OBGYNE / 11.05.2026
Endometriosis Linked to Higher Risk of Congenital Anomalies in Offspring, Large Ontario Study Finds
MedicalResearch.com Interview with:
[caption id="attachment_73653" align="alignleft" width="150"]
Bailey Milne[/caption]
Bailey Milne
PhD Graduate Student | Epidemiology
Queen's University | Department of Public Health Sciences
Kingston, ON
A large population-based study using health administrative data from Ontario examines whether endometriosis is associated with an increased risk of congenital anomalies in offspring — with findings that suggest increased monitoring may be warranted for affected pregnancies.
MedicalResearch.com: What is the background for this study? The study was conducted using health administrative data in Ontario. The data was from 2006 to 2021, which resulted in over 1.4 million mother-baby pairs. Endometriosis is an inflammatory condition where the uterine lining grows outside of the uterus, which can result in painful menstruation, intercourse and bowel movements. Roughly 10% of reproductive aged patients have endometriosis, and of those, 30–60% have infertility.
Bailey Milne[/caption]
Bailey Milne
PhD Graduate Student | Epidemiology
Queen's University | Department of Public Health Sciences
Kingston, ON
A large population-based study using health administrative data from Ontario examines whether endometriosis is associated with an increased risk of congenital anomalies in offspring — with findings that suggest increased monitoring may be warranted for affected pregnancies.
MedicalResearch.com: What is the background for this study? The study was conducted using health administrative data in Ontario. The data was from 2006 to 2021, which resulted in over 1.4 million mother-baby pairs. Endometriosis is an inflammatory condition where the uterine lining grows outside of the uterus, which can result in painful menstruation, intercourse and bowel movements. Roughly 10% of reproductive aged patients have endometriosis, and of those, 30–60% have infertility.
Shani Vaknine[/caption]
Shani Vaknine, Ph.D. candidate
Brain and Behavioral Sciences
The Hebrew University
MedicalResearch.com: What is the background for this study?
Response: We’ve long known that maternal stress during pregnancy can affect her baby’s development, but the molecular mechanisms behind this remained unclear. In our study, we explored how psychosocial stress experienced by the mother in late pregnancy influences tiny molecular fragments in the newborn’s blood. These fragments, called transfer RNA fragments or tRFs, were considered for many years to be disposable, but have recently been shown to have important biological functions.
Dr. Ådén[/caption]
Ulrika Ådén PhD
Professor of Neonatology
Department of Women's and
Children's Health Karolinska
MedicalResearch.com: What is the background for this study?
Response: Children born preterm are at higher risk of cognitive impairment during childhood and later in life. However, an important unresolved question is whether these impairments primarily reflect genetic susceptibility or are driven by the biological consequences of being born too early. Cognitive development is known to have a strong heritable component (~70 %), and previous studies have attempted to disentangle genetic and environmental contributions, for example through sibling comparison designs. Although informative, such approaches have inherent limitations.
In this study, we aimed to investigate long-term cognitive outcomes across a range of gestational age groups including very preterm, moderately preterm, late preterm, and early term, compared to children born full term. Importantly, we accounted for genetic influences as well as a range of potential confounding factors, including prenatal risks and child-specific factors. This approach provides a more nuanced understanding of the extent to which cognitive outcomes associated with preterm birth reflect biological versus inherited risk.
John W. Ayers, PhD, MA
Altman Clinical Translational Research Institute
University of California
San Diego, La Jolla
MedicalResearch.com: What is the background for this study?
Response: Crisis pregnancy centers (CPCs) are frequently at the center of news
and policy debates, yet little data exists about where they operate or
what they actually do. To address this gap, we developed