MedicalResearch.com Interview with:
Dr. Richard L. Young PhD
Associate Professor Adelaide Medical School
The University of Adelaide
Group Leader, Intestinal Nutrient Sensing Group
Centre for Nutrition & Gastrointestinal Diseases
South Australian Health & Medical Research Institute
North Terrace, Adelaide | SA
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: This study was a clinical trial in healthy subjects dosed a sweetener combination (sucralose and acesulfame-K) at a dose to equal 1.5 L of artificial sweetened drink per day. This was given in capsules to dissolve in the proximal intestine (3 capsules per day, 2 weeks) and was a randomised, placebo-controlled double-blind study.
Sweetener treatment increased glucose absorption (assessed by serum 3-O-methy glucose), increased glycemic responses to duodenal glucose infusion and decreased GLP-1 responses.
These data show that intake of these sweeteners in healthy subjects may increase glycemic responses, and are the first to document an effect of these sweeteners to increase glucose absorption in humans.