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Author Interviews, Cancer Research, Genetic Research / 25.04.2025

MedicalResearch.com Interview with: Ulysses Ribeiro M.D., PhD Associate Professor of Digestive Surgery Instituto do Câncer do Estado de São Paulo MedicalResearch.com: What is the background for this study? Response: Gastric cancer (GC) is one of the most common malignancies worldwide, and the 3th leading cause of cancer-related death. Although the diagnosis and treatment have substantially improved in recent years, the five-year survival rate of gastric cancer is still low due to local recurrence and distant metastasis. Gastric cancer is a complex and heterogeneous disease that involves a series of genetic, epigenetic and phenotypic changes. Still, differences in prognosis and response to chemotherapy or immunotherapy are frequently seen in tumors with the same histological type and stage due to various genetic mutations and abnormal signaling pathways underlying the progression of this disease. Thus, the purpose of this study was to perform a whole-gene sequencing to identify variants in genes with prognostic value in patients with gastric cancer who underwent curative surgery. (more…)
Cancer Research, Cannabis, Neurological Disorders, Pain Research / 16.04.2025

Editor’ note:  Cannabis and THCA/HEMP CBD products should have an active ingredient list on the container and have a Certificate of Analysis (COA).  Discuss your use of CBD products with your health care provider.  Dosing of CBD is variable, especially since it is not FDA regulated. CBD may interfere with other medications and should not be used in individuals with certain health conditions, including liver issues. CBD skin care products can be absorbed through the skin and have similar effects. Do not use Cannabis products including edibles and CBD if you are pregnant, nursing or may become pregnant. Do not use cannabis products if driving or operating difficult or dangerous machinery.  You fight through the appointments, the scans, the treatments, and then—when it’s supposed to be over—your body still feels off. For many cancer survivors, especially those who went through chemotherapy, neuropathy doesn’t just fade away. Sometimes it lingers, sometimes it gets worse, and sometimes it shows up in ways that completely change how you move. If you’re dealing with drop foot or numbness, burning, or pain in your feet, you’re not imagining it. You’re not alone. And while it’s incredibly frustrating, there are real things that can help. Understanding What’s Happening To Your Feet Post-cancer neuropathy isn’t just annoying—it can be debilitating. It usually starts because certain chemo drugs damage the nerves, especially in your hands and feet. This damage can mess with how your muscles and nerves talk to each other. So when your brain says “lift your foot,” your body doesn’t always get the message right. Drop foot is one of the more obvious results of that disconnect. It feels like your foot is dragging or slapping the ground when you walk. You might start tripping more, feel unsteady, or start avoiding certain shoes altogether. For others, the issue isn’t how the foot moves but how it feels—like walking on pins and needles, or not feeling it at all. Both are forms of neuropathy, and both can stick around long after treatment ends. The tricky part is that this isn’t something you can just walk off. It’s not about needing to stretch more or push harder. These symptoms come from actual nerve damage, which doesn’t always heal quickly—or fully. (more…)
Author Interviews, Cancer Research, Genetic Research / 15.04.2025

MedicalResearch.com Interview with: Myvizhi Esai Selvan, PhD Instructor of Genetics and Genomics Zeynep H. Gümüş, PhD Associate Professor Icahn School of Medicine at Mount Sinai MedicalResearch.com: What is the background for this study? Response: The germline genome of each individual person has a unique combination of millions of genetic variants that influence virtually all biological processes throughout life, including cancer evolution. In this study, we have investigated the impact of germline variants – genetic defects one is born with – on gene expression and protein abundance in tumors across cancer types. MedicalResearch.com: Would you describe the technique of precision peptidomics? Response: We have leveraged a cohort of 1,064 patients with multiple cancer types to explore the impact of germline variations on cancer-relevant genes through multiple-omics layers: from DNA to RNA, protein abundance and post-translational modifications. To assess the effects of coding variants and their association with cognate proteins, we used precision peptidomics, which is the quantification of peptides carrying genetic variants from individual patients. Through this approach, we mapped 337,469 protein coding germline variants onto patient peptides, revealing their potential impact on protein modifications, protein stability, allele-specific expression, and protein structure by leveraging the relevant protein databases. (more…)
Author Interviews, Dermatology, Medical Imaging, Melanoma / 14.04.2025

