Flibanserin- Addyi -Improved Sexual Health in Women With Hypoactive Sexual Desire Disorder

MedicalResearch.com Interview with:

Dr. Michael Krychman, MD Executive Director: The Southern California Center for Sexual Health and Survivorship, Medical Director: Sexual Medicine at Hoag Hospital Newport Beach CA Clinical faculty member University of Southern California Los Angeles, CA

Dr. Krychman

Dr. Michael Krychman, MD
Executive Director: The Southern California Center for Sexual Health and Survivorship,
Medical Director: Sexual Medicine at Hoag Hospital Newport Beach CA
Clinical faculty member
University of Southern California
Los Angeles, CA

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: This post hoc analysis pooled data from three 24-week, double-blind, placebo-controlled studies (VIOLET, DAISY, and BEGONIA) of flibanserin in premenopausal women with acquired, generalized HSDD5-7. Patients who received flibanserin 100 mg once daily at bedtime (qhs) or placebo were included in the analysis. The Female Sexual Function Index (FSFI) consists of 19 items across 6 domains. Scores range from 2 to 36. Higher scores indicate better sexual functioning. Scores under 26 indicate sexual dysfunction. Analysis of covariance was used to evaluate changes from the first week to week 24 in the FSFI domain and total scores were compared for flibanserin 100 mg qhs versus placebo. For patients who discontinued study participation prior to week 24, the last postbaseline observation was carried forward (LOCF).

Results found that treatment with flibanserin 100 mg qhs produced statistically significant improvement, relative to placebo, on all domains of the FSFI (desire, arousal, lubrication, orgasm, satisfaction and pain) in premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD).

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Community Targeting of High Risk Minority Males Improves HIV Detection and Treatment

MedicalResearch.com Interview with:

Robin Lin Miller, Ph.D. Professor, Ecological-Community Psychology Co-Director, MA in Program Evaluation Chair, Graduate Program in Ecological-Community Psychology Michigan State University East Lansing, MI 48824

Dr. Miller

Robin Lin Miller, Ph.D.
Professor, Ecological-Community Psychology
Co-Director, MA in Program Evaluation
Chair, Graduate Program in Ecological-Community Psychology
Michigan State University
East Lansing, MI 48824
MedicalResearch.com: What is the background for this study?

Response: We wanted to identify promising strategies for providing access to HIV-testing for gay and bisexual male youth. We were especially interested in testing strategies to reach gay and bisexual male youth of color, as they bear a disproportionate burden of the HIV epidemic and are the least likely to be aware of their HIV status. We also wanted to explore approaches to successfully link these youth with HIV-negative test results to diverse HIV prevention services, including pre-exposure prophylaxis, when warranted.

Although some argue that the ideal place to test adolescents and young adults is via emergency rooms and in routine medical care visits, we found that we were able test many more youth with previously undiagnosed HIV-infection through intensive, targeted community outreach efforts. We also tested a much higher proportion of young men of color through targeted outreach.

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LGBTQ+ Patients Have Poor Sleep Compared to Heterosexuals

MedicalResearch.com Interview with:

Jen-Hao Chen PhD Assistant Professor Department of Health Sciences and School of Public Affairs University of Missouri - Columbia

Dr. Jen-Hao Chen

Jen-Hao Chen PhD
Assistant Professor
Department of Health Sciences and School of Public Affairs
University of Missouri – Columbia

MedicalResearch.com: What is the background for this study?

Response: It has been well known that sexual minority adults in the US have worse health as compared with heterosexual peers. Queer folks are found to have poorer physical, mental and behavioral health outcomes because of their marginalized status and social environments. But we know very little about prevalence of sleep problems in the population of sexual minorities compared to heterosexual people. Do sexual minorities lose sleep? Do they wake up more often during the night? Do they sleep less? This study aims to address this important gap in the LGBT health literature. Using recent nationally representative data, we exam whether sexual minority adults have greater odds of having short sleep duration and poor sleep quality. In addition, we also investigate sexual minorities’ sleep in the context of gender and race/ethnicity  Continue reading

High Risk Individuals Are Testing For HIV More Frequently

MedicalResearch.com Interview with:
Qian An, PhD

Epidemiologist/statistician
Division of HIV/AIDS Prevention
CDC

MedicalResearch.com: What is the background for this study?

Response: Since 2006, the Centers for Disease Control and Prevention (CDC) has recommended HIV testing for all persons aged 13-64 years old. Persons at high risk for HIV infection should be tested more frequently. Among sexually active men who have sex with men (MSM), repeat testing is recommended at least annually. An analysis in 2011 suggested that MSM might benefit from more frequent than annual testing.(1)

Among non-MSM, repeat testing is recommended at least annually for persons at high risk, including persons who inject drugs (PWID) and their sex partners, those who have sex in exchange for money or drugs, heterosexuals who have had more than one sex partner since their most recent HIV test, and those whose partners are living with HIV..

