10 Aug Frequent cannabis users show higher cortisol levels at awakening compared to controls
Cannabis and CBD Product Notice: Cannabis and CBD products are not FDA-monitored or approved for the treatment of anxiety, depression, or any other mental health condition and are not legal in all locations. Effects vary significantly between individuals. Do not use if you are pregnant, nursing, or may become pregnant. Keep out of reach of children. Children and pets should not be exposed to these products. Cannabis and CBD products may interact with alcohol and other drugs including prescription medications. Always consult your physician or qualified healthcare provider before using any cannabinoid product, especially if you have an existing health condition or take other medications.
MedicalResearch.com Interview with:
Anita Cservenka, PhD
Associate Professor; Director, Substance Use & Neurocognition Lab
School of Psychological Science, Oregon State University, Corvallis, OR
Dr. Cservenka, PhD[/caption]
MedicalResearch.com: What is the background for this study? What are the main findings?
Dr. Cservenka: There had been limited research on whether frequent cannabis use is associated with changes in individuals' diurnal stress activity, which can be measured by examining the cortisol awakening response. However, some previous studies had shown that the typical rise of cortisol in the morning, which is thought to be a marker of our body's preparation for managing the stressors of the day, may be blunted among individuals with alcohol use disorder. A recent study by Glodosky et al., 2026, also suggested this may be the case among those with chronic cannabis use, so we attempted to replicate those findings. Although we did not find group differences in the cortisol awakening response (the difference in cortisol 30 minutes post-awakening and at the time of awakening) between individuals who engaged in frequent cannabis use relative to controls, we did find that cannabis use may be related to higher levels of cortisol at the time of awakening and this was significantly related to cannabis use consequences.
The ResMed AirSense™ 10 AutoSet™ Tri-Pack is an essential package designed for individuals with sleep apnea who require consistent and effective therapy. This article delves into the key features benefits and frequently asked questions surrounding the ResMed AirSense™ 10 AutoSet™ Tri-Pack offering a guide to help you understand its significance in sleep apnea treatment.
What is the ResMed AirSense™ 10 AutoSet™ Tri-Pack?
The
Dr. Oliva[/caption]
Azahara Oliva PhD
Assistant Professor
Department of Neurobiology and Behavior
Cornell University
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: The background is that we knew for a while now that neurons work hard to consolidate into memories each experience that we have during the day. But at the same time, it is known that sleep restore activity of our body and physiology. How was that possible? How can the neurons in our brain "work hard" during the time that we are supposed to be restoring our vitals? We found that in between their hard work, during sleep, our neurons take "breaks of activity" so our brain can build memories with precision.
Dr. Avinesh Bhar[/caption]
Dr. Parekh[/caption]
Ankit Parekh, PhD
Director of the Sleep And Circadian Analysis (SCAN) Group
Assistant Professor of Medicine
(Pulmonary, Critical Care and Sleep Medicine)
Icahn School of Medicine at Mount Sinai
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Sleep apnea is associated with incident cardiovascular disease, and is a common chronic condition affecting over a billion people worldwide. In diagnosing and treating sleep apnea, it is imperative to establish the type of sleep apnea—whether it is obstructive or central sleep apnea. The differential contribution of central vs. obstructive sleep apnea toward incidental cardiovascular disease in those with significant sleep apnea has not been well studied.
Our group has developed an automated algorithm that deduces on a breath-by-breath level whether reductions in airflow are predominantly due to obstructive or central phenomena. Our algorithm uses several features that are known to be key in distinguishing the type of events and derives a probability of obstruction across each “small” (reduced amplitude) breath. The breath-by-breath probability is then used to determine whether a patient’s burden of sleep apnea is predominantly obstructive or central.
In this work, we analyzed sleep study data from The Osteoporotic Fractures in Men (MrOS) cohort (N=2793) consisting of elderly men, across two visits separated on average by 6.5 years, and derived the probability of obstruction on a breath-by-breath level. The median probability of obstruction for each subject was computed and analyzed against outcomes of cardiovascular disease. We also assessed the stability of the metric in those without any prevalent cardiovascular disease. We find that median probability of obstruction was stable across the two visits, and those with any incident cardiovascular disease had a lower median probability of obstruction: patients with incident cardiovascular outcomes had a significant burden of sleep apnea that was predominantly “central” in nature.
Dr. Traverso[/caption]
Giovanni Traverso MD PhD
Karl Van Tassel (1925) Career Development Professor
Department of Mechanical Engineering
Koch Institute of Integrative Cancer Research
Division of Gastroenterology
Brigham and Women’s Hospital
Harvard Medical School, Boston, MA, USA
MedicalResearch.com: What is the background for this study?
Response: I think its always important to acknowledge that this is a big team effort. We have the teams from MIT, Celero Systems, West Virgnia University (WVU) and Brigham and Women’s Hospital (BWH) all working together on this. For this study, Celero prototyped the devices that we tested in pre-clinical (Swine) models and in a first-in-human study with the team at WVU.
Our lab focuses on the development of ingestible devices for drug delivery and sensing and these have informed the development of these efforts as you can see.