MedicalResearch.com Interview with: Pau Rosés-Gibert, MD Dermatology Department, Hospital Clínic Barcelona University of Barcelona, Fundació Clínic per la recerca biomédica, Institut d’Investigació Biomèdica August Pi i Sunyer, IDIBAPS Diagnosis Dermatologica, Dermavision Solutions Barcelona, Spain and Dermatology Department, Hospital de Figueres, Figueres, Spain MedicalResearch.com: What is the background for this study? Response: Skin cancer monitoring, particularly in high-risk patients with atypical mole syndrome, traditionally relies on total body photography (TBP) combined with digital dermoscopy. This approach, though effective, is slow, labor-intensive, and prone to oversight since clinicians must manually locate and image individual lesions. Recent improvements in automated imaging systems, lighting, and dermoscopy software have raised the potential for fully autonomous systems to streamline this process — leading to the development of the autonomous total body photographic and dermoscopic device tested in this study. (more…)
AACR, Cancer Research / 04.04.2025

MedicalResearch.com Interview with: Prof.  Patrick Tan MD PhD A senior author of the study and Senior Vice-Dean for Research at Duke-NUS Dr. Raghav Sundar MD PhD A senior author of the study and a senior consultant with the Department of Haematology-Oncology at the National University Cancer Institute, Singapore at the time of the research.       MedicalResearch.com: What is the background for this study? What are the gaps in knowledge that you were seeking to fill? Response: Gastric cancer is a serious health issue worldwide and particularly prevalent in parts of Asia, Europe and South America. Gastric cancers are difficult to treat due to frequent resistance to therapies like immunotherapy. There are also many subtypes of gastric cancer, which can now be recognised based on their histological and molecular characteristics. However, recent studies have shown that besides differences between patients, there are also significant variations within a single tumour, further challenging successful treatment. Our study aimed to better understand these intricate interactions and variations occurring within gastric tumours, particularly how these differences evolve and impact the immune microenvironment and patient outcomes. MedicalResearch.com: What are the main findings? Response:  Our study discovered extensive diversity within tumours, revealing two main evolutionary paths in gastric cancer: branched evolution and internal diaspora evolution. Each path was associated with different molecular characteristics, immune microenvironments and clinical outcomes. By analysing tumour samples at a high resolution, the study highlighted specific genes and pathways active in these subgroups that could be targeted for therapy. (more…)
Cancer Research / 28.03.2025

Solid Tumor Types and Oncology Resources Solid tumors are masses of tissue that grow in the organs, muscles or bones and are abnormal. Solid tumors are different from hematologic cancers, solid tumors do not involve blood or bone marrow. Depending on where they come from, they can be categorized as different types of cells, and they arise from either site. Early detection and proper classification of solid tumors have an impact on the treatment and the outcome of the patient. Today, there is medical research and techniques that healthcare professionals have that can diagnose cancer and improve cancer treatment. Information on Solid Tumor Types can assist healthcare professionals in a better understanding of tumor classifications and their implications regarding treatment.

Types of Solid Tumors

Epithelial cells give rise to carcinomas, the most common carcinomas (breast, lung, colorectal, etc.). Breast cancer is the most common cancer diagnosed among women cancer while lung cancer is the main cause of cancer deaths. Also, there is quite a significant incidence rate of colorectal cancer in which the colon or rectum is the location of the issue. The other category is Sarcomas; they develop in connective tissues which include bone, fat and muscle. For example, osteosarcoma commonly affects bones of younger individuals, and liposarcoma usually arises in the fat cells of deep soft tissues. Further, central nervous system (CNS) tumors include tumors of the brain and the spinal cord; the most aggressive is glioblastoma, whilst such tumors have a poor prognosis. When healthcare professionals refer to Oncology Resources, to can get up-to-date information regarding the latest guidelines and developments in cancer treatment (more…)
Mesothelioma / 27.03.2025

Mesothelioma is a rare and aggressive cancer caused primarily by exposure to asbestos. The majority of mesothelioma cases affect the pleural area of the lungs, but the disease can also develop in abdominal, heart, or testicular tissues. The treatment of mesothelioma remains challenging because doctors detect it late, and it advances quickly, yet medical science brings new hope to those affected by this disease. Here are five current treatments available for mesothelioma, giving you and your loved ones hope.

