NYU/NYMC

03 Sep

Posted at 16:58h in Author Interviews, Dermatology, Genetic Research, Hair Care, NYU/NYMC

MedicalResearch.com Interview with:

Lynn Petukhova, PhD

Assistant Professor, Ronald O. Perelman Department of Dermatology

Assistant Professor, Department of Population Health

NYU Grossman School of Medicine

NYU Langone Health

[caption id="attachment_75860" align="alignleft" width="150"] Dr. Petukhova[/caption]

MedicalResearch.com: What is the background for this study? What are the main findings?

Dr. Petukhova: As GLP-1 receptor agonists such as Ozempic and Wegovy are increasingly used for type 2 diabetes and weight loss, questions have emerged about whether these medications may be linked to hair loss. Some cases may reflect telogen effluvium, a temporary shedding that can occur after rapid weight loss or major metabolic stress. However, recent observational studies have suggested there may also be a link with androgenetic alopecia, or patterned hair loss, in some individuals. According to the National Institute of Diabetes and Digestive and Kidney Diseases, GLP-1 receptor agonists are among the most prescribed medication classes for type 2 diabetes and obesity management, making the safety and side effect profile of these drugs a growing area of clinical research. Watch the interview in Video format

25 Feb

Posted at 19:14h in Author Interviews, Infections, Nature, NYU/NYMC
[caption id="attachment_72626" align="aligncenter" width="500"]C. auris- CDC image.jpg Candida auris CDC Image[/caption] MedicalResearch.com Interview with: [caption id="attachment_72627" align="alignleft" width="200"]Vishnu Chaturvedi, Ph.D.Professor of Pathology, Microbiology, and Immunology and of Medicine New York Medical College Vishnu Chaturvedi, Ph.D.[/caption] Vishnu Chaturvedi, Ph.D. Professor of Pathology, Microbiology, and Immunology and of Medicine New York Medical College MedicalResearch.com: What is the background for this study? Response: The research was prompted by the rise of Candida auris (C. auris) as a critical fungal pathogen that has caused global outbreaks in healthcare facilities with high mortality rates. C. auris is particularly difficult to control because it can survive on physical surfaces for extended periods. Current diagnostic methods (such as culture-based approaches or mass spectrometry) are often costly, slow, and require complex equipment in centralized laboratories, which delays effective clinical responses. There is an urgent need for rapid tests that can both identify the fungus and measure its level of drug resistance.

20 Feb

Posted at 00:17h in Author Interviews, Melanoma, NYU/NYMC
[caption id="attachment_72519" align="alignleft" width="200"]Pietro Berico, M.Sc., Ph.D.Postdoctoral research fellow Hernando Lab NYU Grossman School of Medicine NYU Langone Health New York, NY 10016 Dr. Berico[/caption] MedicalResearch.com Interview with: Pietro Berico, M.Sc., Ph.D. Postdoctoral research fellow Hernando Lab NYU Grossman School of Medicine NYU Langone Health New York, NY 1001 MedicalResearch.com: What is the background for this study? Response: “Cutaneous melanoma arises under chronic UV irradiation, which selects for aggressive malignant clones. Paradoxically, its high mutational burden also promotes neoantigen formation and robust immune activation. Consequently, melanoma must establish immune evasion mechanisms from the earliest stages of tumor development. The lack of specific genetic mutational patterns linked to immune escape points toward non-mutational mechanisms, such as epigenetic reprogramming.

20 Oct

Posted at 15:54h in Author Interviews, Diabetes, Kidney Disease, NYU/NYMC, Weight Research
MedicalResearch.com Interview with: [caption id="attachment_71025" align="alignleft" width="225"]Michael A. Weintraub, MDClinical Assistant Professor Department of Medicine NYU Grossman School of Medicine Dr. Weintraub[/caption] Michael A. Weintraub, MD Clinical Assistant Professor Department of Medicine NYU Grossman School of Medicine MedicalResearch.com: What is the background for this study? Response: The study addresses a critical knowledge gap in diabetes management for dialysis patients. Of the 808,000 people on dialysis in the United States, approximately 60% have diabetes and would be eligible for GLP-1 receptor agonists (GLP-1 RAs). However, these medications have not been well-studied in this population because dialysis dependence is frequently an exclusion criterion in clinical trials.

