Addiction, Author Interviews, Pain Research / 01.12.2022
From most prescribed opioid in the US to (almost) discontinued: The demise of Demerol
MedicalResearch.com Interview with:
Lavinia Harrison
Geisinger Commonwealth School of Medicine
Scranton, PA 18509
MedicalResearch.com: What is the background for this study?
Response: The opioid meperidine (Demerol) was widely prescribed in the United States (US) as an analgesic to treat moderate to severe pain. Meperidine was the most used opioid in the US in 1987 and was considered safer than other opioids during acute pancreatitis. Over the past two decades, meperidine has shifted from being frequently prescribed to being used only when patients are experiencing atypical reactions to opioids (e.g., morphine and hydromorphone); to removal from the World Health Organization's essential medication list and receiving strong warnings against its use from many professional organizations including the American Geriatrics Society. The unfortunate Libby Zion (1965-1984) case increased concerns about serotonin syndrome with meperidine.
According to a prior pharmacoepidemiology report, the distribution of meperidine in the United States decreased by 95% between 2001 and 2019 [1]. The aim of the study was to include updated information (2020 and 2021) as well as examine the changes among Medicaid patients [2].
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