, gongs, and tuning forks, to restore the body’s natural frequency. There are many benefits of sound healing, including reducing stress, promoting relaxation, improving sleep, and reducing pain. Sound healing can also be used to treat a wide range of conditions, such as anxiety, depression, PTSD, and addiction. If you are looking for a non-invasive way to improve your health and well-being, sound healing may be right for you. (more…)
Alzheimer's - Dementia, Author Interviews, Nutrition / 26.11.2022

MedicalResearch.com Interview with: Thomas M Holland, MD, MS Assistant Professor Rush Institute for Health Aging Rush College of Medicine & Rush College of Health Sciences https://www.rushu.rush.edu/faculty/thomas-m-holland-md-ms MedicalResearch.com: What is the background for this study? Response: My late mentor Martha Clare Morris, ScD had published a manuscript investigating leafy green intake, and the nutrients found therein, and cognition. I wanted to take this thought a step further and investigate the potential association bioactives, found in vegetables, like leafy greens, has to cognition. Further, this is a continuation of the research I published in the green journal in 2020 associating flavonols to incident Alzheimer’s dementia. This study extends the understanding that flavonols are not only beneficial for the most detrimental outcome of Alzheimer’s dementia (in decreasing the risk), but also advantageous in mitigating components of the, clinical syndrome i.e. decreasing the rate of cognitive decline. (more…)
Alzheimer's - Dementia, Author Interviews, Nutrition / 14.11.2022

MedicalResearch.com Interview with: Alessandro Palmioli PhD Cristina Airoldi PhD Department of Biotechnology and Biosciences, University of Milano-Bicocca, NeuroMI, Center for Neuroscience, University of Milano-Bicocca MedicalResearch.com: What is the background for this study? beer-hopsResponse: We started many years ago by studying some natural and synthetic molecules that were able to counteract the early stages of this disease. With a view to early prevention, we wondered if these molecules could be routinely taken with the diet or dietary supplements. So our studies focused on the search for bioactive molecules present in food and edible plants. Hops are very rich in polyphenolic compounds, and for this reason it is historically used for the production of beer, but also for the preparation of herbal teas and infusions, and its uses in traditional medicine are known. In recent years we have also collected interesting results on Coffee, Sage, Radix Imperatoriae, Cocoa and Cinnamon extracts. (more…)
Mental Health Research, Nursing / 03.11.2022

When thinking about looking after your health, you might not consider your mental health alongside that. It’s just as important, though, as it can affect every area of your life, from your work life to how much rest you get at night. It’s especially important for healthcare professionals to consider how they are doing mentally. That’s because, with such a mentally demanding role, it is all too easy for them to let their mental health slide without realicing it. Unfortunately, that can lead to far more than a slightly stressful workday. Providing access to resources such as a nurses hotline can offer essential support and guidance for those in the healthcare profession, helping them manage their mental well-being effectively. If you’re a healthcare worker, here is why it’s so important to look after your mental well-being. To Show Up to Every Shift healthcare-nursing-burnout Good mental health means you are more likely to take control of your day. Whether you have an early shift or a long one, with a more positive mindset, you are sure to show up and get the work done to the best of your ability. It also means that those that choose their shifts (such as locum pharmacists, GPs, or nurses) will take on more work because they feel like they can manage it. So if you’re a locum healthcare worker, even using a shift-scheduling platform such as Workflare can help you gain more control over your day and, in turn, feel less stressed. (more…)
Author Interviews, JAMA, Mental Health Research, Pediatrics, USPSTF / 20.10.2022

MedicalResearch.com Interview with: Martha Kubik, Ph.D., R.N. Professor, School of Nursing College of Health and Human Services George Mason University Member, U.S. Preventive Services Task Force MedicalResearch.com: What is the background for this study? Response: Too many children and teens in the United States experience mental health conditions including anxiety, depression, and suicidal thoughts or behaviors. There is a critical need to address the mental health of children and adolescents in primary care so that they can get the support they need to thrive. (more…)
Author Interviews, Brigham & Women's - Harvard, Schizophrenia, Sleep Disorders / 18.10.2022