1.   Surgery: Removing the Tumor

With early-diagnosis patients benefit most from surgery, which extends their survival time and enhances their quality of life. Two primary surgical treatments exist for pleural mesothelioma diagnosis:
  • Extrapleural Pneumonectomy (EPP): The aggressive treatment method Extrapleural Pneumonectomy (EPP) requires surgeons to remove both the affected lung and diaphragm segments and the pleural lining surrounding the heart. The operation removes significant tumor mass but requires a long recovery, and it works best for early-stage pleural mesothelioma patients, particularly those with the epithelial cell type, as it tends to respond better to treatment.
  • Pleurectomy/Decortication (P/D): Medical professionals remove the lung lining and chest wall tissues but leave the lung intact. When patients cannot endure whole-lung removal, P/D provides a treatment option that alleviates symptoms and helps prevent disease advancement.
In peritoneal mesothelioma, Cytoreductive Surgery (CRS) is combined with heated intraperitoneal chemotherapy (HIPEC), which has shown promising survival outcomes. Receiving a mesothelioma diagnosis can be overwhelming, and navigating treatment options often comes with emotional and financial challenges. If you're in the area, consulting a Missouri mesothelioma lawyer can help you understand your legal rights and explore compensation options to cover medical expenses related to these advanced treatments. (more…)
Legal-Malpractice, Mesothelioma / 25.03.2025

Mesothelioma is a rare and aggressive cancer primarily caused by asbestos exposure, making legal assistance crucial for affected individuals. Navigating the complexities of legal options can be daunting, but it's essential for securing compensation. This guide provides insights into understanding the legal process and the importance of timely action. Mesothelioma, often linked to asbestos exposure in workplaces, demands specialized legal attention. As someone affected by this condition, you need to understand the intricacies of the legal process that can help you seek justice and compensation. The role of mesothelioma attorney assistance cannot be understated, as experienced lawyers guide you through the lawsuit maze. This article aims to empower you with knowledge about your legal rights and options. (more…)
Mesothelioma, Veterans / 23.03.2025

Mesothelioma is an aggressive type of rare cancer that affects the lungs, heart, or abdomen linings. One of the most at-risk groups for developing mesothelioma is Navy veterans. Due to prolonged asbestos exposure, a material used in naval ships and shipyards, many veterans face a higher likelihood of developing this devastating disease. The Link Between Asbestos Exposure and Mesothelioma Asbestos was commonly used in naval vessels throughout much of the 20th century due to its fire-resistant and insulating properties. Unfortunately, prolonged exposure to asbestos fibers can lead to serious health complications, including mesothelioma. When these fibers are ingested or inhaled, they can be stored in the body, causing inflammation, scarring, and the development of cancerous tumors. Where Was Asbestos Found on Navy Ships? Navy ships were filled with asbestos-containing materials, including:
  • Boiler rooms: Used for insulation around pipes, boilers, and engines.
  • Shipyards: Workers building and repairing ships frequently handled asbestos materials.
  • Insulation materials: Found in walls, ceilings, and floors to protect against extreme temperatures.
  • Gaskets and valves: Used to seal mechanical components, often releasing asbestos fibers during maintenance or repairs.
Navy personnel who worked in these environments, particularly shipyard workers, boiler technicians, and machinist mates, faced some of the highest levels of exposure. (more…)
Legal-Malpractice, Mesothelioma / 22.03.2025

  If you or someone you are close to has been diagnosed with mesothelioma, you do not have the time to waste. It is a serious case, and you need the right attorney fast. However, not just any attorney will do. You need someone who is well-versed in the world of mesothelioma lawsuits. Keep reading to learn how to find the right attorney for your needs.