13 Oct

Posted at 13:41h in Author Interviews, Cancer Research, Dental Research, JAMA, Microbiome, NYU/NYMC, Pancreatic
[caption id="attachment_70956" align="alignleft" width="125"]Jiyoung Ahn, PhDProfessor of Population Health, NYU Grossman School of Medicine Associate Director for Population Science, NYU Perlmutter Cancer Center  NYU Langone Health New York, NY 10016 Dr. Jiyoung Ahn[/caption] MedicalResearch.com Interview with: Jiyoung Ahn, PhD Professor of Population Health, NYU Grossman School of Medicine Associate Director for Population Science, NYU Perlmutter Cancer Center NYU Langone Health New York, NY 10016 MedicalResearch.com: What is the background for this study? Response: About 10 years ago. we reported that people with poor oral health seem to have a greater risk of pancreatic cancer development.  We suspected that this could be due to oral microbiota.  More recently, animal studies, by other groups, showed that bacteria from the mouth can actually travel through saliva into the pancreas. But we didn’t know which exact species of bacteria or fungi might be involved in pancreas cancer development. We therefore conducted this large human study to examine the oral microbiome — including whole bacteria and fungi profiles in the mouth, and to see which bacteria and fungal taxa are associated with subsequent risk of pancreatic cancer development.

23 Jul

Posted at 15:57h in Author Interviews, Environmental Risks, NYU/NYMC
MedicalResearch.com Interview with: [caption id="attachment_69606" align="alignleft" width="225"]Dr. George D. Thurston ScD Professor of Medicine and Population Health Director of the Program in Exposure Assessment and Human Health Effects NYU Grossman School of Medicine Division of Environmental Medicine NYC, NY 10010   Prof. Thurston[/caption] Dr. George D. Thurston Professor of Medicine and Population Health NYU Grossman School of Medicine Division of Environmental Medicine NYC, NY 10010   USA MedicalResearch.com: What is the background for this study? What were some of the chemicals released by the coal-coking plant? Response: Pittsburgh has a long history as the nation's principal source of bituminous coal production and home to iron and coke industries since the late 19th century, and is also known as one of the cities with the highest levels of air pollution and most air-pollution related deaths in the US, to date. The Shenango, Inc Coke Plant was one of the significant industrial emission sources in the area before its closure in January 2016. Coal-coking plants like the Shenango plant utilizes a destructive heated distillation process called pyrolysis to volatilize and drive the impurities out of coal and produce coke, a purer product with higher carbon content for use in iron and steel production. From this process, coke plant operations are known to generate high emissions of complex air pollution mixtures into the ambient air, including particulate matter (PM), sulfur dioxide (SO2), nitrogen oxides (NOx), polycyclic organic matter (POMs), volatile compounds (VOCs), and volatilized trace metals such as arsenic, nickel, selenium, lead, and cobalt. Our study examines the changes in respiratory health in the community residing near the Shenango Coke Plant before vs. after its closure,  providing a direct quantification of the health benefits of such fossil-fuel-related air pollution reductions. 

27 Jun

Posted at 03:14h in Author Interviews, Cancer Research, Chemotherapy, Melanoma, NYU/NYMC
MedicalResearch.com Interview with: [caption id="attachment_69251" align="alignleft" width="156"]Tomas Kirchhoff, PhD (corresponding author)Associate ProfessorLaura and Isaac Perlmutter Cancer Center New York University School of Medicine Dr. Kirchhoff[/caption] Tomas Kirchhoff, PhD (corresponding author) Associate ProfessorLaura and Isaac Perlmutter Cancer Center New York University School of Medicine Robert Ferguson PhD Senior Scientist at NYU Langone Medical Center Kelsey Monson, PhD Immuno-Oncology Postdoctoral Researcher Icahn School of Medicine at Mount Sinai MedicalResearch.com: What is the background for this study? Would you briefly explain how mitochondrial DNA differs from chromosomal DNA? TK: Immune checkpoint blockade has changed the way we treat several cancers, including advanced melanoma. Before these therapies, the treatment options were very limited, but now more than half of patients experience significant tumor shrinkage or disease control. KRM: Despite these advances, many patients still do not respond to treatment. One of the main challenges in cancer medicine today is to find ways to predict which patients will benefit from these therapies before treatment begins. This approach is key to personalizing care and improving outcomes. RF: Mitochondria are small structures inside our cells that produce the energy needed for cells to function. Unlike most of our DNA, mitochondrial DNA is inherited only from the mother. Scientists can categorize this mitochondrial DNA into groups called haplogroups, based on unique variations in the genetic code. These haplogroups can provide insight into how cells produce energy and may affect a person’s health or response to cancer treatment.