MedicalResearch.com Interview with: Michael J. Prerau, Ph.D. Assistant Professor of Medicine, Faculty, Division of Sleep Medicine Harvard Medical School Associate Neuroscientist and Director of the Neurophysiological Signal Processing Core Division of Sleep and Circadian Disorders Department of Medicine Brigham and Women's Hospital MedicalResearch.com: What is the background for this study? Response: The brain is highly active during sleep, which makes it an important, natural way to study neurological health and disease. Scientists typically study brain activity during sleep using the electroencephalogram, or EEG, which measures brainwaves at the scalp. Starting in the mid 1930s, the sleep EEG was first studied by looking at the traces of brainwaves drawn on a paper tape by a machine. Many important features of sleep are still based on what people almost a century ago could most easily observe in the complex waveform traces. Even the latest machine learning and signal processing algorithms for detecting sleep waveforms are judged against their ability to recreate human observation. In this study, the researchers asked: What can we learn if we expand our notion of sleep brainwaves beyond what was historically easy to identify by eye? (more…)
Alzheimer's - Dementia, Author Interviews, Infections, Parkinson's / 22.09.2022

MedicalResearch.com Interview with: Jiangwei Sun PhD Postdoctoral researcher in Prof. Jonas Ludvigsson's group Department of Medical Epidemiology and Biostatistics Karolinska Institutet MedicalResearch.com: What is the background for this study? Response: A potential infectious etiology has been hypothesized for neurodegenerative diseases, as findings in animal studies have demonstrated that infectious processes might impact pathogenesis, phenotype, and progression of neurodegenerative disease. The extrapolation of such findings to a human context is however not straightforward. previous studies have mostly examined the role of specific pathogens on a specific neurodegenerative disease, e.g., herpesvirus for Alzheimer’s disease, and influenza, hepatitis C virus, and Helicobacter pylori for PD, with inconclusive results. Although several studies have also assessed associations between infectious diseases and risk of dementia and AD, influence of potential surveillance bias (greater-than-expected surveillance of disease after infections) and reverse causation (due to for example diagnostic delay of neurodegenerative diseases) on the associations was not always fully addressed. Therefore, whether infection is indeed a risk factor rather a comorbidity or secondary event of neurodegenerative disease remains unknown. In contrast to Alzheimer’s disease, and Parkinson’s disease, the potential link between infection and ALS has been less explored. (more…)
Author Interviews, PLoS, PTSD / 27.07.2022

MedicalResearch.com Interview with: Clare Jensen O’Haire Research Team Center for the Human-Animal Bond Purdue University College of Veterinary Medicine MedicalResearch.com:  What is the background for this study?  Response: Service dogs for PTSD are becoming more common and the evidence shows they can help improve mental health and quality of life for many veterans with PTSD. However, some veterans benefit more than others. Our research goal was to ask for the very first time: Why? (more…)
Author Interviews, Brain Injury, NEJM / 09.06.2022

MedicalResearch.com Interview with: Daniel Perl MD Uniformed Services University of the Health Sciences Professor of Pathology at USUHS and Director of the CNRM's Brain Tissue Repository Uniformed Services University of the Health Sciences Bethesda, Maryland MedicalResearch.com:  What is the background for this study?  Response: Chronic traumatic encephalopathy (CTE) is a brain disorder that is predominantly seen in individuals who have suffered from repeated impact head trauma, such as occurs in former boxers or American football players.  CTE has very specific alterations in the brain and can only be diagnosed at autopsy.  Some have claimed that, in addition to former contact sport participants, individuals who served in the military and were repeatedly exposed to blast (explosions) are also at increased risk for developing CTE.  However, this claim has been based on a rather small number of anecdotal cases.  The DoD/USU Brain Tissue Repository is the only facility in the world that is exclusively dedicated to the collection and study of donated brain specimens derived from deceased active duty and retired service members.  We used the resources of this facility to examine 225 consecutively collected brain specimens for the presence of CTE.  This would to provide a view of how common CTE was in this setting and, when diagnosed, was the disease correlated with prior blast exposure, participation in contact sports and other forms of head trauma, and with certain forms of symptomatology such as development of PTSD, alcohol/substance abuse, death by suicide, etc. (more…)
Author Interviews, COVID -19 Coronavirus, Mental Health Research, Rheumatology / 07.06.2022