1. Experience

Just like you wouldn't trust a general doctor to perform brain surgery, the same rule will apply here. You don't just want any lawyer. You need one who specializes in mesothelioma and asbestos cases. These cases are complex, and they require knowledge of asbestos exposure history, medical evidence, and the tactics that big corporations use to dodge responsibility. (more…)
Legal-Malpractice, Mesothelioma / 19.03.2025

Mesothelioma is a devastating cancer linked to asbestos exposure, affecting many each year. Victims often face overwhelming medical and financial burdens, making legal avenues a crucial consideration. Understanding the available options can empower patients and their families to seek justice and compensation. Mesothelioma is a rare but aggressive form of cancer primarily caused by prolonged exposure to asbestos fibers. This disease often manifests years after initial exposure, leaving many unaware of its impending threat. As the medical community continues to search for effective treatments, understanding the legal pathways becomes essential for patients seeking compensation. Legal recourse offers a means to address not only the medical expenses but also the emotional and financial turmoil faced by affected individuals and their families. Engaging with top rated mesothelioma lawyers can significantly enhance your ability to understand and pursue these legal avenues effectively. (more…)
Author Interviews, Cancer Research, Colon Cancer, Stem Cells / 14.02.2025

MedicalResearch.com Interview with: Slim Mzoughi, PhD Assistant Professor Icahn School of Medicine at Mount Sinai Department of Oncological Sciences Hess Center for Science and Medicine New York, NY 10029 MedicalResearch.com: What is the background for this study? Response: Resistance to current cancer treatments remains one of the biggest challenges in oncology, often leading to cancer recurrence even after patients appear to be in remission. To overcome this obstacle, we first need to understand the mechanisms behind this resistance. For a long time, treatment resistance in colorectal cancer (CRC)—the second deadliest cancer worldwide—has been attributed to a specific group of cells known as LGR5+ cancer stem cells. However, recent studies suggest that simply targeting these cells is insufficient for achieving long-term cancer control. That’s where our study comes in—to uncover why this is the case. MedicalResearch.com:  What are the main findings? Response:  Our study reveals that, early in tumor formation, LGR5+ cancer stem cells undergo molecular changes that render them unrecognizable. These changes cause them to resemble those found in the developing fetal intestine. In a way, this transformation reminds me of the legend of Edward Mordake, where these now fetal-like cells act as the “demon face” of cancer stem cells, resisting and surviving treatment. Crucially, we have identified the mechanism driving this reversion to a fetal-like state, which we term oncofetal-reprogramming. Excitingly, when we targeted the oncofetal cell state alongside existing chemotherapy treatments, this significantly enhanced treatment effectiveness and extended survival in preclinical models, offering new hope for CRC patients. (more…)
Lung Cancer / 05.02.2025

One of the leading causes of cancer-related deaths worldwide is lung cancer. Among the various types of lung cancer, squamous cell carcinoma is a common type that usually develops in the central part of the lungs, commonly in the bronchi, and is majorly caused by smoking. Though any type of cancer diagnosis can be overwhelming, early detection can be a crucial factor as it relates to treatment options and overall survival rates. Let's learn about the role early detection plays below.

Why is early detection important?

No one likes to think of cancer, not to mention getting tested for it. However, when it comes to this type of cancer, early detection increases the odds of a successful treatment. Let's find out why:
  • More treatment options: When this cancer is diagnosed early, patients have more options available, such as radiation, targeted therapy, and surgery. When it is detected at an advanced stage, the treatments are often limited to immunotherapy and chemotherapies, which might not be as effective in removing the disease.
  • Increased survival rates: Early-stage lung cancer has a better prognosis than advanced-stage diseases. According to research, the five-year survival rate of cancer that has not spread beyond the lungs (localized cancer) is around 63% as against 7% when it has spread to distant organs. Catching squamous cell carcinoma early can mean the difference between effective treatment and a tougher battle.
  • Better quality of life: There is no doubt that cancer treatment can be quite tough. However, when this cancer is diagnosed early, the treatment is usually less aggressive, resulting in fewer side effects and a better overall quality of life.
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Cancer Research, Environmental Risks, Mesothelioma / 30.01.2025

  Mesothelioma, a rare, aggressive cancer, often grows on the thin tissue layer that lines the abdomen or lungs. Prolonged exposure to asbestos is considered the primary risk factor for developing this disease because eight out of 10 of those with mesothelioma claim asbestos exposure. Age, gender, and genetics are other mesothelioma risk factors. Discussed below is what you need to know about mesothelioma.