01 Oct

Posted at 19:50h in Author Interviews, Cancer Research, JAMA, Microbiome, NYU/NYMC
MedicalResearch.com Interview with: [caption id="attachment_63665" align="alignleft" width="211"]Jiyoung Ahn, PhDProfessor of Population Health, NYU Grossman School of Medicine Associate Director for Population Science, NYU Perlmutter Cancer Center  NYU Langone Health Smilow Research Building New York, NY 10016 Prof. Ahn[/caption] Jiyoung Ahn, PhD Professor of Population Health, NYU Grossman School of Medicine Associate Director for Population Science, NYU Perlmutter Cancer Center NYU Langone Health Smilow Research Building New York, NY 10016 MedicalResearch.com: What is the background for this study? What are the main findings? Response: We found that oral bacterial species are linked to a collective 50% increased risk of developing head and neck squamous cell carcinoma (HNSCC). Some of these microbes have previously been shown to contribute to periodontal disease, a serious gum infection that can erode the jawbone and the soft tissues surrounding the teeth.

14 Mar

Posted at 18:42h in Author Interviews, COVID -19 Coronavirus, Infections, NYU/NYMC
MedicalResearch.com Interview with: [caption id="attachment_61434" align="alignleft" width="150"]Mukundan G. Attur, PhDAssociate Professor, Department of Medicine NYU Grossman School of Medicine Dr. Attur[/caption] Mukundan G. Attur, PhD Associate Professor, Department of Medicine NYU Grossman School of Medicine MedicalResearch.com: What is the background for this study? What are the main findings? Response:  The study investigates the potential protective effects of a genetic variant of IL1RN against inflammation and severe outcomes, particularly in COVID-19. Previous research indicates that carriers of this genetic variant may experience less severe radiographic knee osteoarthritis and decreased inflammation in rheumatoid arthritis patients. Given the emergence of cytokine release syndrome in COVID-19 patients, the researchers sought to understand whether the same genetic variant could offer protection against inflammation and potential death in COVID-19 cases.

09 Jan

Posted at 00:51h in Author Interviews, Neurological Disorders, NYU/NYMC, Pediatrics
MedicalResearch.com Interview with: [caption id="attachment_61231" align="alignleft" width="200"]Laura Gould, MSc, MA, PTResearch Scientist SUDC Registry and Research Collaborative Comprehensive Epilepsy Center Department of Neurology NYU Langone Grossman School of Medicine Laura Gould[/caption] Laura Gould, MSc, MA, PT Research Scientist SUDC Registry and Research Collaborative Comprehensive Epilepsy Center Department of Neurology NYU Langone Grossman School of Medicine     MedicalResearch.com: What is the background for this study? Response: Sudden Unexplained death in childhood (SUDC) is the unexplained death of a child on or after their 1st birthday that remains unexplained after a comprehensive death investigation. About 400 SUDC occur annually between the ages of 1-18, but more than half occur in toddlers, aged 1-4 years. Since most deaths are sleep related and unwitnessed with unremarkable autopsies, mechanisms of deaths have eluded our understanding. Febrile seizures are common in young children; ~ 3% of US children 6 months to 5 years will experience one. SUDC however has been associated with a 10-fold increase in febrile seizures; our study is the first to implicate them at time of death. The SUDC Registry and Research Collaborative (www.sudcrrc.org) at NYU Langone Health has enrolled over 300 cases of unexplained child death; seven with audiovisual recordings from the child’s bedroom during their last sleep period. More than 80% of the cases enrolled in the registry were children 1-4 years at the time of death. The seven cases with videos were aged 13-27 months with normal development and no pathogenic disease-causing variants by whole exome sequencing.

14 Dec

Posted at 19:19h in Author Interviews, Infections, NYU/NYMC
MedicalResearch.com Interview with: [caption id="attachment_61146" align="alignleft" width="150"]Angélica Cifuentes Kottkamp, MDAssistant Professor of Medicine NYU Grossman School of Medicine Associate Program Director Infectious Diseases & Immunology Fellowship Associate Director for Research & Diversity NYU Langone Vaccine Center & VTEU Attending Physician H+H Bellevue Virology Clinic Division of Infectious Diseases & Immunology NYU Grossman School of Medicine Dr. Angélica Cifuentes Kottkamp[/caption] Angélica Cifuentes Kottkamp, MD Assistant Professor of Medicine NYU Grossman School of Medicine Associate Program Director Infectious Diseases & Immunology Fellowship Associate Director for Research & Diversity NYU Langone Vaccine Center & VTEU Attending Physician H+H Bellevue Virology Clinic Division of Infectious Diseases & Immunology NYU Grossman School of Medicine MedicalResearch.com: What is the background for this study? How does the JYNNEOS vaccine differ from the smallpox vaccine? Response: JYNNEOS vaccine is a smallpox vaccine that was repurposed for Mpox given the similarities between the two viruses (smallpox and mpox). The vaccine (JYNNEOS) had been studied in people without HIV therefore there was a gap in knowledge in how this vaccine, especially the small dose (intradermal dose), would work in patients with HIV. These patients resulted to be the most affected by the mpox outbreak suffering the worse outcomes of the disease with the highest death rates.