MedicalResearch.com Interview with: Kelly Gavigan, MPH Director, Data Management and Analytics Global Healthy Living Foundation MedicalResearch.com:  What is the background for this study?  Response: COVID-19 is of particular concern for people living with autoimmune and rheumatic disease, not only because they have an increased risk of infection but also because of the heightened sense of isolation due to strict social distancing protocols that many patients continue to follow through today. As a result, we wanted to better understand if symptoms among the autoimmune and rheumatic disease patients in our ArthritisPower research registry were impacted throughout the COVID-19 pandemic. We previously conducted and reported on an analysis of patient reported outcome data from the ArthritisPower registry between the months of January 2020 to April 2021 at the American College of Rheumatology Convergence in 2021. We conducted a follow-up analysis between May and December 2021, which is our area of focus in this particular abstract. (more…)
Author Interviews, Brigham & Women's - Harvard, Cognitive Issues, Exercise - Fitness / 23.04.2022

MedicalResearch.com Interview with: Robert A. Stern, Ph.D. Professor of Neurology, Neurosurgery, and Anatomy & Neurobiology Director of Clinical Research, BU CTE Center Senior Investigator, BU Alzheimer’s Disease Research Center Boston University School of Medicine MedicalResearch.com:  What is the background for this study?  Response: The link between playing American football at the professional level and later-life brain disorders like chronic traumatic encephalopathy – or CTE -- and ALS has received increasing attention over the past 15 years. Previous research has shown that former NFL players are more likely to die from CTE and amyotrophic lateral sclerosis (ALS) and more likely to report cognitive impairment, behavioral changes, and dementia during life. Despite previous research focusing on the later-life effects of playing American football at the professional level, the long-term effects of college football participation remain largely unknown. We had two goals for this new investigation. The first was to conduct a survey of the current overall health status, including cognitive and other neurological disorders, of older former college American football players compared with men in the general population. The second goal was to examine the mortality rate and causes of death in a cohort of older former college football players. The target population for this study was all 447 former Notre Dame football players who were listed as seniors on the varsity rosters during the 1964-1980 seasons. This was the era of legendary coaches Ara Parseghian and Dan Devine. I should add that this study was fully independent of the University of Notre Dame. (more…)
Alzheimer's - Dementia, Author Interviews, Race/Ethnic Diversity, UCSF / 20.04.2022

MedicalResearch.com Interview with: Erica Kornblith, PhD Assistant Professor, Psychiatry UCSF Weill Institute for Neurosciences MedicalResearch.com:  What is the background for this study?  What are the main findings?  Response: As the population of the United States grows more diverse and dementia is a serious public health concern, we hoped to understand whether differences in dementia risk exist based on race or ethnicity.  Older studies have shown that Black and Hispanic folks have higher risk of dementia, perhaps due to medical risk factors, diagnostic bias, lack of equal access to health care and education, or the health effects of racism, among other factors.  However, these older studies have been small or limited geographically or by only studying a few race and ethnicity groups. Our study used a nationwide sample of almost two million older Veterans who all had access to care through the Veterans Health Administration (VHA), and we examined 5 race or ethnicity groups: American Indians or Alaska Natives, Asians, Blacks, Hispanics, and Whites. Our results show that dementia risk is higher for Black and Hispanic Veterans compared to white Veterans, even when education and medical factors are considered. (more…)
Aging, Alzheimer's - Dementia, Author Interviews, Brigham & Women's - Harvard, Genetic Research, Nature / 20.04.2022

