Author Interviews, Breast Cancer, Nature / 10.11.2018
Estrogen Receptors More Versatile and Widespread Than Previously Recognized
MedicalResearch.com Interview with:
Prof. Cathrin Brisken MD, PhD
ISREC, School of Life Sciences
Ecole Polytechnique Fédérale (EPFL)
CH-1015 Lausanne, Switzerland
MedicalResearch.com: What is the background for this study?
Response: Estrogen receptor signaling has been well characterized in various in vitro models, like breast cancer cell lines. Understanding estrogen receptor action in complex in vivo context is much more challenging.
We obtained elegant mouse models in which either all estrogen receptor function or specifically either the hormone dependent (AF-2) or the hormone independent (AF-1) function were ablated. Using the mammary glands from these mice we performed tissue recombination studies to discern the role of the different aspects of estrogen receptor signaling in the mouse mammary epithelium and its different cell populations.
(more…)
Prof. Cathrin Brisken MD, PhD
ISREC, School of Life Sciences
Ecole Polytechnique Fédérale (EPFL)
CH-1015 Lausanne, Switzerland
MedicalResearch.com: What is the background for this study?
Response: Estrogen receptor signaling has been well characterized in various in vitro models, like breast cancer cell lines. Understanding estrogen receptor action in complex in vivo context is much more challenging.
We obtained elegant mouse models in which either all estrogen receptor function or specifically either the hormone dependent (AF-2) or the hormone independent (AF-1) function were ablated. Using the mammary glands from these mice we performed tissue recombination studies to discern the role of the different aspects of estrogen receptor signaling in the mouse mammary epithelium and its different cell populations.
(more…)