27 Jun

Posted at 16:33h in Author Interviews, Depression, JAMA, Mental Health Research, NYU/NYMC, USPSTF
MedicalResearch.com Interview with: [caption id="attachment_56129" align="alignleft" width="133"]Gbenga Ogedegbe, MD, MPH Dr. Adolph & Margaret Berger Professor of Population Health Director, Division of Health & Behavior Director Center for Healthful Behavior Change Department of Population Health NYU Langone Health NYU School of Medicine Dr. Ogedegbe[/caption] Gbenga Ogedegbe, MD, MPH Dr. Adolph & Margaret Berger Professor of Population Health Director, Division of Health & Behavior Director Center for Healthful Behavior Change Department of Population Health NYU Langone Health NYU School of Medicine Member of the U.S. Preventive Services Task Force   MedicalResearch.com: What is the background for this study? Response: Depression and anxiety disorders are common mental health conditions affecting the lives of many adults in the U.S. The Task Force cares deeply about the health of people nationwide, so we reviewed the latest evidence on how best to support the mental health of adults in primary care. MedicalResearch.com: What are the main findings? Response:  The evidence shows us that all adults should be screened for depression and those under 65 should also be screened for anxiety. These recommendations apply to everyone without signs or symptoms of depression or anxiety. We also strongly encourage anyone who has signs of depression or anxiety to talk with their clinician so that they can get the care they need.

09 May

Posted at 16:51h in Author Interviews, Infections, JAMA, NYU/NYMC, USPSTF
MedicalResearch.com Interview with: [caption id="attachment_56129" align="alignleft" width="133"]Gbenga Ogedegbe, MD, MPH Dr. Adolph & Margaret Berger Professor of Population Health Director, Division of Health & Behavior Director Center for Healthful Behavior Change Department of Population Health NYU Langone Health NYU School of Medicine Dr. Ogedegbe[/caption] Gbenga Ogedegbe, MD, MPH Dr. Adolph & Margaret Berger Professor of Population Health Director, Division of Health & Behavior Director Center for Healthful Behavior Change Department of Population Health NYU Langone Health NYU School of Medicine Member of the U.S. Preventive Services Task Force MedicalResearch.com: What is the background for this study? Response: Tuberculosis (TB) is a bacterial infection that is spread through the air from one person to another and usually affects the lungs. It’s a significant public health concern in the U.S. People can be infected with TB bacteria but not have any symptoms or be contagious, which is known as a latent TB infection or LTBI. If LTBI is left untreated, it can progress to active TB, which can cause serious health problems and become contagious.

17 Mar

Posted at 15:09h in Author Interviews, Cancer Research, Nature, NYU/NYMC, Pancreatic
MedicalResearch.com Interview with: [caption id="attachment_60185" align="alignleft" width="161"]Aristotelis Tsirigos, Ph.D.Professor of Medicine and Pathology Co-director, Precision Medicine Director, Applied Bioinformatics Laboratories New York University School of Medicine Dr. Tsirigos[/caption] Aristotelis Tsirigos, Ph.D. Professor of Medicine and Pathology Co-director, Precision Medicine Director, Applied Bioinformatics LaboratoriesNew York University School of Medicine MedicalResearch.com: What is the background for this study? Response: Pancreatic cancer is one of the most lethal types of cancer with only 12% of patients surviving more than 5 years after diagnosis. One of the main reasons behind the dismal prognosis is the complexity of the tumor. Pancreatic cancer cells are very heterogenous and interact with different types of non-malignant cells in what is known as the tumor microenvironment.

