Blood Pressure - Hypertension, Mineral Metabolism, Salt-Sodium / 14.09.2013
Hypertension: Lower Chloride Levels Associated with Increased Mortality
MedicalResearch.com Interview with:
Dr Sandosh Padmanabhan
Institute of Cardiovascular and Medical Sciences
University of Glascow, Scotland
MedicalResearch.com: What are the main findings of the study?
Dr. Padmanabhan: In the study "Serum Chloride Is an Independent Predictor of Mortality in Hypertensive Patients" we analysed data on 12,968 patients with hypertension followed up at the Glasgow Blood Pressure Clinic. We found that patients in the lowest quintile of serum Cl− (<100 mmol/L), compared with all other patients, had a 23% higher mortality (all-cause, cardiovascular, and non-cardiovascular). Each 1-mmol/L increase in serum Cl− was associated with a 1.1% to 1.5% lower all-cause mortality, cardiovascular mortality and non-cardiovascular mortality. This was independent of serum concentrations of sodium, bicarbonate or potassium. We did not find any association with longitudinal blood pressure control.
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