MedicalResearch.com Interview with: Michael B. Miller, MD, PhD Instructor, Harvard Medical School Department of Pathology Brigham and Women's Hospital MedicalResearch.com:  What is the background for this study? Would you explain what is meant by somatic genetic changes and how they might occur?  Response: Changes, also called mutations, in the DNA sequence of genes can be passed from parents to their children, and explain why many diseases run in families. This kind of DNA change is called a germline mutation and is present in every cell in a person’s body. Gene mutations can also occur in a subset of cells of a person, in which case they are called somatic mutations. Somatic mutations are well known as a cause of cancer, and recent research has found that somatic mutations can also happen in non-cancerous cells that appear otherwise normal. Recent studies have even found that somatic mutations are present in neurons, cells in the brain that transmit electrical signals and play an important role in how the brain functions. Furthermore, in neurons, somatic mutations increase with age, so we set out to understand if somatic mutations might be playing a role in age-related brain diseases like Alzheimer’s. (more…)
Author Interviews, JAMA, Mental Health Research, Pediatrics, Social Issues / 13.04.2022

MedicalResearch.com Interview with: Regina Triplett, M.D., M.S. Developmental Neuroscience Post-Doctoral Research Scholar Department of Neurology Washington University in St. Louis, MO  MedicalResearch.com:  What is the background for this study?  What are the main findings?  Response: This is an ongoing, longitudinal, prospective study of 399 pairs of mothers studied throughout pregnancy and their infants, designed to investigate exposure to early life adversity (prenatal poverty and stress) on infant brain development and behavior in early childhood. We examined measures of maternal socioeconomic status including neighborhood factors and stress/mental health during pregnancy in relation to data from infant brain MRI scans conducted in the first weeks after birth. We found that poverty during pregnancy is associated with reduced size and folding of infant brains. We found these associations across the whole brain and not specific to one region. (more…)
Author Interviews, Blood Pressure - Hypertension, Cognitive Issues / 05.04.2022

MedicalResearch.com Interview with: Dr. Yangfeng Wu Peking University Clinical Research Institute Peking University MedicalResearch.com:  What is the background for this study?  What are the main findings? Response: It is well-established that elevated blood pressure (BP) at single time point can contribute to increased risks of suffering accelerated cognitive decline, dementia, and mortality. Nevertheless, BP levels could experience significant alterations as time goes, indicating the necessity of monitoring BP longitudinally. In other words, using blood pressure levels measured at baseline to predict future outcomes in a longitudinal cohort with a long-term follow-up period ≥20 years, becomes controversial. Cumulative BP levels have been indicated as a feasible approach for evaluating long-term exposure of BP levels, which might have the ability to respond to this controversy. This is the main reason why we performed this research to evaluate the predictive values of cumulative BP levels, especially additional values beyond baseline blood pressure levels, for future neurocognitive and longevity outcomes. (more…)
Author Interviews, Autism, Medical Imaging / 02.04.2022

MedicalResearch.com Interview with: Alpen ORTUĞ, PhD Postdoctoral Research Fellow​ Massachusetts General Hospital Department of Radiology Martinos Center for Biomedical Imaging Boston, MA   MedicalResearch.com:  What is the background for this study?  What are the main findings? Response: Finding the earliest diagnosis possible for autism spectrum disorder (ASD) is one of the main goals for researchers studying ASD. This study aimed to investigate the critical abnormalities in prenatal brain development in ASD using structural magnetic resonance imaging (MRI). We hypothesized that volumetric analyses of brain segmentations are useful to identify such abnormalities before birth. We have retrospectively analyzed fetal MRI based on the knowledge that the same individuals were later diagnosed with autism spectrum disorder. We have evaluated developmental abnormalities in brain structures of prospective ASD fetuses using volumetric segmentation. The current study is still preliminary, but the ‘insula’ of the brain showed statistically significant volumetric enlargement in prospective ASD patients, compared to the other three control groups.  (more…)
Author Interviews, JAMA, Mental Health Research, USPSTF, Weight Research / 23.03.2022