14 Nov

Posted at 13:59h in Author Interviews, Cancer Research, Lung Cancer, NYU/NYMC
MedicalResearch.com Interview with: [caption id="attachment_59732" align="alignleft" width="150"]Dr. Sally Lau Dr. Sally Lau[/caption] Dr. Sally Lau MD Medical oncologist, NYU Langone’s Perlmutter Cancer Center Assistant professor of medicine NYU Grossman School of Medicine MedicalResearch.com: How big is the problem of lung cancer? Response: Amongst all cancer types, lung cancer is the number 1 killer in the US.

30 Sep

Posted at 18:46h in Author Interviews, JAMA, NYU/NYMC, STD, USPSTF
MedicalResearch.com Interview with: [caption id="attachment_56129" align="alignleft" width="133"]Gbenga Ogedegbe, MD, MPH Dr. Adolph & Margaret Berger Professor of Population Health Director, Division of Health & Behavior Director Center for Healthful Behavior Change Department of Population Health NYU Langone Health NYU School of Medicine Dr. Ogedegbe[/caption] Gbenga Ogedegbe, MD, MPH Dr. Adolph & Margaret Berger Professor of Population Health Director, Division of Health & Behavior Director Center for Healthful Behavior Change Department of Population Health NYU Langone Health NYU School of Medicine Member of the U.S. Preventive Services Task Force   MedicalResearch.com: What is the background for this study? Response: Syphilis has become more common over the past 20 years, after reaching a record low in 2000. The Task Force found that screening people who are at increased risk for syphilis can identify the infection early so it can be treated before problems develop. For that reason, the Task Force recommends screening people who are at increased risk for syphilis infection.

08 Jun

Posted at 13:49h in ASCO, Author Interviews, Cancer Research, COVID -19 Coronavirus, NYU/NYMC
MedicalResearch.com Interview with: Katherine Garcia MD NYU Langone Health MedicalResearch.com:  What is the background for this study?  Response: Studies on cancer patients during the COVID-19 pandemic have shown a decrease in new diagnoses, delays in care, and a shift to later stage disease presentations. Considering that NY has been an epicenter for COVID-19 in the U.S., we investigated its impact on new cancer diagnoses at the two campuses of NYU’s Perlmutter Cancer Center and hypothesized that there would be a decrease in presentations during the peak outbreaks in NY.

10 Mar

Posted at 01:07h in Author Interviews, Dental Research, NYU/NYMC, Tobacco, Tobacco Research
MedicalResearch.com Interview with: Scott Thomas, PhD Assistant Research Scientist, Department of Molecular Pathobiology and Fangxi Xu, Junior Research Scientist & Clinical Research Coordinator Department of Molecular Pathobiology NYU College of Dentistry  MedicalResearch.com:  What is the background for this study?  What are the main findings?  vaping-e-cig-smoking-tobaccoResponse: Cigarette smoking is one of the well-established causes of periodontitis, but the effect of using electronic cigarettes (e-cig), especially its long-term impact on periodontal health, is not yet clearly understood. Considering the increased popularity of e-cig use, especially among teenagers and young adults, and the known effect of high nicotine concentration in e-cigarette products, we conducted this clinical research to see if there were differences in periodontal health between e-cig users, traditional smokers, and nonsmokers. The study consisted of two visits, 6 months apart, where measures of oral and periodontal health were obtained. Our data showed significantly greater clinical attachment loss in the e-cigarette users and cigarette smokers than in the non-smokers at both study visits. In only e-cigarette users, we observed an over 0.2 mm average increase in the clinical attachment loss after 6 months. 

03 Feb

Posted at 18:32h in Author Interviews, COVID -19 Coronavirus, JAMA, NYU/NYMC
MedicalResearch.com Interview with: [caption id="attachment_58722" align="alignleft" width="150"]Andrea B. Troxel, ScD (she/her/hers) Professor and Director, Division of Biostatistics Department of Population Health NYU Grossman School of Medicine NYU Langone Health Dr. Troxel[/caption] Andrea B. Troxel, ScD (she/her/hers) Professor and Director, Division of Biostatistics Department of Population Health NYU Grossman School of Medicine NYU Langone Health MedicalResearch.com:  What is the background for this study?  What are the main findings? Response: This study represents an international collaboration across four continents and six countries, to pool information from studies in different patient populations to generate robust information about the possible benefits of convalescent plasma in treating COVID-19. Because the study was so large and the methods so rigorous, we were able to show that while CP doesn’t benefit all patients, it may have positive effects in certain subgroups.

