Author Interviews, Cancer Research, HPV / 13.06.2025
ASCO25: Roswell Park Researchers Find Risk of Second Primary Malignancies Higher After HPV-Associated Cancers
MedicalResearch.com Interview with:
Pragati Advani MD, MPH, DrPH
Assistant Professor of Oncology, Department of Thoracic Surgery
And on faculty with the Department of Cancer Prevention and Population Sciences
Roswell Park Comprehensive Cancer Center
Buffalo, NY
MedicalResearch.com: What is the background for this study?
Response: In oncology, a study of second primary malignancy (SPM) is an emerging field that is predominantly driven by our success in identifying and treating the first primary cancers (FPCs). HPV is responsible for nearly a third of all infectious agent-related FPCs (including cancer of the oropharynx, anus, vulva, vagina, cervix and penis).
Advances in diagnostic and treatment methods have resulted in improved survivorship among these patients. However, they remain at risk for developing a SPM. No studies thus far had examined the risk of SPMs after HPV-associated FPCs, stratified by cancer site and gender.
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