Using statistical models based on renewal theory, we estimate the mean HIV inter-test interval (ITI) — meaning the average time period (in months) between two successive HIV tests — to describe temporal trends in HIV testing frequency among MSM, PWID and high-risk heterosexuals (HRH) and differences in testing frequency by age and race/ethnicity. A decrease in ITI means individuals are testing more frequently.

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Too Busy? Too Tired? Not in a Relationship? Why are Americans Having Less Sex?

MedicalResearch.com Interview with:

Brooke E. Wells, Ph.D. Associate Professor & PhD Program Director Center for Human Sexuality Studies Widener University One University Place Chester, PA 19013

Dr. Brooke Wells

Brooke E. Wells, Ph.D.
Associate Professor & PhD Program Director
Center for Human Sexuality Studies
Widener University
One University Place
Chester, PA 19013

MedicalResearch.com: What is the background for this study?

Response: It is widely believed that Americans today are more sexually liberated and open than ever before. While research indicates that Americans do indeed have more liberal attitudes about a range of sexual behaviors, Americans are actually reporting fewer sexual partners and higher rates of adult sexual abstinence. But are Americans reporting similar levels of sexual frequency with fewer partners? Our research set out to examine changes over time in sexual frequency to better understand our changing sexual landscape.

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Frequent Cause of Infertility, Pelvic Inflammatory Disease, Often Goes Unrecognized

Dr. Kirsten Kreise

Dr. Kristen Kreisel

MedicalResearch.com Interview with:
Dr. Kristen Kreisel PhD
Epidemiologist at Centers for Disease Control and Prevention
Centers for Disease Control and Prevention

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: Pelvic inflammatory disease (PID), an infection of the female reproductive tract often associated with STDs, is putting millions of women at risk for infertility, ectopic pregnancy and chronic pelvic pain. Our study looked at data from the National Health and Nutrition Examination Survey to estimate the national burden of PID. Findings show an estimated 4.4 percent of sexually-experienced women aged 18-44, or approximately 2.5 million woman nationwide reported a history of PID.

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Married Men Live Longer, Wealthier Lives and Have More Sex

MedicalResearch.com Interview with:

Nicholas H. Wolfinger PhD Professor, Department of Family and Consumer Studies Adjunct Professor, Department of Sociology University of Utah Salt Lake City, UT 84112-0080

Dr. Nicholas Wolfinger

Nicholas H. Wolfinger PhD
Professor, Department of Family and Consumer Studies
Adjunct Professor, Department of Sociology
University of Utah
Salt Lake City, UT 84112-0080

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: W. Bradford Wilcox and I have been studying marriage and divorce for fifteen years. Last year we published Soul Mates: Religion, Sex, Love and Marriage among African Americans and Latinos (Oxford University Press). We’re always looking for opportunities to present our findings to the public, so Valentines Day is a great excuse!

It’s probably too strong a statement to call our new research brief a study, as we’re not offering any novel findings. Instead, we’re just compiling data from different sources—some published by other scholars, some based on our own analysis of national data—to reaffirm a basic point: marriage is good for men in myriad ways (Marriage is also good for women, but they await their own research brief.) In particular, marriage offers these benefits to men:

  • Higher earnings, greater assets and more job stability. Married men make about $16,000 a year more than their single peers with otherwise similar backgrounds.
  • Better sex lives compared to both single and cohabiting men. According to data from the National Health and Social Life Survey, 51 percent of married men report they are extremely emotionally satisfied with sex, compared to 39 percent of cohabiting men and 36 percent of single men.
  • Longer and happier lives. Men who get and stay married live almost 10 years longer than their unmarried peers. Also, young married men are about twice as happy: 43 percent of married men report they are “very happy” with life, compared to 20 percent of single men and 24 percent of cohabiting men.

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Radiofrequency Therapy For The Treatment Of Vaginal Laxity

MedicalResearch.com Interview with:

Dr. Michael Krychman

Dr. Michael Krychman

Dr. Krychman is Executive Director, President, and CEO of the Southern California Center for Sexual Health and Survivorship Medicine and Associate Clinical Professor at the University of California, Irvine, Department of Obstetrics and Gynecology. He is a Member of the International Society for the Study of Women’s Sexual Health (ISSWSH), The International Society for Sexual Medicine (ISSM) and a Certified Sexual Counselor by the American Association of Sexuality Educators, Counselors and Therapists (AASECT). He served as a member of the Standards Committee for the International Society for Sexual Medicine during their 2016 International Consensus Meeting.  

MedicalResearch.com:  What is the background for this technology and study? What are the main findings?