02 Feb

Posted at 18:51h in Author Interviews, Heart Disease, JAMA, NYU/NYMC, USPSTF
MedicalResearch.com Interview with: [caption id="attachment_56129" align="alignleft" width="133"]Gbenga Ogedegbe, MD, MPH Dr. Adolph & Margaret Berger Professor of Population Health Director, Division of Health & Behavior Director Center for Healthful Behavior Change Department of Population Health NYU Langone Health NYU School of Medicine Dr. Ogedegbe[/caption] Gbenga Ogedegbe, MD, MPH Dr. Adolph & Margaret Berger Professor of Population Health Director, Division of Health & Behavior Director Center for Healthful Behavior Change Department of Population Health NYU Langone Health NYU School of Medicine Member of the U.S. Preventive Services Task Force MedicalResearch.com:  What is the background for this study?  What are the main findings?  Response: Atrial Fibrillation (AFib) is the most common type of irregular heartbeat and a major risk factor for stroke, and it often goes undetected. For this recommendation, the Task Force evaluated whether screening adults over the age of 50 who do not have any signs or symptoms of AFib can help prevent strokes. In its evidence review, Task Force expanded its scope to include a search for studies on portable and wearable devices such as smartphones and fitness trackers in addition to electrocardiography (ECG). Despite this consideration, the Task Force found insufficient evidence to recommend for or against screening for AFib. This is consistent with the Task Force’s 2018 recommendation.

23 Jan

Posted at 22:07h in Aging, Author Interviews, Dental Research, Geriatrics, NYU/NYMC
MedicalResearch.com Interview with: [caption id="attachment_58688" align="alignleft" width="200"]Bei Wu, PhD Dean's Professor in Global Health Vice Dean for Research Rory Meyers College of Nursing Affiliated Professor, College of Dentistry Co-Director, NYU Aging Incubator New York University New York, NY 10010 Dr. Bei Wu[/caption] Bei Wu, PhD Dean's Professor in Global Health Vice Dean for Research Rory Meyers College of Nursing Affiliated Professor, College of Dentistry Co-Director, NYU Aging Incubator New York University New York, NY 10010 MedicalResearch.com:  What is the background for this study?    Response: Social isolation and loneliness are global public health concerns. Social isolation is the lack of social contacts and having few people to have regular interactions; while loneliness is the distressing feeling of being alone or separated. Approximately 24% of community-dwelling older adults aged 65 and above are considered to be socially isolated in the United States, and 43% adults aged over 60 years old report feeling lonely. Increasing evidence suggests that social isolation and loneliness are risk factors for older adults’ health outcomes, such as depression, comorbidities, cognitive impairment and dementia, and premature mortality. However, one key limitation in the literature is that only a few studies have examined the impact of social isolation and loneliness on oral health.

17 May

Posted at 22:18h in Author Interviews, Dermatology, Heart Disease, JACC, NYU/NYMC
MedicalResearch.com Interview with: [caption id="attachment_57322" align="alignleft" width="200"]Michael S. Garshick, MD Assistant Professor Department of Medicine Grossman School of Medicine NYU Dr. Garshick[/caption] Michael S. Garshick, MD Assistant Professor Department of Medicine Grossman School of Medicine NYU MedicalResearch.com: What is the background for this study? Response: Patients with psoriasis have a 50% higher risk of cardiovascular disease when compared to patients without psoriasis, the mechanisms of which are still under investigation Dyslipidemia is also highly prevalent in psoriasis including elevation in a variety of lipoproteins causal in atherosclerosis. Lipoprotein(a) is an LDL like particle which is associated with atherosclerosis, atherothrombosis, and the development of clinical cardiovascular disease. Traditionally lipoprotein(a) is felt to be inherited rather than acquired, but some evidence suggest that lipoprotein(a) is elevated in those with underlying inflammatory conditions and associated with systemic inflammation including circulating IL-6. We therefore aimed to determine if lipoprotein(a) is elevated in psoriasis and associated with underlying systemic inflammatory profiles and biomarkers of cardiovascular risk. 

11 May

Posted at 10:32h in Author Interviews, Gender Differences, Heart Disease, NYU/NYMC, Women's Heart Health
MedicalResearch.com Interview with: [caption id="attachment_57403" align="alignleft" width="150"]Darcy Banco, MD, MPH Internal Medicine Resident NYU Langone Health Dr. Banco[/caption] Darcy Banco, MD, MPH Internal Medicine Resident NYU Langone Health MedicalResearch.com: What is the background for this study? Response: We became interested in this question because of recent epidemiological data showing that despite improvements in the number of heart attacks in overall population, that number is rising among young adults (<= 55 years old) and in particular, young women. Compared to young men, young women with heart attack experience more delays in care and have higher mortality and poorer quality of life after heart attack. Despite these findings, there was also a study that asked young adults who had experienced heart attack: “When you first went for help, did the health care providers think that you were having a problem with your heart?” Women were more likely to answer no to this question. Therefore, our study asked: Are young women evaluated and treated differently than men when presenting to the emergency room with symptoms of chest pain?