MedicalResearch.com Interview with: Lori Pbert, Ph.D Professor, Department of Population and Quantitative Health Sciences Associate chief of the Division of Preventive and Behavioral Medicine Founder and Director of the Center for Tobacco Treatment Research and Training University of Massachusetts Medical School Dr. Pbert joined the U.S. Preventive Services Task Force in January 2019 MedicalResearch.com:  What is the background for this study?  Response: This is the first time that the Task Force has looked at the evidence around screening for eating disorders. It was important to address this topic because of the serious harm that these conditions can cause to people’s physical and mental health, and the tremendous toll eating disorders have on individuals and families. MedicalResearch.com:  What are the main findings? Response: After reviewing the limited available research, we determined there is not enough evidence to recommend for or against screening teens and adults for eating disorders in adolescents and adults who do not have signs or symptoms of an eating disorder or concerns about their eating. It’s important to note that this recommendation is not for people who are showing signs or symptoms of eating disorders, like rapid weight loss or gain, slow heart rate, delayed puberty, or a disruption of menstruation, or for those expressing concern about their eating. (more…)
Alzheimer's - Dementia, Author Interviews, Brigham & Women's - Harvard, Sleep Disorders / 18.03.2022

MedicalResearch.com Interview with: Peng Li, Ph.D. Assistant Professor of Medicine, Harvard Medical School Research Director, Medical Biodynamics Program (MBP) Division of Sleep and Circadian Disorders Associate Physiologist, Brigham and Women's Hospital MedicalResearch.com:  What is the background for this study?  Response: People commonly see increased sleep during daytime in older adults. In people with Alzheimer’s disease or dementia, daytime drowsiness or sleepiness are even more common. Prior studies have showed protective effects of short naps on cognitive performance and alertness acutely, while also there are studies that have demonstrated more daytime naps are associated with faster cognitive decline in the long-term. We sought to investigate whether daytime napping behavior predicts future development of Alzheimer’s dementia. And we noted that there had been no studies to date that have documented the longitudinal profile of daytime napping during late life objectively. (more…)
Author Interviews, Blood Pressure - Hypertension, Cognitive Issues, NIH / 12.03.2022

MedicalResearch.com Interview with: Lenore J. Launer, Ph.D. Chief, Laboratory of Epidemiology and Population Sciences Intramural Research Program, National Institute on Aging. MedicalResearch.com:  What is the background for this study?  What are the main findings? Response: Identifying early risk factors and early changes in the brain will have a major impact on future clinical and public health priorities related to the looming epidemic of dementia. Several studies based on older populations suggest mid-life is an important period to start prevention measures. To date control of blood pressure levels has been the most robust and promising candidate to target for prevention of future cognitive impairment. Although several studies have looked at levels of blood pressure and risk for cognitive impairment, it was not known whether trajectories from young adulthood to middle age studies provided additional information about risk. To investigate possible biomarkers of future risk, we chose to examine the association of the mean arterial blood pressure trajectories to indicators of pathology seen on MRI and that are associated with cognition. We highlight the results of the mean arterial blood pressure (MAP) measure, which is an integrated measure of systolic and diastolic blood pressure. (more…)
ADHD, Author Interviews, Cost of Health Care, Eating Disorders, Pharmacology / 09.01.2022

MedicalResearch.com Interview with: Sneha Vaddadi, BS Department of Medical Education Geisinger Commonwealth School of Medicine Scranton, Pennsylvania MedicalResearch.com: What is the background for this study? Response: The prescription stimulants methylphenidate, amphetamine, and lisdexamfetamine, classified as Schedule II substances, are sympathomimetic drugs with therapeutic use widely used in the US for Attention Deficit Hyperactivity Disorder. Changes in criteria for diagnosis of Attention Deficit Hyperactivity Disorder in 2013 and approval of lisdexamfetamine for binge eating disorder in 2015 may have impacted usage patterns. The goal of this study1 was to extend upon past research2 to compare the pharmacoepidemiology of these stimulants in the United States from 2010–2017, including consideration to variation within geographic regions, the Hispanic population, and the Medicaid population. (more…)
Author Interviews, Eating Disorders, Exercise - Fitness, JAMA, Pediatrics / 31.12.2021

MedicalResearch.com Interview with: Sean C. Rose, MD Child Neurology Nationwide Children’s Hospital The Ohio State University, Columbus MedicalResearch.com: What is the background for this study? What are the main findings?  Response: There is conflicting evidence regarding the association between repetitive head impacts during youth contact sports and worse neurocognitive outcomes.   Most research has been conducted in older adults, while the research in children is mostly limited to 1-2 sports seasons. (more…)