Mesothelioma stages

Upon being diagnosed with mesothelioma, the next step is figuring out if and how far it has spread. This is where staging comes in. A cancer stage describes the amount of cancer in the body. Staging helps determine how severe the mesothelioma is and how best it can be treated. There are four mesothelioma stages, which are classified based on size, location, and the number of tumors. They include:
  • Stage 1: Early tumor growth develops along one of the lung’s mesothelial lining.
  • Stage 2: The cancer cells have already spread to the lymph nodes nearby.
  • Stage 3: At this level, the mesothelioma cancer tumors have invaded deeper tissues in distant lymph nodes and close organs.
  • Stage 4: The cancer tumors have spread and reached distant organs.
Knowing your mesothelioma stage at diagnosis can influence your treatment options. (more…)
Author Interviews, Cancer Research / 28.01.2025

MedicalResearch.com Interview with: Christopher Choi, PhD, MBA Senior Vice President of Industry Partnerships Associate Professor of Oncology Technical Director of GMP Engineering & Cell Manufacturing Roswell Park Comprehensive Cancer Center Buffalo, NY MedicalResearch.com: What is the background for this study?  What is a GMP facility? Response: The opening of the Roswell Park GMP Engineering & Cell Manufacturing Facility (GEM) facility marks a significant milestone in advancing cell and gene therapy research at Roswell Park. Our GMP (Good Manufacturing Practice) facility is a specialized manufacturing space designed to produce cell-based and gene-based products under stringent regulatory conditions to ensure product safety, quality and consistency. These facilities are critical for translating innovative research into clinical-grade products that meet regulatory standards for use in patient care. The GEM Facility is part of our commitment to driving the next generation of cancer treatments and other advanced therapies, addressing a critical bottleneck in the development of these transformative technologies. (more…)
Author Interviews, Immunotherapy, Lymphoma / 27.01.2025

MedicalResearch.com Interview with: Joshua Brody MD Director, Lymphoma Immunotherapy Program Icahn School of Medicine at Mount Sinai Hess Center for Science and Medicine New York, New York 10029   MedicalResearch.com: What is the background for this study?
  • Patients with relapsed diffuse large B-cell lymphoma (DLBCL) have poor outcomes.
  • Standard chemotherapy e.g. Gemcitabine + Oxaliplatin (GemOx) yields complete response in ~30% of these patients.
  • Epcoritamab, a CD3xCD20 bispecific antibody immunotherapy was recently approved for relapsed DLBCL as monotherapy but is not yet approved as part of combination therapy.
  • Other immunotherapies e.g. CAR-T have been difficult to combine with standard therapies.
(more…)
Author Interviews, Nutrition, Prostate Cancer / 29.12.2024

By Dr. Dan Sperling M.D., D.A.B.R. Medical Director and Chief of Interventional Uroradiology at the Sperling Prostate Center in Florida Medical Director of its parent practice, the Sperling Medical Group If the name Dr. Dean Ornish rings a bell, it’s probably because over 30 years ago he became the poster boy for preventing heart disease through diet and exercise. His 1990 book, “Dr. Dean Ornish's Program for Reversing Heart Disease,” made the NYTimes best seller list. To this day, when we think of Dr. Ornish, we think of a long and heart-healthy life. Although we don’t link Dr. Ornish with prostate health, there’s good reason to do so—but most men don’t know it. In 2008, the National Academy of Sciences published research  by Dr. Ornish and his team in an article titled “Changes in prostate gene expression in men undergoing an intensive nutrition and lifestyle intervention.” They broke new ground in our understanding of preventing prostate cancer (PCa). Dr. Ornish and his team showed that a comprehensive lifestyle program they designed actually caused changes in gene regulation. They designed an experimental lifestyle protocol and tested is on 30 PCa patients; all 30 had been diagnosed with low-risk PCa and were on Active Surveillance (no other treatment). At the start of the 3-month study, each patient’s biopsy samples were used to profile his PCa gene activity. Then all participants adhered faithfully to the following protocol:
  • A vegan (plant-based) diet (with 10% of calories from fat
  • Physical activity (walking 30 minutes a day for 6 days a week)
  • Stress reduction (yoga, progressive relaxation, breathing, meditation)
  • Dietary supplements (vitamins C and E, soy, fish oil, selenium)
  • A weekly support group to provide advice and sustain adherence to the program.
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Author Interviews, Cancer Research, Lymphoma, Nutrition, University of Pennsylvania / 24.12.2024

