Author Interviews, Cancer Research, Genetic Research / 25.04.2025
DDW25: Genetic Signature of Gastric Cancer Can Help Identify Patients with Poor Outcomes
MedicalResearch.com Interview with:
Ulysses Ribeiro M.D., PhD
Associate Professor of Digestive Surgery
Instituto do Câncer do Estado de São Paulo
MedicalResearch.com: What is the background for this study?
Response: Gastric cancer (GC) is one of the most common malignancies worldwide, and the 3th leading cause of cancer-related death. Although the diagnosis and treatment have substantially improved in recent years, the five-year survival rate of gastric cancer is still low due to local recurrence and distant metastasis.
Gastric cancer is a complex and heterogeneous disease that involves a series of genetic, epigenetic and phenotypic changes. Still, differences in prognosis and response to chemotherapy or immunotherapy are frequently seen in tumors with the same histological type and stage due to various genetic mutations and abnormal signaling pathways underlying the progression of this disease.
Thus, the purpose of this study was to perform a whole-gene sequencing to identify variants in genes with prognostic value in patients with gastric cancer who underwent curative surgery.
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