Response: Viveve Medical, Inc. is a women’s health and wellness company committed to advancing new solutions to improve women’s overall well-being and quality of life.  The internationally patented Viveve® technology and the GENEVEVE™ treatment, incorporates clinically-proven, cryogen-cooled monopolar radiofrequency (CMRF) energy to uniformly deliver non-ablative, deep penetrating volumetric heat into the submucosal layer of the vaginal introitus (opening) while gently cooling surface tissue to generate robust neocollagenesis.  One 30-minute in-office session tightens and restores the tissue around the vaginal introitus addressing the common medical condition of vaginal laxity and can improve a woman’s sexual function.

VIVEVE I is a landmark study.  Results of the VIVEVE I clinical study, “Effect of Single-Treatment, Surface-Cooled Radiofrequency Therapy on Vaginal Laxity and Female Sexual Function: The VIVEVE I Randomized Controlled Trial,” were recently published in the February 2017 issue of the Journal of Sexual Medicine (JSM) under the Female Sexual Function category.   Some of my high-level thoughts to reiterate from this study are:

It is the first-ever large, randomized, sham-controlled study to demonstrate the safety and efficacy of energy-based procedures in gynecological applications, including vaginal laxity, which is a significant medical condition affecting millions of women worldwide that may lead to a reduction in sexual function.

The primary endpoint of the VIVEVE I study was a comparison of the proportion of women reporting no vaginal laxity in the treatment group versus the sham group at 6 months post-treatment.

Subjects receiving the active treatment were three times more likely to report no vaginal laxity at six months versus the sham group (p-value = 0.006).

Statistically significant and sustained improvement in sexual function (baseline FSFI total score ≤26.5) after a single treatment, with an adjusted mean difference in the active group vs sham group of 3.2 at 6 months (p-value = 0.009). “Placebo Effect” in the sham group did not rise above dysfunctional (FSFI ≤26.5) and diminished at 6 months.

Statistically significant improvement in sexual function was achieved in 93% of subjects in the active group vs the sham group in two individual key domains of FSFI (p-value = 0.007).

Bottom line: Geneveve is a safe effective treatment that can be performed as an outpatient in one 30-minute visit to improve sexual function as it has been affected by vaginal laxity.

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About 1 in 189 US Americans Identify as Transgender

MedicalResearch.com Interview with:

Halley Crissman, MD, MPH University of Michigan Resident Physician Department of Obstetrics and Gynecology University of Michigan Ann Arbor, Michigan

Dr. Halley Crissman

Halley Crissman, MD, MPH
University of Michigan
Resident Physician
Department of Obstetrics and Gynecology
University of Michigan
Ann Arbor, Michigan

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: There has been very little data on the epidemiology of the transgender population in the U.S., including basic information regarding the proportion of adults that identify as transgender. Transgender is an identity term for individuals whose gender expression and gender identity does not align with culture expectations and gender norms associated with sex assigned at birth.

Our study used data from the Centers for Disease Control and Prevention 2014 Behavioral Risk Factor Surveillance System to estimate the demographic characteristics of the U.S. adult transgender population compared to the non-transgender population. We found that 0.53% of U.S. adults identified as transgender. Transgender individuals were more likely to be non-white and below the poverty line, were less likely to attend college, and were as likely to be married, living in a rural area, and employed, compared to non-transgender individuals.

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Bright Light Therapy Might Reduce Sexual Dysfunction in Men

MedicalResearch.com Interview with:

Professor Andrea Fagiolini, MD University of Siena Italy

Prof. Andrea Fagiolini

Professor Andrea Fagiolini, MD
University of Siena
Italy

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: We have tested sexual and physiological responses to bright light and found that regular, early-morning, use of a light box – the same that we used to treat Seasonal Affective Disorder – led both to increased testosterone levels and greater reported levels of sexual satisfaction in man with difficulty with sexual desire or with sexual arousal.

We recruited 38 men who had been attending the Urology Department of the University of Siena and had a diagnosis of hypoactive sexual desire disorder or sexual arousal disorder – both conditions which are characterised by a lack of interest in sex. The 38 subjects were then divided the men into two groups. One group received regular treatment with a light box whereas the control (placebo) group was treated via a light box which had been adapted to give out significantly less light. Both groups were treated early in the morning, with treatment lasting half an hour per day. After two weeks of treatment or placebo, we found fairly significant differences between those who received the active light treatment and the controls.

Before treatment, both groups averaged a sexual satisfaction score of around 2 out of 10, but after treatment the group exposed to the bright light was scoring sexual satisfaction scores of around 6.3 – a more than 3-fold increase on the scale we used. In contrast, the control group only showed an average score of around 2.7 after treatment. Also, we found that testosterone levels increased in men who had been given active light treatment. The average testosterone levels in the control group showed no significant change over the course of the treatment – it was around 2.3 ng/ml at both the beginning and the end of the experiment. However, the group given active treatment showed an increase from around 2.1 ng/ml to 3.6 ng/ml after two weeks.

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