MedicalResearch.com Interview with: Shan Liu, PhD, Postdoctoral fellow Perelman School of Medicine University of Pennsylvania MedicalResearch.com: What is the background for this study? Response: Our study provides evidence that the efficacy of CAR T cell immunotherapies can be influenced by an important lifestyle factor: diet.   MedicalResearch.com: What are the main findings? Response:  Our study found that a ketogenic diet can enhance CAR T cell function through its metabolite, β-Hydroxybutyrate (BHB). Importantly, instead of altering the diet, providing BHB via oral supplementation in our preclinical model is sufficient to improve the anti-tumor function of CAR T cells. However, it's important to note that we’re still in the early stages, and we’re not yet recommending any dietary changes or supplements for patients. (more…)
Colon Cancer / 23.12.2024

If you have irregular bowel movements, blood in your stool, weight loss, black stool, pain or other gastrointestinal changes or issues, please see your health care provider as soon as possible. The  US Preventive Services Task Force (USPSTF)  recommends most individuals should start regular colon cancer screening at age 45, earlier if there is a family history of colon cancer or polyps, a history of bowel disease, symptoms or at your provider's recommendation. link-colon-polyps-and-cancer.jpg Colon and colorectal cancer are among the top types of cancer diagnoses worldwide - with countless patients across the globe being diagnosed with either of the two according to data from top health authorities. The cause behind the two? Abnormal cell growth in the colon or rectum. This growth is called a polyp.   And did you know that learning about key facts about polyps and colorectal cancer can save your life? Education is power. Take charge of your colon health by providing yourself with useful information about the aforementioned subject with the pointers below. (more…)
Author Interviews, Cancer Research, Exercise - Fitness, Hematology / 16.12.2024

MedicalResearch.com Interview with: Janine Joseph, MS, MBA Senior Research Specialist Cancer Prevention & Control Roswell Park Comprehensive Cancer Center Buffalo, NY MedicalResearch.com: What is the background for this study? Response: Due to improvements in treatments, patients with multiple myeloma (MM) are experiencing longer lifespans and seeking ways to enhance their quality-of-life.  Fatigue, pain and negative psychological states such as anxiety and depression are common in cancer patients, including patients with MM.  Pain is particularly relevant, as MM can cause painful osteolytic (bone) lesions. The trials we discussed at ASH were aimed at evaluating the effect of exercise, specifically supervised resistance training and unsupervised walking exercise, on these and other states, including physical function and immune profile. (more…)
Author Interviews, Cancer Research, NEJM, NIH, OBGYNE / 05.12.2024

MedicalResearch.com Interview with: Diana W. Bianchi, M.D. Senior Investigator Center for Precision Health Research Director, Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health MedicalResearch.com: What is the background for this study? Response: The ability of prenatal cell-free DNA (cfDNA) sequencing to incidentally detect maternal cancers has been demonstrated by several retrospective studies from commercial or national laboratories. However, there are no standardized approaches to the identification and medical management of prenatal screening results that might indicate a maternal cancer. We sought to prospectively identify DNA sequencing patterns and other biomarkers that could distinguish which women with nonreportable or unusual cfDNA sequencing results had cancer and to determine the best approach for diagnostic work-up of pregnant people who receive these results. (more…)
Cancer Research, Chemotherapy / 26.11.2024