15 Apr

Posted at 13:54h in Author Interviews, Dental Research, Mental Health Research, NYU/NYMC
MedicalResearch.com Interview with: [caption id="attachment_57140" align="alignleft" width="176"]ANGELA R. KAMER, DMD, MS, PhD Associate Professor Periodontology and Implant Dentistry NYU Dentistry Dr. Kamer[/caption] ANGELA R. KAMER, DMD, MS, PhD Associate Professor Periodontology and Implant Dentistry NYU Dentistry MedicalResearch.com: What is the background for this study? Response: The accumulation of amyloid β plaques and neurofibrillary pathology in the brain are pathognomonic to Alzheimer's disease (AD). Brain amyloid deposition begins decades before cognitive dysfunction and is thought to be the first AD pathological feature followed by tau tangle accumulations and other pathologies. The mechanisms by which brain amyloid develops are incompletely understood although inflammation and bacterial imbalances (known as dysbiosis) of the gut and oral cavity may be involved. Periodontal disease affecting more than 50% of elderly is an inflammatory, chronic condition characterized by periodontal tissue destruction and bacterial imbalances. Using PET studies, we showed previously that measures of periodontal destruction were associated with brain amyloid retention in the brain [1]. In this study, we sought to investigate whether subgingival (under the gum line) bacteria associated with Alzheimer’s disease specific pathology, namely amyloidosis and tauopathy.

11 Feb

Posted at 16:53h in Author Interviews, Environmental Risks, NYU/NYMC
MedicalResearch.com Interview with: [caption id="attachment_56638" align="alignleft" width="200"] Dr. Gordon[/caption] Terry Gordon PhD Professor, Department of Environmental Medicine NYU Grossman School of Medicine NYU Langone Health  MedicalResearch.com: What is the background for this study? Response: We are air pollution researcher and interested in unique exposure scenarios.  Based on the work by Dr. Steve Chillrud, Columbia University, we did a study 5 years ago to assess air quality in over 30 subway stations in NYC.  We found poor air quality in all of the underground stations but the air quality was better in some locations.  So we wondered what would be air quality in different transit systems in NE United States.  David Luglio, pre-doctoral candidate, led a team of students to monitor particles in the air of subway stations in metropolitan NYC's MTA, LIRR, and PATH systems, Boston, Philadelphia, and Washington, DC.  

21 Jan

Posted at 16:51h in Author Interviews, NYU/NYMC, Race/Ethnic Diversity, Rheumatology
MedicalResearch.com Interview with: [caption id="attachment_56448" align="alignleft" width="200"]Peter Izmirly, M.D. Associate Professor of Medicine, NYU School of Medicine  Director of Inpatient Rheumatology, Bellevue Hospital Center co-Director, NYU-Hospital for Joint Diseases Lupus Clinic Research Office Address: NYU School of Medicine  New York, NY 10016 Dr. Izmirly[/caption] Peter Izmirly, M.D. Associate Professor of Medicine, NYU School of Medicine Director of Inpatient Rheumatology, Bellevue Hospital Center co-Director, NYU-Hospital for Joint Diseases Lupus Clinic Research Office Address: NYU School of Medicine New York, NY 10016  MedicalResearch.com: What is the background for this study? What are the main findings? Response: Knowing how many people have systemic lupus erythematosus (SLE) is limited, particularly for racial/ethnic subgroups in the United States. Our work provides accurate estimates of who has  (SLE) among the major racial/ethnic groups in the United States and that our estimates for SLE approach the FDA’s definition or a rare disease.