Cancer treatment has made significant advancements over the years, offering hope and extended lifespans to millions of patients worldwide. However, while these treatments are often life-saving, they can come with a wide range of unpleasant side effects that impact daily living. For many patients, managing these side effects becomes an essential part of the recovery journey. Understanding what to expect, and finding strategies to cope, can help improve quality of life during and after cancer treatment. This article explores common side effects of cancer therapies and offers practical tips for living through these challenges. Understanding the Common Side Effects of Cancer Treatment Cancer treatment can involve various methods, including chemotherapy, radiation therapy, immunotherapy, targeted therapies, and surgery. Each type of treatment comes with its own set of side effects, which can vary in intensity depending on the individual's overall health, type of cancer, and the specific therapy used. Some of the most common side effects include:
  • Fatigue: Fatigue is unfortunately one of the most frequent complaints among cancer patients undergoing treatment. Unlike everyday tiredness, cancer-related fatigue can be severe and persistent, making even simple tasks feel overwhelming.
  • Nausea and Vomiting: Chemotherapy and radiation can trigger nausea and vomiting as the body reacts to the aggressive nature of the treatments. While anti-nausea medications can help, these symptoms can still be a significant source of discomfort.
  • Hair Loss: Hair loss is a very well-known side effect of many chemotherapy drugs, which target rapidly dividing cells. This can include hair on the scalp as well as eyebrows, eyelashes, and body hair. For many, this physical change can be emotionally challenging.
  • Mouth Sores and Dryness: Treatments like chemotherapy and radiation can cause sores in the mouth, making it painful to eat, drink, and even speak. Dry mouth, caused by damage to salivary glands, is another common issue that can interfere with taste and oral comfort.
  • Skin Changes: Radiation therapy can lead to skin reactions, including redness, peeling, or darkening of the treated area. Some patients may also experience sensitivity to the sun and a tendency to bruise easily.
  • Cognitive Changes ("Chemo Brain"): Many patients experience difficulties with memory, concentration, and mental clarity during and after chemotherapy, a phenomenon often referred to as "chemo brain." This can make it harder to focus on tasks or remember details.
For more information on symptoms associated with certain cancers like Hodgkin lymphoma, you can visit this resource from Moffitt Cancer Center. (more…)
Author Interviews, Genetic Research, Leukemia, Personalized Medicine / 12.11.2024

MedicalResearch.com Interview with: Professor Ong Sin Tiong Cancer & Stem Cell Biology Signature Research Programme Duke-NUS Medical School, Singapore Dr Yu Mengge Research Fellow, Cancer & Stem Cell Biology Signature Research Programme Duke-NUS Medical School MedicalResearch.com: What is the background for this study? Response: The background of this study is rooted in the observation that certain genetic variations among East Asian populations, notably the BIM deletion polymorphism (BDP), impact treatment outcomes in chronic myeloid leukaemia (CML). Patients with the BDP show resistance to conventional treatments, specifically tyrosine kinase inhibitors like imatinib. This resistance stems from the variant's role in promoting cancer cell survival, which leads to more aggressive disease progression. (more…)
AI and HealthCare, Author Interviews, Breast Cancer, Genetic Research / 06.11.2024

MedicalResearch.com Interview with: Prof. Dina Schneidman-Duhovny PhD Academic researcher Hebrew University of Jerusalem MedicalResearch.com: What is the background for this study? What are the main findings? Response: The study analyzed genetic data of 12 families (~ 40 patients) with high incidence of breast cancer cases. Most families originate from ethnic groups that are poorly represented in public resources. All participants were tested negative to all known breast cancer predisposing genes. We developed a novel approach to study genetic variants utilizing state-of-the-art deep learning models tailored for analysis of familial data. The study highlighted 80 high-risk genes (out of > 1200 genes) and narrowed down on a group of 8 genes circulating in 7 out of 12 families in the study. These genes are involved in a cellular organelle called the peroxisome and play a role in fatty acids metabolism. We show that  these genes significantly affect breast cancer survival and use 3-dimensional protein structural analysis to illustrate the effect of some of the variants on protein structure. These provide strong evidence of the peroxisome involvement in breast cancer predisposition and pathogenicity, and provide potential targets for patient screening and targeted therapies. (more…)
Author Interviews, Ovarian Cancer / 04.11.2024

MedicalResearch.com Interview with: Alessia Baccarini, PhD Assistant Professor Dept. of Immunology and Immunotherapy (DII) Icahn School of Medicine at Mount Sinai New York, New York 10029 MedicalResearch.com: What is the background for this study? Response: Ovarian cancer is characterized by a complex tumor microenvironment (TME) that significantly contributes to resistance against immunotherapy, particularly immune checkpoint blockade (ICB) therapies like anti-PD-1. Understanding the extracellular signals—such as cytokines and chemokines—that ovarian cancer cells utilize to create an immunosuppressive TME is critical for improving treatment outcomes. Our research focuses on elucidating how these signaling factors contribute to tumor growth and immune evasion. We utilized a novel genomic functional approach called Perturb-map to study intratumoral heterogeneity (ITH) in ovarian cancer within a mouse model, allowing us to investigate the communication between ovarian cancer cells and immune cells.  (more…)
Brain Cancer - Brain Tumors, Immunotherapy, Vaccine Studies / 04.11.2024

brain-cancer-glioblastoma Glioblastoma is one of the most challenging cancers to treat due to its aggressive nature and resistance to standard therapies. In recent years, however, the field of glioblastoma immunotherapy has made significant strides, introducing innovative approaches like oncolytic viruses and brain cancer vaccines. These emerging treatments aim to engage the immune system in the fight against glioblastoma, offering new avenues for improving patient outcomes and extending survival rates.

The Current State of Glioblastoma Treatment

  With a median survival rate of only 12-15 months, glioblastoma patients face difficult odds. Traditional treatments often manage to slow tumor growth temporarily, but recurrence is common. This grim reality has motivated researchers to explore innovative therapies that leverage the body’s immune system, including oncolytic viruses and personalized vaccines.

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Author Interviews, Cancer Research, Leukemia, Stem Cells / 01.11.2024

MedicalResearch.com Interview with: Eirini Papapetrou, MD, PhD Professor of Oncological Sciences Professor of Medicine, Hematology and Medical Oncology Director, Center for Advancement of Blood Cancer Therapies Co-Director, Stem Cell Engineering Core Icahn School of Medicine at Mount Sinai New York, NY 10029   MedicalResearch.com: What is the background for this study? What are the main findings? Response: RAS in the most commonly mutated oncogene in human cancers. Particularly in acute myeloid leukemia, about one third of cases have RAS mutations. We set out to understand the role of these mutations in the development of leukemia and in response to treatment. We found that RAS mutations happen late in the course of the disease as progression mutations because they are acquired by more mature leukemic cells coming from preexisting leukemia stem cells (LSCs). Importantly, these more mature cells, upon acquisition of RAS mutations, become leukemia stem cells (LSCs) with different properties than the previous LSCs. Most critically, they develop resistance to a recently FDA-approved drug for the treatment of leukemia, venetoclax (VEN). In addition, these RAS-mutated LSCs give rise to leukemia cells with monocytic differentiation. Both RAS mutations and monocytic differentiation of AML have previously been associated with VEN resistance in clinical studies. We show that it is the RAS mutations that cause both the monocytic differentiation and the VEN resistance. Thus, poor patient outcomes after VEN therapy are driven by RAS mutations and not by monocytic disease.  (more…)
Author Interviews, Breast Cancer, Surgical Research / 26.10.2024

Breast Reconstructive Surgery:

According to BreastCancer.org, the decision to have breast reconstructive surgery doesn’t have to be decided immediately following surgery to remove the breast. It can be done during mastectomy surgery or following surgery, so those who are uncertain about their decision have time to weigh the options before deciding on their best option. There are many things to consider breast reconstruction surgery, including the toll it will take on your body and how your appearance may change from before until after the surgery. Here are some things to consider if you have undergone a mastectomy. These are presented by Cancer.gov:
  • Breasts can be rebuilt using implants that contain either saline or silicone. They can also be rebuilt by using tissue elsewhere in the body.
  • The surgery can be done at the same time as the mastectomy (an immediate reconstruction) or after the surgery when the skin and incisions have had time to heal. Often, treatment is conducted during this healing time.
  • A nipple and areola can be added to the breast during the initial surgery or at a later time.
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