19 Dec

Posted at 22:31h in Author Interviews, COVID -19 Coronavirus, Genetic Research, NYU/NYMC
MedicalResearch.com Interview with: [caption id="attachment_56272" align="alignleft" width="200"]John T. Poirier, PhD Assistant Professor of Medicine, NYU Grossman School of Medicine Director, Preclinical Therapeutics Program Perlmutter Cancer Center An NCI-designated Comprehensive Cancer Center NYU Langone Health Smilow Research Center New York, NY 10016  Dr. Poirier[/caption] John T. Poirier, PhD Assistant Professor of Medicine, NYU Grossman School of Medicine Director, Preclinical Therapeutics Program Perlmutter Cancer Center An NCI-designated Comprehensive Cancer Center NYU Langone Health Smilow Research Center New York, NY 10016  MedicalResearch.com: What is the background for this study? Response: The goal of this study was to identify in as much detail as possible the genes that SARS-CoV-2, the virus that causes COVID-19, needs to successfully infect a human host cell. CRISPR technology played a key role in this research; it was used to disrupt every gene in the human genome in parallel and study which ones were required for infection.

04 Dec

Posted at 17:40h in Author Interviews, COVID -19 Coronavirus, Infections, JAMA, NYU/NYMC, Race/Ethnic Diversity
MedicalResearch.com Interview with: [caption id="attachment_56129" align="alignleft" width="133"]Gbenga Ogedegbe, MD, MPH Dr. Adolph & Margaret Berger Professor of Population Health Director, Division of Health & Behavior Director Center for Healthful Behavior Change Department of Population Health NYU Langone Health NYU School of Medicine Dr. Ogedegbe[/caption] Gbenga Ogedegbe, MD, MPH Dr. Adolph & Margaret Berger Professor of Population Health Director, Division of Health & Behavior Director Center for Healthful Behavior Change Department of Population Health NYU Langone Health NYU School of Medicine MedicalResearch.com: What is the background for this study? Response: The background for the study is the disproportionately higher rates of COVID-19 hospitalizations and deaths in Blacks and Hispanics compared to Whites in major cities across the country. We asked two questions: 1) are there racial/ethnic differences in COVID-19 outcomes (likelihood of testing positive, hospitalizations, severe illness, and deaths) among patients who receive care at NYU Langone Health? If there are differences, are they explained by comorbidity and neighborhood characteristics (poverty, educational status, employment, housing, proportion of Blacks and Hispanics in communities)?

26 Oct

Posted at 23:16h in Author Interviews, Nutrition, NYU/NYMC, Pediatrics, Pediatrics, Technology
MedicalResearch.com Interview with: [caption id="attachment_55746" align="alignleft" width="200"]Marie Bragg, PhD Assistant Professor, Department of Population Health on Health Choice NYU College of Global Public Health Dr. Bragg[/caption] Marie Bragg, PhD Assistant Professor, Department of Population Health on Health Choice NYU College of Global Public Health MedicalResearch.com: What is the background for this study? Response: We know from previous research that children who see food advertisements eat significantly more calories than children who see non-food advertisements. Those studies led the World Health Organization and National Academy of Medicine to issue reports declaring that exposure to food advertising is a major driver of childhood obesity. What we don’t know is how frequently unhealthy food and beverage brands are appearing in YouTube videos posted by Kid Influencers. Kid influences are children whose parents film videos of the child playing with toys, unwrapping presents, eating food, or engaging in other family-friendly activities. The parents then post the videos to YouTube for other children and parents to view for entertainment. 

16 Sep

Posted at 19:56h in AHA Journals, Author Interviews, Blood Pressure - Hypertension, NYU/NYMC, Race/Ethnic Diversity
MedicalResearch.com Interview with: [caption id="attachment_55410" align="alignleft" width="340"]Aisha T. Langford, PhD, MPH Assistant Professor  Department of Population Health Co-Director, CTSI Recruitment and Retention Core  NYU Grossman School of Medicine NYU Langone Health New York, NY 10016 Dr. Langford[/caption] Aisha T. Langford, PhD, MPH Assistant Professor Department of Population Health Co-Director, CTSI Recruitment and Retention Core NYU Grossman School of Medicine NYU Langone Health New York, NY 10016 MedicalResearch.com: What is the background for this study? Response: In 2018, the American Heart Association (AHA) published an updated Scientific Statement on Resistant Hypertension. The term apparent treatment-resistant hypertension (aTRH) is used when pseudoresistance (e.g., white coat effect, medication nonadherence) cannot be excluded. The current study was designed to investigate if Black adults with aTRH, a group disproportionately affected by cardiovascular disease, receive evidence-based approaches to lower blood pressure as recommended in the 2018 AHA Scientific Statement. Specifically, we studied healthy lifestyle factors including not smoking, not consuming alcohol, ≥75 minutes of vigorous-intensity or ≥150 minutes of moderate or vigorous physical activity per week, and body mass index <25 kg/m2; and recommended antihypertensive medication classes among US Black adults.